Hiroki Teraoka


Affiliation: Rakuno Gakuen University
Country: Japan


  1. Xu J, Li Y, Lv Y, Bian C, You X, Endoh D, et al. Molecular Evolution of Tryptophan Hydroxylases in Vertebrates: A Comparative Genomic Survey. Genes (Basel). 2019;10: pubmed publisher
    ..In summary, our current work provides novel insights into the evolution of tph genes in vertebrates from a comprehensive genomic perspective. ..
  2. Teraoka H, Miyagi H, Haraguchi Y, Takase K, Kitazawa T, Noda J. Contamination Status of Seven Elements in Hooded Cranes Wintering in South-West Kyushu, Japan: Comparison with Red-Crowned Cranes in Hokkaido, Japan. Arch Environ Contam Toxicol. 2018;75:557-565 pubmed publisher
    ..One lead poisoning case was confirmed. The results suggest that Hooded cranes wintering in Izumi are not extensively contaminated with the seven elements examined. ..
  3. Tanaka Y, Fujiwara M, Shindo A, Yin G, Kitazawa T, Teraoka H. Aroclor 1254 and BDE-47 inhibit dopaminergic function manifesting as changes in locomotion behaviors in zebrafish embryos. Chemosphere. 2018;193:1207-1215 pubmed publisher
    ..The results suggest that functional inhibition of dopaminergic neurons is involved in hyperactivities of zebrafish embryos caused by Aroclor 1254 and BDE-47. ..
  4. Teraoka H, Kubota A, Dong W, Kawai Y, Yamazaki K, Mori C, et al. Role of the cyclooxygenase 2-thromboxane pathway in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced decrease in mesencephalic vein blood flow in the zebrafish embryo. Toxicol Appl Pharmacol. 2009;234:33-40 pubmed publisher
    ..Taken together, these results point to a role of the prostanoid synthesis pathway via COX2-TBXS-TP in the local circulation failure induced by TCDD in the dorsal midbrain of the zebrafish embryo. ..
  5. Teraoka H, Ogawa A, Kubota A, Stegeman J, Peterson R, Hiraga T. Malformation of certain brain blood vessels caused by TCDD activation of Ahr2/Arnt1 signaling in developing zebrafish. Aquat Toxicol. 2010;99:241-7 pubmed publisher
    ..These results indicate that activation of Ahr2/Arnt1 pathway by TCDD and BNF affects the shape of certain blood vessels in the brain of developing zebrafish. ..
  6. Teraoka H, Okamoto E, Kudo M, Nakayama S, Ikenaka Y, Ishizuka M, et al. Accumulation properties of inorganic mercury and organic mercury in the red-crowned crane Grus japonensis in east Hokkaido, Japan. Ecotoxicol Environ Saf. 2015;122:557-64 pubmed publisher
    ..The results suggest slow accumulation of inorganic mercury in the kidney of red-crowned cranes in east Hokkaido, Japan. ..
  7. request reprint
    Teraoka H, Maruyama Y, Takehana K, Iwanaga T, Hiraga T, Fujita S, et al. Ca(2+) signaling in porcine duodenal glands by muscarinic receptor activation. Am J Physiol Gastrointest Liver Physiol. 2001;280:G729-37 pubmed
    ..These results suggest the presence of M(3) receptors linked to Ca(2+) release in porcine duodenal glands...
  8. Teraoka H, Russell C, Regan J, Chandrasekhar A, Concha M, Yokoyama R, et al. Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. J Neurobiol. 2004;60:275-88 pubmed
    ..Our results show that the pathways involved in induction of hindbrain serotonergic neurons are likely to be conserved in all vertebrates and help establish the zebrafish as a model system to study this important neuronal class. ..
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    Teraoka H, Urakawa S, Nanba S, Nagai Y, Dong W, Imagawa T, et al. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicol Appl Pharmacol. 2006;212:24-34 pubmed
    ..These results indicate that muscle activity is necessary to reveal the underlying functional deficit and suggest that the developmental target of dithiocarbamates impairs trunk plasticity through an unknown mechanism. ..

More Information


  1. request reprint
    Teraoka H, Dong W, Okuhara Y, Iwasa H, Shindo A, Hill A, et al. Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Aquat Toxicol. 2006;78:103-13 pubmed
    ..TCDD may impair jaw growth through other pathway(s) in addition to Hh signaling. ..
  2. Teraoka H, Okuno Y, Nijoukubo D, Yamakoshi A, Peterson R, Stegeman J, et al. Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish. Aquat Toxicol. 2014;154:19-26 pubmed publisher
    ..Finally, induction of COX2b, but not COX2a, by TCDD was seen in eleutheroembryos at 3 dpf. These results suggest a role of the COX2b-thromboxane pathway in precardiac edema formation following TCDD exposure in developing zebrafish. ..
  3. Nijoukubo D, Tanaka Y, Okuno Y, Yin G, Kitazawa T, Peterson R, et al. Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish. Chemosphere. 2016;156:111-117 pubmed publisher
    ..Overall, the results demonstrate a preventive effect of prostacyclin on TCDD-induced pre-cardiac edema in developing zebrafish. ..
  4. request reprint
    Teraoka H, Dong W, Ogawa S, Tsukiyama S, Okuhara Y, Niiyama M, et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: altered regional blood flow and impaired lower jaw development. Toxicol Sci. 2002;65:192-9 pubmed
    ..Reductions in hypobranchial RBC perfusion rate occurred well after the initial retardation in lower jaw development had become apparent, and may contribute further to the effect...