Naomi Osakabe

Summary

Country: Japan

Publications

  1. ncbi request reprint Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats
    Naomi Osakabe
    Health and Bioscience Laboratory, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Exp Biol Med (Maywood) 229:33-9. 2004
  2. ncbi request reprint In vitro antioxidative activity of (-)-epicatechin glucuronide metabolites present in human and rat plasma
    Midori Natsume
    Healthcare R and D Laboratories, Meiji Seika Kaisha Ltd, Sakado shi, Saitama 350 0289, Japan
    Free Radic Res 38:1341-8. 2004
  3. ncbi request reprint Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans
    Seigo Baba
    Food and Health R and D Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    Am J Clin Nutr 85:709-17. 2007
  4. ncbi request reprint Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder
    Seigo Baba
    Food and Health R and D Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    J Nutr 137:1436-41. 2007
  5. ncbi request reprint Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model
    Naomi Osakabe
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Carcinogenesis 25:549-57. 2004
  6. ncbi request reprint Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid
    Seigo Baba
    Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1, Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Life Sci 75:165-78. 2004
  7. ncbi request reprint Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits
    Tohru Kurosawa
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Atherosclerosis 179:237-46. 2005
  8. ncbi request reprint Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat
    Midori Natsume
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    Free Radic Biol Med 34:840-9. 2003
  9. pmc Inhibitory Effects of Conjugated Epicatechin Metabolites on Peroxynitrite-mediated Nitrotyrosine Formation
    Midori Natsume
    Food and Health Laboratories, Meiji Seika Kaisha Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Clin Biochem Nutr 42:50-3. 2008
  10. ncbi request reprint Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice
    Naomi Osakabe
    Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd, Chiyoda Sakado, Japan
    Free Radic Biol Med 33:798-806. 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats
    Naomi Osakabe
    Health and Bioscience Laboratory, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Exp Biol Med (Maywood) 229:33-9. 2004
    ..Our findings suggest that CLP inhibits diabetes-induced cataract formation possibly by virtue of its antioxidative activity...
  2. ncbi request reprint In vitro antioxidative activity of (-)-epicatechin glucuronide metabolites present in human and rat plasma
    Midori Natsume
    Healthcare R and D Laboratories, Meiji Seika Kaisha Ltd, Sakado shi, Saitama 350 0289, Japan
    Free Radic Res 38:1341-8. 2004
    ..In contrast, the other metabolites had light antioxidative activities over the range of physiological concentrations found in plasma...
  3. ncbi request reprint Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans
    Seigo Baba
    Food and Health R and D Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    Am J Clin Nutr 85:709-17. 2007
    ..Cocoa powder is rich in polyphenols such as catechins and procyanidins and has been shown in various models to inhibit LDL oxidation and atherogenesis...
  4. ncbi request reprint Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder
    Seigo Baba
    Food and Health R and D Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    J Nutr 137:1436-41. 2007
    ..The results suggest that polyphenolic substances derived from cocoa powder may contribute to a reduction in LDL cholesterol, an elevation in HDL cholesterol, and the suppression of oxidized LDL...
  5. ncbi request reprint Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model
    Naomi Osakabe
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Carcinogenesis 25:549-57. 2004
    ..Thus, we conclude that part of the anticarcinogenic effects of P.frutescens extract is due to RA via two independent mechanisms: inhibition of the inflammatory response and scavenging of reactive oxygen radicals...
  6. ncbi request reprint Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid
    Seigo Baba
    Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1, Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Life Sci 75:165-78. 2004
    ....
  7. ncbi request reprint Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits
    Tohru Kurosawa
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Atherosclerosis 179:237-46. 2005
    ..Therefore, CLP suppressed the generation of atherosclerosis, and its antioxidative effect appeared to have an important role in its anti-atherosclerotic activity...
  8. ncbi request reprint Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat
    Midori Natsume
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    Free Radic Biol Med 34:840-9. 2003
    ..The presence of these metabolites in blood and urine suggests that catechins are metabolized and circulated in the body after administration of catechin-containing foods...
  9. pmc Inhibitory Effects of Conjugated Epicatechin Metabolites on Peroxynitrite-mediated Nitrotyrosine Formation
    Midori Natsume
    Food and Health Laboratories, Meiji Seika Kaisha Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Clin Biochem Nutr 42:50-3. 2008
    ..4'ME3'G. These results demonstrate that the metabolites of (-)-epicatechin retain antioxidative activity on peroxynitrite-induced oxidative damages to some extent...
  10. ncbi request reprint Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice
    Naomi Osakabe
    Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd, Chiyoda Sakado, Japan
    Free Radic Biol Med 33:798-806. 2002
    ..These results suggest that the liver protection of RA is due to the scavenging or reducing activities-superoxide or peroxynitirite rather than to inhibition of TNF-alpha production...
  11. ncbi request reprint Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro
    Naomi Osakabe
    Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Exp Biol Med (Maywood) 227:51-6. 2002
    ..It is suggested that these compounds contribute to the activity of cacao products to protect LDL from oxidation...
  12. ncbi request reprint Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice
    Makoto Tomaru
    Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
    Nutrition 23:351-5. 2007
    ..The present study examined whether dietary supplementation with cacao liquor proanthocyanidins (CLPr) could prevent elevation of blood glucose levels in mice with diabetes mellitus and obesity...
  13. ncbi request reprint Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects
    Tsutomu Hatano
    Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, 700, Okayama, Japan
    Phytochemistry 59:749-58. 2002
    ..These effects were attributed to the radical-scavenging activity in the peroxidation chain reactions, based on the findings that the cacao polyphenols effectively scavenged the 1,1-diphenyl-2-picrylhydrazyl radical...
  14. ncbi request reprint Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats
    Seigo Baba
    Nutritional Science Center, Health Laboratory, Meiji Seika Kaisha, Ltd, Sakado shi, Saitama, Japan
    Free Radic Biol Med 33:142-8. 2002
    ..Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions...
  15. ncbi request reprint Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice
    Makoto Tomaru
    Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Mol Med 19:17-22. 2007
    ..These results suggest that pulmonary exposure to DEP, PM, enhances steatosis in the liver of obese diabetic subjects possibly via enhanced oxidative stress...
  16. ncbi request reprint Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats
    Megumi Yamagishi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, 158 8501, Tokyo, Japan
    Cancer Lett 185:123-30. 2002
    ..These results indicate that CLPr inhibit in vitro mutagenicity of PhIP, as well as rat pancreatic carcinogenesis in the initiation stage, but not mammary carcinogenesis induced by PhIP...
  17. ncbi request reprint Suppressive effect of cocoa powder on atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits
    Tohru Kurosawa
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha, Ltd, Kanagawa, Japan
    J Atheroscler Thromb 12:20-8. 2005
    ..We consider that antioxidative activity of polyphenols rich in cocoa powder may be a key factor for the anti-atherosclerotic effect...
  18. ncbi request reprint Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model
    Megumi Yamagishi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Lett 191:49-57. 2003
    ..No significant modification in the small intestine, colon or kidney was evident. These results indicate that CLPr exerts chemopreventive effects in the lung without any promoting influence in other major organs...
  19. ncbi request reprint Rosmarinic acid inhibits lung injury induced by diesel exhaust particles
    Chiaki Sanbongi
    Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Saitama, Japan
    Free Radic Biol Med 34:1060-9. 2003
    ..These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects...