Research Topics
Genomes and Genes | Chihiro HisatsuneSummaryAffiliation: RIKEN Brain Science Institute Country: Japan Publications
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Detail Information
Publications
Amplification of Ca2+ signaling by diacylglycerol-mediated inositol 1,4,5-trisphosphate productionChihiro Hisatsune
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
J Biol Chem 280:11723-30. 2005..These results suggest a novel physiological function of DAG, i.e. amplification of Ca2+ signaling by enhancing IP3 production via its positive feedback effect on PLC activity...
Predominant role of type 1 IP3 receptor in aortic vascular muscle contractionHong Zhou
Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Biochem Biophys Res Commun 369:213-9. 2008..Taken together, we concluded that IP(3)R1 plays a predominant role in the function of the vascular smooth muscle in vivo...- Regulation of TRPC6 channel activity by tyrosine phosphorylationChihiro Hisatsune
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
J Biol Chem 279:18887-94. 2004..Thus, our findings demonstrated that tyrosine phosphorylation by Src family PTKs is a novel regulatory mechanism of TRPC6 channel activity... - Isolation of inositol 1,4,5-trisphosphate receptor-associating proteins and selective knockdown using RNA interferenceAkihiro Mizutani
Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama, Japan
Methods Mol Biol 645:133-41. 2010..These methods will provide clues to understand the exact nature of how the signaling complex contributes to the generation of spatio-temporal patterns of intracellular Ca(2+) signals... - Novel compartment implicated in calcium signaling--is it an "induced coupling domain"?Chihiro Hisatsune
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
Sci STKE 2005:pe53. 2005.... - Inositol 1,4,5-trisphosphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor productionChihiro Hisatsune
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
J Neurosci 26:10916-24. 2006.... - The role of Ca2+ signaling in cell function with special reference to exocrine secretionKatsuhiko Mikoshiba
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, Japan
Cornea 27:S3-8. 2008..Type 2 and 3 double-deficient mice show a deficit in saliva and lacrimal and pancreatic juice secretion. Type 1 IP3 receptor influences brain-derived neurotrophic factor production... - Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivoNorio Takata
Laboratory for Neuron Glia Circuit and Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
J Neurosci 31:18155-65. 2011..Our data present coherent lines of in vivo evidence for astrocytic involvement in cortical plasticity. These findings suggest an unexpected role of astrocytes as a gate for cholinergic plasticity in the cortex... 
G-protein-coupled receptor kinase-interacting proteins inhibit apoptosis by inositol 1,4,5-triphosphate receptor-mediated Ca2+ signal regulationSongbai Zhang
Calcium Oscillation Project, International Cooperative Research Project Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
J Biol Chem 284:29158-69. 2009..Thus, we conclude that GIT inhibits apoptosis by modulating the IP(3)R-mediated Ca(2+) signal through a direct interaction with IP(3)R in a cytosolic Ca(2+)-dependent manner...- Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptorChihiro Hisatsune
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
J Biol Chem 282:37225-31. 2007..We conclude that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta2 to TRPM5 activation... - Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neuronsWeihua Cai
Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokane dai, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 279:23691-8. 2004.... - Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesisYukiko Kuroda
Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokane dai, Minato ku, Tokyo 108 8639, Japan
Proc Natl Acad Sci U S A 105:8643-8. 2008..Taken together, we conclude that both Ca(2+) oscillation/calcineurin-dependent and -independent signaling pathways contribute to NFATc1 activation, leading to efficient osteoclastogenesis in vivo... - Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cellsSongbai Zhang
Division of Molecular Neurobiology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Japan
J Biol Chem 278:4048-56. 2003..1N blocks the localization of co-expressed IP(3)R1 at the basolateral membrane domain. These data indicate that 4.1N is required for IP(3)R1 translocation to the basolateral membrane domain in polarized MDCK cells...