Takio Kitazawa

Summary

Affiliation: Rakuno Gakuen University
Country: Japan

Publications

  1. ncbi request reprint Age-dependent reduction of ghrelin- and motilin-induced contractile activity in the chicken gastrointestinal tract
    Takio Kitazawa
    Department of Veterinary Science, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Peptides 43:88-95. 2013
  2. ncbi request reprint Ghrelin does not affect gastrointestinal contractility in rainbow trout and goldfish in vitro
    Takio Kitazawa
    Department of Veterinary Science, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Gen Comp Endocrinol 178:539-45. 2012
  3. ncbi request reprint Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Peptides 28:617-24. 2007
  4. ncbi request reprint Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, 069 8501, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:503-13. 2008
  5. ncbi request reprint Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 554:212-22. 2007
  6. ncbi request reprint Potentiation of motilin-induced contraction by nitric oxide synthase inhibition in the isolated chicken gastrointestinal tract
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Neurogastroenterol Motil 14:3-13. 2002
  7. ncbi request reprint 5-HT(7) receptor and beta(2)-adrenoceptor share in the inhibition of porcine uterine contractility in a muscle layer-dependent manner
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 433:187-97. 2001
  8. pmc M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    J Pharmacol Exp Ther 330:487-93. 2009
  9. pmc Smooth muscle layer-dependent distribution of 5-hydroxytryptamine(7) receptor in the porcine myometrium
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Br J Pharmacol 130:79-89. 2000
  10. ncbi request reprint The mechanisms of alpha(2)-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Eur J Pharmacol 390:185-95. 2000

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Age-dependent reduction of ghrelin- and motilin-induced contractile activity in the chicken gastrointestinal tract
    Takio Kitazawa
    Department of Veterinary Science, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Peptides 43:88-95. 2013
    ..The results suggest an age-related contribution of ghrelin and motilin to the regulation of chicken GI motility...
  2. ncbi request reprint Ghrelin does not affect gastrointestinal contractility in rainbow trout and goldfish in vitro
    Takio Kitazawa
    Department of Veterinary Science, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Gen Comp Endocrinol 178:539-45. 2012
    ..These results suggest diversity of ghrelin function in vertebrates...
  3. ncbi request reprint Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Peptides 28:617-24. 2007
    ..The action would be mediated through the GHS-R, which is highly sensitive to chicken ghrelin...
  4. ncbi request reprint Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, 069 8501, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:503-13. 2008
    ..Activation of M2 receptors alone did not cause uterine contractions; however, M2 receptor activation enhanced M3 receptor-mediated contractions in the mouse uterus...
  5. ncbi request reprint Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 554:212-22. 2007
    ....
  6. ncbi request reprint Potentiation of motilin-induced contraction by nitric oxide synthase inhibition in the isolated chicken gastrointestinal tract
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Neurogastroenterol Motil 14:3-13. 2002
    ..However, NOS inhibition did not modify the myogenic (direct) action of ch-MT in gastric and intestinal smooth muscles of the chicken...
  7. ncbi request reprint 5-HT(7) receptor and beta(2)-adrenoceptor share in the inhibition of porcine uterine contractility in a muscle layer-dependent manner
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 433:187-97. 2001
    ....
  8. pmc M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    J Pharmacol Exp Ther 330:487-93. 2009
    ..Physiologically, this activity may serve to dampen the inhibitory effects of M(2) receptor activation on atrial contractility...
  9. pmc Smooth muscle layer-dependent distribution of 5-hydroxytryptamine(7) receptor in the porcine myometrium
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Br J Pharmacol 130:79-89. 2000
    ..Different inhibition of the contractility by 5-HT is caused by muscle layer-related accumulation of cyclic AMP (CM>LM), due to smooth muscle-layer dependent distribution (CM>LM) of 5-HT(7) receptors...
  10. ncbi request reprint The mechanisms of alpha(2)-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Eur J Pharmacol 390:185-95. 2000
    ..These actions involve a pertussis-toxin-sensitive G protein (probably G(i) type) in the signal transduction pathway...
  11. ncbi request reprint Molecular cloning of growth hormone secretagogue-receptor and effect of quail ghrelin on gastrointestinal motility in Japanese quail
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Regul Pept 158:132-42. 2009
    ..These results suggest a species-specific contribution of GRLN in the regulation of avian gastrointestinal contractility...
  12. doi request reprint Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig
    Takio Kitazawa
    Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Peptides 32:1876-86. 2011
    ..The distribution of GHS-R1a in peripheral tissues was different from that in rats, suggesting that the functional role of ghrelin in the guinea-pig is different from that in other animal species...
  13. ncbi request reprint 5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs
    Mayuko Inoue
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai Midorimachi, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 461:207-18. 2003
    ..The strongest relaxation through 5-HT(7) receptor activation suggests that 5-HT plays an important physiological role in the regulation of porcine oviduct contractility...
  14. doi request reprint A ganglionic stimulant, 1,1-dimethyl-4-phenylpiperazinium, caused both cholinergic and adrenergic responses in the isolated mouse atrium
    Kenta Ochi
    Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 704:7-14. 2013
    ..M2 and M3 muscarinic receptors and β1-adrenoceptor are thought to be involved in these actions...
  15. doi request reprint Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle
    Jinshan Cao
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu Hokkaido 069 8501, Japan
    Prostaglandins Other Lipid Mediat 86:26-34. 2008
    ..Endogenous prostanoid produced by cyclooxygenase can regulate noradrenaline release in an inhibitory manner through activation of these neural prostanoid receptors...
  16. doi request reprint Excitatory and inhibitory 5-hydroxytryptamine (5-HT) receptors expressed in the isolated porcine uterine muscles
    Tatsuro Nakamura
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Eur J Pharmacol 600:123-9. 2008
    ..Endogenous 5-HT containing cells are mainly present in uterine glands of the pig. The possible roles of 5-HT and its receptors in regulation of porcine uterine spontaneous contractility are discussed...
  17. ncbi request reprint Excitatory action of [Leu13]motilin on the gastrointestinal smooth muscle isolated from the chicken
    T Kitazawa
    Department of Veterinary Pharmacology, Faculty of Dairy Science, Rakuno Gakuen University, Ebetsu, Japan
    Peptides 16:1243-52. 1995
    ....
  18. ncbi request reprint Expression of two novel cytochrome P450 3A131 and 3A132 in liver and small intestine of domestic cats
    Kouichi Honda
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    J Vet Med Sci 73:1489-92. 2011
    ..CYP3A132 expression was only detected in liver with much lesser amount. These results suggest the possible major role of CYP3A131 in xenobiotic metabolism including first-pass effects in domestic cats...
  19. doi request reprint Muscarinic receptor subtypes involved in regulation of colonic motility in mice: functional studies using muscarinic receptor-deficient mice
    Takaji Kondo
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 670:236-43. 2011
    ..In conclusion, M(1), M(2) and M(3) receptors regulate colonic motility of the mouse. M(2) and M(3) receptors mediate cholinergic contraction, but M(1) receptors on inhibitory nitrergic nerves counteract muscarinic contraction...
  20. ncbi request reprint Endogenous prostaglandins regulate spontaneous contractile activity of uterine strips isolated from non-pregnant pigs
    Jinshan Cao
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Prostaglandins Other Lipid Mediat 81:93-105. 2006
    ....
  21. ncbi request reprint Uterine region-dependent differences in responsiveness to prostaglandins in the non-pregnant porcine myometrium
    Jinshan Cao
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Prostaglandins Other Lipid Mediat 75:105-22. 2005
    ..Region-related differences in COX-1 and prostanoid receptors might be necessary to produce a gradient of uterine motility decreasing from the cornu to the cervix that manages movement of luminal contents...
  22. ncbi request reprint Pregnancy-associated changes in responsiveness of the porcine myometrium to bioactive substances
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai Midorimachi, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 469:135-44. 2003
    ..According to the pregnancy-associated changes, muscle layer-related differences of responsiveness to bioactive substances in the nonpregnant pigs tend to decrease in the pregnant pigs...
  23. ncbi request reprint Origin of three Red-crowned Cranes Grus japonensis found in northeast Honshu and west Hokkaido, Japan, from 2008 to 2012
    Yoshiaki Miura
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069 8501, Japan
    J Vet Med Sci 75:1241-4. 2013
    ..The third crane in Miyagi in 2010 also showed another type, Gj11. These results suggest that three Red-crowned Cranes appeared in Honshu and west Hokkaido were from the continent...
  24. ncbi request reprint Large-scale survey of mitochondrial D-loop of the red-crowned crane Grus japonensis in Hokkaido, Japan by convenient genotyping method
    Yoshiaki Miura
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069 8501, Japan
    J Vet Med Sci 75:43-7. 2013
    ..Additionally, only Gj2 was identified in twelve feathers from both sexes found in northern Hokkaido. These results suggest scarce genetic diversity in island population of Red-crowned Cranes in Hokkaido, Japan...
  25. doi request reprint Differential display system with vertebrate-common degenerate oligonucleotide primers: uncovering genes responsive to dioxin in avian embryonic liver
    Hiroki Teraoka
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069 8501, Japan
    Environ Sci Technol 46:27-33. 2012
    ..These results highlighted the usefulness of systematically designed novel differential display systems to search genes responsive to chemicals in vertebrates, including wild species, for which transcriptome information is not available...
  26. ncbi request reprint Pharmacological characterization of 5-hydroxytryptamine-induced contraction in the chicken gastrointestinal tract
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Auton Autacoid Pharmacol 26:157-68. 2006
    ..Neural 5-HT receptors similar to 5-HT(3)/5-HT(4) receptors were not found in the chicken proventriculus and ileum...
  27. ncbi request reprint Does motilin stimulate the gastrointestinal motility of the pig? In vitro study using smooth muscle strips and dispersed muscle cells
    T Kitazawa
    Department of Veterinary Pharmacology, Faculty of Dairy Science, Rakuno Gakuen University, Ebe Tsu, Japan
    Gen Pharmacol 27:655-64. 1996
    ....
  28. ncbi request reprint Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity
    Jinshan Cao
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 485:317-27. 2004
    ..The endogenous thromboxane A(2)-TP receptor pathway is thought to play a physiological role in regulation of spontaneous contractile activity in the porcine uterus...
  29. ncbi request reprint Evidence for M2 and M3 muscarinic receptor involvement in cholinergic excitatory junction potentials through synergistic activation of cation channels in the longitudinal muscle of mouse ileum
    Hayato Matsuyama
    Laboratory of Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan
    J Pharmacol Sci 121:227-36. 2013
    ..The results suggest that the wild-type cholinergic EJP is not a simple mixture of M2 and M3 responses, but due to synergistic activation of cation channels by both M2 and M3 receptors in the murine ileal longitudinal muscle...
  30. ncbi request reprint In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium
    Jinshan Cao
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai Midorimachi, Ebetsu, Hokkaido, Japan
    Eur J Pharmacol 442:115-23. 2002
    ....
  31. ncbi request reprint Ghrelin stimulates gastric motility of the guinea pig through activation of a capsaicin-sensitive neural pathway: in vivo and in vitro functional studies
    T Nakamura
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Neurogastroenterol Motil 22:446-52, e107. 2010
    ..Aim of the present study was to clarify the motor-stimulating action of ghrelin in the guinea-pig stomach...
  32. ncbi request reprint Smooth muscle layer-specific variations in the autonomic innervation of bovine myometrium
    T Taneike
    Department of Pharmacology, Faculty of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Gen Pharmacol 32:91-100. 1999
    ....
  33. ncbi request reprint A new method for detecting the abomasal position and characteristics of movement at the onset of the left displacement of the abomasum in cows
    N Itoh
    Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069 8501, Japan
    J Vet Med A Physiol Pathol Clin Med 53:375-8. 2006
    ..A large movement of the magnet from the normal right side to the abnormal left side of the abdominal cavity was observed within 12 h of the onset of abomasal displacement...
  34. ncbi request reprint Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish
    Hiroki Teraoka
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan Electronic address
    Aquat Toxicol 154:19-26. 2014
    ..Finally, induction of COX2b, but not COX2a, by TCDD was seen in eleutheroembryos at 3 dpf. These results suggest a role of the COX2b-thromboxane pathway in precardiac edema formation following TCDD exposure in developing zebrafish...
  35. ncbi request reprint Molecular cloning and expression of cytochrome P450 2D6 in the livers of domestic cats
    Tetsuya Komatsu
    School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan
    J Vet Med Sci 72:1633-6. 2010
    ..CYP2D6 transcripts were expressed predominantly in the liver and to a much lesser in the testis, suggesting the role of xenobiotic metabolism in the liver...
  36. ncbi request reprint Muscle layer- and region-dependent distributions of oxytocin receptors in the porcine myometrium
    T Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, 069-8501, Hokkaido, Japan
    Peptides 22:963-74. 2001
    ..The distribution of the oxytocin receptors differs according to the type of muscle layer (longitudinal muscle > circular muscle) and the region of the uterus...
  37. ncbi request reprint Changes of mercury contamination in red-crowned cranes, Grus japonensis, in East Hokkaido, Japan
    Hiroki Teraoka
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
    Arch Environ Contam Toxicol 63:153-60. 2012
    ..This indicates the possible occurrence of some mercury pollution in Red-crowned cranes' habitat in this region in the 1990s or before...
  38. pmc Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells
    Takashi Sakamoto
    Department of Pathogenetic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Physiol 582:41-61. 2007
    ..The delineation of this pathway is consistent with the formation of a functional unit by the M2-Go protein and the M3-PLC systems predicted to control cationic channels...
  39. ncbi request reprint Intracerebroventricular administration of chicken motilin does not induce hyperphagia in meat-type chicks
    Takashi Bungo
    Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790 8566, Japan
    Physiol Behav 82:199-203. 2004
    ..0 microg) under ad libitum feeding conditions. Therefore, the results presented here suggest that central motilin alone does not induce hyperphagia in meat-type chicks...