Makoto Higuchi

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Biol Chem 280:15229-37. 2005
  2. ncbi request reprint Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochim Biophys Acta 1751:60-7. 2005
  3. ncbi request reprint 19F and 1H MRI detection of amyloid beta plaques in vivo
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitoma 351 0198, Japan
    Nat Neurosci 8:527-33. 2005
  4. doi request reprint Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    FASEB J 26:1204-17. 2012
  5. ncbi request reprint Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function
    Shu Ming Huang
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 281:17941-51. 2006
  6. ncbi request reprint Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation
    Takashi Saito
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Nat Med 11:434-9. 2005
  7. ncbi request reprint [Presymptomatic diagnosis, prevention and therapy]
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    No To Shinkei 57:855-66. 2005
  8. ncbi request reprint Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice
    Jiro Takano
    Laboratories for Proteolytic Neuroscience and Behavioral Genetics, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 280:16175-84. 2005
  9. pmc Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Sci Rep 3:1472. 2013
  10. ncbi request reprint Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice
    Runa Araya
    Yamada Research Unit, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neurobiol Dis 24:334-44. 2006

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Biol Chem 280:15229-37. 2005
    ....
  2. ncbi request reprint Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochim Biophys Acta 1751:60-7. 2005
    ....
  3. ncbi request reprint 19F and 1H MRI detection of amyloid beta plaques in vivo
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitoma 351 0198, Japan
    Nat Neurosci 8:527-33. 2005
    ..This approach could be used in longitudinal studies in mouse models of Alzheimer disease to search for biomarkers associated with amyloid beta pathology as well as to track disease course after treatment with candidate medications...
  4. doi request reprint Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    FASEB J 26:1204-17. 2012
    ..These findings implicate that calpain activation plays a pivotal role in the Aβ-triggered pathological cascade, highlighting a target for pharmacological intervention in the treatment of AD...
  5. ncbi request reprint Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function
    Shu Ming Huang
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 281:17941-51. 2006
    ..This supports the idea that a strategy to reduce Abeta oligomers in the brain by up-regulating neprilysin activity would contribute to alleviation of these symptoms...
  6. ncbi request reprint Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation
    Takashi Saito
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Nat Med 11:434-9. 2005
    ....
  7. ncbi request reprint [Presymptomatic diagnosis, prevention and therapy]
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    No To Shinkei 57:855-66. 2005
  8. ncbi request reprint Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice
    Jiro Takano
    Laboratories for Proteolytic Neuroscience and Behavioral Genetics, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 280:16175-84. 2005
    ..These mutant mice will serve as useful tools for investigating calpain involvement in various diseases...
  9. pmc Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Sci Rep 3:1472. 2013
    ..AAV vector-mediated gene transfer may provide a therapeutic strategy for neurodegenerative diseases, where global transduction of a therapeutic gene into the brain is necessary...
  10. ncbi request reprint Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice
    Runa Araya
    Yamada Research Unit, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neurobiol Dis 24:334-44. 2006
    ..The M5 receptor may represent an attractive novel therapeutic target to ameliorate memory deficits caused by impaired cerebrovascular function...
  11. ncbi request reprint Metabolism of amyloid-beta peptide and Alzheimer's disease
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Pharmacol Ther 108:129-48. 2005
    ..Thus, it may be possible to pharmacologically control brain Abeta levels with somatostatin receptor agonists...
  12. ncbi request reprint [Therapeutic strategy by manipulating some protease activities for Alzheimer's disease]
    Nobuhisa Iwata
    Nihon Yakurigaku Zasshi 131:320-5. 2008
  13. doi request reprint Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination
    Kenji Kanekiyo
    Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN MAX Planck Joint Research Center for Systems Chemical Biology, Global Research Cluster, RIKEN, Saitama 351 0198, Japan
    J Neurosci 33:10037-47. 2013
    ....
  14. ncbi request reprint Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
    Yasumasa Yoshiyama
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 53:337-51. 2007
    ..Thus, hippocampal synaptic pathology and microgliosis may be the earliest manifestations of neurodegenerative tauopathies, and abrogation of tau-induced microglial activation could retard progression of these disorders...
  15. ncbi request reprint Initiation and synergistic fibrillization of tau and alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine
    Science 300:636-40. 2003
    ..This suggests that interactions between alpha-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases...
  16. ncbi request reprint Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins
    Hironori Fujiwara
    Department of Geriatric and Complementary Medicine, Center for Asian Traditional Medicine Research, Tohoku University School of Medicine, Sendai, Japan
    J Neurosci Res 84:427-33. 2006
    ....
  17. ncbi request reprint Neuroimaging in dementia: in vivo amyloid imaging
    Tetsuya Suhara
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Tohoku J Exp Med 215:119-24. 2008
    ....
  18. ncbi request reprint Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
    Jun Maeda
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    J Neurosci 27:10957-68. 2007
    ....
  19. ncbi request reprint [Animal models of tauopathies]
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences
    Rinsho Shinkeigaku 46:928-30. 2006
    ..This technology would greatly facilitate diagnostic workup of patients with suspected tauopathies when combined with appropriate imaging modalities...
  20. ncbi request reprint Animal models of tauopathies
    Makoto Higuchi
    Brain Imaging Project, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Chiba 263 8555, Japan
    Neuropathology 26:491-7. 2006
    ..Moreover, visualization of glial responses in living brains may allow sensitive detection of degenerative changes in the central nervous system...
  21. ncbi request reprint Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model
    Yasumasa Yoshiyama
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    J Neurotrauma 22:1134-41. 2005
    ..The reasons for the augmentation of tau pathologies in only one T44 tau Tg mouse subjected to mrTBI remain to be elucidated...
  22. ncbi request reprint Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy
    Bin Zhang
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Aging, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurosci 24:4657-67. 2004
    ....
  23. ncbi request reprint Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques
    Kumi Sato
    Dojindo Laboratories, Tabaru 2025 5, Mashiki machi, Kumamoto 861 2202, Japan
    Eur J Med Chem 39:573-8. 2004
    ..Because of the possession of a nuclide with a quantized angular momentum, both FSB and [(13)C]BSB are also potential contrast agents for magnetic resonance imaging to locate AD pathologies in vivo...
  24. ncbi request reprint Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease
    Masahiro Maruyama
    Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Ann Neurol 57:832-42. 2005
    ....
  25. ncbi request reprint Tau and axonopathy in neurodegenerative disorders
    Makoto Higuchi
    Neuromolecular Med 2:131-50. 2002
    ....
  26. ncbi request reprint Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration
    Makoto Higuchi
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 35:433-46. 2002
    ..Thus, tau-positive glial lesions similar to human FTDs occur in these Tg mice, and these pathologies are linked to glial and axonal degeneration...
  27. ncbi request reprint Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies
    Makoto Higuchi
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 25:9434-43. 2005
    ..We suggest that similar defects may also occur in sporadic and hereditary human tauopathies with OLG tau pathologies...
  28. doi request reprint Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects
    Rumiana Bakalova
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Bioconjug Chem 19:1135-42. 2008
    ..g., heart rate, blood pressure, diameter and shape of blood vessels), which makes it appropriate for tracing of blood circulation and in vivo multimodal imaging using fluorescent confocal microscopy, two-photon microscopy, and MRI...
  29. ncbi request reprint Correlation between quantitative imaging and behavior in unilaterally 6-OHDA-lesioned rats
    Motoki Inaji
    Brain Imaging Project, National Institute of Radiological Science, 4 9 1 Aragawa, Inage, Chiba 305 8555, Japan
    Brain Res 1064:136-45. 2005
    ....
  30. ncbi request reprint Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam
    John Q Trojanowski
    The Center for Neurodegenerative Disease Research, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Exp Neurol 176:1-11. 2002
    ..Thus, tau Tg mice recapitulate key phenotypic features of ALS/PDC neuropathology in an ethnic minority on Guam, and these animal models provide new opportunities to discover novel therapies for this and related tauopathies...
  31. ncbi request reprint PPARalpha protects proximal tubular cells from acute fatty acid toxicity
    Yuji Kamijo
    Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto, Japan
    J Am Soc Nephrol 18:3089-100. 2007
  32. ncbi request reprint Neuroanatomical correlates of low body weight in Alzheimer's disease: a PET study
    XiaSheng Hu
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi 980 8574, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:1285-9. 2002
    ....
  33. ncbi request reprint Measurement of glycine binding site of N-methyl-D-asparate receptors in living human brain using 4-acetoxy derivative of L-703,717, 4-acetoxy-7-chloro-3-[3-(4-[11c] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomography
    Ryohei Matsumoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:795-800. 2007
    ..This indicates the possibility of in vivo evaluation of NMDA receptors using PET with [11C]AcL703 in living human brain...
  34. ncbi request reprint A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 102:2118-31. 2007
    ....
  35. ncbi request reprint Olfactory dysfunction occurs in transgenic mice overexpressing human tau protein
    Jonathan B Macknin
    Smell and Taste Center, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, 5 Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Brain Res 1000:174-8. 2004
    ..Future studies need to similarly assess other pathogenic markers, as well as their distribution within various sectors of the brain, to determine the specificity of this phenomenon...
  36. ncbi request reprint Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease
    Nobuyuki Okamura
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Am J Psychiatry 159:474-6. 2002
    ..The aim of this study was to establish an objective and reliable index to predict the development of Alzheimer's disease in a large pool of elderly patients with mild cognitive impairment...
  37. ncbi request reprint Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease: a 12-week observer-blind, donepezil monotherapy controlled trial
    Masahiro Maruyama
    J Am Geriatr Soc 54:869-71. 2006
  38. ncbi request reprint Chronic inhibition of nitric oxide production aggravates diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats
    Hiroshi Kamijo
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Nephron Physiol 104:p12-22. 2006
    ..Nitric oxide (NO) is known to play a role in diabetic nephropathy, but the molecular basis for this effect remains unclear...
  39. ncbi request reprint Pharmacokinetics and brain uptake of lactoferrin in rats
    Bin Ji
    Brain Imaging Project, National Institute of Radiological Sciences, Inage Ku, Chiba shi, 263 8555, Japan
    Life Sci 78:851-5. 2006
    ..Markedly high brain uptake was observed for Lf relative to Tf and OX26. Lf might be useful as a ligand for facilitating drug delivery into the brain...
  40. ncbi request reprint [Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands]
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:17-21. 2006
    ..We concluded that PET imaging by PBR ligands is useful for diagnosis of neurodegenerative disorders...
  41. ncbi request reprint Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor
    Jun Maeda
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Brain Res 1157:100-11. 2007
    ..The present findings collectively support the utility of PBR in identifying a unique temporal pattern of astrocytic and microglial activation that conventional glial markers hardly pursue...