Tadafumi Kato

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi Molecular genetics of bipolar disorder
    T Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, 351 0198, Saitama, Japan
    Neurosci Res 40:105-13. 2001
  2. ncbi Genetics of bipolar disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Drugs Today (Barc) 41:335-44. 2005
  3. ncbi Mitochondrial dysfunction as the molecular basis of bipolar disorder: therapeutic implications
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    CNS Drugs 21:1-11. 2007
  4. ncbi Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders
    T Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Mol Psychiatry 10:622-30. 2005
  5. ncbi [Mitochondrial dysfunction in bipolar disorder]
    Tadafumi Kato
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako 351 0198 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:61-72. 2005
  6. ncbi [ER stress response and bipolar disorder]
    Tadafumi Kato
    Tanpakushitsu Kakusan Koso 49:1133-4. 2004
  7. ncbi Mechanisms of altered Ca2+ signalling in transformed lymphoblastoid cells from patients with bipolar disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Japan
    Int J Neuropsychopharmacol 6:379-89. 2003
  8. ncbi The other, forgotten genome: mitochondrial DNA and mental disorders
    T Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama, 351 0198, Japan
    Mol Psychiatry 6:625-33. 2001
  9. ncbi No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Neurosci Lett 338:21-4. 2003
  10. ncbi Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neurosci Lett 417:316-21. 2007

Detail Information

Publications90

  1. ncbi Molecular genetics of bipolar disorder
    T Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, 351 0198, Saitama, Japan
    Neurosci Res 40:105-13. 2001
    ..The role of genomic imprinting is also possible because linkage to 18p11 is limited to paternally transmitted pedigrees. These results warrant further study of molecular genetics of bipolar disorder...
  2. ncbi Genetics of bipolar disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Drugs Today (Barc) 41:335-44. 2005
    ..In addition to monoaminergic and intracellular signaling pathways, recent studies have revealed possible roles for mitochondrial dysfunction, for glutamatergic dysfunction and for the endoplasmic reticulum stress pathway...
  3. ncbi Mitochondrial dysfunction as the molecular basis of bipolar disorder: therapeutic implications
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    CNS Drugs 21:1-11. 2007
    ..Two hypothetical mechanisms are mtDNA neuroplasticity and nonvisual photoreception impairment. Further study of mitochondrial dysfunction in bipolar disorder is expected to be useful for the development of new mood stabilisers...
  4. ncbi Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders
    T Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Mol Psychiatry 10:622-30. 2005
    ..However, if the genetic or epigenetic difference responsible for the discordant phenotype is found, it will have impact on the biology of mental disorder, in which few conclusive molecular genetic evidences have been obtained...
  5. ncbi [Mitochondrial dysfunction in bipolar disorder]
    Tadafumi Kato
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako 351 0198 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:61-72. 2005
    ..Thus, it is possible that bipolar disorder is also a disease caused by the progressive loss of some neuronal cells...
  6. ncbi [ER stress response and bipolar disorder]
    Tadafumi Kato
    Tanpakushitsu Kakusan Koso 49:1133-4. 2004
  7. ncbi Mechanisms of altered Ca2+ signalling in transformed lymphoblastoid cells from patients with bipolar disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Japan
    Int J Neuropsychopharmacol 6:379-89. 2003
    ..These results suggest that all components, i.e. the store-operated calcium channel (SOCC), endoplasmic reticulum, and mitochondria, somehow contribute to the altered Ca2+ signalling in bipolar disorder...
  8. ncbi The other, forgotten genome: mitochondrial DNA and mental disorders
    T Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama, 351 0198, Japan
    Mol Psychiatry 6:625-33. 2001
    ..In bipolar disorder, there is some evidence of parent-of-origin effects and association with mtDNA polymorphisms but further investigation is needed to elucidate the role of mtDNA in mental disorders...
  9. ncbi No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Neurosci Lett 338:21-4. 2003
    ..There was no significant difference of the expression levels. These results did not support the pathophysiological significance of WFS1 in bipolar disorder...
  10. ncbi Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neurosci Lett 417:316-21. 2007
    ..Contribution of common variations of ATF4 and ATF5 to the pathophysiology of bipolar disorder may be minimal if any...
  11. ncbi A family-based and case-control association study of SOX10 in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:477-81. 2006
    ..Haplotype analysis did not reveal significant associations between the two groups. We concluded that genetic variations in the SOX10 gene do not contribute to susceptibility to Japanese schizophrenia...
  12. ncbi Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with schizophrenia in the Japanese population
    Shinsuke Washizuka
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:301-4. 2006
    ..These results suggested that inter-individual variation of the genomic sequence of the promoter region of NDUFV2 might be a genetic risk factor common to bipolar disorder and schizophrenia...
  13. ncbi A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 32:1727-37. 2007
    ..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations...
  14. ncbi A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia
    Mika Aoki-Suzuki
    Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    Biol Psychiatry 57:382-93. 2005
    ..We therefore set out to examine the genetic contribution of human NTNG1 and NTNG2 to schizophrenia...
  15. ncbi Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia
    Shinsuke Washizuka
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan
    Neurosci Res 63:199-204. 2009
    ..02). Our study presented the further evidence of biological significance of NDUFV2 in BD and SZ...
  16. ncbi Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder
    Akiko Hayashi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Japan
    Int J Neuropsychopharmacol 12:33-43. 2009
    ..Altered ER stress response may play a role in the pathophysiology of BD by altering neural development and plasticity...
  17. ncbi Mitochondrial DNA haplogroup analysis in patients with bipolar disorder
    An a Kazuno
    RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:243-7. 2009
    ..However, this association was not replicated in an independent sample set. Possible significances of these findings are discussed...
  18. ncbi Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Psychiatry Clin Neurosci 62:103-8. 2008
    ....
  19. ncbi Functional polymorphisms of HSPA5: possible association with bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako Shi, Saitama, Japan
    Biochem Biophys Res Commun 336:1136-43. 2005
    ..These findings suggested promotor polymorphisms of HSPA5 may affect the interindividual variability of ER stress response and may confer a genetic risk factor for bipolar disorder...
  20. ncbi Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'
    An-A Kazuno
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Psychiatry Clin Neurosci 59:497-503. 2005
    ..However, the subhaplogroup F1b1a may be a good target for association study of 'atypical psychosis'...
  21. ncbi Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain
    Miki Bundo
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Psychiatry Clin Neurosci 64:57-61. 2010
    ..Here we examined the relationship between genetic variations and expression level or RNA editing level of HTR2C in the human brain...
  22. ncbi Association analysis of HSP90B1 with bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Hum Genet 52:794-803. 2007
    ..HSP90B1 may have a pathophysiological role in bipolar disorder in the Japanese population, though further study will be needed to understand the underlying functional mechanisms...
  23. ncbi Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees
    Shinsuke Washizuka
    Laboratories for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Biol Psychiatry 56:483-9. 2004
    ..We previously reported that a polymorphism in the upstream region of NDUFV2, -602G> A, was associated with bipolar disorder in Japanese subjects; however, functional significance of -602G> A was not known...
  24. ncbi Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Psychiatry Clin Neurosci 58:438-40. 2004
    ..Significant difference of genotype distribution was observed, which suggested that the -116C/C genotype is a protective factor for both of the major mental disorders...
  25. ncbi Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation
    Noriaki Nakatani
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Hum Mol Genet 15:1949-62. 2006
    ..Finally, gene network analysis using the currently obtained expression data highlighted cellular growth and nervous system development pathways as potential targets in the molecular pathophysiology of bipolar disorder...
  26. ncbi Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1
    Akiko Hayashi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 376:758-63. 2008
    ..Attenuated upregulation of Npy and Calb1 in Xbp1 knockout neurons was confirmed by quantitative RT-PCR. This finding may be relevant to impaired BDNF-induced neurite extension in Xbp1 knockout neurons...
  27. ncbi Therapeutic implications of down-regulation of cyclophilin D in bipolar disorder
    Mie Kubota
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Int J Neuropsychopharmacol 13:1355-68. 2010
    ..A blood-brain barrier-permeable CypD inhibitor significantly improved the abnormal behaviour of Tg mice at 40 mg/kg.d. These findings collectively suggest that CypD is a promising target for a new drug for BD...
  28. ncbi Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Neurosci Res 61:143-58. 2008
    ..These findings may be relevant to the mood disorder observed in patients with Wolfram disease...
  29. ncbi Neurobehavioral basis of the impaired nurturing in mice lacking the immediate early gene FosB
    Kumi O Kuroda
    Kuroda Research Unit for Affiliative Social Behavior, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Brain Res 1211:57-71. 2008
    ..These results suggest that FosB (-/-) mice have broader neurobehavioral dysfunctions, with which the nurturing defect might share the common mechanism...
  30. ncbi Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder
    Shinsuke Washizuka
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 120:72-8. 2003
    ..0001). Our findings suggest that polymorphisms of the NDUFV2 gene may be one of the genetic risk factors for bipolar disorder...
  31. ncbi Genome-wide association study of schizophrenia in Japanese population
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 6:e20468. 2011
    ..026). The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology...
  32. ncbi Abnormal Ca2+ dynamics in transgenic mice with neuron-specific mitochondrial DNA defects
    Mie Kubota
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 26:12314-24. 2006
    ..These findings suggest that mtDNA defects lead to enhancement of Ca2+ uptake rate via CyP-D downregulation and alter [Ca2+]i dynamics, which may be involved in the pathogenesis of BD...
  33. ncbi Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Genome Res 21:688-96. 2011
    ....
  34. ncbi Mitochondrial DNA-dependent effects of valproate on mitochondrial calcium levels in transmitochondrial cybrids
    An a Kazuno
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, Wako, Japan
    Int J Neuropsychopharmacol 11:71-8. 2008
    ..These finding suggest that valproate may stabilize intracellular calcium only in cells with high mitochondrial calcium levels...
  35. ncbi Methylation status of the reelin promoter region in the brain of schizophrenic patients
    Mamoru Tochigi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Biol Psychiatry 63:530-3. 2008
    ..We intended a technical replication of recent studies that observed hypermethylation of CpG or CpNpG sites in the RELN promoter region in the brain of schizophrenic patients...
  36. ncbi XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako-shi, Saitama, Japan
    J Neurochem 97:545-55. 2006
    ..An electrophoretic mobility shift assay suggested that XBP1 does not directly bind to this sequence. Our results demonstrate that WFS1 is one of the target genes of XBP1 in SH-SY5Y cells...
  37. ncbi Sequence and functional analyses of mtDNA in a maternally inherited family with bipolar disorder and depression
    Kae Munakata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1, Hirosawa, Wako, Saitama 351 0198, Japan
    Mutat Res 617:119-24. 2007
    ..The data did not support our hypothesis that these disorders in this family are caused by mtDNA mutation(s)...
  38. ncbi Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:557-64. 2008
    ..These findings suggest the possible role of ADM and SEPX1 as biomarkers of schizophrenia. The results also support the usefulness of gene expression analysis in LB cells of monozygotic twins discordant for an illness...
  39. ncbi Expression of mitochondria-related genes in lymphoblastoid cells from patients with bipolar disorder
    Shinsuke Washizuka
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Bipolar Disord 7:146-52. 2005
    ....
  40. ncbi Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia
    Kae Munakata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Biol Psychiatry 57:525-32. 2005
    ....
  41. ncbi The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development
    Akiko Hayashi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute RIKEN, Hirosawa, Wako Shi, Saitama, Japan
    J Biol Chem 282:34525-34. 2007
    ..These findings suggest that BDNF initiates UPR signaling in neurites and that Xbp1, which is activated as part of the UPR, conveys the local information from neurites to the nucleus, contributing the neurite outgrowth...
  42. ncbi Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder
    Kae Munakata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Genomics 84:1041-50. 2004
    ..The result of modest functional impairment caused by 3644T-->C suggests that this mutation could increase the risk for bipolar disorder...
  43. ncbi Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Hum Genet 49:227-31. 2004
    ..002 for HSPF1 and P = 0.072 for LIM). We also found the altered expressions of HSPF1 in LCLs from Caucasian patients with bipolar II disorder (P=0.011) and LIM in those from patients with schizophrenia (P = 0.001)...
  44. ncbi DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 25:5376-81. 2005
    ..Therefore, DNA methylation status of the SOX10 CpG island could be an epigenetic sign of oligodendrocyte dysfunction in schizophrenia...
  45. ncbi Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia
    Satoshi Fuke
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Neurosci Lett 439:173-7. 2008
    ..509). These results indicate that aging and sex have effect on accumulation of the common deletion of mtDNA in the prefrontal cortex depending on the diagnosis...
  46. ncbi Effect of mood stabilizers on gene expression in lymphoblastoid cells
    Hiroko Sugawara
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Neural Transm 117:155-64. 2010
    ..Our findings indicate that these two structurally dissimilar mood stabilizers, lithium, and valproate, alter VEGFA expression. VEGFA might be a useful biomarker of their effects on peripheral tissue...
  47. ncbi Preliminary genome-wide association study of bipolar disorder in the Japanese population
    Eiji Hattori
    RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:1110-7. 2009
    ..Sample stratification was virtually negligible. Collectively, this is the first GWAS of BD in the Japanese population. But given the small sample size and the limited genomic coverage, these results should be taken as preliminary...
  48. ncbi Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010
    ..Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses...
  49. ncbi Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama, Japan
    Int J Neuropsychopharmacol 8:515-22. 2005
    ..016). furthermore, POLG expression was significantly up-regulated in bipolar disorder ( p =0.036). Our results suggest that abnormalities in the system maintaining replication of mtdna may underlie bipolar disorder and schizophrenia...
  50. ncbi Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics
    An-A Kazuno
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    PLoS Genet 2:e128. 2006
    ..Our findings suggest that these mtDNA polymorphisms may play a role in the pathophysiology of these complex diseases by affecting mitochondrial matrix pH and intracellular calcium dynamics...
  51. ncbi Relationships between mitochondrial DNA subhaplogroups and intracellular calcium dynamics
    An a Kazuno
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama, Japan
    Mitochondrion 8:164-9. 2008
    ..The cybrid having higher calcium levels was subhaplogroup D4a, characterised by a non-synonymous polymorphism, 13651A>G. These mtDNA subhaplogroups might have functional effects...
  52. ncbi Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Nat Genet 35:171-5. 2003
    ..These results indicate that the -116C-->G polymorphism in XBP1 causes an impairment of its positive feedback system and increases the risk of bipolar disorder...
  53. ncbi Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains
    Mamoru Tochigi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Res 60:184-91. 2008
    ..Interestingly, these two genes were also included in the differentially expressed 99 genes in major depression. It may be worth investigating the genes in relation to suicide or major depression...
  54. ncbi Behavioral and gene expression analyses in heterozygous XBP1 knockout mice: Possible contribution of chromosome 11qA1 locus to prepulse inhibition
    Atsushi Takata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Neurosci Res 68:250-5. 2010
    ..These results support the contribution of chromosome 11qA1 locus to the amount of PPI. Uqcr10 and Nipsnap1 are good candidate genes that could impact PPI...
  55. ncbi Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    PLoS ONE 2:e1306. 2007
    ....
  56. ncbi Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama, Japan
    Cell Calcium 44:92-102. 2008
    ..In this review, the history and recent findings of studies elucidating the role of mitochondrial calcium signaling in bipolar disorder are summarized...
  57. ncbi A marked effect of electroconvulsive stimulation on behavioral aberration of mice with neuron-specific mitochondrial DNA defects
    Takaoki Kasahara
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako Shi, Saitama, Japan
    PLoS ONE 3:e1877. 2008
    ..This model will be useful in developing a safe and effective alternative to lithium or electroconvulsive therapy...
  58. ncbi Association of ANK3 with bipolar disorder confirmed in East Asia
    Atsushi Takata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 156:312-5. 2011
    ..These findings further supported the association between ANK3 and BD, and also suggested the genomic region around rs1938526 as a common risk locus across ethnicities...
  59. ncbi The role of mitochondrial dysfunction in bipolar disorder
    Tadafumi Kato
    Aging and Psychiatric Research Group, Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Drug News Perspect 19:597-602. 2006
    ..Bipolar disorder-like behavioral phenotypes of these mice supported this hypothesis. Thus, development of new mood stabilizers acting on mitochondrial function might be warranted...
  60. ncbi Altered RNA editing of serotonin 2C receptor in a rat model of depression
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Neurosci Res 53:69-76. 2005
    ..These results suggest that alteration of RNA editing of HTR2C may play a role in the pathophysiology of depression and action of antidepressants...
  61. ncbi Estimating RNA editing efficiency of five editing sites in the serotonin 2C receptor by pyrosequencing
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako City, Saitama 351 0198, Japan
    RNA 11:1596-603. 2005
    ..Our method could be a valuable tool in the rapid assessment of RNA editing status, including assessment of natural variations, alterations in disease tissues, and responses to drugs...
  62. ncbi Genetic and expression analyses of FZD3 in schizophrenia
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Biol Psychiatry 56:462-5. 2004
    ..Our study attempted to confirm associations between FZD3 and schizophrenia in Japanese family and case-control samples...
  63. ncbi Mitochondrial calcium response in human transformed lymphoblastoid cells
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Saitama, 351 0198, Wako, Japan
    Life Sci 71:581-90. 2002
    ..In contrast, 10 microM thapsigargin increased [Ca2+]i as well as [Ca2+]m. LCLs may be used for the study of possible pathophysiological role of mitochondrial calcium regulation in human diseases...
  64. ncbi RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan
    Neurosci Lett 346:169-72. 2003
    ..08) and site A in suicide victims (P=0.07). These findings are in accordance with the previous findings, and suggest that altered RNA editing of HTR2C may have some significance in major depression and suicide...
  65. ncbi Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder
    Shinsuke Washizuka
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Int J Neuropsychopharmacol 6:421-4. 2003
    ..05). Our findings suggest that the mtDNA 10398 polymorphism might be related to maintenance lithium treatment response...
  66. ncbi Gene expression profiling in schizophrenia and related mental disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Neuroscientist 12:349-61. 2006
    ..The authors also address the probable causes for the discordance among studies, possible ways to solve the problem, and their preferred approach for data interpretation...
  67. ncbi Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Hum Mol Genet 14:241-53. 2005
    ..Our findings warrant further study of the molecular mechanisms underlying mitochondrial dysfunction in BD and SZ...
  68. ncbi Animal models of bipolar disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Neurosci Biobehav Rev 31:832-42. 2007
    ..This mouse model of bipolar disorder potentially fulfills the three validity criteria, and therefore might be used for future drug development studies...
  69. ncbi [RNA editing of serotonin 2C receptor and major mental disorders]
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako City, Japan
    Yakugaku Zasshi 128:521-5. 2008
    ..Here we review studies examining the relationship between the serotonin 2C receptor and major mental disorders...
  70. ncbi Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan
    Neurosci Res 49:379-85. 2004
    ..The present results may provide some insights into understanding the mechanism of ethanol-induced altered behavioral responses at the molecular level...
  71. ncbi ERK-FosB signaling in dorsal MPOA neurons plays a major role in the initiation of parental behavior in mice
    Kumi O Kuroda
    Laboratory for Molecular Dynamics of Mental Disorder, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Mol Cell Neurosci 36:121-31. 2007
    ..Furthermore, induction of SPRY1 and Rad was impaired in MPOAd of nonparental FosB-knockout mice. These results suggest the pivotal role of ERK-FosB signaling in the initiation of parental care...
  72. ncbi Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    RNA Biol 6:248-53. 2009
    ..Possible significance of genetic variations affecting expression and RNA editing and appropriate animal models that mimic human mental disorders were discussed...
  73. ncbi Molecular genetics of bipolar disorder and depression
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Psychiatry Clin Neurosci 61:3-19. 2007
    ..Finally, this report addresses some possible causes for the lack of replication in this field...
  74. ncbi Molecular neurobiology of bipolar disorder: a disease of 'mood-stabilizing neurons'?
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Trends Neurosci 31:495-503. 2008
    ..The important next step in the neurobiological study of bipolar disorder is identification of the neural systems that are responsible for this disorder...
  75. ncbi Epigenetic profiling in schizophrenia and major mental disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan
    Neuropsychobiology 60:5-11. 2009
    ....
  76. ncbi Association study between the TNXB locus and schizophrenia in a Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 144:305-9. 2007
    ..Although these associations became insignificant after Bonferroni correction, the findings might provide support for the association of the TNXB locus or its adjacent region of the NOTCH4 locus with schizophrenia...
  77. ncbi A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Hokkaido, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:204-8. 2008
    ..We found that the allele frequency of Ser796 was significantly higher in non-responders than in responders. Further investigation is warranted to confirm our findings...
  78. ncbi Mitochondrial dysfunction in bipolar disorder: from 31P-magnetic resonance spectroscopic findings to their molecular mechanisms
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders Brain Science Institute, RIKEN Saitama 351-0198, Japan
    Int Rev Neurobiol 63:21-40. 2005
  79. ncbi Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder
    Akira Yoshimi
    Division of Clinical Science and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Aichi, 468 8503, Japan
    Schizophr Res 100:334-41. 2008
    ..Our findings suggest that PPP1R1B SNPs are unlikely to be related to the development of schizophrenia and bipolar disorder in the Japanese population...
  80. ncbi Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060 8638, Japan
    Neurosci Lett 391:7-10. 2005
    ..Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments...
  81. ncbi Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Res 56:154-8. 2006
    ..The results might be similar to a previous Asian study, but specific haplotypes suggested for the association differed between the studies. Studies with more markers and subjects may be required before firm conclusions can be reached...
  82. ncbi Maternal separation stress drastically decreases expression of transthyretin in the brains of adult rat offspring
    Kazuhisa Kohda
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Neuropsychopharmacol 9:201-8. 2006
    ..Our findings indicate that the CP, in addition to the neuronal and glial system, might play an important role in determining stress susceptibility...
  83. ncbi Lithium response and -116C/G polymorphism of XBP1 in Japanese patients with bipolar disorder
    Chihiro Kakiuchi
    Int J Neuropsychopharmacol 8:631-2. 2005
  84. ncbi The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder
    Ryota Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Biol Psychiatry 57:1097-102. 2005
    ..The BCR gene encodes a Rho GTPase activating protein, which is known to play important roles in neurite growth and axonal guidance...
  85. ncbi Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population
    Xuan Zhang
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, 113 8655 Japan
    Schizophr Res 79:175-80. 2005
    ..Haplotype analysis did not support the association between the patients and controls. The present study suggests that the DISC1/TRAX locus may not have a major role in Japanese schizophrenia...
  86. ncbi No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, 113 8655 Japan
    Schizophr Res 88:260-4. 2006
    ..Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population...
  87. ncbi XBP1 gene polymorphism (-116C/G) and personality
    Chieko Kato
    Department of Psychiatry, University of Tokyo, Bunkyo ku, Japan
    Am J Med Genet B Neuropsychiatr Genet 136:103-5. 2005
    ..The result is provisional and should be interpreted with caution, partly because the previous study suggested the allele as a risk allele for bipolar disorder. Further studies are required to confirm the results...
  88. ncbi Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Neurosci Lett 369:1-3. 2004
    ..Further investigations are necessary to examine the relationship in the different peripheral blood cells and/or in larger samples from patients with bipolar disorder...
  89. ncbi A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia
    Yasue Horiuchi
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Biol Psychiatry 59:434-9. 2006
    ..In the present study, we examined whether polymorphisms in PDLIM5 are associated with schizophrenia...
  90. ncbi No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Biol Psychiatry 56:376-8. 2004
    ....