Mariko Hatakeyama

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. pmc Topological analysis of MAPK cascade for kinetic ErbB signaling
    Takashi Nakakuki
    Cellular Systems Biology Team, Computational and Experimental Systems Biology Group, RIKEN Genomic Sciences Center, Tsurumi ku, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e1782. 2008
  2. pmc Function approximation approach to the inference of reduced NGnet models of genetic networks
    Shuhei Kimura
    Faculty of Engineering, Tottori University, 4 101 Koyama Minami, Tottori, Japan
    BMC Bioinformatics 9:23. 2008
  3. ncbi request reprint System properties of ErbB receptor signaling for the understanding of cancer progression
    Mariko Hatakeyama
    Cellular Systems Biology Team, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Mol Biosyst 3:111-6. 2007
  4. ncbi request reprint Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase
    M Hatakeyama
    Bioinformatics Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Oncogene 23:5023-31. 2004
  5. ncbi request reprint Novel mechanism of interaction of p85 subunit of phosphatidylinositol 3-kinase and ErbB3 receptor-derived phosphotyrosyl peptides
    Atsushi Suenaga
    Bioinformatics Group and Protein Research Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Biol Chem 280:1321-6. 2005
  6. doi request reprint Mutation of epidermal growth factor receptor is associated with MIG6 expression
    Takeshi Nagashima
    Cellular Systems Modeling Team, Computational Systems Biology Research Group, Advanced Computational Sciences Department, RIKEN Advanced Science Institute, Yokohama, Kanagawa, Japan
    FEBS J 276:5239-51. 2009
  7. pmc Molecular dynamics simulations reveal that Tyr-317 phosphorylation reduces Shc binding affinity for phosphotyrosyl residues of epidermal growth factor receptor
    Atsushi Suenaga
    Computational and Experimental System Biology Group, RIKEN Genomic Sciences Center, Yokohama, Kanagawa 230 0046, Japan
    Biophys J 96:2278-88. 2009
  8. ncbi request reprint Quantitative transcriptional control of ErbB receptor signaling undergoes graded to biphasic response for cell differentiation
    Takeshi Nagashima
    Cellular Systems Biology Team, Computational and Experimental Systems Biology Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Yokohama, Kanagawa 230 0045, Japan
    J Biol Chem 282:4045-56. 2007
  9. ncbi request reprint Expression of the ErbB4 receptor causes reversal regulation of PP2A in the Shc signal transduction pathway in human cancer cells
    Noriko Yumoto
    Cellular Systems Biology Team, Computational and Experimental Systems Biology Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    Mol Cell Biochem 285:165-71. 2006
  10. ncbi request reprint Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations
    Atsushi Suenaga
    Bioinformatics Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Biol Chem 279:4657-62. 2004

Detail Information

Publications20

  1. pmc Topological analysis of MAPK cascade for kinetic ErbB signaling
    Takashi Nakakuki
    Cellular Systems Biology Team, Computational and Experimental Systems Biology Group, RIKEN Genomic Sciences Center, Tsurumi ku, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e1782. 2008
    ..Such characteristics of the signaling cause the preferential binding of the Grb2-SOS complex to heterodimer-mediated signaling molecules...
  2. pmc Function approximation approach to the inference of reduced NGnet models of genetic networks
    Shuhei Kimura
    Faculty of Engineering, Tottori University, 4 101 Koyama Minami, Tottori, Japan
    BMC Bioinformatics 9:23. 2008
    ..On the basis of this problem definition, we propose in this study a new method to infer reduced NGnet models of genetic networks...
  3. ncbi request reprint System properties of ErbB receptor signaling for the understanding of cancer progression
    Mariko Hatakeyama
    Cellular Systems Biology Team, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Mol Biosyst 3:111-6. 2007
    ..Spatio-temporal analyses of the cellular process can explain the biochemical role of the receptor tyrosine kinases in cancer development from a system point of view...
  4. ncbi request reprint Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase
    M Hatakeyama
    Bioinformatics Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Oncogene 23:5023-31. 2004
    ..The present study suggests that B-Raf kinase, which was specifically activated in the cells coexpressing ErbB1 and ErbB4 receptors, elevates total ERK activity within the cell and, therefore, can induce cellular transformation...
  5. ncbi request reprint Novel mechanism of interaction of p85 subunit of phosphatidylinositol 3-kinase and ErbB3 receptor-derived phosphotyrosyl peptides
    Atsushi Suenaga
    Bioinformatics Group and Protein Research Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Biol Chem 280:1321-6. 2005
    ..91. The total electrostatic solvation energy between the N-SH2 domain and P-peptide was the dominant factor for its binding affinity...
  6. doi request reprint Mutation of epidermal growth factor receptor is associated with MIG6 expression
    Takeshi Nagashima
    Cellular Systems Modeling Team, Computational Systems Biology Research Group, Advanced Computational Sciences Department, RIKEN Advanced Science Institute, Yokohama, Kanagawa, Japan
    FEBS J 276:5239-51. 2009
    ..Taking all the above together, an EGFR mutation can cause transcriptional changes to accommodate the activation potency of the original signaling pathway at the cellular level...
  7. pmc Molecular dynamics simulations reveal that Tyr-317 phosphorylation reduces Shc binding affinity for phosphotyrosyl residues of epidermal growth factor receptor
    Atsushi Suenaga
    Computational and Experimental System Biology Group, RIKEN Genomic Sciences Center, Yokohama, Kanagawa 230 0046, Japan
    Biophys J 96:2278-88. 2009
    ..e., tyrosine phosphorylation of Shc within its linker region regulates the binding affinity of SH2 and PTB domains for phosphorylated Shc partners, with important implications for signaling dynamics...
  8. ncbi request reprint Quantitative transcriptional control of ErbB receptor signaling undergoes graded to biphasic response for cell differentiation
    Takeshi Nagashima
    Cellular Systems Biology Team, Computational and Experimental Systems Biology Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Yokohama, Kanagawa 230 0045, Japan
    J Biol Chem 282:4045-56. 2007
    ....
  9. ncbi request reprint Expression of the ErbB4 receptor causes reversal regulation of PP2A in the Shc signal transduction pathway in human cancer cells
    Noriko Yumoto
    Cellular Systems Biology Team, Computational and Experimental Systems Biology Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    Mol Cell Biochem 285:165-71. 2006
    ..Thus, PP2A regulates the ERK activity in a cell-specific manner, and it is speculated that distinct regulation of PP2A in the ErbB4 receptor signalling pathway may cause a difference in progression of cancer phenotypes...
  10. ncbi request reprint Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations
    Atsushi Suenaga
    Bioinformatics Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Biol Chem 279:4657-62. 2004
    ....
  11. pmc A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling
    Mariko Hatakeyama
    RIKEN Genomic Sciences Center, 1 7 22 Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Biochem J 373:451-63. 2003
    ....
  12. ncbi request reprint Phosphoproteome and transcriptome analyses of ErbB ligand-stimulated MCF-7 cells
    Takeshi Nagashima
    Computational and Experimental Systems Biology Group, RIKEN Genomic Sciences Center, Yokohama, Kanagawa 230 0045, Japan
    Cancer Genomics Proteomics 5:161-8. 2008
    ..05). The proteome datasets of EGF and HRG contain molecules that are related to Axon guidance, ErbB signaling and VEGF signaling at a high rate...
  13. pmc Integrative genome-wide expression analysis bears evidence of estrogen receptor-independent transcription in heregulin-stimulated MCF-7 cells
    Takeshi Nagashima
    Computational and Experimental Systems Biology Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan
    PLoS ONE 3:e1803. 2008
    ..6%) and 13 E2-regulated (30.8%) gene groups. These results indicated that while E2 and HRG may induce common TFs, the regulatory mechanisms that govern HRG- and E2-induced gene expression differ...
  14. ncbi request reprint Molecular dynamics, free energy, and SPR analyses of the interactions between the SH2 domain of Grb2 and ErbB phosphotyrosyl peptides
    Atsushi Suenaga
    Bioinformatics Group, RIKEN Genomic Sciences Center, Yokohama, Kanagawa, Japan
    Biochemistry 42:5195-200. 2003
    ....
  15. ncbi request reprint OBIYagns: a grid-based biochemical simulator with a parameter estimator
    Shuhei Kimura
    Bioinformatics Group, RIKEN Genomic Sciences Center, 1 7 22 Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Bioinformatics 20:1646-8. 2004
    ..OBIYagns can be applied to larger system biology-oriented simulation projects...
  16. ncbi request reprint Inference of S-system models of genetic networks using a cooperative coevolutionary algorithm
    Shuhei Kimura
    Bioinformatics Group, RIKEN Genomic Sciences Center 1 7 22 Suehiro cho, Tsurumi, Yokohama 230 0045, Japan
    Bioinformatics 21:1154-63. 2005
    ..To verify the effectiveness of the proposed method, we apply it to two artificial genetic network inference problems. Finally, the proposed method is used to analyze the actual DNA microarray data...
  17. pmc Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses
    Marc R Birtwistle
    Department of Chemical Engineering, University of Delaware, Newark, DE, USA
    Mol Syst Biol 3:144. 2007
    ..Sensitivity analysis leads to the hypothesis that ERK activation is robust to parameter perturbation at high ligand doses, while Akt activation is not...
  18. ncbi request reprint Comparison of the characteristic of estrogenic action patterns of beta-HCH and heregulin beta1 in MCF-7 human breast cancer cells
    Mariko Hatakeyama
    Department of Environmental Toxicology and the Center for Environmental Health Sciences, University of California, Davis, CA 95616, USA
    J Biochem Mol Toxicol 16:209-19. 2002
    ..These differences may account for their differential sensitivities to 4-hydroxytamoxifen...
  19. ncbi request reprint Compensation effect of the MAPK cascade on formation of phospho-protein gradients
    Takashi Naka
    Faculty of Information Science, Kyushu Sangyo University, Matsukadai 2 3 1, Higashi ku, Fukuoka 813 8503, Japan
    Biosystems 83:167-77. 2006
    ....
  20. ncbi request reprint The International Consortium on Systems Biology of Receptor Tyrosine Kinase Regulatory Networks
    Yoshiyuki Sakaki
    Syst Biol (Stevenage) 152:53-4. 2005