Toru Mori

Summary

Affiliation: Research Institute of Tuberculosis
Country: Japan

Publications

  1. ncbi Recent trends in tuberculosis, Japan
    T Mori
    Research Institute of Tuberculosis and Anti Tuberculosis Association, Japan
    Emerg Infect Dis 6:566-8. 2000
  2. ncbi Specific detection of tuberculosis infection: an interferon-gamma-based assay using new antigens
    Toru Mori
    Research Institute of Tuberculosis, 3 1 24 Matsuyama, Kiyose, Tokyo 204 8533, Japan
    Am J Respir Crit Care Med 170:59-64. 2004
  3. ncbi [Tuberculosis and society]
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533, Japan
    Kekkaku 78:95-100. 2003
  4. ncbi [Reform of Japan's NTP and its technical perspectives]
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association JATA, Tokyo
    Kekkaku 79:587-604. 2004
  5. ncbi [Cost-effectiveness analysis of QuantiFERON-TB 2nd generation used for detection of tuberculosis infection in contact investigations]
    Toru Mori
    Research Institute of Tuberculosis, JATA, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533 Japan
    Kekkaku 80:675-86. 2005
  6. ncbi [Effects of prophylaxis on QuantiFERON TB-2G responses among children]
    Kazue Higuchi
    Immunology Division, Research Institute of Tuberculosis, Japan Anti Tuberculosis Association JATA Matsuyama, Tokyo, Japan
    Kekkaku 83:603-9. 2008
  7. ncbi Screening for tuberculosis infection using whole-blood interferon-gamma and Mantoux testing among Japanese healthcare workers
    Nobuyuki Harada
    Immunology Division, Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, 3 1 24 Matsuyama, Kiyose, Tokyo 204 8533, Japan
    Infect Control Hosp Epidemiol 27:442-8. 2006
  8. ncbi [Basic characteristics of a novel diagnostic method (QuantiFERON TB-2G) for latent tuberculosis infection with the use of Mycobacterium tuberculosis-specific antigens, ESAT-6 and CFP-10]
    Nobuyuki Harada
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association JATA, Tokyo, Japan
    Kekkaku 79:725-35. 2004
  9. ncbi Comparison of performance in two diagnostic methods for tuberculosis infection
    Kazue Higuchi
    The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo, Japan
    Med Microbiol Immunol 198:33-7. 2009
  10. ncbi Interferon-gamma responses after isoniazid chemotherapy for latent tuberculosis
    Kazue Higuchi
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Tokyo, Japan
    Respirology 13:468-72. 2008

Detail Information

Publications52

  1. ncbi Recent trends in tuberculosis, Japan
    T Mori
    Research Institute of Tuberculosis and Anti Tuberculosis Association, Japan
    Emerg Infect Dis 6:566-8. 2000
    ..The success rate for treatment of smear-positive patients is 78%. Multidrug-resistant strains of Mycobacterium tuberculosis are rare...
  2. ncbi Specific detection of tuberculosis infection: an interferon-gamma-based assay using new antigens
    Toru Mori
    Research Institute of Tuberculosis, 3 1 24 Matsuyama, Kiyose, Tokyo 204 8533, Japan
    Am J Respir Crit Care Med 170:59-64. 2004
    ..tuberculosis infection was 89.0%. The results demonstrate that the whole blood IFN-gamma assay using CFP-10 and ESAT-6 was highly specific and sensitive for M. tuberculosis infection and was unaffected by BCG vaccination status...
  3. ncbi [Tuberculosis and society]
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533, Japan
    Kekkaku 78:95-100. 2003
    ..Studies in tuberculosis, both basic and epidemiological, as well as multidisciplinary, should be further encouraged from such a point of view, in order to lay such interconnections bare, on which the new control strategy should be based...
  4. ncbi [Reform of Japan's NTP and its technical perspectives]
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association JATA, Tokyo
    Kekkaku 79:587-604. 2004
    ..It is for that reason that the Japanese Society of Tuberculosis should aggressively join the global movement to stop TB along with the general public of Japan...
  5. ncbi [Cost-effectiveness analysis of QuantiFERON-TB 2nd generation used for detection of tuberculosis infection in contact investigations]
    Toru Mori
    Research Institute of Tuberculosis, JATA, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533 Japan
    Kekkaku 80:675-86. 2005
    ..A cost-effectiveness analysis was made on the usefulness of QFT that was used in the contacts investigation of a group of subject exposed to tuberculosis infection...
  6. ncbi [Effects of prophylaxis on QuantiFERON TB-2G responses among children]
    Kazue Higuchi
    Immunology Division, Research Institute of Tuberculosis, Japan Anti Tuberculosis Association JATA Matsuyama, Tokyo, Japan
    Kekkaku 83:603-9. 2008
    ..To study the effect of treatment of latent tuberculosis infection (LTBI) on QuantiFERON TB-2G (QFT-2G) test results...
  7. ncbi Screening for tuberculosis infection using whole-blood interferon-gamma and Mantoux testing among Japanese healthcare workers
    Nobuyuki Harada
    Immunology Division, Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, 3 1 24 Matsuyama, Kiyose, Tokyo 204 8533, Japan
    Infect Control Hosp Epidemiol 27:442-8. 2006
    ....
  8. ncbi [Basic characteristics of a novel diagnostic method (QuantiFERON TB-2G) for latent tuberculosis infection with the use of Mycobacterium tuberculosis-specific antigens, ESAT-6 and CFP-10]
    Nobuyuki Harada
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association JATA, Tokyo, Japan
    Kekkaku 79:725-35. 2004
    ..To determine the optimum cut-off level of a newly developed method for diagnosing tuberculosis infection based on whole-blood interferon-gamma measurement, and to study the basic characteristics of the method...
  9. ncbi Comparison of performance in two diagnostic methods for tuberculosis infection
    Kazue Higuchi
    The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo, Japan
    Med Microbiol Immunol 198:33-7. 2009
    ..The difference in the performance between T-SPOT and QFT-G and biological relevance of each system in diagnosing M. tuberculosis infection should be further explored...
  10. ncbi Interferon-gamma responses after isoniazid chemotherapy for latent tuberculosis
    Kazue Higuchi
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Tokyo, Japan
    Respirology 13:468-72. 2008
    ..We investigated IFN-gamma responses in subjects with latent TB infection before and after isoniazid (INH) chemotherapy...
  11. ncbi Analysis of an interferon-gamma release assay for monitoring the efficacy of anti-tuberculosis chemotherapy
    Kiyoko Takayanagi
    Department of Respiratory Medicine, Double Barred Cross Hospital, Japan Anti Tuberculosis Association, Tokyo 204 8533, Japan
    Jpn J Infect Dis 64:133-8. 2011
    ..Although it was shown that anti-tuberculosis treatment generally reduced the specific release of IFN-γ, the effect is so variable that it could be used as a monitor of progress of chemotherapy with great care and reservation...
  12. ncbi Computerized surveillance system of tuberculosis in Japan: its evolution, achievement and challenges
    Masako Ohmori
    The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association JATA, Tokyo, Japan
    Kekkaku 87:15-23. 2012
    ..An important role of the Research Institute of Tuberculosis is to support the planning and execution of TB control with provision of useful epidemiological information from the system...
  13. ncbi Comparison of the sensitivity and specificity of two whole blood interferon-gamma assays for M. tuberculosis infection
    Nobuyuki Harada
    The Research Institute of Tuberculosis, 3 1 24, Matsuyama, Kiyose City, Tokyo 204 8533, Japan
    J Infect 56:348-53. 2008
    ..To compare the sensitivity and the specificity of the QuantiFERON-TB Gold (QFT-G) and QuantiFERON-TB Gold In Tube (QFT-GIT) diagnostic tests for Mycobacterium tuberculosis infection...
  14. ncbi [Usefulness of a novel diagnostic method of tuberculosis infection, QuantiFERON TB-2G, in an outbreak of tuberculosis]
    Nobuyuki Harada
    Immunology Division, Research Institute of Tuberculosis, JATA, Tokyo, Japan
    Kekkaku 79:637-43. 2004
    ..The purpose of this study was to evaluate QuantiFERON TB-2G (QFT), a novel method of detecting tuberculosis infection among contacts of a tuberculosis patient by determining the whole-blood interferongamma response to the specific antigens...
  15. ncbi Use of QuantiFERON-TB Gold to investigate tuberculosis contacts in a high school
    Kazue Higuchi
    Research Institute of Tuberculosis, Tokyo, Japan
    Respirology 12:88-92. 2007
    ..QuantiFERON-TB Gold (QFT-G) was employed in a contact investigation in a high school to evaluate its performance in adolescents...
  16. ncbi [Frequency of MDR-TB/XDR-TB strains isolated from chronic pulmonary tuberculosis patients in Japan]
    Yuko Kazumi
    Pathology Division, Mycobacterium Reference Center, Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Tokyo
    Kekkaku 82:891-6. 2007
    ..To observe the frequency of MDR-TB/XDR-TB strains isolated from chronic pulmonary tuberculosis patients in Japan...
  17. ncbi Transmission of specific genotype streptomycin resistant strains of Mycobacterium tuberculosis in the Tokyo Metropolitan Area in Japan
    Akihiro Ohkado
    Department of Epidemiology and Clinical Research, Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Matsuyama 3 1 24, Kiyose, Tokyo, Japan
    BMC Infect Dis 9:138. 2009
    ..tuberculosis in the TMA as observed in the above incident, and to identify the possible transmission routes of the strains among people living in urban settings in Japan...
  18. ncbi Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis
    Hiroki Ando
    Department of Infectious Diseases, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Antimicrob Agents Chemother 54:1793-9. 2010
    ..On the basis of our results and known mutations associated with INH resistance, we developed a new hybridization-based line probe assay for rapid detection of INH-resistant M. tuberculosis isolates...
  19. ncbi Assessment of nosocomial transmission of tuberculosis in a psychiatric hospital using a whole blood interferon-gamma assay
    Nobuyuki Harada
    Mycobacterium Reference Center, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Tokyo 204 8533, Japan
    Jpn J Infect Dis 61:415-8. 2008
    ....
  20. ncbi Relationship between whole-blood interferon-gamma responses and the risk of active tuberculosis
    Kazue Higuchi
    Immunology Division, Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, 3 1 24, Matsuyama, Kiyose, Tokyo 204 8533, Japan
    Tuberculosis (Edinb) 88:244-8. 2008
    ....
  21. ncbi [Analysis of tuberculosis infection among foreigners using QuantiFeron TB-2G test]
    Kazue Higuchi
    Immunology Division, Research Institute of Tuberculosis, JATA, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533, Japan
    Kekkaku 82:515-21. 2007
    ..The purpose of this study was to investigate contacts of a tuberculosis patient among foreigners using QuantiFERON TB-2G (QFT-2G) test...
  22. ncbi Comprehensive multicenter evaluation of a new line probe assay kit for identification of Mycobacterium species and detection of drug-resistant Mycobacterium tuberculosis
    Satoshi Mitarai
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Tokyo, Japan
    J Clin Microbiol 50:884-90. 2012
    ..0% and 92.9%, respectively. The kit was able to identify mycobacterial bacilli at the species level, as well as drug-resistant phenotypes, with a high sensitivity and specificity...
  23. ncbi Usefulness of interferon-gamma release assays for diagnosing TB infection and problems with these assays
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, 3 1 24 Matsuyama, Kiyose, Tokyo, 204 8533, Japan
    J Infect Chemother 15:143-55. 2009
    ..However, there are discordant reports that warrant further study...
  24. ncbi [Trends of tuberculosis researches in Japan and the roles of Kekkaku]
    Toru Mori
    Leprosy Research Center, National Institute of Infectious Diseases
    Kekkaku 84:519-22. 2009
    ..Finally, the roles for Kekkaku as a journal in Japanese language to activate the researches in Japan were discussed and some proposals were made...
  25. ncbi [A survey on the onset of tuberculosis in nursing homes]
    Shinji Shishido
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533, Japan
    Kekkaku 78:691-7. 2003
    ..To obtain the informations how to promote early detection and prevention of nosocomial infection of tuberculosis in nursing homes for the elderly...
  26. ncbi [Gene-based testing of Mycobacterium tuberculosis]
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association
    Nippon Rinsho 63:353-7. 2005
  27. ncbi [Current status of multidrug-resistant tuberculosis in Japan: a literature review and meta-analysis]
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association JATA, Tokyo 204 8533, Japan
    Kekkaku 87:565-75. 2012
    ..This will be a major challenge to the promotion of clinical studies and the control of MDR-TB in Japan...
  28. ncbi Evaluation of major membrane protein-II as a tool for serodiagnosis of leprosy
    Yumi Maeda
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Microbiol Lett 272:202-5. 2007
    ..These percentage values were significantly higher than these values obtained for existing phenolic glycolipid-I based methods, suggesting that MMP-II antibody detection would facilitate the diagnosis of leprosy...
  29. ncbi Tuberculosis in the global aging population
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo 204 8533, Japan
    Infect Dis Clin North Am 24:751-68. 2010
    ..This article examines the current and possible future status of TB in the elderly, focusing on epidemiology, risk factors, preventive treatment strategies, and clinical disease...
  30. ncbi 2. Current tuberculosis problem in Japan and its control
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Tokyo
    Intern Med 41:56-7. 2002
  31. ncbi [Clinical guidelines for tuberculosis of Japan compared with those of other countries]
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association
    Nihon Rinsho 69:1400-7. 2011
    ..They also stress the importance of support of patients for treatment completion, but the ways to realize it are delicately different among them...
  32. ncbi [Investigation on preventive measures of tuberculosis infection and onset of tuberculosis in nursing homes for the aged]
    Shinji Shishido
    Research Institute of Tuberculosis, JATA, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533, Japan
    Kekkaku 77:341-6. 2002
    ..We outlined the essential points for concrete measures to prevent tuberculosis infection in nursing homes for the aged...
  33. ncbi Correlation between suspended particles in the environmental air and causes of disease among inhabitants: cross-sectional studies using the vital statistics and air pollution data in Japan
    Kazuro Iwai
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533, Japan
    Environ Res 99:106-17. 2005
    ..Multivariate regression analysis of confounding factors, smoking rate, population density, and hormone-related factors revealed consistent significance of SPM/cPM(2.5) in these diseases...
  34. ncbi [Tuberculosis in the patients undergoing haemodialysis in Japan, 1996]
    Yuka Sasaki
    Division of Thoracic Disease, National Chiba Higashi Hospital, 673, Nitona cho, Chuo Ku, Chiba shi, Chiba 260 8712, Japan
    Kekkaku 77:51-9. 2002
    ..As patients undergoing haemodialysis have the factors which suppress the cell-mediated immunity, it is required to restudy the measures to prevent development of tuberculosis, management and treatment in the future...
  35. ncbi [Progress in the field of pulmonary medicine in the last 100 years: Mass screening for tuberculosis]
    Toru Mori
    Nippon Naika Gakkai Zasshi 91:1656-9. 2002
  36. ncbi [Results of repeated QFT-2G checkings at two-year interval and their comparison with TST results introduced into infection control program for staffs working at a hospital with isolation wards for tuberculosis]
    Yutsuki Nakajima
    National Hospital Organization Tokyo National Hospital, Japan
    Kekkaku 83:445-50. 2008
    ..Recently, a new technique, QFT-2G, is evaluated highly to detect TB infection, especially in BCG vaccinated individuals. We examined hospital staffs twice at two-year interval using QFT-2G and TST, and compared these data...
  37. ncbi Microepidemics of tuberculosis revealed by DNA-fingerprinting of M. tuberculosis
    Toru Mori
    Intern Med 43:177-8. 2004
  38. ncbi Survey of human immunodeficiency virus (HIV)-seropositive patients with mycobacterial infection in Japan
    Yayoi Otsuka
    International Medical Center of Japan, Toyama 1-21-1, Shinjuku-ku, Tokyo 162-8655, Japan
    J Infect 51:364-74. 2005
    ..The results indicate that no particular clones of M. tuberculosis or M. avium prevail in HIV-seropositive patients in Japan. Further monitoring of mycobacterial infection associated with HIV infection in Japan should be continued...
  39. ncbi [Variation in yield of needle scars with multipuncture BCG vaccination]
    Yoshiyuki Sugishita
    Infectious Disease Control Section Health and Safety Office Bureau of Social Welfare and Public Health, Tokyo Metropolitan Government
    Nippon Koshu Eisei Zasshi 52:1045-9. 2005
    ..Poor technique was presumed responsible for small numbers of scars and technical training is therefore necessary in order to improve the BCG vaccination outcome...
  40. ncbi [Detection of tuberculosis infection using a whole blood interferon gamma assay in a contact investigation--evaluation using quantiFERon TB-2G]
    Hirofumi Miyashita
    Fukui Public Health Center, 2 8 8, Nishikida, Fukui shi, Fukui 918 8540 Japan
    Kekkaku 80:557-64. 2005
    ..The purpose of this study was to evaluate the usefulness of a novel method of detecting tuberculosis infection, QuantiFERON TB-2G (QFT), in a large scale contact investigation when an outbreak of mass tuberculosis infection was suspected...
  41. ncbi Detection of multidrug resistance in Mycobacterium tuberculosis
    Jun ichiro Sekiguchi
    International Medical Center of Japan, 1 21 1 Toyama, Shinjuku, Tokyo 162 8655, Japan
    J Clin Microbiol 45:179-92. 2007
    ..In conclusion, our new method is useful for rapid detection of multiple-drug-resistant M. tuberculosis and for identifying novel mutations in drug-resistant M. tuberculosis...
  42. ncbi [Usefulness of QuantiFERON TB-2G in contact investigation of a tuberculosis outbreak in a university]
    Kazushi Funayama
    Yokohama City Kohoku Public Health and Welfare Center, 26 1, Daizutocho, Kohoku Ku, Yokohama shi, Kanagawa 222 0032 Japan
    Kekkaku 80:527-34. 2005
    ..e., a novel technique for detecting tuberculosis infection based on the whole blood interferon-gamma response to specific antigens, in the investigation of a tuberculosis outbreak among university students...
  43. ncbi MDR-TB--its characteristics and control in Asia-Pacific rim symposium in USJCMSP 10th international conference on emerging infectious diseases in the Pacific rim
    Toru Mori
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1, Aobacho, Higashimurayama shi, Tokyo 189 0002, Japan
    Tuberculosis (Edinb) 87:S5-9. 2007
    ..These efforts would be more effective if there were further technical innovation in diagnosis and treatment, supported by a strong political commitment...
  44. ncbi Development and evaluation of a line probe assay for rapid identification of pncA mutations in pyrazinamide-resistant mycobacterium tuberculosis strains
    Jun ichiro Sekiguchi
    Department of Infectious Diseases, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku, Tokyo 162 8655, Japan
    J Clin Microbiol 45:2802-7. 2007
    ..This assay can be used with sputa from tuberculosis patients. It appears to be reliable and widely applicable and, given its simplicity and rapid performance, will be a valuable tool for diagnostic use...
  45. ncbi [Utility of QuantiFERON TB-2G for tuberculosis contact investigations in public health services]
    Akiko Kowada
    Katsushika City Kanamachi Community Health Center
    Nihon Koshu Eisei Zasshi 54:434-9. 2007
    ..The objective of the present study was to examine the utility of QuantiFERON TB-2G (QFT) in tuberculosis contact investigations performed by a public health center...
  46. ncbi Diagnosis of active tuberculous serositis by antigen-specific interferon-gamma response of cavity fluid cells
    Haruyuki Ariga
    Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital, Japan
    Clin Infect Dis 45:1559-67. 2007
    ....
  47. ncbi [Usefulness of QuantiFERONTB-2G in a suspected case of drug resistant tuberculosis outbreak in a university]
    Muneyoshi Masuda
    Takarazuka Health and Welfare Office, 3 5 22, Obayashi, Takarazuka shi, Hyogo 665 0034, Japan
    Kekkaku 83:7-11. 2008
    ..To diagnose M. tuberculosis infection and select subjects for chemoprophylaxis in a contact investigation, we used the whole blood interferon-gamma response test, QuantiFERONTB-2G (QFT), and examined the usefulness of QFT...
  48. ncbi [Tuberculosis]
    Toru Mori
    Leprosy Research Center, National Institute of Infectious Diseases
    Nippon Rinsho 65:443-8. 2007
  49. ncbi [The present situation of daily life of tuberculosis patients treated in hospitals with beds for tuberculosis in Japan]
    Fumio Yamagishi
    Department of Respiratory Diseases, National Chiba Higashi Hospital, 673, Nitona cho, Chuo Ku, Chiba shi, Chiba 260 8712, Japan
    Kekkaku 77:609-14. 2002
    ..Judging from the above findings, it appears that many tuberculosis patients under hospital treatment are not spending a pleasant daily hospital life...
  50. ncbi [The new Tuberculosis Control Program of Japan]
    Toru Mori
    Leprosy Research Center, National Institute of Infectious Diseases
    Kansenshogaku Zasshi 80:345-52. 2006
    ..This reminds us of the United States' remarkable experience of the tuberculosis resurgence in the late 1980's and early 1990's, after 15 years of abandonment of the governmental efforts during 1970s...
  51. ncbi [Prevention of nosocomial infection of tuberculosis]
    Yutsuki Nakajima
    Fukujuji Hospital, Japan Anti-Tuberculosis Association
    Nippon Rinsho 61:682-7. 2003
  52. ncbi [A new horizon of tuberculosis control and research]
    Toru Mori
    Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
    Nippon Rinsho 61:153-9. 2003
    ..Japan's TB control programme is being revised drastically in order to meet the change in the TB epidemiology, aiming at realization of the DOTS concept adapted into the Japanese setting of patient care...