Mototsugu Eiraku

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. doi request reprint Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe, Japan
    Nat Protoc 7:69-79. 2012
  2. doi request reprint Self-organizing optic-cup morphogenesis in three-dimensional culture
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 472:51-6. 2011
  3. pmc Relaxation-expansion model for self-driven retinal morphogenesis: a hypothesis from the perspective of biosystems dynamics at the multi-cellular level
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe, Japan
    Bioessays 34:17-25. 2012
  4. doi request reprint Self-formation of optic cups and storable stratified neural retina from human ESCs
    Tokushige Nakano
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 10:771-85. 2012
  5. doi request reprint Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals
    Teruko Danjo
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    J Neurosci 31:1919-33. 2011
  6. pmc Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex
    Taisuke Kadoshima
    Laboratory of Organogenesis and Neurogenesis and Four Dimensional Tissue Analysis Unit, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 110:20284-9. 2013
  7. doi request reprint Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 3:519-32. 2008
  8. pmc Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture
    Makoto Nasu
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe, Japan
    PLoS ONE 7:e53024. 2012
  9. doi request reprint In vitro organogenesis in three dimensions: self-organising stem cells
    Yoshiki Sasai
    Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe, Japan
    Development 139:4111-21. 2012
  10. doi request reprint Self-formation of layered neural structures in three-dimensional culture of ES cells
    Mototsugu Eiraku
    Unit for Four Dimensional Tissue Analysis, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Curr Opin Neurobiol 22:768-77. 2012

Collaborators

Detail Information

Publications12

  1. doi request reprint Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe, Japan
    Nat Protoc 7:69-79. 2012
    ..In contrast, the cortical differentiation culture can be started without exogenous extracellular matrix proteins, and it generates stratified cortical epithelia consisting of four distinct layers in 13 d...
  2. doi request reprint Self-organizing optic-cup morphogenesis in three-dimensional culture
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 472:51-6. 2011
    ..We demonstrate that optic-cup morphogenesis in this simple cell culture depends on an intrinsic self-organizing program involving stepwise and domain-specific regulation of local epithelial properties...
  3. pmc Relaxation-expansion model for self-driven retinal morphogenesis: a hypothesis from the perspective of biosystems dynamics at the multi-cellular level
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe, Japan
    Bioessays 34:17-25. 2012
    ..This model involves three consecutive local rules (relaxation, apical constriction, and expansion), and its computer simulation recapitulates the optic-cup morphogenesis in silico...
  4. doi request reprint Self-formation of optic cups and storable stratified neural retina from human ESCs
    Tokushige Nakano
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 10:771-85. 2012
    ..This storage method at an intermediate step during the time-consuming differentiation process provides a versatile solution for quality control in large-scale preparation of clinical-grade retinal tissues...
  5. doi request reprint Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals
    Teruko Danjo
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    J Neurosci 31:1919-33. 2011
    ..We discuss a model of the antagonistic Fgf8 and Fgf15/19 signaling in rostral-caudal subpallial patterning and compare it with the roles of these molecules in cortical patterning...
  6. pmc Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex
    Taisuke Kadoshima
    Laboratory of Organogenesis and Neurogenesis and Four Dimensional Tissue Analysis Unit, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 110:20284-9. 2013
    ..Thus, human neocorticogenesis involves intrinsic programs that enable the emergence of complex neocortical features. ..
  7. doi request reprint Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 3:519-32. 2008
    ..Thus, spatial and temporal aspects of early corticogenesis are recapitulated and can be manipulated in this ESC culture...
  8. pmc Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture
    Makoto Nasu
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe, Japan
    PLoS ONE 7:e53024. 2012
    ..Thus, our results indicate that laminin-entactin ECM promotes the formation of structurally stable telencephalic tissues in 3D ESC culture, and supports the morphogenetic recapitulation of cortical development...
  9. doi request reprint In vitro organogenesis in three dimensions: self-organising stem cells
    Yoshiki Sasai
    Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe, Japan
    Development 139:4111-21. 2012
    ..We also attempt to interpret the results of previous in vivo studies of retinal development in light of the self-organising nature of the retina...
  10. doi request reprint Self-formation of layered neural structures in three-dimensional culture of ES cells
    Mototsugu Eiraku
    Unit for Four Dimensional Tissue Analysis, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Curr Opin Neurobiol 22:768-77. 2012
    ..A simple in vitro system using ESCs is useful for elucidating mechanistic dynamics in the complex orchestration of neural development...
  11. doi request reprint Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells
    Masatoshi Ohgushi
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 7:225-39. 2010
    ..Thus, the Abr-dependent "Rho-high/Rac-low" state plays a decisive role in initiating the dissociation-induced actomyosin hyperactivation and apoptosis in hESCs...
  12. pmc Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation
    Takafumi Wataya
    Organogenesis and Neurogenesis Group and Division of Human Stem Cell Technology, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 105:11796-801. 2008
    ..These findings indicate that, instead of the addition of inductive signals, minimization of exogenous patterning signaling plays a key role in rostral hypothalamic specification of neural progenitors derived from pluripotent cells...