Tomohiro Kurosaki

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. pmc Paradox of B cell-targeted therapies
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan
    J Clin Invest 118:3260-3. 2008
  2. doi request reprint Tyrosine kinases and their substrates in B lymphocytes
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
    Immunol Rev 228:132-48. 2009
  3. doi request reprint B cell signaling and fate decision
    Tomohiro Kurosaki
    WPI Immunology Frontier Research Center, Osaka University, Japan
    Annu Rev Immunol 28:21-55. 2010
  4. doi request reprint The study of B cells and antibodies in Japan: a historical perspective
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int Immunol 22:217-26. 2010
  5. doi request reprint Ca2+ signaling and STIM1
    Tomohiro Kurosaki
    Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Japan
    Prog Biophys Mol Biol 103:51-8. 2010
  6. doi request reprint Unique properties of memory B cells of different isotypes
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    Immunol Rev 237:104-16. 2010
  7. doi request reprint Regulation of BCR signaling
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Immunol 48:1287-91. 2011
  8. pmc Preferential localization of IgG memory B cells adjacent to contracted germinal centers
    Yuichi Aiba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 107:12192-7. 2010
  9. doi request reprint Repression of the transcription factor Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation
    Kohei Kometani
    Laboratory for Lymphocyte Differentiation, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Immunity 39:136-47. 2013
  10. pmc CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway
    Kohei Kometani
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Turumi ku, Kanagawa 230 0045, Japan
    J Exp Med 208:1447-57. 2011

Collaborators

Detail Information

Publications66

  1. pmc Paradox of B cell-targeted therapies
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan
    J Clin Invest 118:3260-3. 2008
    ....
  2. doi request reprint Tyrosine kinases and their substrates in B lymphocytes
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
    Immunol Rev 228:132-48. 2009
    ....
  3. doi request reprint B cell signaling and fate decision
    Tomohiro Kurosaki
    WPI Immunology Frontier Research Center, Osaka University, Japan
    Annu Rev Immunol 28:21-55. 2010
    ..As a new type of post-transcriptional regulator, microRNAs have emerged to influence the development and function of B cells by affecting the expression of target mRNAs...
  4. doi request reprint The study of B cells and antibodies in Japan: a historical perspective
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int Immunol 22:217-26. 2010
    ..It also details the importance of the germinal center in generating B-cell memory and the terminal differentiation of B cells as antibody-secreting plasma cells...
  5. doi request reprint Ca2+ signaling and STIM1
    Tomohiro Kurosaki
    Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Japan
    Prog Biophys Mol Biol 103:51-8. 2010
    ..In this review, we summarize the mechanism by which STIM1 regulates SOCE, and also its role in the control of mast cell functions and allergic responses...
  6. doi request reprint Unique properties of memory B cells of different isotypes
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    Immunol Rev 237:104-16. 2010
    ..The IgM and IgG type memory B cells reside in distinct locations and appear to possess distinct origins and effector functions, together orchestrating humoral memory responses...
  7. doi request reprint Regulation of BCR signaling
    Tomohiro Kurosaki
    Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Immunol 48:1287-91. 2011
    ..In this review, I will briefly present our studies that have clarified the molecular components of signaling cascades, mainly focusing on data using DT40 B cells and their genetic variants...
  8. pmc Preferential localization of IgG memory B cells adjacent to contracted germinal centers
    Yuichi Aiba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 107:12192-7. 2010
    ..These results implicate this peri-GC region as an important site for survival and reactivation of memory B cells...
  9. doi request reprint Repression of the transcription factor Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation
    Kohei Kometani
    Laboratory for Lymphocyte Differentiation, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Immunity 39:136-47. 2013
    ..In addition, our results suggest that repression of the Bach2 transcription factor, which results from antigen experience, contributes to predisposition of IgG1 memory B cells to differentiate into plasma cells. ..
  10. pmc CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway
    Kohei Kometani
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Turumi ku, Kanagawa 230 0045, Japan
    J Exp Med 208:1447-57. 2011
    ..Together, our results suggest that CIN85 links the BCR to IKK-β activation, thereby contributing to T cell-independent immune responses...
  11. ncbi request reprint Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase
    Yuichi Aiba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Japan
    Blood 111:1497-503. 2008
    ..Together, our data suggest that BCAP and CD19 have complementary roles in BCR-mediated PI3K activation, thereby, at least in part, contributing to B-cell development...
  12. doi request reprint ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation
    Tomoharu Yasuda
    Laboratory for Lymphocyte Differentiation, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Sci Signal 4:ra25. 2011
    ..Thus, our study suggests that cytokines stimulate ERKs to induce the production of Blimp-1 and that ERKs thereby contribute to the process of cellular differentiation...
  13. doi request reprint The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production
    Masanori Matsumoto
    Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
    Immunity 34:703-14. 2011
    ..This resulted in exacerbation of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. Our data establish STIM-dependent SOC influx as a key signal for B cell regulatory function required to limit autoimmunity...
  14. doi request reprint Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion
    Tomoharu Yasuda
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Immunity 28:499-508. 2008
    ..Together, our results identify a crucial role for Erk kinases in regulating B cell development by initiating transcriptional regulatory network and thereby pre-BCR-mediated cell expansion...
  15. pmc IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells
    Hisaaki Shinohara
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 204:3285-93. 2007
    ..The activated IKKbeta does not merely function as an effector enzyme but also modifies the upstream signaling complex through a feedback mechanism, thereby optimizing the strength and duration of the nuclear factor kappaB signal...
  16. doi request reprint Surf4 modulates STIM1-dependent calcium entry
    Yoko Fujii
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Biochem Biophys Res Commun 422:615-20. 2012
    ..Deletion of Surf4 in DT40 B cells resulted in marked increase of SOCE and facilitation of STIM1 clustering upon store-depletion. These findings suggest the modulatory function of Surf4 for STIM1-mediated SOCE...
  17. ncbi request reprint BANK negatively regulates Akt activation and subsequent B cell responses
    Yuichi Aiba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Immunity 24:259-68. 2006
    ..Together, our findings suggest that BANK attenuates CD40-mediated Akt activation, thereby preventing hyperactive B cell responses...
  18. doi request reprint Essential roles of mgcRacGAP in multilineage differentiation and survival of murine hematopoietic cells
    Takayuki Yamada
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Suehiro cho 1 7 22, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Biochem Biophys Res Commun 372:941-6. 2008
    ..Taken together, mgcRacGAP is now shown to play a indispensable role in the development of hematopoietic cells in vivo...
  19. doi request reprint Regulation of NF-kappaB-dependent T cell activation and development by MEKK3
    Hisaaki Shinohara
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    Int Immunol 21:393-401. 2009
    ..Furthermore, T cell-specific deletion of MEKK3 resulted in reduced numbers of thymocytes and peripheral T cells. Thus, our results provide genetic evidence that MEKK3 plays a crucial role in adaptive immunity...
  20. pmc Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G
    Hideki Sanjo
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Mol Cell Biol 27:1236-46. 2007
    ..Notably, this defect was countered by overexpression of the antiapoptotic factor Bcl-2. Together, our results suggest that ERK2 plays a key role in efficient generation of antigen-specific IgG-bearing B cells by promoting their survival...
  21. pmc PLC-gamma2 is essential for formation and maintenance of memory B cells
    Masaki Hikida
    Laboratory for Lymphocyte Differentiation, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 206:681-9. 2009
    ..Collectively, our data suggest that PLC-gamma2 conveys a survival signal to GC and memory B cells and that this signal is required for a productive secondary immune response...
  22. ncbi request reprint Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses
    Yoshihiro Baba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 1 7 22, Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 9:81-8. 2008
    ..Thus, STIM1 is key in promoting the Ca2+ influx that is essential for FcepsilonRI-mediated mast cell activation and anaphylaxis...
  23. ncbi request reprint [Regulation of B cell receptor signaling]
    Tomohiro Kurosaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 10 15 Fumizono cho, Moriguchi 570 8506, Japan
    Seikagaku 75:1505-15. 2003
  24. doi request reprint Physiological function and molecular basis of STIM1-mediated calcium entry in immune cells
    Yoshihiro Baba
    Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
    Immunol Rev 231:174-88. 2009
    ....
  25. doi request reprint Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling
    Hisaaki Shinohara
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    Immunol Rev 232:300-18. 2009
    ..In this review, we focus on recent advances that illuminate the fine tuning mechanisms of NF-kappaB activation by BCR signaling and have increased our comprehension of complex signal systems...
  26. doi request reprint Impact of Ca2+ signaling on B cell function
    Yoshihiro Baba
    Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
    Trends Immunol 32:589-94. 2011
    ..Here, we summarize the B cell signaling pathways that lead to SOCE, the role of Ca(2+) signals in B cell regulatory function, and how a breakdown in the balance of Ca(2+) signals is associated with immune-related disease...
  27. doi request reprint FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Immunol 183:5502-10. 2009
    ..These results, together with previous genetic data, suggest that augmented inhibition of BCR-mediated signaling by FCRL3 with the disease-risk genotype alter the activation threshold and promote tolerance breakdown in B cells...
  28. pmc PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
    Hisaaki Shinohara
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 202:1423-31. 2005
    ..Hence, our data suggest that phosphorylation of CARMA1, mediated by PKCbeta, brings two key protein kinases, TAK1 and IKK, into close proximity, thereby allowing TAK1 to phosphorylate IKK...
  29. pmc Essential immunoregulatory role for BCAP in B cell development and function
    Tetsuo Yamazaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Osaka, Japan
    J Exp Med 195:535-45. 2002
    ..These findings demonstrate that BCAP plays a pivotal immunoregulatory role in B cell development and humoral immune responses...
  30. ncbi request reprint Regulation of lymphocyte fate by Ras/ERK signals
    Tomoharu Yasuda
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa, Japan
    Cell Cycle 7:3634-40. 2008
    ..Moreover, candidate immediate early genes that regulate lymphocyte proliferation and differentiation have emerged...
  31. ncbi request reprint Retardation of the G2-M phase progression on gene disruption of RNA binding protein Sam68 in the DT40 cell line
    Qing Hua Li
    Department of Microbiology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, 570 8506, Osaka, Japan
    FEBS Lett 525:145-50. 2002
    ..Our results indicate that Sam68 may play a critical role in G2-M progression in a manner independent of the control of Cyclin/Cdc2 kinase activity...
  32. pmc Enhanced NK-cell development and function in BCAP-deficient mice
    Alexander W MacFarlane
    Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111 2497, USA
    Blood 112:131-40. 2008
    ..Our data support a model in which blunting of BCAP-mediated activation signaling in developing NK cells promotes functionality, terminal maturation, and long-term survival...
  33. pmc Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells
    Tomoharu Yasuda
    Department of Oncology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 196:51-63. 2002
    ..These results demonstrate that Cbl-b positively regulates BCR-mediated Ca2+ signaling, most likely by influencing the Btk/BLNK/PLC-gamma2 complex formation...
  34. pmc Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
    Michele Weber
    Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, England, UK
    J Exp Med 205:853-68. 2008
    ..Thus, we demonstrate the importance of cooperation between components of the microsignalosome in the amplification of signaling and propagation of B cell spreading, which is critical for appropriate B cell activation...
  35. doi request reprint A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation
    Rika Ouchida
    Laboratory for Immune Diversity, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama 230 0045, Japan
    Immunity 29:33-43. 2008
    ..These results identify a lysosomal protein important for CD3zeta degradation and illustrate a unique mechanism for the control of surface TCR expression and T cell activation...
  36. ncbi request reprint Genetic analysis of B cell signaling
    Hisaaki Shinohara
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045
    Subcell Biochem 40:145-87. 2006
    ..Here, based upon the recent data, mainly obtained from the DT40 system, we discuss several new aspects on mechanisms by which BCR signals are propagated and modified...
  37. pmc Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases
    S Clare Chung
    Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 177:317-28. 2007
    ..The action of kinases on Icrac activation does not arise from control of the expression level of the stromal interaction molecule 1 and Orai1 proteins...
  38. ncbi request reprint DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes
    Keiji Masuda
    Laboratory for Immune Diversity, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama 230 0045, Japan
    J Biol Chem 282:17387-94. 2007
    ..These results reveal genetic and biochemical interactions between POLH and POLQ and suggest that POLQ might cooperate with POLH to generate some of the A/T mutations during the somatic hypermutation of Ig genes...
  39. ncbi request reprint Contribution of BCAP to maintenance of mature B cells through c-Rel
    Tetsuo Yamazaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
    Nat Immunol 4:780-6. 2003
    ..These results indicate BCAP is essential in the maintenance of mature B cells through functional coupling with c-Rel...
  40. ncbi request reprint Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK
    Sachiko Johmura
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, 10 15 Fumizono cho, Moriguchi 570 8506, Japan
    Immunity 18:777-87. 2003
    ..Hence, our findings suggest that Grb2 and BLNK cooperate to localize Vav into membrane rafts, thereby contributing to optimal activation of Vav in B cells...
  41. pmc The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction
    Kazuko Saeki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    EMBO J 22:3015-26. 2003
    ..These data suggest that Raftlin plays a pivotal role in the formation and/or maintenance of lipid rafts, therefore regulating BCR-mediated signaling...
  42. ncbi request reprint [Immunoregulatory role for BCAP in B cell development and function]
    Tetsuo Yamazaki
    Tanpakushitsu Kakusan Koso 47:2242-7. 2002
  43. ncbi request reprint Checks and balances on developing B cells
    Tomohiro Kurosaki
    Nat Immunol 4:13-5. 2003
  44. pmc BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins
    Christopher W Chiu
    Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 21:6461-72. 2002
    ..These data demonstrate the importance of coordinate phosphorylation of molecular scaffolds, and provide insights into how assembly of macromolecular complexes is required for normal receptor function...
  45. ncbi request reprint Regulation of B-cell signal transduction by adaptor proteins
    Tomohiro Kurosaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Japan
    Nat Rev Immunol 2:354-63. 2002
    ..In addition, adaptor molecules participate in establishing negative- or positive-feedback regulatory loops in signalling networks, thereby fine-tuning the B-cell response...
  46. ncbi request reprint Regulation of B cell fates by BCR signaling components
    Tomohiro Kurosaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, and Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 570 8506, Moriguchi, Japan
    Curr Opin Immunol 14:341-7. 2002
    ..To establish the optimal signaling intensity and duration, the BCR utilizes positive and negative regulatory molecules. Studies are beginning to reveal how these molecules maintain immunological homeostasis and tolerance...
  47. ncbi request reprint Bruton's tyrosine kinase regulates B cell antigen receptor-mediated JNK1 response through Rac1 and phospholipase C-gamma2 activation
    Kazunori Inabe
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
    FEBS Lett 514:260-2. 2002
    ..Since PLC-gamma2 is also required for BCR-mediated JNK1 response, our results suggest that Btk regulates Rac1 pathway as well as PLC-gamma2 pathway, both of which contribute to the BCR-mediated JNK1 response...
  48. pmc Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes
    Yasuo Mori
    Center for Integrative Bioscience, Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    J Exp Med 195:673-81. 2002
    ....
  49. ncbi request reprint Developmental differences in B cell receptor-induced signal transduction
    Dorottya Kovesdi
    Department of Immunology, Lorand Eotvos University, H 1117 Pázmány Péter sétány 1 C, Budapest, Hungary
    Cell Signal 14:563-72. 2002
    ..Further results indicate that the cell lines representing the immature stage are more sensitive to BCR-, CD19- and type II receptors binding the Fc part of IgG (Fc gamma RIIb)-mediated signals than mature B cells...
  50. pmc The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival
    Hiroaki Niiro
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    J Exp Med 195:143-9. 2002
    ..Furthermore, Bam32(-/-) cells were more susceptible to BCR-induced death. Taken together, these findings suggest that Bam32 functions to regulate BCR-induced signaling and cell survival most likely in germinal centers...
  51. pmc Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathway
    Shengli Hao
    Immunology Research Laboratories, Cell and Developmental Biology Graduate Program, The Pennsylvania State University, University Park, PA 16802, USA
    EMBO J 22:4166-77. 2003
    ..These data suggest that combinatorial assembly of signaling pathways emanating from the BCR differentially regulate NFAT and SRF, to activate gene expression...
  52. pmc Coupling between B cell receptor and phospholipase C-gamma2 is essential for mature B cell development
    Masaki Hikida
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
    J Exp Med 198:581-9. 2003
    ..Therefore, our data suggest that the BAFF-R-mediated survival signal, provided by PLC-gamma2, is not sufficient to promote B cell maturation, and that, in addition, activation of PLC-gamma2 by BCR is required for B cell development...
  53. pmc Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes
    Motohiro Nishida
    Division of Molecular and Cellular Physiology, Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki, Aichi 444 8585, Japan
    EMBO J 22:4677-88. 2003
    ..We suggest that coupling of Ca2+ entry with PLCgamma2 translocation and activation controls the amplification and co-ordination of receptor signalling...
  54. pmc Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes
    Jeroen P Roose
    Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0795, USA
    Mol Cell Biol 27:2732-45. 2007
    ..We hypothesize that this mechanism enables lymphocytes to maximally respond to physiologically low levels of stimulation...
  55. ncbi request reprint Combined deficiencies in Bruton tyrosine kinase and phospholipase Cgamma2 arrest B-cell development at a pre-BCR+ stage
    Shengli Xu
    Laboratory of Molecular and Cellular Immunology, Biomedical Sciences Institute, Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673
    Blood 109:3377-84. 2007
    ..Interestingly, immunoglobulin heavy chain allelic exclusion remained intact in the absence of Btk and PLCgamma2. Overall, our results suggest that Btk and PLCgamma2 have combinatorial roles in regulating pre-B cell differentiation...
  56. pmc Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum
    Yoshihiro Baba
    Laboratory for Lymphocyte Differentiation and Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 103:16704-9. 2006
    ....
  57. ncbi request reprint Establishment of lymphotoxin beta receptor signaling-dependent cell lines with follicular dendritic cell phenotypes from mouse lymph nodes
    Yumiko Nishikawa
    Department of Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Okayama, Japan
    J Immunol 177:5204-14. 2006
    ..Thus, pFL and FL-Y cells may be useful for providing insight into the functional role for FDCs in GC...
  58. ncbi request reprint Regulation of cytokinesis by mgcRacGAP in B lymphocytes is independent of GAP activity
    Takayuki Yamada
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Fumizono cho 10 15, Moriguchi, Osaka 570 8506, Japan
    Exp Cell Res 312:3517-25. 2006
    ....
  59. ncbi request reprint Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes
    Keiji Masuda
    Laboratory for Antigen Receptor Diversity, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama 230 0045, Japan
    DNA Repair (Amst) 5:1384-91. 2006
    ....
  60. ncbi request reprint Phospholipase Cgamma2 dosage is critical for B cell development in the absence of adaptor protein BLNK
    Shengli Xu
    Laboratory of Immunology, Center for Molecular Medicine and Institute of Molecular and Cell Biology, Singapore
    J Immunol 176:4690-8. 2006
    ....
  61. ncbi request reprint Ikaros has a crucial role in regulation of B cell receptor signaling
    Kalle Pekka Nera
    Turku Graduate School of Biomedical Sciences, University of Turku, Turku, Finland
    Eur J Immunol 36:516-25. 2006
    ..These results indicate that the absolute need of Ikaros for development, cell fate decisions and maintenance of B cells is due to the enhancement of BCR signaling...
  62. ncbi request reprint The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathway
    Shiang Jong Tzeng
    Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 280:35247-54. 2005
    ..These results define a novel Abl family kinase-dependent Fc gammaRIIB1 signaling pathway that functions independently of the BCR in controlling antigen-driven B cell responses...
  63. ncbi request reprint Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes
    Björn Stork
    Department of Biochemistry and Molecular Immunology, University of Bielefeld, 33615 Bielefeld, Germany
    Immunity 21:681-91. 2004
    ....
  64. pmc Functional analysis of the green fluorescent protein-tagged inositol 1,4,5-trisphosphate receptor type 3 in Ca(2+) release and entry in DT40 B lymphocytes
    Takao Morita
    Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Biochem J 382:793-801. 2004
    ..The present study demonstrates that GFP-IP(3)R3 could compensate for native IP(3)R in both IP(3)-induced Ca(2+) release and BCR-mediated Ca(2+) entry...
  65. ncbi request reprint Microarray analysis of Lyn-deficient B cells reveals germinal center-associated nuclear protein and other genes associated with the lymphoid germinal center
    Zeljka Korade Mirnics
    Department of Pediatrics, University of Pittsburgh, School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 172:4133-41. 2004
    ..The presence of Lyn enhanced PU.1 expression in a Northern blot. Thus, the following new signaling pathway has been described: Lyn-->PU.1-->GANP...
  66. ncbi request reprint Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement
    Kazunori Inabe
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Blood 99:584-9. 2002
    ..Thus, these results provide evidence that BCAP serves as an adaptor molecule for CD19 to activate the PI3K pathway in B cells...