Waka Ohishi

Summary

Affiliation: Radiation Effects Research Foundation
Country: Japan

Publications

  1. doi request reprint Risk factors for hepatocellular carcinoma in a Japanese population: a nested case-control study
    Waka Ohishi
    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
    Cancer Epidemiol Biomarkers Prev 17:846-54. 2008
  2. doi request reprint Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma
    Waka Ohishi
    Department of Clinical Studies, Hiroshima, Japan
    Hepatology 53:1237-45. 2011
  3. pmc Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses
    Waka Ohishi
    Department of Clinical Studies, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima, 732 0815, Japan
    J Clin Microbiol 44:4593-5. 2006
  4. doi request reprint Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b
    Yoshimasa Hashimoto
    Division of Frontier Medical Science, Department of Medical and Molecular Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    J Med Virol 83:981-8. 2011
  5. doi request reprint Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b
    Tomokazu Kawaoka
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN The Institute of Physical and Chemical Research, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Hepatol 54:408-14. 2011
  6. doi request reprint Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B
    Keiko Arataki
    Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    J Med Virol 85:789-98. 2013
  7. doi request reprint Serum interleukin-6 associated with hepatocellular carcinoma risk: a nested case-control study
    Waka Ohishi
    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
    Int J Cancer 134:154-63. 2014
  8. pmc Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle
    C Nelson Hayes
    Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    PLoS ONE 7:e47490. 2012
  9. ncbi request reprint Identification of rare polymerase variants of hepatitis B virus using a two-stage PCR with peptide nucleic acid clamping
    Waka Ohishi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Med Virol 72:558-65. 2004
  10. doi request reprint Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients
    Hiromi Abe
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Hepatol 53:439-43. 2010

Collaborators

Detail Information

Publications26

  1. doi request reprint Risk factors for hepatocellular carcinoma in a Japanese population: a nested case-control study
    Waka Ohishi
    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
    Cancer Epidemiol Biomarkers Prev 17:846-54. 2008
    ..However, few cohort studies have incorporated, in a strict and in-depth manner, hepatitis B virus (HBV) and hepatitis C virus (HCV) infections or investigated synergism between such factors...
  2. doi request reprint Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma
    Waka Ohishi
    Department of Clinical Studies, Hiroshima, Japan
    Hepatology 53:1237-45. 2011
    ..The RR of non-B, non-C HCC at 1 Gy was 1.90 (1.02-3.92) without adjustment for alcohol consumption, BMI, or smoking habit and 2.74 (1.26-7.04) with such adjustment...
  3. pmc Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses
    Waka Ohishi
    Department of Clinical Studies, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima, 732 0815, Japan
    J Clin Microbiol 44:4593-5. 2006
    ..The results indicated that freeze-dried sera as well as frozen sera can be useful for serological and molecular biological analyses of HBV and HCV...
  4. doi request reprint Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b
    Yoshimasa Hashimoto
    Division of Frontier Medical Science, Department of Medical and Molecular Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    J Med Virol 83:981-8. 2011
    ..In conclusion, host (IL-28B polymorphism) and viral (aa 70) factors independently affect response to combination therapy...
  5. doi request reprint Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b
    Tomokazu Kawaoka
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN The Institute of Physical and Chemical Research, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Hepatol 54:408-14. 2011
    ....
  6. doi request reprint Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B
    Keiko Arataki
    Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    J Med Virol 85:789-98. 2013
    ..025). These results suggest that serum micro-RNA levels are significantly associated with multiple aspects of HBV infection. The biological meaning of the correlation between microRNA-122 and HBsAg and should be investigated further...
  7. doi request reprint Serum interleukin-6 associated with hepatocellular carcinoma risk: a nested case-control study
    Waka Ohishi
    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
    Int J Cancer 134:154-63. 2014
    ..The association is especially pronounced among subjects with obesity. ..
  8. pmc Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle
    C Nelson Hayes
    Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    PLoS ONE 7:e47490. 2012
    ..Conversely, HBx localized non-specifically in the nucleus and cytoplasm, and no interaction between AGO2 and HBx was detected. SiRNA ablation of AGO2 suppressed production of HBV DNA and HBs antigen in the supernatant...
  9. ncbi request reprint Identification of rare polymerase variants of hepatitis B virus using a two-stage PCR with peptide nucleic acid clamping
    Waka Ohishi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Med Virol 72:558-65. 2004
    ..Examination of rare variants should enhance the understanding of the mechanism for emergence of drug-resistant HBV variants and help in developing strategies for new antiviral drugs...
  10. doi request reprint Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients
    Hiromi Abe
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Hepatol 53:439-43. 2010
    ..An allele associated with a favorable response (rs8099917 T), which is the major allele in the majority of Asian, American, and European populations, has also been found to be associated with spontaneous eradication of the virus...
  11. pmc Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines
    Kazuaki Chayama
    Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan
    J Gastroenterol 48:1-12. 2013
    ..In this review we summarize current treatment options in Japan and discuss how we treat patients with chronic HCV infection...
  12. doi request reprint Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis
    Kengo Yoshida
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Hum Immunol 72:821-6. 2011
    ..This study suggests that T(H)1 immunity is enhanced by persistent HCV infection and that percentages of peripheral T(H)1, T(C)1, and NK cells may help predict progression of liver fibrosis...
  13. doi request reprint Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: a clinical health study
    Yoshimi Tatsukawa
    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima and Nagasaki, Japan
    J Radiol Prot 33:281-93. 2013
    ....
  14. doi request reprint Prevention of hepatitis B virus reactivation in immunosuppressive therapy or chemotherapy
    Waka Ohishi
    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
    Clin Exp Nephrol 15:634-40. 2011
    ..The foundation of the aforementioned management, regardless of HBsAg status, is administration of nucleoside analogues, with their powerful anti-viral properties, when HBV DNA levels reach detectable levels...
  15. pmc Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivors
    Kengo Yoshida
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    PLoS ONE 9:e91985. 2014
    ..Given the fact that obesity increases the risk of numerous age-related diseases, attenuated immune competence is a possible mechanistic link between obesity and disease development among the elderly. ..
  16. pmc Comparison between oscillometric- and Doppler-ABI in elderly individuals
    Ikuno Takahashi
    Department of Clinical Studies, Radiation Effects Research Foundation RERF, Minami Ku, Hiroshima, Japan
    Vasc Health Risk Manag 9:89-94. 2013
    ..65). Our findings indicate that oscillometric devices can provide more accurate estimation of the prevalence of PAD in elderly individuals than the conventional Doppler method...
  17. doi request reprint Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy
    Shosuke Kitamura
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Antivir Ther 15:1087-97. 2010
    ..Despite the importance of these two predictive factors for combination therapy, their interaction is poorly understood...
  18. doi request reprint A report from the 2013 international workshop: radiation and cardiovascular disease, Hiroshima, Japan
    Ikuno Takahashi
    Department of Clinical Studies, Radiation Effects Research Foundation RERF, Hiroshima, Japan
    J Radiol Prot 33:869-80. 2013
    ..Epidemiological, clinical and experimental studies at doses of less than 1 Gy are necessary to clarify the effects of radiation on CVD risk. ..
  19. doi request reprint Effects of IL-10 haplotype and atomic bomb radiation exposure on gastric cancer risk
    Tomonori Hayashi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 180:60-9. 2013
    ....
  20. doi request reprint Proportional hazards regression in epidemiologic follow-up studies: an intuitive consideration of primary time scale
    John Cologne
    Departments of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Epidemiology 23:565-73. 2012
    ..Given the potential for biased risk estimates, age should be considered as the preferred time scale for proportional-hazards regression with epidemiologic follow-up data when confounding by age is a concern...
  21. ncbi request reprint Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver
    Atsushi Yamaguchi
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Dig Dis Sci 50:1361-71. 2005
    ..There findings may contribute to the understanding of HCV-related steatosis, induction of reactive oxygen species, and carcinogenesis...
  22. ncbi request reprint Rare quasispecies in the YMDD motif of hepatitis B virus detected by polymerase chain reaction with peptide nucleic acid clamping
    Waka Ohishi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, 734 8551, Japan
    Intervirology 46:355-61. 2003
    ....
  23. ncbi request reprint Treatment of chronic hepatitis B with nucleos(t)ide analogues
    Waka Ohishi
    Department of Clinical Studies, Radiation Effects Research Foundation Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Hepatol Res 42:219-25. 2012
    ..HBV core-related antigen (HBcrAg) level or HBV DNA level are considered useful markers for the appearance of such drug-resistant viruses...
  24. ncbi request reprint [Detection of hepatitis C virus RNA]
    Waka Ohishi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
    Nihon Rinsho 62:214-8. 2004
  25. ncbi request reprint Evolution of hepatitis C virus quasispecies during ribavirin and interferon-alpha-2b combination therapy and interferon-alpha-2b monotherapy
    Keiko Arataki
    Department of Internal Medicine, Kure Medical Association Hospital, Kure shi, and Department of Medicine and Molecular Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Intervirology 49:352-61. 2006
    ....
  26. ncbi request reprint [Hepatitis D virus infection]
    Waka Ohishi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
    Nihon Rinsho 61:245-8. 2003