Yoko Aida


Affiliation: RIKEN Brain Science Institute
Country: Japan


  1. Bai L, Yokoyama K, Watanuki S, Ishizaki H, Takeshima S, Aida Y. Development of a new recombinant p24 ELISA system for diagnosis of bovine leukemia virus in serum and milk. Arch Virol. 2019;164:201-211 pubmed publisher
    ..Thus, the p24 ELISA is a robust and reliable assay for detecting BLV antibodies in serum or milk, making it is a useful tool for large-scale BLV screening. ..
  2. Siarot L, Chutiwitoonchai N, Sato H, Chang H, Sato H, Fujino M, et al. Identification of human immunodeficiency virus type-1 Gag-TSG101 interaction inhibitors by high-throughput screening. Biochem Biophys Res Commun. 2018;503:2970-2976 pubmed publisher
    ..These results suggest that our established HTS system is an indispensable tool for the identification of HIV-1 Gag-TSG101 interaction inhibitors. ..
  3. He P, Takeshima S, Tada S, Akaike T, Ito Y, Aida Y. pH-sensitive carbonate apatite nanoparticles as DNA vaccine carriers enhance humoral and cellular immunity. Vaccine. 2014;32:6199-205 pubmed publisher
    ..This study is the first to demonstrate the promising potential of CO₃Ap nanoparticles for DNA vaccine delivery. ..
  4. Zahoor M, Xue G, Sato H, Aida Y. Genome-wide transcriptional profiling reveals that HIV-1 Vpr differentially regulates interferon-stimulated genes in human monocyte-derived dendritic cells. Virus Res. 2015;208:156-63 pubmed publisher
    ..Taken together, our findings are the first to demonstrate that HIV-1 Vpr induces ISGs and activates the type I IFN signaling pathway in human DCs, and provide insights into the role of Vpr in HIV-1 pathogenesis. ..
  5. Ohno A, Takeshima S, Matsumoto Y, Aida Y. Risk factors associated with increased bovine leukemia virus proviral load in infected cattle in Japan from 2012 to 2014. Virus Res. 2015;210:283-90 pubmed publisher
    ..Taken together, these findings may help to formulate a plan for eliminating BLV from contaminated farms. This is the first nationwide study to estimate BLV proviral load in Japanese cattle. ..
  6. Bai L, Takeshima S, Isogai E, Kohara J, Aida Y. Novel CD8(+) cytotoxic T cell epitopes in bovine leukemia virus with cattle. Vaccine. 2015;33:7194-7202 pubmed publisher
    ..Moreover, at least one CD8(+) CTL epitope derived from gp30 was identified in each of the four calves. These results indicate that BLV gp30 may be the best candidate for the development of a BLV vaccine. ..
  7. Bai L, Otsuki H, Sato H, Kohara J, Isogai E, Takeshima S, et al. Identification and characterization of common B cell epitope in bovine leukemia virus via high-throughput peptide screening system in infected cattle. Retrovirology. 2015;12:106 pubmed publisher
    ..Our results have important implications for disease control and diagnosis. ..
  8. Yuan Y, Kitamura Muramatsu Y, Saito S, Ishizaki H, Nakano M, Haga S, et al. Detection of the BLV provirus from nasal secretion and saliva samples using BLV-CoCoMo-qPCR-2: Comparison with blood samples from the same cattle. Virus Res. 2015;210:248-54 pubmed publisher
  9. Polat M, Takeshima S, Hosomichi K, Kim J, Miyasaka T, Yamada K, et al. A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis. Retrovirology. 2016;13:4 pubmed publisher
    ..We conclude that at least seven BLV genotypes (genotypes-1, -2, -4, -5, -6, -7, and -9) are circulating in South America. ..

More Information


  1. Takeshima S, Watanuki S, Ishizaki H, Matoba K, Aida Y. Development of a direct blood-based PCR system to detect BLV provirus using CoCoMo primers. Arch Virol. 2016;161:1539-46 pubmed publisher
    ..Therefore, the method is extremely cost-effective and the risk of a false-positive result due to DNA contamination is very low. ..
  2. Miyatake H, Sanjoh A, Murakami T, Murakami H, Matsuda G, Hagiwara K, et al. Molecular Mechanism of HIV-1 Vpr for Binding to Importin-?. J Mol Biol. 2016;428:2744-57 pubmed publisher
    ..These results, which represent the first reported crystallographic analysis of Vpr, demonstrate the multifunctional aspects that enable Vpr interaction with a variety of cellular proteins. ..
  3. Takeshima S, Corbi Botto C, Giovambattista G, Aida Y. Genetic diversity of BoLA-DRB3 in South American Zebu cattle populations. BMC Genet. 2018;19:33 pubmed publisher
  4. Sato H, Watanuki S, Murakami H, Sato R, Ishizaki H, Aida Y. Development of a luminescence syncytium induction assay (LuSIA) for easily detecting and quantitatively measuring bovine leukemia virus infection. Arch Virol. 2018;163:1519-1530 pubmed publisher
    ..The fluorescing syncytia was easily detected by eye and automated scanning and LuSIA counts correlated strongly with the proviral load of infected cattle (R2 = 0.8942). ..
  5. Chutiwitoonchai N, Mano T, Kakisaka M, Sato H, Kondoh Y, Osada H, et al. Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development. Virology. 2017;507:32-39 pubmed publisher
  6. Polat M, Moe H, Shimogiri T, Moe K, Takeshima S, Aida Y. The molecular epidemiological study of bovine leukemia virus infection in Myanmar cattle. Arch Virol. 2017;162:425-437 pubmed publisher
    ..This study provides information regarding BLV infection levels in Myanmar and confirms that genotype-10 is circulating in Myanmar. ..
  7. Takeshima S, Sasaki S, Meripet P, Sugimoto Y, Aida Y. Single nucleotide polymorphisms in the bovine MHC region of Japanese Black cattle are associated with bovine leukemia virus proviral load. Retrovirology. 2017;14:24 pubmed publisher
  8. Chutiwitoonchai N, Aida Y. NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear Export of NP via a CRM1-Dependent Pathway. Viruses. 2016;8: pubmed publisher
    ..These findings reveal a distinct mechanism for nuclear export of the influenza virus and identify the NXT1/NP interaction as a potential target for antiviral drug development. ..
  9. Polat M, Takeshima S, Aida Y. Epidemiology and genetic diversity of bovine leukemia virus. Virol J. 2017;14:209 pubmed publisher
    ..Finally, we summarize the various BLV genotypes identified by the phylogenetic analyses of the whole genome and env gp51 sequences of BLV strains in different countries and discuss the distribution of BLV genotypes worldwide. ..
  10. Kakisaka M, Yamada K, Yamaji Hasegawa A, Kobayashi T, Aida Y. Intrinsically disordered region of influenza A NP regulates viral genome packaging via interactions with viral RNA and host PI(4,5)P2. Virology. 2016;496:116-126 pubmed publisher
    ..Secondly, vRNP assemble by interacting with PI(4,5)P2 at the PM via IDR2. These findings suggest that PI(4,5)P2 functions as the determinant of vRNP accumulation at the PM. ..
  11. Kamata M, Nitahara Kasahara Y, Miyamoto Y, Yoneda Y, Aida Y. Importin-alpha promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr. J Virol. 2005;79:3557-64 pubmed
    ..These observations indicate that importin-alpha functions as a mediator for the nuclear entry of Vpr. ..
  12. Kakisaka M, Mano T, Aida Y. A high-throughput screening system targeting the nuclear export pathway via the third nuclear export signal of influenza A virus nucleoprotein. Virus Res. 2016;217:23-31 pubmed publisher
    ..The present HTS system provides a useful strategy for the identification of inhibitors targeting the nuclear export of NP via its NES3 sequence. ..
  13. request reprint
    Aida Y, Matsuda G. Role of Vpr in HIV-1 nuclear import: therapeutic implications. Curr HIV Res. 2009;7:136-43 pubmed