Kinya Nagata

Summary

Affiliation: R and D Center
Country: Japan

Publications

  1. ncbi Selective expression of a novel surface molecule by human Th2 cells in vivo
    K Nagata
    R and D Center, BioMedical Laboratories, Kawagoe, Saitama, Japan
    J Immunol 162:1278-86. 1999
  2. ncbi Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
    H Hirai
    R and D Center, BML, Saitama 350 1101, Japan
    J Exp Med 193:255-61. 2001
  3. ncbi The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes
    Kinya Nagata
    R and D Centre, Bio Medical Laboratories, Inc, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    Prostaglandins Leukot Essent Fatty Acids 69:169-77. 2003
  4. ncbi CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)
    K Nagata
    Research and Development Center, BioMedical Laboratories, Inc, 1361 1 Matoba, Kawagoe, Saitama, Japan
    FEBS Lett 459:195-9. 1999
  5. ncbi Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2
    Hiroyuki Hirai
    R and D Center, BML, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    J Immunol 168:981-5. 2002
  6. ncbi Effects of prostaglandin D2 on helper T cell functions
    Kazuya Tanaka
    Department of Advanced Medicine and Development, BML, Inc, Saitama 350-1101, Japan
    Biochem Biophys Res Commun 316:1009-14. 2004
  7. ncbi Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor
    Hiroyuki Hirai
    Department of Advanced Medicine and Development, R and D Center, BML, Inc, Saitama 350 1101, Japan
    Biochem Biophys Res Commun 307:797-802. 2003
  8. ncbi Granulysin induces cell death with nuclear accumulation
    Yasushi Takamori
    Research and Development Center, BioMedical Laboratories, Inc, Kawagoe, Saitama, Japan
    J Med Dent Sci 52:1-7. 2005
  9. ncbi Reevaluation of quantitative flow cytometric analysis for TLR2 on monocytes using F(ab')2 fragments of monoclonal antibodies
    Ryutaro Oba
    Department of Advanced Medicine and Development, BML Inc, Saitama, Japan
    Cytometry A 79:247-55. 2011
  10. ncbi Granulysin in human serum as a marker of cell-mediated immunity
    Kazuyuki Ogawa
    R and D Center, BML, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    Eur J Immunol 33:1925-33. 2003

Collaborators

Detail Information

Publications27

  1. ncbi Selective expression of a novel surface molecule by human Th2 cells in vivo
    K Nagata
    R and D Center, BioMedical Laboratories, Kawagoe, Saitama, Japan
    J Immunol 162:1278-86. 1999
    ..Together, these results indicate that CRTH2 is selectively expressed in vivo in an activated state of Th2 cells including allergen-responsive Th2 cells, suggesting its pivotal roles in ongoing Th2-type immune reactions...
  2. ncbi Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
    H Hirai
    R and D Center, BML, Saitama 350 1101, Japan
    J Exp Med 193:255-61. 2001
    ..In addition, CRTH2, but not DP, mediates PGD2-dependent cell migration of blood eosinophils and basophils. Thus, PGD2 is likely involved in multiple aspects of allergic inflammation through its dual receptor systems, DP and CRTH2...
  3. ncbi The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes
    Kinya Nagata
    R and D Centre, Bio Medical Laboratories, Inc, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    Prostaglandins Leukot Essent Fatty Acids 69:169-77. 2003
    ..The data suggest that the PGD(2)/CRTH2 system play important roles in allergic inflammation through its stimulatory effects on Th2 cells, eosinophils, and basophils...
  4. ncbi CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)
    K Nagata
    Research and Development Center, BioMedical Laboratories, Inc, 1361 1 Matoba, Kawagoe, Saitama, Japan
    FEBS Lett 459:195-9. 1999
    ..These findings implied the involvement of CRTH2 in mast cell-mediated immune responses such as allergic reactions...
  5. ncbi Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2
    Hiroyuki Hirai
    R and D Center, BML, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    J Immunol 168:981-5. 2002
    ..These results suggest the involvement of CRTH2 in mediating some of therapeutic and/or unwanted side effects of indomethacin, independently of cyclooxygenases and peroxisome proliferator-activated receptors...
  6. ncbi Effects of prostaglandin D2 on helper T cell functions
    Kazuya Tanaka
    Department of Advanced Medicine and Development, BML, Inc, Saitama 350-1101, Japan
    Biochem Biophys Res Commun 316:1009-14. 2004
    ..Thus, PGD(2) favors Th2 functions through CRTH2 while restraining Th1 functions via DP, which may contribute to development of Th2-dominated status in allergic inflammations...
  7. ncbi Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor
    Hiroyuki Hirai
    Department of Advanced Medicine and Development, R and D Center, BML, Inc, Saitama 350 1101, Japan
    Biochem Biophys Res Commun 307:797-802. 2003
    ..The results demonstrated here indicate that mouse CRTH2 is the functional ortholog of human CRTH2 and paves the way for future analysis of the in vivo functions of CRTH2...
  8. ncbi Granulysin induces cell death with nuclear accumulation
    Yasushi Takamori
    Research and Development Center, BioMedical Laboratories, Inc, Kawagoe, Saitama, Japan
    J Med Dent Sci 52:1-7. 2005
    ..These results suggest that granulysin enters the nucleus of target cells and induces apoptosis...
  9. ncbi Reevaluation of quantitative flow cytometric analysis for TLR2 on monocytes using F(ab')2 fragments of monoclonal antibodies
    Ryutaro Oba
    Department of Advanced Medicine and Development, BML Inc, Saitama, Japan
    Cytometry A 79:247-55. 2011
    ....
  10. ncbi Granulysin in human serum as a marker of cell-mediated immunity
    Kazuyuki Ogawa
    R and D Center, BML, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    Eur J Immunol 33:1925-33. 2003
    ....
  11. ncbi Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Veterinary Pathobiology and Purdue Cancer Center, and Biochemistry and Molecular Biology Program, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 171:152-8. 2003
    ....
  12. ncbi Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    Am J Pathol 173:653-64. 2008
    ..These data support a new apoptosis pathway for trophoblasts via uNK-derived granulysin, suggesting that granulysin is involved in spontaneous abortion...
  13. ncbi CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice
    Rie Nomiya
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Immunol 180:5680-8. 2008
    ..These results suggest that the PGD(2)-CRTH2 interaction is elevated following sensitization and plays a proinflammatory role in the pathophysiology of allergic rhinitis, especially pollinosis in mice...
  14. ncbi Cyclooxygenase-2/prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation
    Yoshiki Shiraishi
    Division of Pulmonary Medicine, Department of Medicine, Shinanomachi Research Park, Keio University School of Medicine, Tokyo, Japan
    J Immunol 180:541-9. 2008
    ....
  15. ncbi Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor
    Takahiro Satoh
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Immunol 177:2621-9. 2006
    ..These findings indicate that the PGD(2)-CRTH2 system plays a significant role in chronic allergic skin inflammation. CRTH2 may represent a novel therapeutic target for treatment of human allergic disorders, including atopic dermatitis...
  16. ncbi Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis
    Hiroshi Fujishima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 24:S66-S70. 2005
    ..In the present study, both eosinophil toxic activity for corneal epithelial cells and chemotaxis induced by PGD2 in normal volunteers were investigated. Expression of CRTH2 in normal subjects was also measured...
  17. ncbi Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner
    Toshihiko Michimata
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan
    Mol Hum Reprod 8:181-7. 2002
    ....
  18. ncbi Distributions of endometrial NK cells, B cells, T cells, and Th2/Tc2 cells fail to predict pregnancy outcome following recurrent abortion
    Toshihiko Michimata
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Japan
    Am J Reprod Immunol 47:196-202. 2002
    ..CONCLUSION: We could not predict pregnancy outcome by immunophenotypic analysis of endometrium in women with recurrent abortion...
  19. ncbi Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells
    Anja Langenkamp
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 33:474-82. 2003
    ..These results indicate a complex chemokine receptor regulation dependent on both T cell activation and differentiation state. In addition, they reveal the existence of DC-specific cues for the regulation of T cell migratory capacity...
  20. ncbi Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
    Mara Messi
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland
    Nat Immunol 4:78-86. 2003
    ..Thus, most human CD4+ T cells retain both memory and flexibility of cytokine gene expression...
  21. ncbi Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation
    Mark S Sundrud
    Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, TN 37232-2363, USA
    J Immunol 171:3542-9. 2003
    ..These findings have important implications in understanding the molecular mechanisms of human T cell differentiation and for devising novel therapeutic strategies aimed at immunomodulation of skewed effector T cell responses...
  22. ncbi Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis
    Masahiro Iwasaki
    Department of Molecular Biology, Toho University School of Medicine, Tokyo, Japan
    J Invest Dermatol 119:609-16. 2002
    ..Our results suggest the involvement of the prostaglandin D2/CRTH2 system in both normal and pathogenic T helper 2 responses...
  23. ncbi Exhaustive exercise induces differential changes in serum granulysin and circulating number of natural killer cells
    Xiumin Zhang
    Department of Medicine and Science in Sports and Exercise, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 210:117-24. 2006
    ..Our results support the hypothesis that exhaustive exercise-induced changes in the circulating number of NK cells represent a redistribution of lymphocytes, rather than the change in the size of whole-body NK cell population...
  24. ncbi Differential expression of CCR5 and CRTH2 on infiltrated cells in colonic mucosa of patients with ulcerative colitis
    Koji Matsuzaki
    Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
    J Gastroenterol Hepatol 18:1081-8. 2003
    ..The Th1/Th2 imbalance in colonic mucosa may be related to the disease progression of UC...
  25. ncbi Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: its usefulness as a marker of graft-versus-host reaction
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Hematol 81:340-8. 2006
    ..These results indicate that increased release of granulysin presents alloreactivity and serum granulysin is useful as a marker of GVHD in SCT...
  26. ncbi Toll-like receptor 2 expression level on monocytes in patients with viral infections: monitoring infection severity
    Takashi Kajiya
    Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan
    J Infect 57:249-59. 2008
    ..Clinical observations of other viral infections also indicated that TLR2 levels were compatible with infection severity. TLR2 expression level on monocytes might serve as a unique biomarker useful in viral infectious diseases...
  27. ncbi Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy
    Chikako Hayano
    Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Japan
    Am J Reprod Immunol 48:57-62. 2002
    ..We investigated a novel serum protein, killer-specific secretory protein of 37 kDa (Ksp37), produced by cytotoxic lymphocytes, during pregnancy...