Shinji Masui

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. pmc An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology Minatojima minamimachi 2 2 3, Kobe, Japan
    Nucleic Acids Res 33:e43. 2005
  2. ncbi request reprint Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, Minatojima minamimachi 2 2 3, Chu o ku, Kobe, Hyogo 650 0047, Japan
    Nat Cell Biol 9:625-35. 2007
  3. pmc Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minamimachi, Kobe, Hyogo 650 0047, Japan
    BMC Dev Biol 8:45. 2008
  4. pmc Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells
    Yuhki Nakatake
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, Minatojima minamimachi 2 2 3, Chu o ku, Kobe 650 0047, Japan
    Mol Cell Biol 26:7772-82. 2006
  5. pmc Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells
    Hitoshi Niwa
    Stem Cell Regulation Research, Area of Molecular Therapeutics, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita C, Osaka 565 0871, Japan
    Mol Cell Biol 22:1526-36. 2002
  6. pmc The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical School, Saitama 350 1241, Japan
    Mol Cell Biol 24:4207-20. 2004
  7. ncbi request reprint [Transcriptional network maintaining pluripotency of embryonic stem cells]
    Shinji Masui
    Tanpakushitsu Kakusan Koso 53:164-8. 2008
  8. pmc Differentiation of embryonic stem cells is induced by GATA factors
    Junji Fujikura
    Stem Cell Regulation Research, Area of Molecular Therapeutics, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Genes Dev 16:784-9. 2002
  9. pmc Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data
    Alexei A Sharov
    Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    BMC Genomics 9:269. 2008
  10. doi request reprint Consequence of the loss of Sox2 in the developing brain of the mouse
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    FEBS Lett 582:2811-5. 2008

Collaborators

Detail Information

Publications10

  1. pmc An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology Minatojima minamimachi 2 2 3, Kobe, Japan
    Nucleic Acids Res 33:e43. 2005
    ..We believe that use of this system will strongly accelerate molecular biological research using ES cells...
  2. ncbi request reprint Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, Minatojima minamimachi 2 2 3, Chu o ku, Kobe, Hyogo 650 0047, Japan
    Nat Cell Biol 9:625-35. 2007
    ..These results indicate that the essential function of Sox2 is to stabilize ES cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression...
  3. pmc Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minamimachi, Kobe, Hyogo 650 0047, Japan
    BMC Dev Biol 8:45. 2008
    ..However, its function in pluripotent stem cells including embryonic stem (ES) cells remained unclear although its involvement in visceral endoderm differentiation in F9 embryonal carcinoma (EC) cells was reported...
  4. pmc Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells
    Yuhki Nakatake
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, Minatojima minamimachi 2 2 3, Chu o ku, Kobe 650 0047, Japan
    Mol Cell Biol 26:7772-82. 2006
    ..DNA microarray analysis revealed that a subset of putative Oct3/4 target genes may be regulated in the same manner. Our findings shed light on a novel function of Oct3/4 in ES cells...
  5. pmc Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells
    Hitoshi Niwa
    Stem Cell Regulation Research, Area of Molecular Therapeutics, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita C, Osaka 565 0871, Japan
    Mol Cell Biol 22:1526-36. 2002
    ..Interestingly, however, Oct-3/4 target gene expression elicited by the N- and C-terminal transactivation domains is not identical, indicating that at least one class of genes activated by Oct-3/4 is not required for ES cell propagation...
  6. pmc The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical School, Saitama 350 1241, Japan
    Mol Cell Biol 24:4207-20. 2004
    ..Thus, SRR2 is the first example of an enhancer in which a single regulatory core sequence is involved in multipotent-state-specific expression in two different stem cells, i.e., ES and neural stem cells...
  7. ncbi request reprint [Transcriptional network maintaining pluripotency of embryonic stem cells]
    Shinji Masui
    Tanpakushitsu Kakusan Koso 53:164-8. 2008
  8. pmc Differentiation of embryonic stem cells is induced by GATA factors
    Junji Fujikura
    Stem Cell Regulation Research, Area of Molecular Therapeutics, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Genes Dev 16:784-9. 2002
    ..We believe that this is the first report of a physiological differentiation event induced by the ectopic expression of a transcription factor in ES cells...
  9. pmc Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data
    Alexei A Sharov
    Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    BMC Genomics 9:269. 2008
    ..However, many responding genes with binding sites may not be direct targets because response may be mediated by other genes and ChIP-binding site may not be functional in terms of transcription regulation...
  10. doi request reprint Consequence of the loss of Sox2 in the developing brain of the mouse
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    FEBS Lett 582:2811-5. 2008
    ..We found that expression level of Sox3 is elevated in Sox2 null developing brain, probably mitigating the effects of loss of Sox2...