Research Topics
Genomes and Genes
| Tomohiro KurosakiSummaryAffiliation: RIKEN Brain Science Institute Country: Japan Publications
| Collaborators
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Detail Information
Publications
Paradox of B cell-targeted therapiesTomohiro Kurosaki
Laboratory of Lymphocyte Differentiation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan
J Clin Invest 118:3260-3. 2008....
Tyrosine kinases and their substrates in B lymphocytesTomohiro Kurosaki
Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
Immunol Rev 228:132-48. 2009....- B cell signaling and fate decisionTomohiro Kurosaki
WPI Immunology Frontier Research Center, Osaka University, Japan
Annu Rev Immunol 28:21-55. 2010..As a new type of post-transcriptional regulator, microRNAs have emerged to influence the development and function of B cells by affecting the expression of target mRNAs... - The study of B cells and antibodies in Japan: a historical perspectiveTomohiro Kurosaki
Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
Int Immunol 22:217-26. 2010..It also details the importance of the germinal center in generating B-cell memory and the terminal differentiation of B cells as antibody-secreting plasma cells... - Ca2+ signaling and STIM1Tomohiro Kurosaki
Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Japan
Prog Biophys Mol Biol 103:51-8. 2010..In this review, we summarize the mechanism by which STIM1 regulates SOCE, and also its role in the control of mast cell functions and allergic responses... - Unique properties of memory B cells of different isotypesTomohiro Kurosaki
Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
Immunol Rev 237:104-16. 2010..The IgM and IgG type memory B cells reside in distinct locations and appear to possess distinct origins and effector functions, together orchestrating humoral memory responses... - Regulation of BCR signalingTomohiro Kurosaki
Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
Mol Immunol 48:1287-91. 2011..In this review, I will briefly present our studies that have clarified the molecular components of signaling cascades, mainly focusing on data using DT40 B cells and their genetic variants... - Preferential localization of IgG memory B cells adjacent to contracted germinal centersYuichi Aiba
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
Proc Natl Acad Sci U S A 107:12192-7. 2010..These results implicate this peri-GC region as an important site for survival and reactivation of memory B cells... - CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathwayKohei Kometani
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Turumi ku, Kanagawa 230 0045, Japan
J Exp Med 208:1447-57. 2011..Together, our results suggest that CIN85 links the BCR to IKK-β activation, thereby contributing to T cell-independent immune responses... 
Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinaseYuichi Aiba
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Japan
Blood 111:1497-503. 2008..Together, our data suggest that BCAP and CD19 have complementary roles in BCR-mediated PI3K activation, thereby, at least in part, contributing to B-cell development...- ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiationTomoharu Yasuda
Laboratory for Lymphocyte Differentiation, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa 230 0045, Japan
Sci Signal 4:ra25. 2011..Thus, our study suggests that cytokines stimulate ERKs to induce the production of Blimp-1 and that ERKs thereby contribute to the process of cellular differentiation... - The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 productionMasanori Matsumoto
Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
Immunity 34:703-14. 2011..This resulted in exacerbation of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. Our data establish STIM-dependent SOC influx as a key signal for B cell regulatory function required to limit autoimmunity... - Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansionTomoharu Yasuda
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Immunity 28:499-508. 2008..Together, our results identify a crucial role for Erk kinases in regulating B cell development by initiating transcriptional regulatory network and thereby pre-BCR-mediated cell expansion... - IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cellsHisaaki Shinohara
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
J Exp Med 204:3285-93. 2007..The activated IKKbeta does not merely function as an effector enzyme but also modifies the upstream signaling complex through a feedback mechanism, thereby optimizing the strength and duration of the nuclear factor kappaB signal... - Surf4 modulates STIM1-dependent calcium entryYoko Fujii
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
Biochem Biophys Res Commun 422:615-20. 2012..Deletion of Surf4 in DT40 B cells resulted in marked increase of SOCE and facilitation of STIM1 clustering upon store-depletion. These findings suggest the modulatory function of Surf4 for STIM1-mediated SOCE... - BANK negatively regulates Akt activation and subsequent B cell responsesYuichi Aiba
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Immunity 24:259-68. 2006..Together, our findings suggest that BANK attenuates CD40-mediated Akt activation, thereby preventing hyperactive B cell responses... - PLC-gamma2 is essential for formation and maintenance of memory B cellsMasaki Hikida
Laboratory for Lymphocyte Differentiation, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa 230 0045, Japan
J Exp Med 206:681-9. 2009..Collectively, our data suggest that PLC-gamma2 conveys a survival signal to GC and memory B cells and that this signal is required for a productive secondary immune response... - Essential roles of mgcRacGAP in multilineage differentiation and survival of murine hematopoietic cellsTakayuki Yamada
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Suehiro cho 1 7 22, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Biochem Biophys Res Commun 372:941-6. 2008..Taken together, mgcRacGAP is now shown to play a indispensable role in the development of hematopoietic cells in vivo... - Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin GHideki Sanjo
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Mol Cell Biol 27:1236-46. 2007..Notably, this defect was countered by overexpression of the antiapoptotic factor Bcl-2. Together, our results suggest that ERK2 plays a key role in efficient generation of antigen-specific IgG-bearing B cells by promoting their survival... - Regulation of NF-kappaB-dependent T cell activation and development by MEKK3Hisaaki Shinohara
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
Int Immunol 21:393-401. 2009..Furthermore, T cell-specific deletion of MEKK3 resulted in reduced numbers of thymocytes and peripheral T cells. Thus, our results provide genetic evidence that MEKK3 plays a crucial role in adaptive immunity... - Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responsesYoshihiro Baba
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 1 7 22, Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Nat Immunol 9:81-8. 2008..Thus, STIM1 is key in promoting the Ca2+ influx that is essential for FcepsilonRI-mediated mast cell activation and anaphylaxis... - Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signalingHisaaki Shinohara
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
Immunol Rev 232:300-18. 2009..In this review, we focus on recent advances that illuminate the fine tuning mechanisms of NF-kappaB activation by BCR signaling and have increased our comprehension of complex signal systems... - Physiological function and molecular basis of STIM1-mediated calcium entry in immune cellsYoshihiro Baba
Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
Immunol Rev 231:174-88. 2009.... - [Regulation of B cell receptor signaling]Tomohiro Kurosaki
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan
Seikagaku 75:1505-15. 2003 - Impact of Ca2+ signaling on B cell functionYoshihiro Baba
Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
Trends Immunol 32:589-94. 2011..Here, we summarize the B cell signaling pathways that lead to SOCE, the role of Ca(2+) signals in B cell regulatory function, and how a breakdown in the balance of Ca(2+) signals is associated with immune-related disease... - FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signalingYuta Kochi
Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
J Immunol 183:5502-10. 2009..These results, together with previous genetic data, suggest that augmented inhibition of BCR-mediated signaling by FCRL3 with the disease-risk genotype alter the activation threshold and promote tolerance breakdown in B cells... - PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1Hisaaki Shinohara
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
J Exp Med 202:1423-31. 2005..Hence, our data suggest that phosphorylation of CARMA1, mediated by PKCbeta, brings two key protein kinases, TAK1 and IKK, into close proximity, thereby allowing TAK1 to phosphorylate IKK... - Regulation of lymphocyte fate by Ras/ERK signalsTomoharu Yasuda
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa, Japan
Cell Cycle 7:3634-40. 2008..Moreover, candidate immediate early genes that regulate lymphocyte proliferation and differentiation have emerged... - Essential immunoregulatory role for BCAP in B cell development and functionTetsuo Yamazaki
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Osaka, Japan
J Exp Med 195:535-45. 2002..These findings demonstrate that BCAP plays a pivotal immunoregulatory role in B cell development and humoral immune responses... - Retardation of the G2-M phase progression on gene disruption of RNA binding protein Sam68 in the DT40 cell lineQing Hua Li
Department of Microbiology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, 570 8506, Osaka, Japan
FEBS Lett 525:145-50. 2002..Our results indicate that Sam68 may play a critical role in G2-M progression in a manner independent of the control of Cyclin/Cdc2 kinase activity... - [Immunoregulatory role for BCAP in B cell development and function]Tetsuo Yamazaki
Tanpakushitsu Kakusan Koso 47:2242-7. 2002 - The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transductionKazuko Saeki
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
EMBO J 22:3015-26. 2003..These data suggest that Raftlin plays a pivotal role in the formation and/or maintenance of lipid rafts, therefore regulating BCR-mediated signaling... - Checks and balances on developing B cellsTomohiro Kurosaki
Nat Immunol 4:13-5. 2003 - Genetic analysis of B cell signalingHisaaki Shinohara
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa 230-0045
Subcell Biochem 40:145-87. 2006..Here, based upon the recent data, mainly obtained from the DT40 system, we discuss several new aspects on mechanisms by which BCR signals are propagated and modified... - BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteinsChristopher W Chiu
Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
EMBO J 21:6461-72. 2002..These data demonstrate the importance of coordinate phosphorylation of molecular scaffolds, and provide insights into how assembly of macromolecular complexes is required for normal receptor function... - Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagementKazunori Inabe
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
Blood 99:584-9. 2002..Thus, these results provide evidence that BCAP serves as an adaptor molecule for CD19 to activate the PI3K pathway in B cells... - Regulation of B-cell signal transduction by adaptor proteinsTomohiro Kurosaki
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Japan
Nat Rev Immunol 2:354-63. 2002..In addition, adaptor molecules participate in establishing negative- or positive-feedback regulatory loops in signalling networks, thereby fine-tuning the B-cell response... - Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cellsTomoharu Yasuda
Department of Oncology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
J Exp Med 196:51-63. 2002..These results demonstrate that Cbl-b positively regulates BCR-mediated Ca2+ signaling, most likely by influencing the Btk/BLNK/PLC-gamma2 complex formation... - Regulation of B cell fates by BCR signaling componentsTomohiro Kurosaki
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, and Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 570 8506, Moriguchi, Japan
Curr Opin Immunol 14:341-7. 2002..To establish the optimal signaling intensity and duration, the BCR utilizes positive and negative regulatory molecules. Studies are beginning to reveal how these molecules maintain immunological homeostasis and tolerance... - Bruton's tyrosine kinase regulates B cell antigen receptor-mediated JNK1 response through Rac1 and phospholipase C-gamma2 activationKazunori Inabe
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570-8506, Japan
FEBS Lett 514:260-2. 2002..Since PLC-gamma2 is also required for BCR-mediated JNK1 response, our results suggest that Btk regulates Rac1 pathway as well as PLC-gamma2 pathway, both of which contribute to the BCR-mediated JNK1 response... - Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytesYasuo Mori
Center for Integrative Bioscience, Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
J Exp Med 195:673-81. 2002.... - Developmental differences in B cell receptor-induced signal transductionDorottya Kovesdi
Department of Immunology, Lorand Eotvos University, H 1117 Pázmány Péter sétány 1 C, Budapest, Hungary
Cell Signal 14:563-72. 2002..Further results indicate that the cell lines representing the immature stage are more sensitive to BCR-, CD19- and type II receptors binding the Fc part of IgG (Fc gamma RIIb)-mediated signals than mature B cells... - The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survivalHiroaki Niiro
Department of Microbiology, University of Washington, Seattle, WA 98195, USA
J Exp Med 195:143-9. 2002..Furthermore, Bam32(-/-) cells were more susceptible to BCR-induced death. Taken together, these findings suggest that Bam32 functions to regulate BCR-induced signaling and cell survival most likely in germinal centers... - A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradationRika Ouchida
Laboratory for Immune Diversity, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama 230 0045, Japan
Immunity 29:33-43. 2008..These results identify a lysosomal protein important for CD3zeta degradation and illustrate a unique mechanism for the control of surface TCR expression and T cell activation... - Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNKSachiko Johmura
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan
Immunity 18:777-87. 2003..Hence, our findings suggest that Grb2 and BLNK cooperate to localize Vav into membrane rafts, thereby contributing to optimal activation of Vav in B cells... - Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigenMichele Weber
Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, England, UK
J Exp Med 205:853-68. 2008..Thus, we demonstrate the importance of cooperation between components of the microsignalosome in the amplification of signaling and propagation of B cell spreading, which is critical for appropriate B cell activation... - Regulation of cytokinesis by mgcRacGAP in B lymphocytes is independent of GAP activityTakayuki Yamada
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Fumizono cho 10 15, Moriguchi, Osaka 570 8506, Japan
Exp Cell Res 312:3517-25. 2006.... - Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genesKeiji Masuda
Laboratory for Antigen Receptor Diversity, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama 230 0045, Japan
DNA Repair (Amst) 5:1384-91. 2006.... - Phospholipase Cgamma2 dosage is critical for B cell development in the absence of adaptor protein BLNKShengli Xu
Laboratory of Immunology, Center for Molecular Medicine and Institute of Molecular and Cell Biology, Singapore
J Immunol 176:4690-8. 2006.... - Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytesMotohiro Nishida
Division of Molecular and Cellular Physiology, Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki, Aichi 444-8585, Japan
EMBO J 22:4677-88. 2003..We suggest that coupling of Ca2+ entry with PLCgamma2 translocation and activation controls the amplification and co-ordination of receptor signalling... - Ikaros has a crucial role in regulation of B cell receptor signalingKalle Pekka Nera
Turku Graduate School of Biomedical Sciences, University of Turku, Turku, Finland
Eur J Immunol 36:516-25. 2006..These results indicate that the absolute need of Ikaros for development, cell fate decisions and maintenance of B cells is due to the enhancement of BCR signaling... - The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathwayShiang Jong Tzeng
Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
J Biol Chem 280:35247-54. 2005..These results define a novel Abl family kinase-dependent Fc gammaRIIB1 signaling pathway that functions independently of the BCR in controlling antigen-driven B cell responses... - Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytesBjörn Stork
Department of Biochemistry and Molecular Immunology, University of Bielefeld, 33615 Bielefeld, Germany
Immunity 21:681-91. 2004.... - Functional analysis of the green fluorescent protein-tagged inositol 1,4,5-trisphosphate receptor type 3 in Ca(2+) release and entry in DT40 B lymphocytesTakao Morita
Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
Biochem J 382:793-801. 2004..The present study demonstrates that GFP-IP(3)R3 could compensate for native IP(3)R in both IP(3)-induced Ca(2+) release and BCR-mediated Ca(2+) entry... - Establishment of lymphotoxin beta receptor signaling-dependent cell lines with follicular dendritic cell phenotypes from mouse lymph nodesYumiko Nishikawa
Department of Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Tsushima-naka, Okayama, Japan
J Immunol 177:5204-14. 2006..Thus, pFL and FL-Y cells may be useful for providing insight into the functional role for FDCs in GC... - Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulumYoshihiro Baba
Laboratory for Lymphocyte Differentiation and Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Proc Natl Acad Sci U S A 103:16704-9. 2006.... - Contribution of BCAP to maintenance of mature B cells through c-RelTetsuo Yamazaki
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
Nat Immunol 4:780-6. 2003..These results indicate BCAP is essential in the maintenance of mature B cells through functional coupling with c-Rel... - Enhanced NK-cell development and function in BCAP-deficient miceAlexander W MacFarlane
Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111 2497, USA
Blood 112:131-40. 2008..Our data support a model in which blunting of BCAP-mediated activation signaling in developing NK cells promotes functionality, terminal maturation, and long-term survival... - Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathwayShengli Hao
Immunology Research Laboratories, Cell and Developmental Biology Graduate Program, The Pennsylvania State University, University Park, PA 16802, USA
EMBO J 22:4166-77. 2003..These data suggest that combinatorial assembly of signaling pathways emanating from the BCR differentially regulate NFAT and SRF, to activate gene expression... - Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinasesS Clare Chung
Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 177:317-28. 2007..The action of kinases on Icrac activation does not arise from control of the expression level of the stromal interaction molecule 1 and Orai1 proteins... - DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genesKeiji Masuda
Laboratory for Immune Diversity, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama 230 0045, Japan
J Biol Chem 282:17387-94. 2007..These results reveal genetic and biochemical interactions between POLH and POLQ and suggest that POLQ might cooperate with POLH to generate some of the A/T mutations during the somatic hypermutation of Ig genes... - Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytesJeroen P Roose
Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0795, USA
Mol Cell Biol 27:2732-45. 2007..We hypothesize that this mechanism enables lymphocytes to maximally respond to physiologically low levels of stimulation... - Combined deficiencies in Bruton tyrosine kinase and phospholipase Cgamma2 arrest B-cell development at a pre-BCR+ stageShengli Xu
Laboratory of Molecular and Cellular Immunology, Biomedical Sciences Institute, Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673
Blood 109:3377-84. 2007..Interestingly, immunoglobulin heavy chain allelic exclusion remained intact in the absence of Btk and PLCgamma2. Overall, our results suggest that Btk and PLCgamma2 have combinatorial roles in regulating pre-B cell differentiation... - Coupling between B cell receptor and phospholipase C-gamma2 is essential for mature B cell developmentMasaki Hikida
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
J Exp Med 198:581-9. 2003..Therefore, our data suggest that the BAFF-R-mediated survival signal, provided by PLC-gamma2, is not sufficient to promote B cell maturation, and that, in addition, activation of PLC-gamma2 by BCR is required for B cell development... - Microarray analysis of Lyn-deficient B cells reveals germinal center-associated nuclear protein and other genes associated with the lymphoid germinal centerZeljka Korade Mirnics
Department of Pediatrics, University of Pittsburgh, School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
J Immunol 172:4133-41. 2004..1 binding site reduced activity in wild-type cells and had no effect in Lyn-deficient cells. The presence of Lyn enhanced PU.1 expression in a Northern blot. Thus, the following new signaling pathway has been described: Lyn-->PU.1-->GANP...