Toru Kondo

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. pmc Glioblastoma formation from cell population depleted of Prominin1-expressing cells
    Kenji Nishide
    Department of Biology, Graduate School of Science, Kobe University, Kobe, 657 8601, Japan corrected
    PLoS ONE 4:e6869. 2009
  2. ncbi request reprint Epigenetic alchemy for cell fate conversion
    Toru Kondo
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Curr Opin Genet Dev 16:502-7. 2006
  3. ncbi request reprint Stem cell-like cancer cells in cancer cell lines
    Toru Kondo
    Laboratory for Cell Lineage Modulation, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Cancer Biomark 3:245-50. 2007
  4. ncbi request reprint Brain cancer stem-like cells
    Toru Kondo
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Eur J Cancer 42:1237-42. 2006
  5. doi request reprint Combination of a ptgs2 inhibitor and an epidermal growth factor receptor-signaling inhibitor prevents tumorigenesis of oligodendrocyte lineage-derived glioma-initiating cells
    Takuichiro Hide
    Laboratory for Cell Lineage Modulation, Center for Developmental Biology, RIKEN, Kobe, Japan
    Stem Cells 29:590-9. 2011
  6. ncbi request reprint Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation
    Takuichiro Hide
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, Kobe, Japan
    Cancer Res 69:7953-9. 2009
  7. doi request reprint Essential role of the Hedgehog signaling pathway in human glioma-initiating cells
    Tatsuya Takezaki
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, Kobe, Japan
    Cancer Sci 102:1306-12. 2011
  8. doi request reprint DNA methyltransferase 1 is essential for initiation of the colon cancers
    Rena Morita
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Mol Pathol 94:322-9. 2013
  9. pmc Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells
    Akari Takahashi
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan Cancer Diagnosis Laboratory, Japan Science and Technology Agency Innovation Plaza Hokkaido, Japan Science and Technology Agency, Kita ku, Sapporo, Japan
    PLoS ONE 8:e69095. 2013
  10. ncbi request reprint [Common mechanism underlying oligodendrocyte development and oligodendrogliomagenesis]
    Toru Kondo
    RIKKEN Center for Developmental Biology, Laboratory for Cell Lineage Modulation, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Brain Nerve 61:741-51. 2009

Collaborators

Detail Information

Publications25

  1. pmc Glioblastoma formation from cell population depleted of Prominin1-expressing cells
    Kenji Nishide
    Department of Biology, Graduate School of Science, Kobe University, Kobe, 657 8601, Japan corrected
    PLoS ONE 4:e6869. 2009
    ..We show here that the tamoxifen-treated GICs-LD (GICs-DTA) form tumor-spheres in culture and transplantable GBM in vivo. Thus, our studies demonstrate that Prom1-expressing cells are dispensable for gliomagenesis in this mouse model...
  2. ncbi request reprint Epigenetic alchemy for cell fate conversion
    Toru Kondo
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Curr Opin Genet Dev 16:502-7. 2006
    ..Thus, epigenetic research might generate the alchemy required to convert any non-neural stem cells into functional neural stem cells, which are few and difficult to extract from the adult central nervous system...
  3. ncbi request reprint Stem cell-like cancer cells in cancer cell lines
    Toru Kondo
    Laboratory for Cell Lineage Modulation, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Cancer Biomark 3:245-50. 2007
    ..In this review I summarize the recent progress in CSC research using cancer cell lines...
  4. ncbi request reprint Brain cancer stem-like cells
    Toru Kondo
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Eur J Cancer 42:1237-42. 2006
    ..The purified cancer stem-like cells, but not the other cancer cells, self-renew and form tumours when transplanted in vivo. Thus, cancer stem-like cells in brain tumours might be a crucial target for anti-brain tumour therapy...
  5. doi request reprint Combination of a ptgs2 inhibitor and an epidermal growth factor receptor-signaling inhibitor prevents tumorigenesis of oligodendrocyte lineage-derived glioma-initiating cells
    Takuichiro Hide
    Laboratory for Cell Lineage Modulation, Center for Developmental Biology, RIKEN, Kobe, Japan
    Stem Cells 29:590-9. 2011
    ..Together, these findings suggest that GBM can arise from either OPCs or NSCs and that the therapeutic targets for GBM might be different, depending on each GIC's cell-of-origin...
  6. ncbi request reprint Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation
    Takuichiro Hide
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, Kobe, Japan
    Cancer Res 69:7953-9. 2009
    ..Together with the clinical evidence showing that downregulation of sox11 mRNA correlates with a significant decrease in survival, these findings suggest that Sox11 prevents gliomagenesis by blocking the expression of oncogenic plagl1...
  7. doi request reprint Essential role of the Hedgehog signaling pathway in human glioma-initiating cells
    Tatsuya Takezaki
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, Kobe, Japan
    Cancer Sci 102:1306-12. 2011
    ..Taken together, these results show that the Hedgehog→ Gli→Cdc2 signaling cascade plays a role in the proliferation and malignancy of glioma-initiating cells...
  8. doi request reprint DNA methyltransferase 1 is essential for initiation of the colon cancers
    Rena Morita
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Mol Pathol 94:322-9. 2013
    ..Taken together, these results indicate that DNMT1 is essential for maintenance of colon CSCs/CICs and that short-term suppression of DNMT1 might be sufficient to disrupt CSCs/CICs...
  9. pmc Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells
    Akari Takahashi
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan Cancer Diagnosis Laboratory, Japan Science and Technology Agency Innovation Plaza Hokkaido, Japan Science and Technology Agency, Kita ku, Sapporo, Japan
    PLoS ONE 8:e69095. 2013
    ....
  10. ncbi request reprint [Common mechanism underlying oligodendrocyte development and oligodendrogliomagenesis]
    Toru Kondo
    RIKKEN Center for Developmental Biology, Laboratory for Cell Lineage Modulation, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Brain Nerve 61:741-51. 2009
    ..In this review, I summarize the mechanism of oligodendrocyte development and present how the oligodendrocyte research can help to understand and to investigate the mechanism of oligodendroglioma development...
  11. doi request reprint Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells
    Hiromi Takanaga
    Center for Developmental Biology, RIKEN, Kobe, Japan
    Stem Cells 27:165-74. 2009
    ..Thus these data reveal a novel transcriptional cascade, involving Gli2 --> Sox2 --> Hes5, which maintains the undifferentiated state of telencephalic NE cells...
  12. doi request reprint Brain tumor stem cells as research and treatment targets
    Takuichiro Hide
    Laboratory for Cell Lineage Modulation, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Brain Tumor Pathol 25:67-72. 2008
    ..Research focused on BTSCs as treatment targets may contribute to the discovery of new therapeutic strategies...
  13. ncbi request reprint Mouse induced glioma-initiating cell models and therapeutic targets
    Toru Kondo
    RIKEN Center for Developmental Biology, Kobe, Japan
    Anticancer Agents Med Chem 10:471-80. 2010
    ..These findings suggest that Sox11 and Plagl1 work as a tumor suppressor and oncogene, respectively, in GBM and are potential therapeutic targets...
  14. doi request reprint Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population
    Takashi Mori
    Department of Pathology, Sapporo Medical University, School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Mol Pathol 92:27-32. 2012
    ..These observations indicate that expression in the CSC/CIC population is essential to achieve tumor regression and that fusing antigens to the N-terminal region of Hsp90 enhances the anti-tumor effect...
  15. pmc Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells
    Yuki Kujuro
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 107:8259-64. 2010
    ..These results suggest that Ecrg4 is a factor linking neural-cell senescence and aging...
  16. pmc Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation
    Takao Setoguchi
    Centre for Brain Repair, University of Cambridge, E D Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    J Cell Biol 166:963-8. 2004
    ..We propose that the AKT-stimulated export of OLIG2 from the nucleus of NSCs is essential for the astrocyte differentiation...
  17. pmc Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    Toru Kondo
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 101:781-6. 2004
    ..We propose that many cancer cell lines contain a minor subpopulation of stem cells that is enriched in an SP, can be maintained indefinitely in culture, and is crucial for their malignancy...
  18. pmc Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells
    Costas A Lyssiotis
    The Skaggs Institute of Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torry Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:14982-7. 2007
    ..This series of experiments demonstrates that global histone acetylation, induced by HDAC inhibition, can partially reverse the lineage restriction of OPCs, thereby inducing developmental plasticity...
  19. ncbi request reprint [Cancer stem cells in cancer cell lines]
    Takao Setoguchi
    University of Cambridge Center for Brain Repair
    Tanpakushitsu Kakusan Koso 50:1995-2000. 2005
  20. ncbi request reprint Cancer stem cells persist in many cancer cell lines
    Takao Setoguchi
    University of Cambridge Center for Brain Repair, The E D Adrian Building, Forvie Site, Robinson Way, Cambridge, UK
    Cell Cycle 3:414-5. 2004
    ..We propose that many cancer cell lines contain a minor subpopulation of stem cells that is enriched in a SP, can be maintained indefinitely in culture, and is crucial for their malignancy...
  21. ncbi request reprint Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings
    Mireya Marin-Husstege
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Glia 54:285-96. 2006
    ..These data support the role of Id4 as oligodendrocyte differentiation inhibitor with the ability to differentially regulate the expression and subcellular distribution of myelin gene products...
  22. ncbi request reprint Id4 is required for the correct timing of neural differentiation
    Lynn Bedford
    Institute of Genetics, Queen s Medical Centre, School of Biology, The University of Nottingham, UK
    Dev Biol 280:386-95. 2005
    ..Together, these in vivo and in vitro data suggest a crucial role for Id4 in regulating NPC proliferation and differentiation...
  23. pmc Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells
    Toru Kondo
    Medical Research Council Laboratory for Molecular Cell Biology, Cell Biology Unit, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 18:2963-72. 2004
    ..Our findings suggest that the conversion of OPCs to NSLCs depends on progressive chromatin remodeling, mediated in part by Brca1 and Brm...
  24. ncbi request reprint A role for Noggin in the development of oligodendrocyte precursor cells
    Toru Kondo
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit and the Biology Department, University College London, London WC1E 6BT, UK
    Dev Biol 267:242-51. 2004
    ..These findings suggest that BMPs in FCS are largely responsible for the 2A-inducing activity of FCS and that Noggin may normally inhibit the formation of 2As in the developing CNS...
  25. ncbi request reprint A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo
    David W Hampton
    ICORD, University of British Columbia, Vancouver, BC, Canada
    Eur J Neurosci 26:3024-35. 2007
    ..This potential conversion of inhibitory OPCs to type 2 astrocyte-like cells in vivo suggests that endogenous BMPs, unmasked by noggin antagonism, might be exploited to manipulate cell fate following CNS trauma...