Research Topics
Genomes and Genes
| Kazuya IwamotoSummaryAffiliation: RIKEN Brain Science Institute Country: Japan Publications
| Collaborators
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Detail Information
Publications
DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophreniaKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
J Neurosci 25:5376-81. 2005..Therefore, DNA methylation status of the SOX10 CpG island could be an epigenetic sign of oligodendrocyte dysfunction in schizophrenia...- [RNA editing of serotonin 2C receptor and major mental disorders]Kazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako City, Japan
Yakugaku Zasshi 128:521-5. 2008..Here we review studies examining the relationship between the serotonin 2C receptor and major mental disorders... - Gene expression profiling in schizophrenia and related mental disordersKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
Neuroscientist 12:349-61. 2006..The authors also address the probable causes for the discordance among studies, possible ways to solve the problem, and their preferred approach for data interpretation... 
Epigenetic profiling in schizophrenia and major mental disordersKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan
Neuropsychobiology 60:5-11. 2009....- Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophreniaKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
Psychiatry Clin Neurosci 62:103-8. 2008.... 
Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflowKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
PLoS ONE 2:e1306. 2007....- A family-based and case-control association study of SOX10 in schizophreniaKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
Am J Med Genet B Neuropsychiatr Genet 141:477-81. 2006..Haplotype analysis did not reveal significant associations between the two groups. We concluded that genetic variations in the SOX10 gene do not contribute to susceptibility to Japanese schizophrenia... - A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophreniaMika Aoki-Suzuki
Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
Biol Psychiatry 57:382-93. 2005..We therefore set out to examine the genetic contribution of human NTNG1 and NTNG2 to schizophrenia... - Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brainMiki Bundo
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
Psychiatry Clin Neurosci 64:57-61. 2010..Here we examined the relationship between genetic variations and expression level or RNA editing level of HTR2C in the human brain... - Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorderTadafumi Kato
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
Neurosci Res 61:143-58. 2008..These findings may be relevant to the mood disorder observed in patients with Wolfram disease... - Altered RNA editing of serotonin 2C receptor in a rat model of depressionKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
Neurosci Res 53:69-76. 2005..These results suggest that alteration of RNA editing of HTR2C may play a role in the pathophysiology of depression and action of antidepressants... - Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophreniaKae Munakata
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Biol Psychiatry 57:525-32. 2005.... - Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophreniaShinsuke Washizuka
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan
Neurosci Res 63:199-204. 2009..02). Our study presented the further evidence of biological significance of NDUFV2 in BD and SZ... - Genome-wide association study of schizophrenia in Japanese populationKazuo Yamada
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
PLoS ONE 6:e20468. 2011..026). The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology... - Effect of mood stabilizers on gene expression in lymphoblastoid cellsHiroko Sugawara
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
J Neural Transm 117:155-64. 2010..Our findings indicate that these two structurally dissimilar mood stabilizers, lithium, and valproate, alter VEGFA expression. VEGFA might be a useful biomarker of their effects on peripheral tissue... - Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neuronsKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Genome Res 21:688-96. 2011.... - Genetic and expression analyses of FZD3 in schizophreniaMasayuki Ide
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
Biol Psychiatry 56:462-5. 2004..Our study attempted to confirm associations between FZD3 and schizophrenia in Japanese family and case-control samples... - Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigreesShinsuke Washizuka
Laboratories for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
Biol Psychiatry 56:483-9. 2004..We previously reported that a polymorphism in the upstream region of NDUFV2, -602G> A, was associated with bipolar disorder in Japanese subjects; however, functional significance of -602G> A was not known... - Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophreniaChihiro Kakiuchi
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama, Japan
Int J Neuropsychopharmacol 8:515-22. 2005..016). furthermore, POLG expression was significantly up-regulated in bipolar disorder ( p =0.036). Our results suggest that abnormalities in the system maintaining replication of mtdna may underlie bipolar disorder and schizophrenia... - Evaluation of whole genome amplification methods using postmortem brain samplesKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
J Neurosci Methods 165:104-10. 2007.... - Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorderYoshimi Iwayama
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010..Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses... - Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brainsMamoru Tochigi
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Neurosci Res 60:184-91. 2008..Interestingly, these two genes were also included in the differentially expressed 99 genes in major depression. It may be worth investigating the genes in relation to suicide or major depression... - Methylation status of the reelin promoter region in the brain of schizophrenic patientsMamoru Tochigi
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
Biol Psychiatry 63:530-3. 2008..We intended a technical replication of recent studies that observed hypermethylation of CpG or CpNpG sites in the RELN promoter region in the brain of schizophrenic patients... - Therapeutic implications of down-regulation of cyclophilin D in bipolar disorderMie Kubota
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
Int J Neuropsychopharmacol 13:1355-68. 2010..A blood-brain barrier-permeable CypD inhibitor significantly improved the abnormal behaviour of Tg mice at 40 mg/kg.d. These findings collectively suggest that CypD is a promising target for a new drug for BD... - The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain developmentAkiko Hayashi
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute RIKEN, Hirosawa, Wako Shi, Saitama, Japan
J Biol Chem 282:34525-34. 2007..These findings suggest that BDNF initiates UPR signaling in neurites and that Xbp1, which is activated as part of the UPR, conveys the local information from neurites to the nucleus, contributing the neurite outgrowth... - Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorderChihiro Kakiuchi
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
Nat Genet 35:171-5. 2003..These results indicate that the -116C-->G polymorphism in XBP1 causes an impairment of its positive feedback system and increases the risk of bipolar disorder... - Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholicsKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan
Neurosci Res 49:379-85. 2004..The present results may provide some insights into understanding the mechanism of ethanol-induced altered behavioral responses at the molecular level... - Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophreniaKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
J Hum Genet 49:227-31. 2004..002 for HSPF1 and P = 0.072 for LIM). We also found the altered expressions of HSPF1 in LCLs from Caucasian patients with bipolar II disorder (P=0.011) and LIM in those from patients with schizophrenia (P = 0.001)... - Estimating RNA editing efficiency of five editing sites in the serotonin 2C receptor by pyrosequencingKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako City, Saitama 351 0198, Japan
RNA 11:1596-603. 2005..Our method could be a valuable tool in the rapid assessment of RNA editing status, including assessment of natural variations, alterations in disease tissues, and responses to drugs... - RNA editing of serotonin 2C receptor in human postmortem brains of major mental disordersKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan
Neurosci Lett 346:169-72. 2003..08) and site A in suicide victims (P=0.07). These findings are in accordance with the previous findings, and suggest that altered RNA editing of HTR2C may have some significance in major depression and suicide... - Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell linesHiroko Sugawara
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
Epigenetics 6:508-15. 2011..These findings suggest that LCLs should be used for DNA methylation studies with caution as the methylation patterns of promoter regions in LCLs are not always the same as those in PBLs... - Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysisKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
Hum Mol Genet 14:241-53. 2005..Our findings warrant further study of the molecular mechanisms underlying mitochondrial dysfunction in BD and SZ... - Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorderTadafumi Kato
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
J Hum Genet 56:779-83. 2011..97, P=0.046). This study was the first to suggest a possible role of gene expression analysis of ANK3, RASGRP1 and POLG1 in the LCLs as potential biomarkers of BD... - Survey of the effect of genetic variations on gene expression in human prefrontal cortex and its application to genetics of psychiatric disordersKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Neurosci Res 70:238-42. 2011..We found that SNPs in the AKAP10 and PRKCI genes are significantly associated with bipolar disorder and gene expression variation... - Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studiesKazuya Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
RNA Biol 6:248-53. 2009..Possible significance of genetic variations affecting expression and RNA editing and appropriate animal models that mimic human mental disorders were discussed... - Comprehensive gene expression analysis in bipolar disorderTadafumi Kato
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
Can J Psychiatry 52:763-71. 2007..To review recent findings by DNA microarray in bipolar disorder (BD)... - Expression analysis of actin-related genes as an underlying mechanism for mood disordersNoriaki Nakatani
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Biochem Biophys Res Commun 352:780-6. 2007..These data suggest that the balance of actin dynamics might be altered towards actin depolymerization in mood disorders... - No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humansTadafumi Kato
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
Neurosci Lett 338:21-4. 2003..There was no significant difference of the expression levels. These results did not support the pathophysiological significance of WFS1 in bipolar disorder... - [Gene expression in mental diseases--from DNA to RNA]Tadashi Kato
Seishin Shinkeigaku Zasshi 106:49-52. 2004 - The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved in the onset of neurodegenerative diseasesYu Tzu Huang
Department of Biological Science, Graduate School of Sciences, The University of Tokyo, Tokyo 113 0033, Japan
Neurosci Lett 382:175-8. 2005.... - Maternal separation stress drastically decreases expression of transthyretin in the brains of adult rat offspringKazuhisa Kohda
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Int J Neuropsychopharmacol 9:201-8. 2006..Our findings indicate that the CP, in addition to the neuronal and glial system, might play an important role in determining stress susceptibility...