Hiroshi Kawamoto

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. doi request reprint A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Immunol Rev 238:23-36. 2010
  2. doi request reprint A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 230 0045, Japan
    Trends Immunol 30:193-200. 2009
  3. doi request reprint A revised scheme for developmental pathways of hematopoietic cells: the myeloid-based model
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    Int Immunol 22:65-70. 2010
  4. ncbi request reprint A close developmental relationship between the lymphoid and myeloid lineages
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Trends Immunol 27:169-75. 2006
  5. doi request reprint Adult T-cell progenitors retain myeloid potential
    Haruka Wada
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Nature 452:768-72. 2008
  6. doi request reprint An essential developmental checkpoint for production of the T cell lineage
    Tomokatsu Ikawa
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Science 329:93-6. 2010
  7. doi request reprint Notch activation in thymic epithelial cells induces development of thymic microenvironments
    Kyoko Masuda
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Mol Immunol 46:1756-67. 2009
  8. ncbi request reprint T cell lineage determination precedes the initiation of TCR beta gene rearrangement
    Kyoko Masuda
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    J Immunol 179:3699-706. 2007
  9. ncbi request reprint The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCRbeta chains than fetal progenitors
    Min Lu
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    J Immunol 175:5848-56. 2005
  10. doi request reprint Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Nat Immunol 9:1113-21. 2008

Collaborators

Detail Information

Publications35

  1. doi request reprint A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Immunol Rev 238:23-36. 2010
    ..The validity of the myeloid-based model of hematopoiesis will be discussed in reference to these two issues, developmental potential and cell fate...
  2. doi request reprint A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 230 0045, Japan
    Trends Immunol 30:193-200. 2009
    ....
  3. doi request reprint A revised scheme for developmental pathways of hematopoietic cells: the myeloid-based model
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    Int Immunol 22:65-70. 2010
    ..This article describes and compares these models and outlines recent evidence supporting the myeloid-based model...
  4. ncbi request reprint A close developmental relationship between the lymphoid and myeloid lineages
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Trends Immunol 27:169-75. 2006
    ..Recent evidence challenges the dichotomy model in the adult, and it is proposed here that the alternative myeloid-based model is applicable to both fetal and adult hematopoiesis...
  5. doi request reprint Adult T-cell progenitors retain myeloid potential
    Haruka Wada
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Nature 452:768-72. 2008
    ..Our findings argue against the classical dichotomy model in which T cells are derived from CLPs; instead, they support the validity of the myeloid-based model for both adult and fetal haematopoiesis...
  6. doi request reprint An essential developmental checkpoint for production of the T cell lineage
    Tomokatsu Ikawa
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Science 329:93-6. 2010
    ..Our study thus identifies the earliest checkpoint during T cell development and shows that it is Bcl11b-dependent...
  7. doi request reprint Notch activation in thymic epithelial cells induces development of thymic microenvironments
    Kyoko Masuda
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Mol Immunol 46:1756-67. 2009
    ..The present approach using non-T lineage cells for the in vitro construction of thymic environments may also provide a novel tool for thymus regeneration and T cell production in immunocompromised individuals...
  8. ncbi request reprint T cell lineage determination precedes the initiation of TCR beta gene rearrangement
    Kyoko Masuda
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    J Immunol 179:3699-706. 2007
    ..These results indicated that the determination step of progenitors to the T cell lineage is a separable event from TCRbeta rearrangement...
  9. ncbi request reprint The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCRbeta chains than fetal progenitors
    Min Lu
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    J Immunol 175:5848-56. 2005
    ..We propose that the AT is colonized by T/NK/dendritic cell tripotential progenitors with much higher potential to form diversity in TCRbeta chains than FT progenitors...
  10. doi request reprint Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Nat Immunol 9:1113-21. 2008
    ..Our results show how an initial lineage-specification signal can be amplified and stabilized during the lineage-commitment process...
  11. pmc Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines
    Hiroshi Watarai
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    PLoS Biol 10:e1001255. 2012
    ..In this study we demonstrated that the IL-17RB⁺iNKT cell subsets develop distinct from classical iNKT cell developmental stages in the thymus and play important roles in the pathogenesis of airway diseases...
  12. ncbi request reprint A new clonal assay system for lymphoid and myeloid lineages
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Methods Mol Med 105:345-58. 2005
    ..By examining cells from murine fetal tissues with this assay, we have succeeded in elucidating the process of lineage restrictions in early hematopoiesis...
  13. pmc Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1
    Wooseok Seo
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    J Exp Med 209:1255-62. 2012
    ..Collectively, these results demonstrate that Runx1-Cbfβ complexes are essential to facilitate B lineage specification, in part via epigenetic activation of the Ebf1 gene...
  14. pmc A novel gene essential for the development of single positive thymocytes
    Kiyokazu Kakugawa
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Kanagawa, Japan
    Mol Cell Biol 29:5128-35. 2009
    ..We generated E430004N04Rik-deficient mice, and their phenotype was virtually identical to that of the ENU mutant mice, thereby confirming that this gene is essential for the development of SP thymocytes...
  15. doi request reprint Thymic cysts originate from Foxn1 positive thymic medullary epithelium
    Eric Vroegindeweij
    Laboratory for Lymphocyte Development, RIKEN Research Centre for Allergy and Immunology, Yokohama, Japan
    Mol Immunol 47:1106-13. 2010
    ..The 2D-phenotype of cyst-lining TECs is not caused by a downregulation of Foxn1 expression, since a significant proportion of these cells in the embryonic and adult thymus continues to express Foxn1 at the protein level...
  16. doi request reprint Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells
    Raul Vizcardo
    Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Cell Stem Cell 12:31-6. 2013
    ..The present study therefore illustrates an approach for cloning and expanding functional antigen-specific CD8(+) T cells that might be applicable in cell-based therapy of cancer...
  17. ncbi request reprint Myeloid cells
    Hiroshi Kawamoto
    Research Center for Immunology and Allergy, RIKEN, Yokohama 230 0045, Japan
    Int J Biochem Cell Biol 36:1374-9. 2004
    ..Genetic alterations in myeloid cells may cause an abnormal increase in mature myeloid or blast cells resulting in chronic or acute myelogenous leukemia...
  18. doi request reprint Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Valpha14-Jalpha18 TCRalpha gene
    Hiroshi Watarai
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    Blood 115:230-7. 2010
    ..The cloned ES culture system offers a new opportunity for the elucidation of the molecular events on NKT-cell development and for the establishment of NKT-cell therapy...
  19. ncbi request reprint Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells
    Atsushi Hijikata
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, Japan
    Bioinformatics 23:2934-41. 2007
    ..To address this, we constructed an open-access database that enabled us to cross-reference transcriptomic and proteomic data obtained from immune cells...
  20. ncbi request reprint [The process of lineage commitment in hematopoiesis]
    Hiroshi Kawamoto
    Rinsho Ketsueki 43:274-7. 2002
  21. ncbi request reprint The common myelolymphoid progenitor: a key intermediate stage in hemopoiesis generating T and B cells
    Min Lu
    Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Immunol 169:3519-25. 2002
    ..T and B cell progenitors may be derived from the CMLP through the previously identified myeloid/T and myeloid/B bipotent stages, respectively...
  22. pmc E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
    Tomokatsu Ikawa
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 203:1329-42. 2006
    ....
  23. ncbi request reprint Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains
    Hiroshi Kawamoto
    Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Eur J Immunol 33:606-15. 2003
    ..Such an extensive proliferation of progenitors after the restriction to the T cell lineage may be an essential process ensuring the clonal diversification of TCRbeta chains...
  24. ncbi request reprint Thymic anlage is colonized by progenitors restricted to T, NK, and dendritic cell lineages
    Kyoko Masuda
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    J Immunol 174:2525-32. 2005
    ..These results provide direct evidence that the progenitors restricted to the T/NK/dendritic cell lineage selectively immigrate into the thymus...
  25. ncbi request reprint [Prethymic and intrathymic pathway of T cell development]
    Hiroshi Kawamoto
    Tanpakushitsu Kakusan Koso 47:2159-65. 2002
  26. ncbi request reprint Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice
    Daisuke Ishida
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, 606 8501, Kyoto, Japan
    Cancer Cell 4:55-65. 2003
    ..These results unveiled a role of Rap1 in myeloproliferative stem cell disorders and a tumor suppressor function of SPA-1...
  27. ncbi request reprint Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors
    Wilfred T V Germeraad
    Department of Internal Medicine, Academic Hospital Maastricht, Maastricht, The Netherlands
    J Histochem Cytochem 51:1225-35. 2003
    ..This study underlines the plasticity of thymic epithelium and shows that the unique organization of the thymic epithelium is dependent on both oxygen and crosstalk signals derived from developing thymocytes...
  28. pmc Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice
    Daisuke Ishida
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Japan
    Proc Natl Acad Sci U S A 100:10919-24. 2003
    ....
  29. ncbi request reprint T/NK bipotent progenitors in the thymus retain the potential to generate dendritic cells
    Hui Qing Shen
    Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    J Immunol 171:3401-6. 2003
    ..Although the DC potential is lost with the progression of the differentiation stage, some of the T/NK bipotential progenitors still retain their DC potential even at the CD44(+)CD25(+) stage...
  30. ncbi request reprint Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent
    Tomokatsu Ikawa
    Division of Biological Sciences, 0377 University of California, San Diego, La Jolla, CA 92093, USA
    Immunity 20:349-60. 2004
    ..These observations indicate that E2A-deficient hematopoietic progenitor cells remain pluripotent after long-term culture in vitro and that E2A proteins play a critical role in B cell commitment...
  31. ncbi request reprint Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway
    Masaki Miyazaki
    Department of Immunology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    J Immunol 174:2507-16. 2005
    ..Collectively, these data indicate that mel-18 contributes to the maintenance of the active state of the Hes-1 gene as a cellular memory system, thereby supporting the expansion of early T progenitors...
  32. pmc Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors
    Kyoko Masuda
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    EMBO J 24:4052-60. 2005
    ..These findings disclose a prethymic stage of T-cell development programmed for immigration of the thymus, which is genetically separable from intrathymic stages...
  33. doi request reprint Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression
    Masaki Miyazaki
    Department of Immunology, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Immunity 28:231-45. 2008
    ..Our results indicate that this epigenetic regulation critically contributes to the survival of the activated pre-T cells, thereby supporting their proliferation during the DN-DP transition...
  34. ncbi request reprint Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes
    Yan Xing
    Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Mol Immunol 45:2028-37. 2008
    ..G5PR is essential for the survival of DP cells during thymocyte development...
  35. ncbi request reprint Impaired T-cell differentiation in the thymus at the early stages of acute pathogenic chimeric simian-human immunodeficiency virus (SHIV) infection in contrast to less pathogenic SHIV infection
    Makiko Motohara
    Laboratory of Primate Model, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoinkawara Machi, Sakyo ku, Kyoto 606 8507, Japan
    Microbes Infect 8:1539-49. 2006
    ..These differences suggest that dysfunction of thymic maturation makes an important contribution to the irreversible depletion of circulating CD4+ T cells in vivo...