Kazuya Iwamoto

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 25:5376-81. 2005
  2. ncbi request reprint [RNA editing of serotonin 2C receptor and major mental disorders]
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako City, Japan
    Yakugaku Zasshi 128:521-5. 2008
  3. ncbi request reprint Gene expression profiling in schizophrenia and related mental disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Neuroscientist 12:349-61. 2006
  4. doi request reprint Epigenetic profiling in schizophrenia and major mental disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan
    Neuropsychobiology 60:5-11. 2009
  5. doi request reprint Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Psychiatry Clin Neurosci 62:103-8. 2008
  6. pmc Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    PLoS ONE 2:e1306. 2007
  7. ncbi request reprint A family-based and case-control association study of SOX10 in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:477-81. 2006
  8. ncbi request reprint A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia
    Mika Aoki-Suzuki
    Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    Biol Psychiatry 57:382-93. 2005
  9. doi request reprint Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain
    Miki Bundo
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Psychiatry Clin Neurosci 64:57-61. 2010
  10. doi request reprint Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Neurosci Res 61:143-58. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 25:5376-81. 2005
    ..Therefore, DNA methylation status of the SOX10 CpG island could be an epigenetic sign of oligodendrocyte dysfunction in schizophrenia...
  2. ncbi request reprint [RNA editing of serotonin 2C receptor and major mental disorders]
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako City, Japan
    Yakugaku Zasshi 128:521-5. 2008
    ..Here we review studies examining the relationship between the serotonin 2C receptor and major mental disorders...
  3. ncbi request reprint Gene expression profiling in schizophrenia and related mental disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Neuroscientist 12:349-61. 2006
    ..The authors also address the probable causes for the discordance among studies, possible ways to solve the problem, and their preferred approach for data interpretation...
  4. doi request reprint Epigenetic profiling in schizophrenia and major mental disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan
    Neuropsychobiology 60:5-11. 2009
    ....
  5. doi request reprint Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Psychiatry Clin Neurosci 62:103-8. 2008
    ....
  6. pmc Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    PLoS ONE 2:e1306. 2007
    ....
  7. ncbi request reprint A family-based and case-control association study of SOX10 in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:477-81. 2006
    ..Haplotype analysis did not reveal significant associations between the two groups. We concluded that genetic variations in the SOX10 gene do not contribute to susceptibility to Japanese schizophrenia...
  8. ncbi request reprint A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia
    Mika Aoki-Suzuki
    Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    Biol Psychiatry 57:382-93. 2005
    ..We therefore set out to examine the genetic contribution of human NTNG1 and NTNG2 to schizophrenia...
  9. doi request reprint Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain
    Miki Bundo
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Psychiatry Clin Neurosci 64:57-61. 2010
    ..Here we examined the relationship between genetic variations and expression level or RNA editing level of HTR2C in the human brain...
  10. doi request reprint Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Neurosci Res 61:143-58. 2008
    ..These findings may be relevant to the mood disorder observed in patients with Wolfram disease...
  11. ncbi request reprint Altered RNA editing of serotonin 2C receptor in a rat model of depression
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Neurosci Res 53:69-76. 2005
    ..These results suggest that alteration of RNA editing of HTR2C may play a role in the pathophysiology of depression and action of antidepressants...
  12. ncbi request reprint Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia
    Kae Munakata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Biol Psychiatry 57:525-32. 2005
    ....
  13. doi request reprint Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia
    Shinsuke Washizuka
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan
    Neurosci Res 63:199-204. 2009
    ..02). Our study presented the further evidence of biological significance of NDUFV2 in BD and SZ...
  14. pmc Genome-wide association study of schizophrenia in Japanese population
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 6:e20468. 2011
    ..026). The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology...
  15. doi request reprint Effect of mood stabilizers on gene expression in lymphoblastoid cells
    Hiroko Sugawara
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Neural Transm 117:155-64. 2010
    ..Our findings indicate that these two structurally dissimilar mood stabilizers, lithium, and valproate, alter VEGFA expression. VEGFA might be a useful biomarker of their effects on peripheral tissue...
  16. pmc Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Genome Res 21:688-96. 2011
    ....
  17. ncbi request reprint Genetic and expression analyses of FZD3 in schizophrenia
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Biol Psychiatry 56:462-5. 2004
    ..Our study attempted to confirm associations between FZD3 and schizophrenia in Japanese family and case-control samples...
  18. ncbi request reprint Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees
    Shinsuke Washizuka
    Laboratories for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Biol Psychiatry 56:483-9. 2004
    ..We previously reported that a polymorphism in the upstream region of NDUFV2, -602G> A, was associated with bipolar disorder in Japanese subjects; however, functional significance of -602G> A was not known...
  19. ncbi request reprint Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama, Japan
    Int J Neuropsychopharmacol 8:515-22. 2005
    ..016). furthermore, POLG expression was significantly up-regulated in bipolar disorder ( p =0.036). Our results suggest that abnormalities in the system maintaining replication of mtdna may underlie bipolar disorder and schizophrenia...
  20. ncbi request reprint Evaluation of whole genome amplification methods using postmortem brain samples
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Neurosci Methods 165:104-10. 2007
    ....
  21. doi request reprint Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010
    ..Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses...
  22. ncbi request reprint Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains
    Mamoru Tochigi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Res 60:184-91. 2008
    ..Interestingly, these two genes were also included in the differentially expressed 99 genes in major depression. It may be worth investigating the genes in relation to suicide or major depression...
  23. ncbi request reprint Methylation status of the reelin promoter region in the brain of schizophrenic patients
    Mamoru Tochigi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Biol Psychiatry 63:530-3. 2008
    ..We intended a technical replication of recent studies that observed hypermethylation of CpG or CpNpG sites in the RELN promoter region in the brain of schizophrenic patients...
  24. doi request reprint Therapeutic implications of down-regulation of cyclophilin D in bipolar disorder
    Mie Kubota
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Int J Neuropsychopharmacol 13:1355-68. 2010
    ..A blood-brain barrier-permeable CypD inhibitor significantly improved the abnormal behaviour of Tg mice at 40 mg/kg.d. These findings collectively suggest that CypD is a promising target for a new drug for BD...
  25. ncbi request reprint The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development
    Akiko Hayashi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute RIKEN, Hirosawa, Wako Shi, Saitama, Japan
    J Biol Chem 282:34525-34. 2007
    ..These findings suggest that BDNF initiates UPR signaling in neurites and that Xbp1, which is activated as part of the UPR, conveys the local information from neurites to the nucleus, contributing the neurite outgrowth...
  26. ncbi request reprint Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Nat Genet 35:171-5. 2003
    ..These results indicate that the -116C-->G polymorphism in XBP1 causes an impairment of its positive feedback system and increases the risk of bipolar disorder...
  27. ncbi request reprint Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Neurosci Res 49:379-85. 2004
    ..The present results may provide some insights into understanding the mechanism of ethanol-induced altered behavioral responses at the molecular level...
  28. ncbi request reprint Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Hum Genet 49:227-31. 2004
    ..002 for HSPF1 and P = 0.072 for LIM). We also found the altered expressions of HSPF1 in LCLs from Caucasian patients with bipolar II disorder (P=0.011) and LIM in those from patients with schizophrenia (P = 0.001)...
  29. pmc Estimating RNA editing efficiency of five editing sites in the serotonin 2C receptor by pyrosequencing
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako City, Saitama 351 0198, Japan
    RNA 11:1596-603. 2005
    ..Our method could be a valuable tool in the rapid assessment of RNA editing status, including assessment of natural variations, alterations in disease tissues, and responses to drugs...
  30. ncbi request reprint RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama, 351 0198, Japan
    Neurosci Lett 346:169-72. 2003
    ..08) and site A in suicide victims (P=0.07). These findings are in accordance with the previous findings, and suggest that altered RNA editing of HTR2C may have some significance in major depression and suicide...
  31. pmc Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines
    Hiroko Sugawara
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Epigenetics 6:508-15. 2011
    ..These findings suggest that LCLs should be used for DNA methylation studies with caution as the methylation patterns of promoter regions in LCLs are not always the same as those in PBLs...
  32. ncbi request reprint Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Hum Mol Genet 14:241-53. 2005
    ..Our findings warrant further study of the molecular mechanisms underlying mitochondrial dysfunction in BD and SZ...
  33. doi request reprint Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    J Hum Genet 56:779-83. 2011
    ..97, P=0.046). This study was the first to suggest a possible role of gene expression analysis of ANK3, RASGRP1 and POLG1 in the LCLs as potential biomarkers of BD...
  34. doi request reprint Survey of the effect of genetic variations on gene expression in human prefrontal cortex and its application to genetics of psychiatric disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Res 70:238-42. 2011
    ..We found that SNPs in the AKAP10 and PRKCI genes are significantly associated with bipolar disorder and gene expression variation...
  35. ncbi request reprint Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    RNA Biol 6:248-53. 2009
    ..Possible significance of genetic variations affecting expression and RNA editing and appropriate animal models that mimic human mental disorders were discussed...
  36. ncbi request reprint Comprehensive gene expression analysis in bipolar disorder
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Can J Psychiatry 52:763-71. 2007
    ..To review recent findings by DNA microarray in bipolar disorder (BD)...
  37. ncbi request reprint Expression analysis of actin-related genes as an underlying mechanism for mood disorders
    Noriaki Nakatani
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Biochem Biophys Res Commun 352:780-6. 2007
    ..These data suggest that the balance of actin dynamics might be altered towards actin depolymerization in mood disorders...
  38. ncbi request reprint No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Neurosci Lett 338:21-4. 2003
    ..There was no significant difference of the expression levels. These results did not support the pathophysiological significance of WFS1 in bipolar disorder...
  39. ncbi request reprint [Gene expression in mental diseases--from DNA to RNA]
    Tadashi Kato
    Seishin Shinkeigaku Zasshi 106:49-52. 2004
  40. ncbi request reprint The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved in the onset of neurodegenerative diseases
    Yu Tzu Huang
    Department of Biological Science, Graduate School of Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Neurosci Lett 382:175-8. 2005
    ....
  41. ncbi request reprint Maternal separation stress drastically decreases expression of transthyretin in the brains of adult rat offspring
    Kazuhisa Kohda
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Neuropsychopharmacol 9:201-8. 2006
    ..Our findings indicate that the CP, in addition to the neuronal and glial system, might play an important role in determining stress susceptibility...