Toshihide Ono

Summary

Affiliation: Otsuka GEN Research Institute
Country: Japan

Publications

  1. ncbi request reprint Prediction of GPCR-G protein coupling specificity using features of sequences and biological functions
    Toshihide Ono
    Laboratory of Bioinformatics, Otsuka Pharmaceutical Co, Ltd, Kawauchi cho, Tokushima 771 0192, Japan
    Genomics Proteomics Bioinformatics 4:238-44. 2006
  2. ncbi request reprint Automated extraction of information on protein-protein interactions from the biological literature
    T Ono
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, 463 10 Kagasuno, Kawauchi cho, Tokushima, 771 0192, Japan
    Bioinformatics 17:155-61. 2001
  3. ncbi request reprint Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain
    S Okuno
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, 463 10 Kagasuno, Kawauchi cho, Tokushima 771 0192, Japan
    Genet Res 77:183-90. 2001
  4. ncbi request reprint Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats
    S Okuno
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, 463 10 Kagasuno, Kawauchi cho, Tokushima, 771 0192, Japan
    Genomics 62:350-5. 1999
  5. ncbi request reprint Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats
    Y Yamasaki
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Clin Exp Pharmacol Physiol 27:881-6. 2000
  6. ncbi request reprint Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat
    T K Watanabe
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Clin Exp Pharmacol Physiol 28:28-42. 2001
  7. ncbi request reprint Mouse chromosome 19 and distal rat chromosome 1: a chromosome segment conserved in evolution
    Y Yamasaki
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, 463 10 Kagasuno, Kawauchi cho, Tokushima 771 0192, Japan
    Hereditas 134:23-34. 2001
  8. ncbi request reprint Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats: possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene
    N Kanemoto
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, 463-10, Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan
    Pathol Int 51:133-9. 2001
  9. ncbi request reprint Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats
    S Okuno
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Kawauchi cho, Tokushima, Japan
    Diabetes Obes Metab 4:309-18. 2002
  10. ncbi request reprint Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat
    Takeshi K Watanabe
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Clin Exp Pharmacol Physiol 32:355-66. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Prediction of GPCR-G protein coupling specificity using features of sequences and biological functions
    Toshihide Ono
    Laboratory of Bioinformatics, Otsuka Pharmaceutical Co, Ltd, Kawauchi cho, Tokushima 771 0192, Japan
    Genomics Proteomics Bioinformatics 4:238-44. 2006
    ..The combination of sequence analysis and text mining improves the prediction accuracy for GPCR-G protein coupling specificity, and also provides clues for understanding GPCR signaling...
  2. ncbi request reprint Automated extraction of information on protein-protein interactions from the biological literature
    T Ono
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, 463 10 Kagasuno, Kawauchi cho, Tokushima, 771 0192, Japan
    Bioinformatics 17:155-61. 2001
    ..Our aim is to develop an efficient method for extracting information on protein-protein interaction from scientific literature...
  3. ncbi request reprint Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain
    S Okuno
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, 463 10 Kagasuno, Kawauchi cho, Tokushima 771 0192, Japan
    Genet Res 77:183-90. 2001
    ..We conclude that single-allele correction of an impaired genetic pathway can generate a substantial therapeutic effect, despite the complex polygenic nature of type II diabetic syndromes...
  4. ncbi request reprint Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats
    S Okuno
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, 463 10 Kagasuno, Kawauchi cho, Tokushima, 771 0192, Japan
    Genomics 62:350-5. 1999
    ..The other significant QTL localizes to the chromosome 8 marker D8Mit2, in a region where several apo-lipoprotein genes are clustered...
  5. ncbi request reprint Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats
    Y Yamasaki
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Clin Exp Pharmacol Physiol 27:881-6. 2000
    ..Thus, alterations at the Dmo1 locus are a major risk factor for pathogenesis in the strain, a finding that agrees with physiological studies that indicate a role for dyslipidaemia in the type II diabetic syndrome of OLETF rats...
  6. ncbi request reprint Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat
    T K Watanabe
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Clin Exp Pharmacol Physiol 28:28-42. 2001
    ..5. The results of the present study show that single-allele correction of a genetic defect of the Dmo1 locus can generate a substantial therapeutic effect, despite the complex polygenic nature of type II diabetic syndromes...
  7. ncbi request reprint Mouse chromosome 19 and distal rat chromosome 1: a chromosome segment conserved in evolution
    Y Yamasaki
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, 463 10 Kagasuno, Kawauchi cho, Tokushima 771 0192, Japan
    Hereditas 134:23-34. 2001
    ..This segment now constitutes the entire MMU19 and a large segment distally on RNO1q in the mouse and rat, respectively...
  8. ncbi request reprint Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats: possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene
    N Kanemoto
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, 463-10, Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan
    Pathol Int 51:133-9. 2001
    ..This implied the possibility that Cckar deficiency could result in a predisposition towards pancreatic duct hyperplasia...
  9. ncbi request reprint Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats
    S Okuno
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Kawauchi cho, Tokushima, Japan
    Diabetes Obes Metab 4:309-18. 2002
    ..To evaluate possible metabolic and pathological improvements generated by correction of the Dmo1 genetic pathway, we produced congenic lines, in which both OLETF Dmo1 alleles are replaced by the F344-derived genome...
  10. ncbi request reprint Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat
    Takeshi K Watanabe
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Clin Exp Pharmacol Physiol 32:355-66. 2005
    ..5. Taken together, these results demonstrate that the mutated GPR10 receptor is responsible for the hyperphagia leading to obesity and dyslipidaemia in the obese diabetic strain rat...
  11. ncbi request reprint Cloning and characterization of novel mouse and human secretory phospholipase A(2)s
    J Ishizaki
    Shionogi Research Laboratories, Shionogi and Co, Ltd, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 274:24973-9. 1999
    ..The expression of a novel sPLA(2) mRNA was elevated in the thymus after treatment with endotoxin in rats as well as in group IIA sPLA(2)-deficient mice, suggesting its functional role in the progression of the inflammatory process...
  12. ncbi request reprint Simultaneous visualization of Q-bands and FISH signals using a novel fluorochrome
    Y Kondoh
    Aisin Cosmos R and D Co, Ltd, Kariya, Aichi, Japan
    Cytogenet Cell Genet 71:96-8. 1995
    ..The FISH staining method permits simultaneous detection of orange HNPP signals on chromosomal sites labeled by Q-banding, allowing the assignment of small (440-1,200 bp) probes...
  13. ncbi request reprint [Effect of tiapride on the activity of neuroleptics and other kinds of drugs in mice and rats]
    H Satoh
    Product Development Laboratories, Fujisawa Pharmaceutical Co, Ltd, Osaka, Japan
    Nippon Yakurigaku Zasshi 91:71-80. 1988
    ..Our findings suggest that tiapride should be used with care in patients taking neuroleptics, but can be used freely in patients on other kinds of drugs...