Chihiro Hisatsune

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint Regulation of TRPC6 channel activity by tyrosine phosphorylation
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 279:18887-94. 2004
  2. ncbi request reprint Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 282:37225-31. 2007
  3. pmc IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Japan
    Front Neural Circuits 7:156. 2013
  4. doi request reprint Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction
    Hong Zhou
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 369:213-9. 2008
  5. ncbi request reprint Inositol 1,4,5-trisphosphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor production
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
    J Neurosci 26:10916-24. 2006
  6. ncbi request reprint Amplification of Ca2+ signaling by diacylglycerol-mediated inositol 1,4,5-trisphosphate production
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 280:11723-30. 2005
  7. doi request reprint Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice
    Takeyuki Sugawara
    Laboratories for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 33:12186-96. 2013
  8. ncbi request reprint Novel compartment implicated in calcium signaling--is it an "induced coupling domain"?
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Sci STKE 2005:pe53. 2005
  9. ncbi request reprint Isolation of inositol 1,4,5-trisphosphate receptor-associating proteins and selective knockdown using RNA interference
    Akihiro Mizutani
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama, Japan
    Methods Mol Biol 645:133-41. 2010
  10. doi request reprint The role of Ca2+ signaling in cell function with special reference to exocrine secretion
    Katsuhiko Mikoshiba
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, Japan
    Cornea 27:S3-8. 2008

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Regulation of TRPC6 channel activity by tyrosine phosphorylation
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 279:18887-94. 2004
    ..Thus, our findings demonstrated that tyrosine phosphorylation by Src family PTKs is a novel regulatory mechanism of TRPC6 channel activity...
  2. ncbi request reprint Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 282:37225-31. 2007
    ..We conclude that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta2 to TRPM5 activation...
  3. pmc IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Japan
    Front Neural Circuits 7:156. 2013
    ..These findings implicate IP3R1-dependent PC firing patterns in cerebellum in motor coordination and the expression of dystonia through the olivo-cerebellar pathway. ..
  4. doi request reprint Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction
    Hong Zhou
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 369:213-9. 2008
    ..Taken together, we concluded that IP(3)R1 plays a predominant role in the function of the vascular smooth muscle in vivo...
  5. ncbi request reprint Inositol 1,4,5-trisphosphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor production
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
    J Neurosci 26:10916-24. 2006
    ....
  6. ncbi request reprint Amplification of Ca2+ signaling by diacylglycerol-mediated inositol 1,4,5-trisphosphate production
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 280:11723-30. 2005
    ..These results suggest a novel physiological function of DAG, i.e. amplification of Ca2+ signaling by enhancing IP3 production via its positive feedback effect on PLC activity...
  7. doi request reprint Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice
    Takeyuki Sugawara
    Laboratories for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 33:12186-96. 2013
    ....
  8. ncbi request reprint Novel compartment implicated in calcium signaling--is it an "induced coupling domain"?
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Sci STKE 2005:pe53. 2005
    ....
  9. ncbi request reprint Isolation of inositol 1,4,5-trisphosphate receptor-associating proteins and selective knockdown using RNA interference
    Akihiro Mizutani
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama, Japan
    Methods Mol Biol 645:133-41. 2010
    ..These methods will provide clues to understand the exact nature of how the signaling complex contributes to the generation of spatio-temporal patterns of intracellular Ca(2+) signals...
  10. doi request reprint The role of Ca2+ signaling in cell function with special reference to exocrine secretion
    Katsuhiko Mikoshiba
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, Japan
    Cornea 27:S3-8. 2008
    ..Type 2 and 3 double-deficient mice show a deficit in saliva and lacrimal and pancreatic juice secretion. Type 1 IP3 receptor influences brain-derived neurotrophic factor production...
  11. ncbi request reprint Striatum-specific expression of Cre recombinase using the Gpr88 promoter in mice
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI 2 1 Hirosawa, Wako City, Saitama, 351 0198, Japan
    Transgenic Res 22:1241-7. 2013
    ..Medium spiny neurons within the caudate-putamen exhibited Cre activity. Thus, Gpr88-Cre Tg mice could be a useful tool for analyzing the function of the basal ganglia by using Cre/loxP systems. ..
  12. pmc Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye
    Takaaki Inaba
    Department of Ophthalmology, Keio University School of Medicine, Shinjuku, Tokyo, Japan Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama, Japan
    PLoS ONE 9:e99205. 2014
    ..These results suggested that IP3Rs are essential for tear secretion in both parasympathetic and sympathetic pathways and that Itpr2-/-;Itpr3-/- mice could be a new dry eye mouse model with symptoms that mimic those of SS. ..
  13. doi request reprint Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo
    Norio Takata
    Laboratory for Neuron Glia Circuit and Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 31:18155-65. 2011
    ..Our data present coherent lines of in vivo evidence for astrocytic involvement in cortical plasticity. These findings suggest an unexpected role of astrocytes as a gate for cholinergic plasticity in the cortex...
  14. pmc G-protein-coupled receptor kinase-interacting proteins inhibit apoptosis by inositol 1,4,5-triphosphate receptor-mediated Ca2+ signal regulation
    Songbai Zhang
    Calcium Oscillation Project, International Cooperative Research Project Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 284:29158-69. 2009
    ..Thus, we conclude that GIT inhibits apoptosis by modulating the IP(3)R-mediated Ca(2+) signal through a direct interaction with IP(3)R in a cytosolic Ca(2+)-dependent manner...
  15. pmc Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis
    Yukiko Kuroda
    Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 105:8643-8. 2008
    ..Taken together, we conclude that both Ca(2+) oscillation/calcineurin-dependent and -independent signaling pathways contribute to NFATc1 activation, leading to efficient osteoclastogenesis in vivo...
  16. ncbi request reprint Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons
    Weihua Cai
    Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 279:23691-8. 2004
    ....
  17. pmc Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells
    Songbai Zhang
    Division of Molecular Neurobiology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Japan
    J Biol Chem 278:4048-56. 2003
    ..1N blocks the localization of co-expressed IP(3)R1 at the basolateral membrane domain. These data indicate that 4.1N is required for IP(3)R1 translocation to the basolateral membrane domain in polarized MDCK cells...