Yasuo Yoshioka

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc The emerging role of high-dose-rate (HDR) brachytherapy as monotherapy for prostate cancer
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Radiat Res 54:781-8. 2013
  2. doi request reprint Monotherapeutic high-dose-rate brachytherapy for prostate cancer: a dose reduction trial
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Japan Electronic address
    Radiother Oncol 110:114-9. 2014
  3. pmc Feasibility and accuracy of relative electron density determined by virtual monochromatic CT value subtraction at two different energies using the gemstone spectral imaging
    Toshiyuki Ogata
    Department of Radiology, Osaka University Hospital, 2 15 Yamadaoka, Suita, Osaka, Japan
    Radiat Oncol 8:83. 2013
  4. pmc Patterns of radiotherapy practice for biliary tract cancer in Japan: results of the Japanese radiation oncology study group (JROSG) survey
    Fumiaki Isohashi
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 D 10 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Radiat Oncol 8:76. 2013
  5. pmc Analysis of late toxicity associated with external beam radiation therapy for prostate cancer with uniform setting of classical 4-field 70 Gy in 35 fractions: a survey study by the Osaka Urological Tumor Radiotherapy Study Group
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Radiat Res 54:113-25. 2013
  6. pmc Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older
    Hideya Yamazaki
    Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566 Japan
    Radiat Oncol 5:116. 2010
  7. ncbi request reprint Evaluation of anatomy-based dwell position and inverse optimization in high-dose-rate brachytherapy of prostate cancer: a dosimetric comparison to a conventional cylindrical dwell position, geometric optimization, and dose-point optimization
    Yasuo Yoshioka
    Division of Radiation Oncology, Shizuoka Cancer Center Hospital, Japan
    Radiother Oncol 75:311-7. 2005
  8. ncbi request reprint High-dose-rate brachytherapy without external beam irradiation for locally advanced prostate cancer
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate Schoolf of Medicine, Japan
    Radiother Oncol 80:62-8. 2006
  9. doi request reprint Current status and perspectives of brachytherapy for prostate cancer
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Clin Oncol 14:31-6. 2009
  10. ncbi request reprint External-beam radiotherapy for clinically localized prostate cancer in Osaka, Japan, 1995-2006: time trends, outcome, and risk stratification
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Strahlenther Onkol 185:446-52. 2009

Detail Information

Publications116 found, 100 shown here

  1. pmc The emerging role of high-dose-rate (HDR) brachytherapy as monotherapy for prostate cancer
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Radiat Res 54:781-8. 2013
    ..All these developments point to the emerging role of HDR brachytherapy as monotherapy for prostate cancer. ..
  2. doi request reprint Monotherapeutic high-dose-rate brachytherapy for prostate cancer: a dose reduction trial
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Japan Electronic address
    Radiother Oncol 110:114-9. 2014
    ..To report preliminary results of our second regimen with 45.5 Gy/7 fractions aiming to reduce toxicity, compared with our first regimen with 54 Gy/9 fractions, using high-dose-rate (HDR) brachytherapy as monotherapy for prostate cancer...
  3. pmc Feasibility and accuracy of relative electron density determined by virtual monochromatic CT value subtraction at two different energies using the gemstone spectral imaging
    Toshiyuki Ogata
    Department of Radiology, Osaka University Hospital, 2 15 Yamadaoka, Suita, Osaka, Japan
    Radiat Oncol 8:83. 2013
    ..The purpose of this study was to investigate the feasibility of this method to obtain RED from virtual monochromatic CT images obtained by the gemstone spectral imaging (GSI) mode with fast-kVp switching...
  4. pmc Patterns of radiotherapy practice for biliary tract cancer in Japan: results of the Japanese radiation oncology study group (JROSG) survey
    Fumiaki Isohashi
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 D 10 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Radiat Oncol 8:76. 2013
    ..The patterns of radiotherapy (RT) practice for biliary tract cancer (BTC) in Japan are not clearly established...
  5. pmc Analysis of late toxicity associated with external beam radiation therapy for prostate cancer with uniform setting of classical 4-field 70 Gy in 35 fractions: a survey study by the Osaka Urological Tumor Radiotherapy Study Group
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Radiat Res 54:113-25. 2013
    ..With a uniform setting of classical 4-field 70 Gy/35 fractions, the use of CT simulation and the resultant reduction in portal field size were significantly associated with reduced late GI toxicity, especially with less rectal bleeding...
  6. pmc Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older
    Hideya Yamazaki
    Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566 Japan
    Radiat Oncol 5:116. 2010
    ..To examine the role of brachytherapy for aged patients 80 or more in the trend of rapidly increasing number...
  7. ncbi request reprint Evaluation of anatomy-based dwell position and inverse optimization in high-dose-rate brachytherapy of prostate cancer: a dosimetric comparison to a conventional cylindrical dwell position, geometric optimization, and dose-point optimization
    Yasuo Yoshioka
    Division of Radiation Oncology, Shizuoka Cancer Center Hospital, Japan
    Radiother Oncol 75:311-7. 2005
    ....
  8. ncbi request reprint High-dose-rate brachytherapy without external beam irradiation for locally advanced prostate cancer
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate Schoolf of Medicine, Japan
    Radiother Oncol 80:62-8. 2006
    ..The purpose of the current report is to evaluate the feasibility, toxicity and efficacy of this regimen, with more patient accrual and longer follow-up...
  9. doi request reprint Current status and perspectives of brachytherapy for prostate cancer
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Clin Oncol 14:31-6. 2009
    ..Mutual understanding and cooperation among urologists, radiation oncologists, and medical physicists is essential to enhance brachytherapy for prostate cancer...
  10. ncbi request reprint External-beam radiotherapy for clinically localized prostate cancer in Osaka, Japan, 1995-2006: time trends, outcome, and risk stratification
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Strahlenther Onkol 185:446-52. 2009
    ....
  11. ncbi request reprint Prostate Risk Index (PRIX) as a new method of risk classification for clinically localized prostate cancer
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Strahlenther Onkol 183:490-6. 2007
    ....
  12. doi request reprint Monotherapeutic high-dose-rate brachytherapy for prostate cancer: five-year results of an extreme hypofractionation regimen with 54 Gy in nine fractions
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 80:469-75. 2011
    ..To evaluate an extreme hypofractionation regimen with 54 Gy in nine fractions provided by high-dose-rate (HDR) brachytherapy as monotherapy for prostate cancer by reporting 5-year clinical results...
  13. ncbi request reprint Impact of mitochondrial DNA on radiation sensitivity of transformed human fibroblast cells: clonogenic survival, micronucleus formation and cellular ATP level
    Yasuo Yoshioka
    Department of Multidisciplinary Radiotherapy, Osaka University Graduate School of Medicine, Osaka, Suita, 565 0871, Japan
    Radiat Res 162:143-7. 2004
    ..These results may imply the presence of an MN expression pathway that is dependent on the intrinsic ATP level and that may be compensated and lead to an equivalent level of clonogenic survival...
  14. ncbi request reprint High-dose-rate brachytherapy as monotherapy for localized prostate cancer: a retrospective analysis with special focus on tolerance and chronic toxicity
    Yasuo Yoshioka
    Department of Multidisciplinary Radiotherapy, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Radiat Oncol Biol Phys 56:213-20. 2003
    ..To examine retrospectively fractionated high-dose-rate brachytherapy as monotherapy for localized prostate cancer with special focus on tolerance and toxicity, especially chronic toxicity...
  15. ncbi request reprint High-dose-rate interstitial brachytherapy as a monotherapy for localized prostate cancer: treatment description and preliminary results of a phase I/II clinical trial
    Y Yoshioka
    Division of Multidisciplinary Radiotherapy, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 48:675-81. 2000
    ..To improve results for localized prostate cancer, a prospective clinical trial of hyperfractionated Iridium-192 high-dose-rate (HDR) brachytherapy as a monotherapy was initiated...
  16. ncbi request reprint Correlation between dosimetric parameters and late rectal and urinary toxicities in patients treated with high-dose-rate brachytherapy used as monotherapy for prostate cancer
    Koji Konishi
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 75:1003-7. 2009
    ..To evaluate the correlation between dosimetric parameters and late rectal and urinary toxicities in high-dose-rate brachytherapy (HDR-BT) used as monotherapy for prostate cancer...
  17. doi request reprint Suppression of nanosilica particle-induced inflammation by surface modification of the particles
    Tomohiro Morishige
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Arch Toxicol 86:1297-307. 2012
    ..These results provide basic information that will be useful for the development of safe nanomaterials...
  18. doi request reprint LIGHT protein suppresses tumor growth by augmentation of immune response
    Tomohiro Morishige
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka, 565 0871, Japan
    Immunol Lett 127:33-8. 2009
    ..These results indicate that LIGHT protein efficiently evokes the systemic tumor-specific immune response, and thus induces tumor suppression...
  19. pmc Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy
    Xinglei Yao
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Mol Ther 19:1619-25. 2011
    ..These results indicate that Adv-PEG(CGKRK) has potential as a prototype Adv with suitable efficacy and safety for systemic cancer gene therapy against both primary tumors and metastases...
  20. ncbi request reprint Rectal dose and source strength of the high-dose-rate iridium-192 both affect late rectal bleeding after intracavitary radiation therapy for uterine cervical carcinoma
    Fumiaki Isohashi
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Radiat Oncol Biol Phys 77:758-64. 2010
    ....
  21. doi request reprint The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture
    Tomohiro Morishige
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biomaterials 31:6833-42. 2010
    ..Our results reveal a part of NLRP3 activation pathway and provide basic information that should help to create safe and effective forms of SPs...
  22. ncbi request reprint Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration
    Xinglei Yao
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Biol Pharm Bull 33:1073-6. 2010
    ..These results demonstrated that PEG-Ad-TERT can be regarded as a prototype Adv with suitable efficacy and safety for systemic cancer gene therapy against both metastatic and primary tumors...
  23. doi request reprint Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models
    Tomohiro Morishige
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Int Immunopharmacol 10:26-33. 2010
    ..These results suggest that the secreted form of LIGHT might be the optimal form for cancer gene therapy...
  24. pmc Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice
    Tokuyuki Yoshida
    Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Part Fibre Toxicol 10:41. 2013
    ..Here we examined the localization and biological responses of intranasally administered amorphous nanosilica particles in mice, focusing on the coagulation system...
  25. ncbi request reprint Impact of the addition of concurrent chemotherapy to pelvic radiotherapy in surgically treated stage IB1-IIB cervical cancer patients with intermediate-risk or high-risk factors: a 13-year experience
    Mika Okazawa
    Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka University Graduate School of Medicine, Japan
    Int J Gynecol Cancer 23:567-75. 2013
    ..To identify groups of patients who derive clinical benefit from postoperative adjuvant concurrent chemoradiotherapy (CCRT), we retrospectively investigated the survival outcomes of surgically treated early-stage cervical cancer patients...
  26. ncbi request reprint High-dose-rate brachytherapy combined with long-term hormonal therapy for high-risk prostate cancer: results of a retrospective analysis
    Ryoong Jin Oh
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Japan
    Radiat Med 24:58-64. 2006
    ..High-dose-rate (HDR) brachytherapy combined with hormonal therapy (HTx), without the addition of external beam radiation therapy (EBRT) for high-risk prostate cancer was evaluated retrospectively...
  27. doi request reprint Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody
    Mai Yoshikawa
    Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Blood 121:2804-13. 2013
    ..These findings indicate that cell-internalizing activity plays an important role in the biodistribution and therapeutic effects of ADCs. Further, Robo4 can be an effective marker for tumor vascular targeting...
  28. doi request reprint Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure
    Hiromi Nabeshi
    Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Nanotechnology 23:045101. 2012
    ..These results would provide useful information for ensuring the safety of nanomaterials (NMs) and open new frontiers in biological fields by the use of NMs...
  29. doi request reprint Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning
    Yasuhiro Abe
    Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, 7 6 8 Saito Asagi, Ibaraki, Osaka, Japan
    Biomaterials 32:5498-504. 2011
    ..In summary, our one-step competitive panning system is a simple, useful and effective technology for isolating receptor-selective mutant proteins...
  30. doi request reprint Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation
    Tokuyuki Yoshida
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka 565 0871, Japan
    Toxicol Lett 199:383-8. 2010
    ..In addition, allogeneic T-cell-stimulation assay showed that the urban aerosol could activate T cells through maturation of DCs. These results indicate that urban aerosols can induce allergic airway diseases through activation of DCs...
  31. doi request reprint Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant
    Yohei Mukai
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Mol Biol 385:1221-9. 2009
    ..This phage display technique can be used to efficiently construct functional mutants for analysis of the TNF structure-function relationship, which might facilitate in silico drug design based on receptor selectivity...
  32. doi request reprint Effect of high-dose-rate 192Ir source activity on late rectal bleeding after intracavitary radiation therapy for uterine cervix cancer
    Osamu Suzuki
    Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari, Osaka, Japan
    Int J Radiat Oncol Biol Phys 71:1329-34. 2008
    ..This retrospective study analyzed the effect of the activity of high-dose-rate (HDR) (192)Ir source on late rectal bleeding after HDR intracavitary radiotherapy (ICRT) in patients with uterine cervix cancer...
  33. doi request reprint Mutants of lymphotoxin-α with augmented cytotoxic activity via TNFR1 for use in cancer therapy
    Tomohiro Morishige
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cytokine 61:578-84. 2013
    ..Our data suggest that the kinetics of LTα binding to TNFR1 play an important role in signal transduction patterns, and a TNFR1-selective LTα mutant with augmented bioactivity would be a superior candidate for cancer therapy...
  34. doi request reprint Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells
    Tokuyuki Yoshida
    Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 427:748-52. 2012
    ..We hope that our results will contribute to the development of safer nanomaterials...
  35. doi request reprint Dose-volume histogram predictors of chronic gastrointestinal complications after radical hysterectomy and postoperative concurrent nedaplatin-based chemoradiation therapy for early-stage cervical cancer
    Fumiaki Isohashi
    Department of Radiation Oncology, Osaka University Hospital, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 85:728-34. 2013
    ....
  36. doi request reprint Megavoltage cone beam computed tomography dose and the necessity of reoptimization for imaging dose-integrated intensity-modulated radiotherapy for prostate cancer
    Yuichi Akino
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 82:1715-22. 2012
    ..Here, we investigated the effects of imaging dose and the necessity for additional optimization when using intensity-modulated radiotherapy (IMRT) to treat prostate cancer...
  37. ncbi request reprint Lymph node metastasis of early oral tongue cancer after interstitial radiotherapy
    Hideya Yamazaki
    Department of Radiology, Toyonaka Municipal Hospital, Toyonaka City, Osaka, Japan
    Int J Radiat Oncol Biol Phys 58:139-46. 2004
    ..To examine the prognostic factors for lymph node metastasis after brachytherapy for early (T1-T2N0M0) oral tongue cancer...
  38. doi request reprint Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2
    Hiroko Shibata
    National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    Cytokine 50:75-83. 2010
    ..These results indicate tmTNF variants might prove useful for the functional analysis of signaling through TNF receptors...
  39. ncbi request reprint Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape
    Kohei Yamashita
    Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka, 565 0871, Japan
    Inflammation 33:276-80. 2010
    ..These results indicate that long and thick MWCNT, but not short and thin MWCNT, cause DNA damage and severe inflammatory effects. These findings might provide useful information for constructing novel CNTs with safety...
  40. ncbi request reprint TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection
    Xinglei Yao
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 362:419-24. 2007
    ..Our results suggest that Adv in which transgene expression is driven by the TERT promoter are a promising prototype of tumor-targeting vectors for effective and safe cancer gene therapy...
  41. doi request reprint Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency
    Yasuo Yoshioka
    The Center for Advanced Medical Engineering and Informatics, Osaka University, 1 6, Yamadaoka, Suita, Osaka, 565 0871, Japan
    Life Sci 83:747-55. 2008
    ..In this study, we attempted to generate novel Tat-Advs (Advs conjugated with the HIV Tat-derived peptide, a protein-transduction domain (PTD)) to broaden Adv tropism and enhance transduction efficiency...
  42. ncbi request reprint Postoperative concurrent nedaplatin-based chemoradiotherapy improves survival in early-stage cervical cancer patients with adverse risk factors
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Gynecol Oncol 115:482-7. 2009
    ..The aim of this study was to evaluate the efficacy of postoperative nedaplatin-based concurrent chemoradiotherapy (CCRT) in patients with FIGO stage IA2-IIB cervical cancer with adverse risk factors...
  43. doi request reprint Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells
    Toshiro Hirai
    Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 427:553-6. 2012
    ....
  44. pmc Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection
    Toshiro Hirai
    Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka 565 0871, Japan
    Part Fibre Toxicol 9:3. 2012
    ..Thus, in this study, we investigated the relationship between the size of SPs and adjuvant activity using a model for atopic dermatitis...
  45. doi request reprint Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (γ-glutamic acid) nanoparticles
    Yohei Mukai
    Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565 0871, Japan
    J Immunol 187:6249-55. 2011
    ..These findings imply that the ER-endosome complex is key for the efficient cross-presentation of Ags encapsulated in γ-PGA NPs...
  46. doi request reprint Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor
    Tomohiro Morishige
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 393:888-93. 2010
    ..Furthermore, mLIGHT-Lys(-) was not trapped by the nonfunctional DcR3, despite binding to its functional receptors. These results suggest that mLIGHT-Lys(-) might be a useful candidate for cancer therapy...
  47. doi request reprint Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system
    Yasuo Yoshioka
    The Center for Advanced Medical Engineering and Informatics, Osaka University, 1 6, Yamadaoka, Suita, Osaka, 565 0871, Japan
    Biomaterials 31:1935-43. 2010
    ..We also showed that the K84Q mutation contributed to the enhanced activity via TNFR1, and K39S lowered activity via TNFR2. R1selLT likely will be useful in cancer therapy and in analysis of the LT alpha structure-function relationship...
  48. ncbi request reprint Simple PEG conjugation of SPIO via an Au-S bond improves its tumor targeting potency as a novel MR tumor imaging agent
    Hiroki Kojima
    Center for Advanced Medical Engineering and Informatics, Osaka University, Suita, Japan
    Bioconjug Chem 21:1026-31. 2010
    ..In addition, because the synthesis of PEG-Au/Feridex is simple and high yields are easily produced, PEG-modified SPIO for tumor diagnosis can be prepared on an industrial scale with low cost...
  49. doi request reprint Radical hysterectomy with adjuvant radiotherapy versus definitive radiotherapy alone for FIGO stage IIB cervical cancer
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Gynecol Oncol 123:241-7. 2011
    ..The aim of this study was to compare the treatment outcomes and adverse effects of radical hysterectomy followed by adjuvant radiotherapy with definitive radiotherapy alone in patients with FIGO stage IIB cervical cancer...
  50. ncbi request reprint Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage
    Takashi Nagano
    Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nanotechnology 24:405102. 2013
    ..Like ALT and AST, miR-122 may be a useful biomarker of nSP70. We believe that these findings will help in the establishment of a nanomaterials safety-assessment system...
  51. doi request reprint Estimation of rectal dose using daily megavoltage cone-beam computed tomography and deformable image registration
    Yuichi Akino
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan Department of Radiology, Osaka University Hospital, Suita, Osaka, Japan Electronic address
    Int J Radiat Oncol Biol Phys 87:602-8. 2013
    ..Here, we developed a method to estimate the rectal dose in prostate intensity modulated radiation therapy with consideration to interfractional organ motion using daily megavoltage cone-beam computed tomography (MVCBCT)...
  52. doi request reprint Hypofractionated stereotactic radiation therapy in three to five fractions for vestibular schwannoma
    Masahiro Morimoto
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Japan
    Jpn J Clin Oncol 43:805-12. 2013
    ..To retrospectively examine the outcomes of hypofractionated stereotactic radiation therapy in three to five fractions for vestibular schwannomas...
  53. doi request reprint Antitumor mechanism of intratumoral injection with IL-12-expressing adenoviral vector against IL-12-unresponsive tumor
    Naoko Kanagawa
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 372:821-5. 2008
    ..The present data provide evidence that the antitumor effect of IL-12 gene transduction in a local tumor site is dependent on induced alterations of the tumor microenvironment and systemic immunity...
  54. doi request reprint Significance of tumor volume related to peritumoral edema in intracranial meningioma treated with extreme hypofractionated stereotactic radiation therapy in three to five fractions
    Masahiro Morimoto
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Jpn J Clin Oncol 41:609-16. 2011
    ..To investigate the treatment results of intracranial meningiomas treated with hypofractionated stereotactic radiation therapy in three to five fractions...
  55. doi request reprint Postoperative whole pelvic radiotherapy plus concurrent chemotherapy versus extended-field irradiation for early-stage cervical cancer patients with multiple pelvic lymph node metastases
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Gynecol Oncol 120:94-100. 2011
    ....
  56. doi request reprint Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials
    Kazuma Higashisaka
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biomaterials 32:3-9. 2011
    ..We believe this study will contribute to the development of global risk assessment techniques for nanomaterials...
  57. ncbi request reprint High-dose-rate interstitial brachytherapy for mobile tongue cancer: influence of the non-irradiated period
    Naoya Kakimoto
    Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Osaka 565 0871, Japan
    Anticancer Res 26:3933-7. 2006
    ..The purpose of this study was to evaluate the results of high-dose-rate (HDR) interstitial brachytherapy (ISBT) for early mobile tongue cancer and to examine whether the non-irradiated period affected treatment results...
  58. ncbi request reprint Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen
    Takayuki Okamoto
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 323:583-91. 2004
    ..Using this non-immune mouse antibody library, we also obtained MAbs for VEGF, VEGF receptor 2, TNF-alpha, and Pseudomonas Exotoxin, confirming the high quality of the library and its suitability for this application...
  59. doi request reprint High-dose-rate interstitial brachytherapy for previously untreated cervical carcinoma
    Fumiaki Isohashi
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Brachytherapy 8:234-9. 2009
    ..The aim of the study was to evaluate the results of high-dose-rate interstitial brachytherapy (HDR-ISBT) for patients with advanced cervical carcinoma in which intracavitary radiation therapy may result in a suboptimal dose distribution...
  60. ncbi request reprint Concurrent weekly nedaplatin, external beam radiotherapy and high-dose-rate brachytherapy in patients with FIGO stage IIIb cervical cancer: a comparison with a cohort treated by radiotherapy alone
    Seiji Mabuchi
    Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan
    Gynecol Obstet Invest 69:224-32. 2010
    ....
  61. ncbi request reprint Verification of air-kerma strength of 125I seed for permanent prostate implants in Japan
    Iori Sumida
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Int J Clin Oncol 14:525-8. 2009
    ..To assure the physical quality of brachytherapy, we investigated the difference between measured and manufacturer's stated source strengths in a single model SourceTech Medical (STM)1251 (125)I seed...
  62. doi request reprint Objective and longitudinal assessment of dermatitis after postoperative accelerated partial breast irradiation using high-dose-rate interstitial brachytherapy in patients with breast cancer treated with breast conserving therapy: reduction of moisture det
    Eiichi Tanaka
    Department of Radiation Oncology, National Hospital Organization, Osaka National Hospital, Osaka, Japan
    Int J Radiat Oncol Biol Phys 81:1098-104. 2011
    ..To objectively evaluate the radiation dermatitis caused by accelerated partial breast irradiation (APBI) using high-dose-rate interstitial brachytherapy...
  63. pmc The usefulness of an independent patient-specific treatment planning verification method using a benchmark plan in high-dose-rate intracavitary brachytherapy for carcinoma of the uterine cervix
    Yutaka Takahashi
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, Japan
    J Radiat Res 53:936-44. 2012
    ..These results suggest that our method is easy and useful for independent verification of patient-specific treatment planning QA...
  64. ncbi request reprint Optimization of dose distribution for HDR brachytherapy of the prostate using Attraction-Repulsion Model
    Iori Sumida
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Radiat Oncol Biol Phys 64:643-9. 2006
    ..To optimize dose distribution for high-dose-rate brachytherapy for prostate cancer, we have developed a new algorithm named Attraction-Repulsion Model (ARM). In this study, we compared the ARM with geometric optimization (GO)...
  65. ncbi request reprint Radiotherapy targeting cancer stem cells: current views and future perspectives
    Kazuhiko Ogawa
    Department of Radiation Oncology, Graduate School of Medicine, Osaka University, 2 2 D10, Yamadaoka, Suita, Osaka, 565 0871, Japan
    Anticancer Res 33:747-54. 2013
    ..Further elucidation of pathways that regulate CSCs may provide insights into the identification of other potential therapeutic targets and development of novel innovative therapies...
  66. ncbi request reprint Phage display and PEGylation of therapeutic proteins
    Yohei Mukai
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Comb Chem High Throughput Screen 8:145-52. 2005
    ..These innovative protein-drug systems are discussed in this review...
  67. doi request reprint Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy
    Tomohiro Morishige
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Biomaterials 31:3357-63. 2010
    ..Our data provide valuable information for construction of more functional LIGHT mutants that might be powerful tools for cancer therapy...
  68. ncbi request reprint Development of amphiphilic gamma-PGA-nanoparticle based tumor vaccine: potential of the nanoparticulate cytosolic protein delivery carrier
    Tomoaki Yoshikawa
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 366:408-13. 2008
    ..Our findings suggest that the gamma-PGA NP system is suitable for the intracellular delivery of protein-based drugs as well as tumor vaccines...
  69. ncbi request reprint Results of low- and high-dose-rate interstitial brachytherapy for T3 mobile tongue cancer
    Naoya Kakimoto
    Department of Oral and Maxillofacial Radiology, Division of Oral Developmental Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Radiother Oncol 68:123-8. 2003
    ..To evaluate the treatment results of low-dose-rate (LDR) and high-dose-rate (HDR) interstitial brachytherapy (ISBT) for T3 mobile tongue cancer...
  70. ncbi request reprint Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window
    Hiroko Shibata
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Clin Cancer Res 10:8293-300. 2004
    ..In this study, the optimization of antitumor therapy with tumor necrosis factor-alpha (TNF-alpha) was attempted...
  71. doi request reprint Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice
    Yuki Morishita
    Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 420:297-301. 2012
    ..Taken together, our results suggest that nSP70 can penetrate the blood-testis barrier and the nuclear membranes of spermatocytes without producing apparent testicular injury...
  72. doi request reprint Structure-activity relationship of T-cell receptors based on alanine scanning
    Shogo Narimatsu
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 415:558-62. 2011
    ..Our results provide fundamental information for constructing mutant TCRs with high binding affinity...
  73. doi request reprint Lysine-deficient lymphotoxin-α mutant for site-specific PEGylation
    Shogo Narimatsu
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cytokine 56:489-93. 2011
    ..These results suggest that site-specific PEGylated LT-K0 may be useful in cancer therapy...
  74. doi request reprint Transduction of adenovirus vectors modified with cell-penetrating peptides
    Yusuke Eto
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka 565 0871, Japan
    Peptides 30:1548-52. 2009
    ..The results obtained in this research encourage the use of CPP-peptide-modified Advs as an attractive tool for transducing cells and as useful platform vectors for gene therapy and basic research...
  75. ncbi request reprint Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer
    Yusuke Eto
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Biol Pharm Bull 33:1540-4. 2010
    ..These results suggest that systemic administration of PEG-Ad with an appropriate PEG modification rate has the potential to reduce the production of antibodies against Adv and increase the therapeutic response against metastatic cancer...
  76. ncbi request reprint What is the optimum minimum segment size used in step and shoot IMRT for prostate cancer?
    Yutaka Takahashi
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Radiat Res 51:543-52. 2010
    ..0 cm plan, but in only limited regions in the MSS 1.5 cm plan. Our data suggest that the MSS should be determined with regard to both planning quality and dosimetric accuracy...
  77. doi request reprint Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B
    Tomohiro Morishige
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 392:160-5. 2010
    ..Our results provide basic information for the creation of safe and effective novel forms of TiO2...
  78. doi request reprint Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
    Kohei Yamashita
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Nanotechnol 6:321-8. 2011
    ..These detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups...
  79. ncbi request reprint Urinary 8-hydroxy-2'-deoxyguanosine excretion as a biomarker for estimating DNA oxidation in patients undergoing external radiotherapy and/or brachytherapy
    Hideya Yamazaki
    Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease, Nakamichi 1 3 3, Higashinari, Osaka City, Osaka 537 8511, Japan
    Oncol Rep 13:847-51. 2005
    ..However, radiotherapy reduced 8-OHdG excretion levels in patients with cervical cancer, whereas interstitial radiotherapy transiently increased these levels in patients with prostate cancer...
  80. ncbi request reprint Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen
    Yasuo Yoshioka
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biomed Mater Res A 70:219-23. 2004
    ..Thus, poly(VP-co-VL) may be a useful polymeric carrier for drug delivery to the spleen. This study will provide useful information to design optimal polymeric carriers with targeting capacity to the spleen and liver...
  81. ncbi request reprint Development of PEGylated adenovirus vector with targeting ligand
    Yusuke Eto
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Pharm 354:3-8. 2008
    ..In this review, we describe the molecular biology of Ads and outline this PEGylation approach including our data...
  82. ncbi request reprint Preliminary results of magnetic resonance imaging-aided high-dose-rate interstitial brachytherapy for recurrent uterine carcinoma after curative surgery
    Tadayuki Kotsuma
    Department of Radiation Oncology, Osaka University Graduate School of Medicine
    J Radiat Res 52:329-34. 2011
    ..Another patient, who had been treated with ISBT alone, developed grade 2 urinary constriction. Our imaging-aided HDR-ISBT for post-operative recurrence of uterine carcinoma was found to be practical with promising preliminary results...
  83. pmc Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice
    Tokuyuki Yoshida
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka 565 0871, Japan
    Nanoscale Res Lett 6:195. 2011
    ..This study provides the foundations for the establishment of safe and effective forms of nanosilica particles...
  84. doi request reprint Direct cell entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery
    Kazumasa Kamei
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Biomaterials 30:1809-14. 2009
    ..This technology is a useful tool for extending Ad tropism and enhancing transduction efficiency. GoldMAN also makes possible the effective use of various biomolecules within the cell because of its interesting cell-entry mechanism...
  85. ncbi request reprint Tumor-targeting CTL expressing a single-chain Fv specific for VEGFR2
    Naoko Kanagawa
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 394:54-8. 2010
    ..These findings indicate that the creation of CTL capable of targeting tumor vascular endothelial cells by scFv-expression technique is considerably promising for improvement of efficacy in adoptive immunotherapy...
  86. doi request reprint Weekly verification of dosimetric data for virtual wedge using a 2D diode detector array
    Toshiyuki Ogata
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Med Dosim 36:246-9. 2011
    ..We also verified generally good reproducibility for the dose distribution. The 2-D diode detector array was thus found to be useful as a tool for weekly VW QA...
  87. pmc Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages
    Hiromi Nabeshi
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nanoscale Res Lett 6:93. 2011
    ..Our results suggest that optimization of the surface characteristics of silica nanoparticles will contribute to the development of safer forms of NMs...
  88. ncbi request reprint [Creation of TNFR1-selective antagonist and its therapeutic effects]
    Tetsuya Nomura
    Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Yakugaku Zasshi 130:63-8. 2010
    ..These results would provide widely the strategy of regulating protein function in molecular level and would show the attractive approach to create safe and effective medical drug reducing side-effects...
  89. ncbi request reprint [High-dose-rate interstitial brachytherapy using inverse planning for locally advanced cervical cancer]
    Yasuo Yoshioka
    Division of Radiation Oncology, Shizuoka Cancer Center Hospital
    Nihon Igaku Hoshasen Gakkai Zasshi 63:171-6. 2003
    ..The calculation time of the computer was fast enough. This is the first report in Japan on the clinical use of IP in interstitial brachytherapy, and it implies the usefulness of IP...
  90. ncbi request reprint Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists
    Yohei Mukai
    Osaka University, Yamadaoka, Suita, Japan
    J Biochem 146:167-72. 2009
    ..Knowledge of these structure-function relationships will facilitate the design of novel TNF inhibitors based on the cytokine structure...
  91. ncbi request reprint [Application of bioactive mutant TNF alpha to a mucosal vaccine adjuvant]
    Hiroyuki Kayamuro
    National Institute of Biomedical Innovation, Laboratory of Pharmaceutical Proteomics, Ibaraki, Osaka, Japan
    Yakugaku Zasshi 130:55-61. 2010
    ..In this report, we examined the potential of mTNF-K90R as a mucosal adjuvant and evaluated its effectiveness and safety...
  92. doi request reprint Orally administered apple procyanidins protect against experimental inflammatory bowel disease in mice
    Yasuo Yoshioka
    Division of Foods, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Int Immunopharmacol 8:1802-7. 2008
    ..The combined anti-inflammatory and immunomodulatory effects of ACT on intestinal epithelial cells and IEL suggest that it may be an effective oral preventive agent for inflammatory bowel diseases...
  93. ncbi request reprint [Evaluation of biological influence of nano-materials using toxicokinetic and toxicoproteomic approach]
    Tomoaki Yoshikawa
    Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation, Ibaraki City, Japan
    Yakugaku Zasshi 128:1715-25. 2008
    ..In this review article, we describe the assumptions and challenges in the field of nanotoxicity and describe advances for studying nanotoxicity of nanosilicas using toxicokinetics/toxicoproteomics both in vivo and in vitro...
  94. ncbi request reprint Novel correction methods as alternatives for the six-dimensional correction in CyberKnife treatment
    Osamu Suzuki
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Radiat Med 25:31-7. 2007
    ..We developed novel correction methods for translating rotational errors into 3D, with the aim of making their correction safer than with 6D correction and as accurate as possible...
  95. doi request reprint Prognostic factors for survival in patients with recurrent cervical cancer previously treated with radiotherapy
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Gynecol Cancer 20:834-40. 2010
    ..The aim of this study was to identify the prognostic factors and to establish a model for the prediction of life expectancy in patients with recurrent cervical cancer that had previously been treated with radiotherapy...
  96. ncbi request reprint Postoperative radiation therapy after complete resection of thymoma has little impact on survival
    Tomoki Utsumi
    Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    Cancer 115:5413-20. 2009
    ..Furthermore, to the authors' knowledge, the relation between postoperative radiation therapy and cell type classified by the World Health Organization (WHO) is not known...
  97. ncbi request reprint [Nano-safety science for assuring the safety of nanomaterials]
    Yasuo Yoshioka
    The Center for Advanced Medical Engineering and Informatics, Osaka University, Suita, Osaka, Japan
    Nihon Eiseigaku Zasshi 65:487-92. 2010
    ..Our study will help to improve the quality of human life by establishing standards for the safe use of nanomaterials...
  98. ncbi request reprint Solution of the structure of the TNF-TNFR2 complex
    Yohei Mukai
    Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, Osaka, Japan
    Sci Signal 3:ra83. 2010
    ..Additionally, we also demonstrated that TNF-TNFR2 formed aggregates on the surface of cells, which may be required for signal initiation. These results may contribute to the design of therapeutics for autoimmune diseases...
  99. doi request reprint A case of bullous pemphigoid exacerbated by irradiation after breast conservative radiotherapy
    Fumiaki Isohashi
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Jpn J Clin Oncol 41:811-3. 2011
    ..Increasing the dosage of oral steroid and minocycline resulted in relief of bullous pemphigoid, although patchy skin pigmentation remained especially in the irradiated skin...
  100. pmc Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes
    Hiromi Nabeshi
    Osaka University, Japan
    Part Fibre Toxicol 8:1. 2011
    ..Specifically, we evaluated the relationship between particle size of nSP and the in vitro biological effects using human keratinocyte cells (HaCaT)...
  101. ncbi request reprint [Nanosafety studies of nanomaterials about biodistribution and immunotoxicity]
    Yasuo Yoshioka
    The Center for Advanced Medical Engineering and Informatics, Osaka University
    Yakugaku Zasshi 131:221-4. 2011
    ..We consider that our study will improve the quality of human life by safely using nanomaterials, which can benefit society in general...