Affiliation: Pharmaceutical Research Division
- The novel compound TDN-345 induces synthesis/secretion of nerve growth factor in C6-10A glioma cellsH Fukumoto
Pharmaceutical Research Laboratories I, Takeda Chemical Ind Ltd, Osaka, Japan
Brain Res 774:87-93. 1997..The results of the present study suggest the existence of a signal transduction pathway for NGF synthesis/secretion which is not mediated by cAMP...
- A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's diseaseHiroaki Fukumoto
Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Yodogawa ku, Osaka 532 8686, Japan
J Neurosci 30:11157-66. 2010..These results support the feasibility of BACE1 inhibition with a noncompetitive inhibitor as disease-modifying as well as symptomatic therapy for AD...