Yuko Hirai

Summary

Affiliation: Radiation Effects Research Foundation
Country: Japan

Publications

  1. ncbi request reprint X-irradiation induces up-regulation of ATM gene expression in wild-type lymphoblastoid cell lines, but not in their heterozygous or homozygous ataxia-telangiectasia counterparts
    Y Hirai
    Department of Radiobiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Jpn J Cancer Res 92:710-7. 2001
  2. ncbi request reprint Heterozygous individuals bearing a founder mutation in the XPA DNA repair gene comprise nearly 1% of the Japanese population
    Yuko Hirai
    Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Hiroshima, Japan
    Mutat Res 601:171-8. 2006
  3. ncbi request reprint Electron spin resonance analysis of tooth enamel does not indicate exposures to large radiation doses in a large proportion of distally-exposed A-bomb survivors
    Yuko Hirai
    Departments of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan
    J Radiat Res 52:600-8. 2011
  4. doi request reprint Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells
    Asao Noda
    Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    J Cell Sci 125:5280-7. 2012
  5. doi request reprint Gamma-ray and neutron dosimetry by EPR and AMS, using tooth enamel from atomic-bomb survivors: a mini review
    Nori Nakamura
    Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Radiat Prot Dosimetry 149:79-83. 2012
  6. doi request reprint Easy detection of GFP-positive mutants following forward mutations at specific gene locus in cultured human cells
    Asao Noda
    Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Mutat Res 721:101-7. 2011
  7. ncbi request reprint Uneven distributions of naïve and memory T cells in the CD4 and CD8 T-cell populations derived from a single stem cell in an atomic bomb survivor: implications for the origins of the memory T-cell pools in adulthood
    Yoichiro Kusunoki
    Department of Radiobiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ward, Hiroshima, 732 0815 Japan
    Radiat Res 157:493-9. 2002
  8. ncbi request reprint Two-dimensional complementary deoxyribonucleic acid electrophoresis revealing up-regulated human epididymal protein-1 and down-regulated CL-100 in thyroid papillary carcinoma
    Jun ichi Asakawa
    Radiation Effects Research Foundation, Hiroshima 732 0815, Japan
    Endocrinology 143:4422-8. 2002
  9. doi request reprint Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama study
    N Hagiwara
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Neurol 15:481-6. 2008

Detail Information

Publications9

  1. ncbi request reprint X-irradiation induces up-regulation of ATM gene expression in wild-type lymphoblastoid cell lines, but not in their heterozygous or homozygous ataxia-telangiectasia counterparts
    Y Hirai
    Department of Radiobiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Jpn J Cancer Res 92:710-7. 2001
    ..These results suggest that the normal ATM gene responds to ionizing radiation by up-regulating its activity, whereas none of the mutant ATM genes we studied were able to respond in this way...
  2. ncbi request reprint Heterozygous individuals bearing a founder mutation in the XPA DNA repair gene comprise nearly 1% of the Japanese population
    Yuko Hirai
    Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Hiroshima, Japan
    Mutat Res 601:171-8. 2006
    ..88%. This rate, if representative, implies that there are about 1 million carriers of the XPA founder mutation in the Japanese population. Thus, investigation of their cancer risk may be warranted...
  3. ncbi request reprint Electron spin resonance analysis of tooth enamel does not indicate exposures to large radiation doses in a large proportion of distally-exposed A-bomb survivors
    Yuko Hirai
    Departments of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan
    J Radiat Res 52:600-8. 2011
    ..The results did not support claims that a large fraction of distally-exposed survivors received large doses (e.g. 1 Gy) of external penetrating radiation resulting from residual radiation...
  4. doi request reprint Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells
    Asao Noda
    Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    J Cell Sci 125:5280-7. 2012
    ..Thus, understanding the biology of unrepairable damage will provide new insights into the long-term effects of radiation...
  5. doi request reprint Gamma-ray and neutron dosimetry by EPR and AMS, using tooth enamel from atomic-bomb survivors: a mini review
    Nori Nakamura
    Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Radiat Prot Dosimetry 149:79-83. 2012
    ..The results for the measured ratios were on average ~85 % of the calculated ratios by DS02 (but within the 95 % confidence bounds of the simulated results), which lends support to DS02-derived neutron doses to the survivors...
  6. doi request reprint Easy detection of GFP-positive mutants following forward mutations at specific gene locus in cultured human cells
    Asao Noda
    Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Mutat Res 721:101-7. 2011
    ....
  7. ncbi request reprint Uneven distributions of naïve and memory T cells in the CD4 and CD8 T-cell populations derived from a single stem cell in an atomic bomb survivor: implications for the origins of the memory T-cell pools in adulthood
    Yoichiro Kusunoki
    Department of Radiobiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ward, Hiroshima, 732 0815 Japan
    Radiat Res 157:493-9. 2002
    ....
  8. ncbi request reprint Two-dimensional complementary deoxyribonucleic acid electrophoresis revealing up-regulated human epididymal protein-1 and down-regulated CL-100 in thyroid papillary carcinoma
    Jun ichi Asakawa
    Radiation Effects Research Foundation, Hiroshima 732 0815, Japan
    Endocrinology 143:4422-8. 2002
    ..Our study showed that two-dimensional cDNA electrophoresis is a useful method of detecting differentially expressed genes in human diseases as demonstrated for HE-1 and CL-100 in papillary carcinoma...
  9. doi request reprint Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama study
    N Hagiwara
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Neurol 15:481-6. 2008
    ..We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke...