Yuta Kochi

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. doi request reprint Genetics of rheumatoid arthritis: underlying evidence of ethnic differences
    Yuta Kochi
    University of Tokyo Hospital, Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    J Autoimmun 32:158-62. 2009
  2. doi request reprint PADI4 polymorphism predisposes male smokers to rheumatoid arthritis
    Yuta Kochi
    Correspondence to Dr Yuta Kochi, Laboratory for Autoimmune Diseases, CGM, RIKEN, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Ann Rheum Dis 70:512-5. 2011
  3. pmc A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese
    Yukinori Okada
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    PLoS Genet 8:e1002455. 2012
  4. pmc Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese
    Keiko Myouzen
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    PLoS Genet 8:e1002949. 2012
  5. doi request reprint A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 42:515-9. 2010
  6. doi request reprint FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Immunol 183:5502-10. 2009
  7. doi request reprint Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population
    Akari Suzuki
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Nat Genet 40:1224-9. 2008
  8. doi request reprint The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
    Kenichi Shimane
    Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 62:574-9. 2010
  9. doi request reprint Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus
    Keiko Myouzen
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Tokyo 113 0033, Japan
    Hum Mol Genet 19:2313-20. 2010
  10. doi request reprint An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes
    Kenichi Shimane
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Rheumatology (Oxford) 52:1172-82. 2013

Detail Information

Publications22

  1. doi request reprint Genetics of rheumatoid arthritis: underlying evidence of ethnic differences
    Yuta Kochi
    University of Tokyo Hospital, Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    J Autoimmun 32:158-62. 2009
    ....
  2. doi request reprint PADI4 polymorphism predisposes male smokers to rheumatoid arthritis
    Yuta Kochi
    Correspondence to Dr Yuta Kochi, Laboratory for Autoimmune Diseases, CGM, RIKEN, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Ann Rheum Dis 70:512-5. 2011
    ....
  3. pmc A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese
    Yukinori Okada
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    PLoS Genet 8:e1002455. 2012
    ..05). As AFF1 transcripts were prominently expressed in CD4(+) and CD19(+) peripheral blood lymphocytes, up-regulation of AFF1 may cause the abnormality in these lymphocytes, leading to disease onset...
  4. pmc Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese
    Keiko Myouzen
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    PLoS Genet 8:e1002949. 2012
    ..These results suggest that the NF-κB pathway plays a role in pathogenesis and would be a rational target for treatment of rheumatoid arthritis...
  5. doi request reprint A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 42:515-9. 2010
    ..Moreover, CCR6DNP was associated with susceptibility to Graves' and Crohn's diseases. These results suggest that CCR6 is critically involved in IL-17-driven autoimmunity in human diseases...
  6. doi request reprint FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Immunol 183:5502-10. 2009
    ..These results, together with previous genetic data, suggest that augmented inhibition of BCR-mediated signaling by FCRL3 with the disease-risk genotype alter the activation threshold and promote tolerance breakdown in B cells...
  7. doi request reprint Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population
    Akari Suzuki
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Nat Genet 40:1224-9. 2008
    ..CD244 is a genetic risk factor for rheumatoid arthritis and may have a role in the autoimmune process shared by rheumatoid arthritis and systemic lupus erythematosus...
  8. doi request reprint The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
    Kenichi Shimane
    Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 62:574-9. 2010
    ..The aim of this study was to assess the role of TNFAIP3 in the development of SLE and RA in Japanese subjects...
  9. doi request reprint Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus
    Keiko Myouzen
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Tokyo 113 0033, Japan
    Hum Mol Genet 19:2313-20. 2010
    ..Therefore, EGR2 is a genetic risk factor for SLE, in which increased gene expression may contribute to SLE pathogenesis...
  10. doi request reprint An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes
    Kenichi Shimane
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Rheumatology (Oxford) 52:1172-82. 2013
    ..Conclusion. We identified HLA-DRB1 alleles associated with SLE and RA in a Japanese population and demonstrated a shared susceptibility of DRB1*09:01 between the diseases as well as its effect on autoantibody production...
  11. doi request reprint Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1
    Yukinori Okada
    Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 60:3582-90. 2009
    ..To examine the risk of anti-cyclic citrullinated peptide (anti-CCP) antibody positivity in rheumatoid arthritis (RA) patients carrying certain haplotypes in the HLA region...
  12. doi request reprint Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population
    Shu Kobayashi
    Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 58:1940-6. 2008
    ..The present study was undertaken to investigate the effect of STAT4 on susceptibility to RA and SLE in the Japanese...
  13. pmc A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
    Yuta Kochi
    Laboratory for Rheumatic Diseases, SNP Research Center, RIKEN, Yokohama 230 0045, Japan
    Nat Genet 37:478-85. 2005
    ..We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity...
  14. doi request reprint The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population
    Chikashi Terao
    Center for Genomic Medicine, Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hum Mol Genet 20:2680-5. 2011
    ....
  15. doi request reprint Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis
    Yuta Kochi
    Center for Genomic Medicine, RIKEN, Tokyo, Japan
    Nat Rev Rheumatol 6:290-5. 2010
    ..In addition to the most-studied and well-characterized gene HLA-DRB1, we will also describe examples of the gene-environment interactions between PADI4 and smoking, and the gene-gene interactions between PTPN22 and FCRL3...
  16. doi request reprint Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
    Yukinori Okada
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:511-6. 2012
    ..This provided evidence of shared genetic risks of rheumatoid arthritis between the populations...
  17. ncbi request reprint Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences
    Yuta Kochi
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 50:63-71. 2004
    ..To examine the entire HLA region for loci (other than the DRB1 locus) associated with rheumatoid arthritis (RA) susceptibility, by typing HLA-DRB1 alleles and multiple single-nucleotide polymorphisms (SNPs) in the Japanese population...
  18. ncbi request reprint Genetic background of tolerance breakdown in rheumatoid arthritis
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN
    Nihon Rinsho Meneki Gakkai Kaishi 33:48-56. 2010
    ..On the other hand, genes regulating the activity of lymphocytes such as PTPN22 and FCRL3 may influence auto-reactivity of individual lymphocytes. Taken together, combination of these genetic factors accelerates autoimmune response in RA...
  19. doi request reprint A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population
    Tetsuya Oishi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato, Tokyo, 108 8639, Japan
    J Hum Genet 53:151-62. 2008
    ..Individuals with risk genotype of both ITPR3 and NKX2.5 loci have higher risk for SLE (odds ratio=5.77). Our data demonstrate that genetic and functional interactions of ITPR3 and NKX2.5 play a crucial role in the pathogenesis of SLE...
  20. doi request reprint Insight from genome-wide association studies in rheumatoid arthritis and multiple sclerosis
    Akari Suzuki
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, The Institute of Physical and Chemical Research RIKEN, Tsurumi ku, Yokohama City, Kanagawa, Japan
    FEBS Lett 585:3627-32. 2011
    ..This review focuses on the search for genetic variants that influence the susceptibility to RA and MS as typical autoimmune diseases and discusses the future of GWAS...
  21. ncbi request reprint [Genetics of autoimmune and collagen diseases]
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN
    Nihon Rinsho 67:1103-7. 2009
    ....
  22. pmc Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases
    Hirofumi Shoda
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Arthritis Res Ther 8:R166. 2006
    ..We therefore conclude that IL-32 is closely associated with TNFalpha, and contributes to the exacerbation of TNFalpha-related inflammatory arthritis and colitis...