Shohei Hori

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. doi request reprint Regulatory T cell plasticity: beyond the controversies
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
    Trends Immunol 32:295-300. 2011
  2. doi request reprint Rethinking the molecular definition of regulatory T cells
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi, Yokohama 230 0045, Japan
    Eur J Immunol 38:928-30. 2008
  3. doi request reprint c-Rel: a pioneer in directing regulatory T-cell lineage commitment?
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Japan
    Eur J Immunol 40:664-7. 2010
  4. doi request reprint Developmental plasticity of Foxp3+ regulatory T cells
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Japan
    Curr Opin Immunol 22:575-82. 2010
  5. ncbi request reprint Foxp3: a critical regulator of the development and function of regulatory T cells
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Microbes Infect 6:745-51. 2004
  6. doi request reprint Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, RIKEN, Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Science 323:1488-92. 2009
  7. ncbi request reprint Control of autoimmunity by naturally arising regulatory CD4+ T cells
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, The Institute for Physical and Chemical Research RIKEN, Yokohama 230 0045, Japan
    Adv Immunol 81:331-71. 2003
  8. doi request reprint Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
    Takahisa Miyao
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Immunity 36:262-75. 2012
  9. ncbi request reprint Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
  10. pmc Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    Noriko Komatsu
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Proc Natl Acad Sci U S A 106:1903-8. 2009

Collaborators

Detail Information

Publications27

  1. doi request reprint Regulatory T cell plasticity: beyond the controversies
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
    Trends Immunol 32:295-300. 2011
    ....
  2. doi request reprint Rethinking the molecular definition of regulatory T cells
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi, Yokohama 230 0045, Japan
    Eur J Immunol 38:928-30. 2008
    ..However, emerging evidence challenges these views and suggests that the Treg lineage may be determined by a higher-order regulatory process that ensures stable and high levels Foxp3 expression...
  3. doi request reprint c-Rel: a pioneer in directing regulatory T-cell lineage commitment?
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Japan
    Eur J Immunol 40:664-7. 2010
    ..These findings collectively suggest that c-Rel may act as a pioneer transcription factor in initiating Foxp3 transcription in Treg precursors in the thymus...
  4. doi request reprint Developmental plasticity of Foxp3+ regulatory T cells
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Japan
    Curr Opin Immunol 22:575-82. 2010
    ..Recent studies of Foxp3 gene regulation have provided a framework to dissect the molecular mechanisms underlying Treg cell lineage commitment and plasticity...
  5. ncbi request reprint Foxp3: a critical regulator of the development and function of regulatory T cells
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Microbes Infect 6:745-51. 2004
    ..This review discusses the critical role for this transcription factor in the development and function of regulatory T cells...
  6. doi request reprint Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, RIKEN, Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Science 323:1488-92. 2009
    ..Thus, environmental cues present in gut Peyer's patches promote the selective differentiation of distinct helper T cell subsets, such as TFH cells...
  7. ncbi request reprint Control of autoimmunity by naturally arising regulatory CD4+ T cells
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, The Institute for Physical and Chemical Research RIKEN, Yokohama 230 0045, Japan
    Adv Immunol 81:331-71. 2003
    ..Furthermore, reduction or dysfunction of the CD25+ CD4+ regulatory T cell population can be responsible for certain autoimmune diseases in humans...
  8. doi request reprint Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
    Takahisa Miyao
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Immunity 36:262-75. 2012
    ..This study establishes that Treg cells constitute a stable cell lineage, whose committed state in a changing environment is ensured by DNA demethylation of the Foxp3 locus irrespectively of ongoing Foxp3 expression...
  9. ncbi request reprint Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  10. pmc Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    Noriko Komatsu
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Proc Natl Acad Sci U S A 106:1903-8. 2009
    ..These results demonstrate that natural Foxp3(+) T cells are a heterogeneous population consisting of a committed T(reg) lineage and an uncommitted subpopulation with developmental plasticity...
  11. pmc Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice
    Michio Tomura
    Research Center for Allergy and Immunology, RIKEN, Yokohama City, Japan
    J Clin Invest 120:883-93. 2010
    ..Together, our results suggest that Tregs in circulation infiltrate the periphery, traffic to DLNs, and then recirculate back to the skin, contributing to the downregulation of cutaneous immune responses...
  12. ncbi request reprint Enhanced efficacy of regulatory T cell transfer against increasing resistance, by elevated Foxp3 expression induced in arthritic murine hosts
    Junko Ohata
    Research Center for Allergy and Immunology, RIKEN, Yokohama, Japan
    Arthritis Rheum 56:2947-56. 2007
    ..To investigate the efficacy of type II collagen-reactive Foxp3-expressing T cell transfer in suppressing collagen-induced arthritis (CIA) in relation to disease progression...
  13. doi request reprint Stability of regulatory T-cell lineage
    Shohei Hori
    Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    Adv Immunol 112:1-24. 2011
    ..This review will focus on recent advances in our understanding of how the stability and adaptability of Treg cell lineage is regulated and how it might be perturbed in a changing environment...
  14. pmc The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
    Yasutaka Motomura
    Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
    Nat Immunol 12:450-9. 2011
    ..Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells...
  15. ncbi request reprint Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    Haruhiko Yagi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Int Immunol 16:1643-56. 2004
    ..Furthermore, regulatory T cells de novo produced from normal naive T cells by FOXP3 transduction can be instrumental for treatment of autoimmune/inflammatory diseases and negative control of various immune responses...
  16. ncbi request reprint CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice
    Shohei Hori
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Eur J Immunol 32:1282-91. 2002
    ..Our results indicate an essential role for CD25(+)CD4(+) T cells in the control of PC-driven immunopathology, and suggest that in immunocompromised hosts PC pneumonia may result from a deficiency in regulatory T cells...
  17. ncbi request reprint Regulatory T cells, derived from naïve CD4+CD25- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance
    Jian Guo Chai
    Transplantation Biology Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London
    Transplantation 79:1310-6. 2005
    ..This study investigated whether Treg cells generated from naive CD4+ T cells by Foxp3 gene transfer could induce transplantation tolerance...
  18. pmc Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    Ruka Setoguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 201:723-35. 2005
    ..Furthermore, impairment of this negative feedback loop via IL-2 can be a cause and a predisposing factor for autoimmune disease...
  19. ncbi request reprint Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice
    Shohei Hori
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Eur J Immunol 32:3729-35. 2002
    ..These observations thus exclude peripheral differentiation of Treg in this particular system, and indicate that expansion of thymically committed cells ensures the maintenance of the peripheral Treg pool in the adult...
  20. pmc Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice
    Shohei Hori
    Instituto Gulbenkian de Ciencia, Apartado 14, 2781 901 Oeiras, Portugal
    Proc Natl Acad Sci U S A 99:8213-8. 2002
    ..Taken together, these results indicate that specificity to MBP is required for effector functions but is not sufficient for thymic selection/commitment of CD25(+)4(+) T(reg) preventing EAE...
  21. ncbi request reprint A new statistical method for quantitative analyses: application to the precise quantification of T cell receptor repertoires
    Shohei Hori
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2781 901 Oeiras, Portugal
    J Immunol Methods 268:159-70. 2002
    ..This approach provides the first precise method able to measure the diversity of the antigen receptor repertoire inside a complex cell population by the use of a single straightforward technique...
  22. ncbi request reprint Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance
    Shimon Sakaguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Novartis Found Symp 252:6-16; discussion 16-23, 106-14. 2003
    ....
  23. ncbi request reprint Regulatory cells in transplantation
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Novartis Found Symp 252:177-88; discussion 188-93, 203-10. 2003
    ....
  24. pmc Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras
    Noriko Komatsu
    Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Proc Natl Acad Sci U S A 104:8959-64. 2007
    ....
  25. ncbi request reprint Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
    Kenji Ichiyama
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 283:17003-8. 2008
    ..We propose that induction of Foxp3 is the mechanism for the suppression of Th17 and polarization into inducible Treg...
  26. ncbi request reprint Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin
    Yuan Min Wang
    Centre for Kidney Research, Children s Hospital at Westmead, and Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, New South Wales 2145, Sydney, Australia
    J Am Soc Nephrol 17:697-706. 2006
    ..01). It is concluded that Foxp3-transduced Treg cells may have a therapeutic role in protecting against immune injury and disease progression in chronic proteinuric renal disease...
  27. ncbi request reprint Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
    Shimon Sakaguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Immunol Rev 212:8-27. 2006
    ....