Takao K Hensch

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint Critical period plasticity in local cortical circuits
    Takao K Hensch
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Nat Rev Neurosci 6:877-88. 2005
  2. ncbi request reprint Excitatory-inhibitory balance and critical period plasticity in developing visual cortex
    Takao K Hensch
    Laboratory for Neuronal Circuit Development, Critical Period Mechanisms Research Group, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Prog Brain Res 147:115-24. 2005
  3. ncbi request reprint Critical period regulation
    Takao K Hensch
    Laboratory for Neuronal Circuit Development, Critical Period Mechanisms Research Group, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Annu Rev Neurosci 27:549-79. 2004
  4. ncbi request reprint Optimization of somatic inhibition at critical period onset in mouse visual cortex
    Hiroyuki Katagiri
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neuron 53:805-12. 2007
  5. ncbi request reprint Specific GABAA circuits for visual cortical plasticity
    Michela Fagiolini
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Science 303:1681-3. 2004
  6. ncbi request reprint Rapid critical period induction by tonic inhibition in visual cortex
    Youichi Iwai
    Laboratory for Neuronal Circuit Development, The Institute of Physical and Chemical Research RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 23:6695-702. 2003
  7. pmc Columnar architecture sculpted by GABA circuits in developing cat visual cortex
    Takao K Hensch
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Science 303:1678-81. 2004
  8. ncbi request reprint Experience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator
    Nobuko Mataga
    Laboratory for Neuronal Circuit Development, Institute of Physical and Chemical Research RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neuron 44:1031-41. 2004
  9. pmc A theory of the transition to critical period plasticity: inhibition selectively suppresses spontaneous activity
    Taro Toyoizumi
    Center for Theoretical Neuroscience and Department of Neuroscience, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, Yokohama 226 8503, Japan Electronic address
    Neuron 80:51-63. 2013
  10. pmc Permissive proteolytic activity for visual cortical plasticity
    Nobuko Mataga
    Laboratory for Neuronal Circuit Development, Institute of Physical and Chemical Research RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Proc Natl Acad Sci U S A 99:7717-21. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Critical period plasticity in local cortical circuits
    Takao K Hensch
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Nat Rev Neurosci 6:877-88. 2005
    ..The reactivation of this process, and subsequent recovery of function in conditions such as amblyopia, can now be studied with realistic circuit models that might generalize across systems...
  2. ncbi request reprint Excitatory-inhibitory balance and critical period plasticity in developing visual cortex
    Takao K Hensch
    Laboratory for Neuronal Circuit Development, Critical Period Mechanisms Research Group, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Prog Brain Res 147:115-24. 2005
  3. ncbi request reprint Critical period regulation
    Takao K Hensch
    Laboratory for Neuronal Circuit Development, Critical Period Mechanisms Research Group, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Annu Rev Neurosci 27:549-79. 2004
    ....
  4. ncbi request reprint Optimization of somatic inhibition at critical period onset in mouse visual cortex
    Hiroyuki Katagiri
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neuron 53:805-12. 2007
    ..Site-specific optimization of perisomatic GABA response may thus trigger experience-dependent development in visual cortex...
  5. ncbi request reprint Specific GABAA circuits for visual cortical plasticity
    Michela Fagiolini
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Science 303:1681-3. 2004
    ..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants...
  6. ncbi request reprint Rapid critical period induction by tonic inhibition in visual cortex
    Youichi Iwai
    Laboratory for Neuronal Circuit Development, The Institute of Physical and Chemical Research RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 23:6695-702. 2003
    ..Thus, enhanced tonic signaling through GABA(A) receptors rapidly creates a milieu for plasticity within neocortex capable of triggering a critical period for ocular dominance independent of visual experience itself...
  7. pmc Columnar architecture sculpted by GABA circuits in developing cat visual cortex
    Takao K Hensch
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Science 303:1678-81. 2004
    ..An inverse agonist (DMCM) produced the opposite effect. Thus, intracortical inhibitory circuits shape the geometry of incoming thalamic arbors, suggesting that cortical columnar architecture depends on neuronal activity...
  8. ncbi request reprint Experience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator
    Nobuko Mataga
    Laboratory for Neuronal Circuit Development, Institute of Physical and Chemical Research RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neuron 44:1031-41. 2004
    ..An extracellular mechanism for structural remodeling that is limited to the binocular zone upon proper detection of competing inputs thus links early sensory experience to visual function...
  9. pmc A theory of the transition to critical period plasticity: inhibition selectively suppresses spontaneous activity
    Taro Toyoizumi
    Center for Theoretical Neuroscience and Department of Neuroscience, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, Yokohama 226 8503, Japan Electronic address
    Neuron 80:51-63. 2013
    ..More broadly, hierarchical organization of sensory-motor pathways may develop through a cascade of CPs induced as circuit maturation progresses from "lower" to "higher" cortical areas. ..
  10. pmc Permissive proteolytic activity for visual cortical plasticity
    Nobuko Mataga
    Laboratory for Neuronal Circuit Development, Institute of Physical and Chemical Research RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Proc Natl Acad Sci U S A 99:7717-21. 2002
    ....
  11. doi request reprint Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity
    Sayaka Sugiyama
    Lab for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Cell 134:508-20. 2008
    ..Thus, the experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit...
  12. ncbi request reprint Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation
    Ikuo Ogiwara
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 27:5903-14. 2007
    ..Our data indicate that Nav1.1 plays critical roles in the spike output from PV interneurons and, furthermore, that the specifically altered function of these inhibitory circuits may contribute to epileptic seizures in the mice...
  13. doi request reprint Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility
    Toshimitsu Suzuki
    Laboratory for Neurogenetics, RIKEN Brain Science Institute BSI, Wako Shi, 351 0198 Saitama, Japan
    Hum Mol Genet 18:1099-109. 2009
    ..These observations seem to further suggest that decrease or loss of function of myoclonin1 may be the molecular basis for epilepsies caused by EFHC1 mutations...
  14. ncbi request reprint Recovery in the blink of an eye
    Takao K Hensch
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neuron 48:166-8. 2005
    ..Ramoa and colleagues now find that binocular recovery from monocular occlusion can be extraordinarily rapid, independent of protein synthesis, and precise. Reactivation of latent connections may then reverse amblyopia...
  15. pmc Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex
    John J Renger
    Laboratory for Neuronal Circuit Development, Institute of Physical and Chemical Research RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 99:1041-6. 2002
    ..Short-term depression that was unaffected by mGluR2 deletion may better reflect circuit refinement in vivo...
  16. ncbi request reprint Reciprocal interaction of sleep and synaptic plasticity
    Hiroyuki Miyamoto
    Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, Japan
    Mol Interv 3:404-17. 2003
    ..This overview synthesizes these converging perspectives across a variety of brain regions and species. We propose the developing visual pathway as a fruitful model for comprehensive understanding of sleep and synaptic plasticity...
  17. pmc Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling
    Michela Fagiolini
    Neuronal Circuit Development, Institute of Physical and Chemical Research, RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 100:2854-9. 2003
    ..Taken together, our results demonstrate that the cellular basis generating individual sensory response properties is separable in the developing neocortex...
  18. pmc IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Japan
    Front Neural Circuits 7:156. 2013
    ..These findings implicate IP3R1-dependent PC firing patterns in cerebellum in motor coordination and the expression of dystonia through the olivo-cerebellar pathway. ..
  19. ncbi request reprint Controlling the critical period
    Takao K Hensch
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neurosci Res 47:17-22. 2003
    ..This overview synthesizes both perspectives across a variety of brain regions and species. A deeper understanding of critical periods will form the basis for novel international efforts to "nurture the brain"...
  20. doi request reprint Critical period revisited: impact on vision
    Hirofumi Morishita
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Neurobiol 18:101-7. 2008
    ..Novel pharmacological or environmental interventions now hold great therapeutic promise based on a deeper understanding of critical period mechanisms...