Kei Nakachi

Summary

Affiliation: Radiation Effects Research Foundation
Country: Japan

Publications

  1. doi request reprint Sixty years of follow-up of Hiroshima and Nagasaki survivors: current progress in molecular epidemiology studies
    Kei Nakachi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation RERF, 5 2 Hijiyama Park, Minami Ku, Hiroshima shi, Hiroshima 732 0815, Japan
    Mutat Res 659:109-17. 2008
  2. ncbi request reprint Japan-US Cooperative Cancer Research Seminar on molecular epidemiological characteristics of lung and colon cancer development among atomic-bomb survivors, Bethesda, USA, February 23-24, 2006
    Kei Nakachi
    Department of Radiobiology Molecular Epidemiology, Hijiyama Park, Hiroshima City, Hiroshima, Japan
    Cancer Sci 97:1279-82. 2006
  3. ncbi request reprint Can teatime increase one's lifetime?
    Kei Nakachi
    Department of Epidemiology, Radiation Effects Research Foundation, Hijiyama, Minami Ku, Hiroshima 732 0815, Japan
    Ageing Res Rev 2:1-10. 2003
  4. ncbi request reprint Perspectives on cancer immuno-epidemiology
    Kei Nakachi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732 0815, Japan
    Cancer Sci 95:921-9. 2004
  5. ncbi request reprint A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 14:465-70. 2005
  6. ncbi request reprint A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer
    Yoichi Hamai
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 72:133-8. 2005
  7. doi request reprint RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose
    Kiyohiro Hamatani
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima shi, Hiroshima 732 0815, Japan
    Cancer Res 68:7176-82. 2008
  8. ncbi request reprint A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    J Cancer Res Clin Oncol 131:19-25. 2005
  9. pmc Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects
    Tomonori Hayashi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ward, Hiroshima 732 0815 Japan
    FASEB J 26:4765-73. 2012
  10. doi request reprint Caspase-independent cell death without generation of reactive oxygen species in irradiated MOLT-4 human leukemia cells
    Kengo Yoshida
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Cell Immunol 255:61-8. 2009

Detail Information

Publications65

  1. doi request reprint Sixty years of follow-up of Hiroshima and Nagasaki survivors: current progress in molecular epidemiology studies
    Kei Nakachi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation RERF, 5 2 Hijiyama Park, Minami Ku, Hiroshima shi, Hiroshima 732 0815, Japan
    Mutat Res 659:109-17. 2008
    ....
  2. ncbi request reprint Japan-US Cooperative Cancer Research Seminar on molecular epidemiological characteristics of lung and colon cancer development among atomic-bomb survivors, Bethesda, USA, February 23-24, 2006
    Kei Nakachi
    Department of Radiobiology Molecular Epidemiology, Hijiyama Park, Hiroshima City, Hiroshima, Japan
    Cancer Sci 97:1279-82. 2006
  3. ncbi request reprint Can teatime increase one's lifetime?
    Kei Nakachi
    Department of Epidemiology, Radiation Effects Research Foundation, Hijiyama, Minami Ku, Hiroshima 732 0815, Japan
    Ageing Res Rev 2:1-10. 2003
    ..These results indicate that daily consumption of green tea in sufficient amounts will help to prolong life by avoiding pre-mature death, particularly death caused by cancer...
  4. ncbi request reprint Perspectives on cancer immuno-epidemiology
    Kei Nakachi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732 0815, Japan
    Cancer Sci 95:921-9. 2004
    ....
  5. ncbi request reprint A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 14:465-70. 2005
    ..In conclusion, a Thr to Arg single nucleotide polymorphism in the extracellular domain of DR4 could not be associated with the development and progression of gastric cancer...
  6. ncbi request reprint A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer
    Yoichi Hamai
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 72:133-8. 2005
    ..We examined whether this polymorphism is correlated with the development and malignant phenotypes of gastric cancer...
  7. doi request reprint RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose
    Kiyohiro Hamatani
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima shi, Hiroshima 732 0815, Japan
    Cancer Res 68:7176-82. 2008
    ..03). These findings were confirmed by multivariate logistic regression analysis. These results suggest that RET/PTC rearrangements play an important role in radiation-associated thyroid carcinogenesis...
  8. ncbi request reprint A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    J Cancer Res Clin Oncol 131:19-25. 2005
    ..The purpose of this study was to investigate the relation between the -1562 C/T polymorphism and the development and progression of gastric cancer...
  9. pmc Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects
    Tomonori Hayashi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ward, Hiroshima 732 0815 Japan
    FASEB J 26:4765-73. 2012
    ..The results suggest that collectively, radiation exposure, in conjunction with natural aging, may enhance the persistent inflammatory status of A-bomb survivors...
  10. doi request reprint Caspase-independent cell death without generation of reactive oxygen species in irradiated MOLT-4 human leukemia cells
    Kengo Yoshida
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Cell Immunol 255:61-8. 2009
    ....
  11. doi request reprint Effects of NKG2D haplotypes on the cell-surface expression of NKG2D protein on natural killer and CD8 T cells of peripheral blood among atomic-bomb survivors
    Kazue Imai
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Hum Immunol 73:686-91. 2012
    ..Our findings indicate that the NKG2D haplotypes are associated with the expression levels of NKG2D protein on NK and CD8 T cells, resulting in inter-individual variations in human cytotoxic response...
  12. ncbi request reprint A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    J Cancer Res Clin Oncol 130:259-65. 2004
    ..In the light of these findings, we investigated whether this SNP in the MMP-1 promoter is associated with the development, differentiation, and progression of gastric cancer...
  13. doi request reprint Lung cancer susceptibility among atomic bomb survivors in relation to CA repeat number polymorphism of epidermal growth factor receptor gene and radiation dose
    Kengo Yoshida
    Department of Radiobiology Molecular Epidemiology and Department of Statistics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ward, Hiroshima City 732 0815, Japan
    Carcinogenesis 30:2037-41. 2009
    ..Our findings imply that the EGFR pathway plays a crucial role in assessing individual susceptibility to lung adenocarcinoma in relation to radiation exposure...
  14. doi request reprint Memory CD4 T-cell subsets discriminated by CD43 expression level in A-bomb survivors
    Seishi Kyoizumi
    Department of Radiobiology, Yasuda Women s University, Hiroshima, Japan
    Int J Radiat Biol 86:56-62. 2010
    ..To evaluate the maintenance of T-cell memory within A-bomb survivors 60 years after radiation exposure, we examined functionally distinct memory CD4 T-cell subsets in the peripheral blood lymphocytes of the survivors...
  15. doi request reprint Effects of IL-10 haplotype and atomic bomb radiation exposure on gastric cancer risk
    Tomonori Hayashi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 180:60-9. 2013
    ....
  16. pmc Improved PCR amplification for molecular analysis using DNA from long-term preserved formalin-fixed, paraffin-embedded lung cancer tissue specimens
    Masataka Taga
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Int J Clin Exp Pathol 6:76-9. 2013
    ....
  17. doi request reprint Improved method for analysis of RNA present in long-term preserved thyroid cancer tissue of atomic bomb survivors
    Kiyohiro Hamatani
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Thyroid 20:43-9. 2010
    ..In this study, we established an improved 5' rapid amplification of cDNA ends (RACE) method using a small amount of RNA extracted from archival thyroid cancer tissue specimens...
  18. ncbi request reprint Individual variation of somatic gene mutability in relation to cancer susceptibility: prospective study on erythrocyte glycophorin a gene mutations of atomic bomb survivors
    Seishi Kyoizumi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Cancer Res 65:5462-9. 2005
    ....
  19. ncbi request reprint Identification of the NKG2D haplotypes associated with natural cytotoxic activity of peripheral blood lymphocytes and cancer immunosurveillance
    Tomonori Hayashi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Cancer Res 66:563-70. 2006
    ..Individuals who are genetically predisposed to have low or high natural cytotoxic activity can in part be determined by NKG2D haplotyping, which in turn reveals an increased or decreased risk of cancer development...
  20. ncbi request reprint Long-term effects of radiation dose on inflammatory markers in atomic bomb survivors
    Tomonori Hayashi
    Department of Radiobiology Molecular Epidemiology, Hiroshima University Faculty of Dentistry, Hiroshima, Japan
    Am J Med 118:83-6. 2005
  21. doi request reprint Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis
    Kengo Yoshida
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Hum Immunol 72:821-6. 2011
    ..This study suggests that T(H)1 immunity is enhanced by persistent HCV infection and that percentages of peripheral T(H)1, T(C)1, and NK cells may help predict progression of liver fibrosis...
  22. doi request reprint Radiation-dose response of glycophorin A somatic mutation in erythrocytes associated with gene polymorphisms of p53 binding protein 1
    Kengo Yoshida
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Mutat Res 755:49-54. 2013
    ..It is also possible that 53BP1 plays a significant role in DNA double-strand break repair in HSCs following radiation exposure. ..
  23. pmc Linkage between Dendritic and T Cell Commitments in Human Circulating Hematopoietic Progenitors
    Seishi Kyoizumi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732 0815, Japan
    J Immunol 192:5749-60. 2014
    ..The findings suggest a strong linkage between DC and T cell commitments, which may be imprinted in circulating lymphoid-primed multipotent progenitors or in more upstream HPCs. ..
  24. pmc Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells
    Seishi Kyoizumi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732 0815, Japan
    J Immunol 190:6164-72. 2013
    ..The age-associated increase in NK over T cell commitment might occur in precursor cells with T/NK/myeloid potential...
  25. doi request reprint Increased DNA damage in hematopoietic cells of mice with graft-versus-host disease
    Yoichiro Kusunoki
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Mutat Res 689:59-64. 2010
    ..The results indicate that GVHD, without irradiation, can induce genomic damage associated with inflammatory reactions manifested by increased TNF-alpha levels...
  26. ncbi request reprint The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose
    Keiko Takahashi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Mol Carcinog 46:242-8. 2007
    ..039 and P=0.010, respectively). These results suggest that involvement of BRAF mutation in thyroid carcinogenesis in exposed people may differ from that in the nonexposed people...
  27. doi request reprint T-cell immunosenescence and inflammatory response in atomic bomb survivors
    Yoichiro Kusunoki
    Department of Radiobiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 174:870-6. 2010
    ....
  28. pmc Rearranged anaplastic lymphoma kinase (ALK) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors
    Kiyohiro Hamatani
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Minami Ku, Hiroshima, Japan
    Thyroid 22:1153-9. 2012
    ....
  29. ncbi request reprint Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus
    Takahiko Ogawa
    Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Cancer Res 65:9771-8. 2005
    ..These results support a cancer therapeutic and preventive role for specific HDAC inhibitors...
  30. ncbi request reprint Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer
    Reiko Ito
    Department of Radiobiology Molecular Epidemiology, Radiation Effect Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima, Japan
    Virchows Arch 447:717-22. 2005
    ..These results suggested that the expression of CDH17 was characteristic of the advanced gastric carcinoma that is associated with poor prognosis...
  31. ncbi request reprint Conventional case-cohort design and analysis for studies of interaction
    John Cologne
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Int J Epidemiol 41:1174-86. 2012
    ..Furthermore, although the large number of options for design and analysis of case-cohort studies may be daunting, they can be reduced to a few simple recommendations...
  32. pmc Associations of ionizing radiation and breast cancer-related serum hormone and growth factor levels in cancer-free female A-bomb survivors
    Eric J Grant
    Department of Epidemiology, Radiation Effects Research Foundation, Minamiku, Hiroshima, Japan
    Radiat Res 176:678-87. 2011
    ..No associations with radiation were observed in serum levels of progesterone, prolactin, IGFBP-3 or ferritin...
  33. pmc Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells
    Masaru Ohara
    Department of Bacteriology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Infect Immun 76:4783-91. 2008
    ..Both occur via the mitochondrial membrane disruption pathway...
  34. doi request reprint Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Minami Ku, Hiroshima, Japan
    Int J Cancer 124:1112-21. 2009
    ..026 and p = 0.024, respectively). These results suggest that the characteristics of tumor-associated stromal cells differ between GCs from exposed and nonexposed patients...
  35. ncbi request reprint Short-term culture and gammaH2AX flow cytometry determine differences in individual radiosensitivity in human peripheral T lymphocytes
    Kanya Hamasaki
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Environ Mol Mutagen 48:38-47. 2007
    ..These results suggest that the FCM-based gammaH2AX assay using cultured T lymphocytes might be useful for the rapid and reliable assessment of individual radiation sensitivity involved in DNA damage repair...
  36. ncbi request reprint Radiation sensitivity and genomic instability in the hematopoietic system: Frequencies of micronucleated reticulocytes in whole-body X-irradiated BALB/c and C57BL/6 mice
    Kanya Hamasaki
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Cancer Sci 98:1840-4. 2007
    ....
  37. ncbi request reprint Decreases in percentages of naïve CD4 and CD8 T cells and increases in percentages of memory CD8 T-cell subsets in the peripheral blood lymphocyte populations of A-bomb survivors
    Mika Yamaoka
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 161:290-8. 2004
    ..These results suggest that the prior A-bomb exposure has induced long-lasting deficits in both naïve CD4 and CD8 T- cell populations along with increased proportions of these particular subsets of the memory CD8 T-cell population...
  38. ncbi request reprint Improved RT-PCR amplification for molecular analyses with long-term preserved formalin-fixed, paraffin-embedded tissue specimens
    Kiyohiro Hamatani
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima shi, Hiroshima 732 0815, Japan
    J Histochem Cytochem 54:773-80. 2006
    ..Namely, the preheating in citrate buffer (pH 4.0) of RNA extracted from long-term preserved tissue specimens resulted in significantly increased efficiency of RT-PCR...
  39. ncbi request reprint Radiation-induced apoptosis of stem/progenitor cells in human umbilical cord blood is associated with alterations in reactive oxygen and intracellular pH
    Tomonori Hayashi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hijyama Park, Minami Ward, Hiroshima, Japan
    Mutat Res 556:83-91. 2004
    ....
  40. pmc Demethylation of promoter C region of estrogen receptor alpha gene is correlated with its enhanced expression in estrogen-ablation resistant MCF-7 cells
    Tetsuya Sogon
    Department of Molecular Epidemiology, Hiroshima University Graduate School of Biomedical Sciences, Radiation Effects Research Foundation, 5 2, Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    J Steroid Biochem Mol Biol 105:106-14. 2007
    ..Our findings imply that demethylation of promoter C region in the ERalpha gene is in part responsible for the enhanced expression of ERalpha gene in LTED cells...
  41. ncbi request reprint Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway
    Takahiko Ogawa
    Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    J Cell Sci 117:2087-96. 2004
    ....
  42. ncbi request reprint HLA haplotype is associated with diabetes among atomic bomb survivors
    Tomonori Hayashi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Hum Immunol 64:910-6. 2003
    ..These results suggest that individuals with specific HLA haplotypes may have an increased risk of diabetes with increased-dose categories...
  43. ncbi request reprint [Smoking as a risk factor for pancreatic cancer]
    Hidetaka Eguchi
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation
    Nihon Rinsho 64:10-3. 2006
  44. ncbi request reprint Improving the efficiency of nested case-control studies of interaction by selecting controls using counter matching on exposure
    John B Cologne
    Departments of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Int J Epidemiol 33:485-92. 2004
    ....
  45. ncbi request reprint A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer
    Kazuya Kuraoka
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 107:593-6. 2003
    ..The association of HER-2 genotype with clinicopathologic characteristics of gastric cancer was also suggested, which has to be confirmed with a larger sample size...
  46. ncbi request reprint Single nucleotide polymorphisms in the EXO1 gene and risk of colorectal cancer in a Japanese population
    Hiromasa Yamamoto
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Carcinogenesis 26:411-6. 2005
    ..This is the first report to provide evidence for an association of EXO1 gene polymorphisms with colorectal cancer risk. The EXO1 genotypes were not associated with any clinicopathological characteristics in colorectal cancer patients...
  47. ncbi request reprint Excess concordance of cancer incidence and lifestyles in married couples (Japan): survival analysis of paired rate data
    Shizue Izumi
    Department of Statistics RERF 5 2 Hijiyama Park Minami ku Hiroshima 732 0815 Japan izumi rerf or jp
    Cancer Causes Control 15:551-8. 2004
    ..A population-based cohort study was conducted to examine concordance of cancer incidence and lifestyle in married couples...
  48. ncbi request reprint The association between RAD18 Arg302Gln polymorphism and the risk of human non-small-cell lung cancer
    Hirotaka Kanzaki
    Department of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Cancer Res Clin Oncol 134:211-7. 2008
    ..We therefore investigated the relationship between the polymorphism and the development and progression of human NSCLC...
  49. ncbi request reprint Detection of plasma hnRNP B1 mRNA, a new cancer biomarker, in lung cancer patients by quantitative real-time polymerase chain reaction
    Eisaburo Sueoka
    Department of Internal Medicine, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Lung Cancer 48:77-83. 2005
    ..These results indicate that plasma hnRNP B1 mRNA is a useful non-invasive markers for detection of lung cancer...
  50. ncbi request reprint Stability of frozen serum levels of insulin-like growth factor-I, insulin-like growth factor-II, insulin-like growth factor binding protein-3, transforming growth factor beta, soluble Fas, and superoxide dismutase activity for the JACC study
    Yoshinori Ito
    Department of Public Health, Fujita Health University School of Health Sciences, Japan
    J Epidemiol 15:S67-73. 2005
    ..We conducted to investigate whether levels of serum components measured after 9 years of frozen storage are stable or not...
  51. ncbi request reprint Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population
    Hirotaka Kanzaki
    Department of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    Oncol Rep 18:1171-5. 2007
    ..30-10.6, respectively). These results suggested that the RAD18 Arg302Gln polymorphism is associated with the risk of CRC. This report provides evidence for an association between the RAD18 Arg302Gln polymorphism and human CRC risk...
  52. ncbi request reprint Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population
    Hirotaka Kanzaki
    Department of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    Int J Mol Med 18:279-84. 2006
    ..This is the first report to show an association between the AXIN2 SNP and lung cancer risk...
  53. ncbi request reprint Soluble Fas level and cancer mortality: findings from a nested case-control study within a large-scale prospective study
    Akiko Tamakoshi
    Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan
    Int J Cancer 123:1913-6. 2008
    ..Our results suggest that serum sFas has a possibility to detect people at high risk for cancer prior to diagnosis, since it increased before cancer diagnosis in those apparently healthy people...
  54. ncbi request reprint Allelic length of a CA dinucleotide repeat in the egfr gene correlates with the frequency of amplifications of this sequence--first results of an inter-ethnic breast cancer study
    Horst Buerger
    Institute of Pathology, University of Munster, Albert Schweitzer Strasse 33, 48139 Münster, Germany
    J Pathol 203:545-50. 2004
    ..This new knowledge about mechanisms of regulation of EGFR expression might serve as an additional basis for evaluating anti-EGFR-based therapies...
  55. ncbi request reprint Detection and discrimination of preneoplastic and early stages of lung adenocarcinoma using hnRNP B1 combined with the cell cycle-related markers p16, cyclin D1, and Ki-67
    Masaki Tominaga
    Department of Pathology, Saga Medical School, Saga 849 8501, Japan
    Lung Cancer 40:45-53. 2003
    ..In addition, combined analysis of hnRNP B1 and cell cycle-related genes, such as cyclin D1 and p16, might aid in discrimination of AAH from early adenocarcinoma...
  56. ncbi request reprint Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance
    Keiji Tanimoto
    Department of Translational Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Carcinogenesis 24:1779-83. 2003
    ..The elevated transactivation capacity of variant forms of HIF-1alpha implies a role of HIF-1alpha polymorphisms in generating individually different tumor progression...
  57. ncbi request reprint Prediction of prognosis of estrogen receptor-positive breast cancer with combination of selected estrogen-regulated genes
    Nobuyuki Yoshida
    Division of Endocrinology, Saitama Cancer Center Research Institute, Saitama Cancer Center Hospital, Kita adachi gun, Saitama 362 0806, Japan
    Cancer Sci 95:496-502. 2004
    ....
  58. ncbi request reprint Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients
    Yasuhito Yuasa
    Department of Molecular Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Carcinogenesis 26:193-200. 2005
    ..Thus, diet could be an important factor determining the methylation status of genes such as CDX2 and the resultant aberrant expression of genes involved in carcinogenesis...
  59. ncbi request reprint Green tea: cancer preventive beverage and/or drug
    Hirota Fujiki
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, 770 8514, Tokushima, Japan
    Cancer Lett 188:9-13. 2002
    ..An approach to develop green tea capsules as a cancer preventive drug in the US is discussed, aiming at taking full advantage of this cancer preventive beverage...
  60. ncbi request reprint Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk
    Hirotaka Kanzaki
    Department of Molecular Genetics, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700 8558, Japan
    Cancer Lett 238:128-34. 2006
    ..The increased risk of the heterozygous genotype is intriguing, implying a close relation with the dimerization feature of RASSF1 proteins...
  61. pmc Adaptation to estradiol deprivation causes up-regulation of growth factor pathways and hypersensitivity to estradiol in breast cancer cells
    Richard J Santen
    Division of Endocrinology and Metabolism, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Adv Exp Med Biol 630:19-34. 2008
    ....
  62. doi request reprint Exon 19 of EGFR mutation in relation to the CA-repeat polymorphism in intron 1
    Naoko Sueoka-Aragane
    Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
    Cancer Sci 99:1180-7. 2008
    ..The mechanism likely involves enhanced intrinsic expression of EGFR mRNA and activated EGF/EGFR signaling that accompany shorter CA-repeats...
  63. ncbi request reprint Mutation profile of EGFR gene detected by denaturing high-performance liquid chromatography in Japanese lung cancer patients
    Naoko Sueoka
    Department of Internal Medicine, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    J Cancer Res Clin Oncol 133:93-102. 2007
    ..The purpose of the present study is to apply DHPLC as a screening system of detection of EGFR mutations for large scaled population...
  64. ncbi request reprint High-throughput spectrophotometric assay of reactive oxygen species in serum
    Ikue Hayashi
    Central Research Laboratory, Hiroshima University Faculty of Dentistry, 1 2 3 Kasumi, Minami Ward, Hiroshima 734 8553, Japan
    Mutat Res 631:55-61. 2007
    ..Our preliminary results on cigarette smoking imply that this assay system has potential for application in various epidemiological and clinical settings...
  65. ncbi request reprint Involvement of TNF-alpha changes in human cancer development, prevention and palliative care
    Hirota Fujiki
    Saitama Cancer Center, Ina, Kitaadachi gun, Saitama 362 0806, Japan
    Mech Ageing Dev 123:1655-63. 2002
    ....