Rikio Yoshimura

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. ncbi request reprint Treatment of bladder tumors and benign prostatic hyperplasia with a new TUR system using physiological saline as perfusate
    Rikio Yoshimura
    Department of Urology, Osaka City University Medical School, 1 4 3 Asahi machi, Abenoku, Osaka, 545 8585, Japan
    World J Surg 30:473-7. 2006
  2. pmc The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Biologics 2:725-32. 2008
  3. pmc Peroxisome Proliferator-Activated Receptor-gamma Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    PPAR Res 2008:249849. 2008
  4. pmc Relationship between arachidonic acid pathway and human renal cell carcinoma
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka City University Hospital, Abeno Ku, Osaka, Japan
    Onco Targets Ther 1:41-8. 2008
  5. ncbi request reprint Study of cyclooxygenase-2 in renal cell carcinoma
    Rikio Yoshimura
    Department of Urology, Osaka City University Hospital, Abenoku, Osaka 545 8585, Japan
    Int J Mol Med 13:229-33. 2004
  6. ncbi request reprint The effects of cyclooxygenase-2 inhibitors on urological cancer cells
    Rikio Yoshimura
    Department of Urology, Osaka City University Hospital, Abeno Ku, Osaka 545 8585, Japan
    Int J Mol Med 13:789-93. 2004
  7. ncbi request reprint Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors
    Rikio Yoshimura
    Department of Urology, Osaka City University Medical School, 1 4 3 Asahi machi, Abenoku, Osaka 545 8585, Japan
    J Urol 170:1994-9. 2003
  8. ncbi request reprint The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells
    Rikio Yoshimura
    Department of Urology, Osaka City University Graduate School of Medicine, University Hospital, 1 4 3 Asahi machi, Abenoku, Osaka 545 8585, Japan
    Int J Mol Med 12:861-5. 2003
  9. ncbi request reprint Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor
    Rikio Yoshimura
    Department of Urology, Osaka City Graduate School of Medicine, 1 4 3 Asahi machi, Abenoku, Osaka 545 8585, Japan
    Int J Mol Med 13:41-6. 2004
  10. ncbi request reprint Urinary extracellular matrix measurement as a reliable and cost effective diagnostic tool for bladder tumors
    Rikio Yoshimura
    Department of Urology, Osaka City University Hospital, Graduate School of Medicine, 1 4 3 Asahi machi, Abeno, Osaka 545 8585, Japan
    Int J Mol Med 13:127-31. 2004

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Treatment of bladder tumors and benign prostatic hyperplasia with a new TUR system using physiological saline as perfusate
    Rikio Yoshimura
    Department of Urology, Osaka City University Medical School, 1 4 3 Asahi machi, Abenoku, Osaka, 545 8585, Japan
    World J Surg 30:473-7. 2006
    ..Thus, in comparison with conventional TUR, this new system is both significantly safer and more cost effective...
  2. pmc The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Biologics 2:725-32. 2008
    ..In this review, we report the expression of COX-2, LOX and PPAR-gamma in human prostate cancer tissues as well as the effects of COX-2 and LOX inhibitors and PPAR-gamma ligand...
  3. pmc Peroxisome Proliferator-Activated Receptor-gamma Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    PPAR Res 2008:249849. 2008
    ..These results demonstrated that the generated PPAR-gamma in PC and TC cells might play an important role in the tumorigenesis. PPAR-gamma may become a new target in the treatment of PC and TC...
  4. pmc Relationship between arachidonic acid pathway and human renal cell carcinoma
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka City University Hospital, Abeno Ku, Osaka, Japan
    Onco Targets Ther 1:41-8. 2008
    ..PPAR-γ is one target for cell growth modulation of NSAIDs. In this review, we report the expression of COX-2, LOX and PPAR-γ in human renal cell carcinoma tissues as well as the effects of COX-2 and LOX inhibitors and PPAR-γ ligand...
  5. ncbi request reprint Study of cyclooxygenase-2 in renal cell carcinoma
    Rikio Yoshimura
    Department of Urology, Osaka City University Hospital, Abenoku, Osaka 545 8585, Japan
    Int J Mol Med 13:229-33. 2004
    ..However, no marked difference was seen among grades or between stages. These results demonstrate that the generated COX-2 in human renal cell carcinoma plays an important role in the proliferation of malignant renal cells...
  6. ncbi request reprint The effects of cyclooxygenase-2 inhibitors on urological cancer cells
    Rikio Yoshimura
    Department of Urology, Osaka City University Hospital, Abeno Ku, Osaka 545 8585, Japan
    Int J Mol Med 13:789-93. 2004
    ..Thus, using only down-regulation of arachidonic acid (AA) metabolizing enzyme, COX may be an unsuccessful approach in providing new anti-cancer therapies...
  7. ncbi request reprint Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors
    Rikio Yoshimura
    Department of Urology, Osaka City University Medical School, 1 4 3 Asahi machi, Abenoku, Osaka 545 8585, Japan
    J Urol 170:1994-9. 2003
    ..They are now believed to have important roles in tumor promotion, progression and metastasis. The involvement of lipoxygenase expression and function in tumor growth and metastasis has been reported in human tumor cell lines...
  8. ncbi request reprint The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells
    Rikio Yoshimura
    Department of Urology, Osaka City University Graduate School of Medicine, University Hospital, 1 4 3 Asahi machi, Abenoku, Osaka 545 8585, Japan
    Int J Mol Med 12:861-5. 2003
    ..PPAR-gamma ligands may mediate potent antiproliferative effects against RCC, BT and PC cells through differentiation. Thus, PPAR-gamma may become a new target in treatment of urological tumors...
  9. ncbi request reprint Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor
    Rikio Yoshimura
    Department of Urology, Osaka City Graduate School of Medicine, 1 4 3 Asahi machi, Abenoku, Osaka 545 8585, Japan
    Int J Mol Med 13:41-6. 2004
    ..These results suggest 12-LOX may play a role in the progression of RCC in human tissue, and its inhibitors may become anticancer agents in human RCC...
  10. ncbi request reprint Urinary extracellular matrix measurement as a reliable and cost effective diagnostic tool for bladder tumors
    Rikio Yoshimura
    Department of Urology, Osaka City University Hospital, Graduate School of Medicine, 1 4 3 Asahi machi, Abeno, Osaka 545 8585, Japan
    Int J Mol Med 13:127-31. 2004
    ..Evaluation of the results is relatively simple and accurate and the running cost of measuring U-ECM is significantly lower than other tests...
  11. ncbi request reprint Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists
    Rikio Yoshimura
    Department of Urology, Osaka City University Medical School, Osaka, Japan
    Int J Cancer 104:597-602. 2003
    ..PPAR-gamma is expressed in bladder tumor, and results suggest that PPAR-gamma ligands may mediate potent antiproliferative effects against BT cells. Thus, PPAR-gamma has the ability to become a new target in treatment of bladder tumor...
  12. ncbi request reprint A novel approach to anticancer therapies: peroxisome proliferator activator-receptor-gamma as a new target therapy in the treatment of human urological cancer
    M Matsuyama
    Department of Urology, Osaka City University Hospital, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Endocr Metab Immune Disord Drug Targets 9:76-83. 2009
    ..These results demonstrated that generated PPAR-gamma in urological cancer cells may play an important role in carcinogensis and become a new target therapy in the treatment of urological cancer...
  13. pmc Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats
    Atsushi Omoto
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Arthritis Res Ther 7:R1174-82. 2005
    ..We suggest that copper deficiency induced by TM is a potent approach both to inhibit the progression of rheumatoid arthritis with minimal adverse effects and to improve the well-being of rheumatoid arthritis patients...
  14. ncbi request reprint 5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Oncol Rep 14:73-9. 2005
    ..LOX, especially 5-LOX, is induced in RCC, and the results suggest that the 5-LOX inhibitor may mediate potent anti-proliferative effects against RCC cells. Thus, 5-LOX may become a new target in treatment of RCC...
  15. ncbi request reprint Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Int J Oncol 24:821-7. 2004
    ..LOX is induced in prostate cancer, and our results suggest that LOX inhibitors may mediate potent antiproliferative effects against prostate cancer cells. Thus, LOX may become a new target in treatment of prostate cancer...
  16. ncbi request reprint Expression of peroxisome proliferator-activated receptors in human testicular cancer and growth inhibition by its agonists
    Taro Hase
    Department of Urology, Osaka City University Medical School, Abenoku, Osaka, Japan
    Urology 60:542-7. 2002
    ..However, the expression of PPARs and the effects of PPAR-gamma ligand in testis have not been examined...
  17. ncbi request reprint Relationship between lipoxygenase and human testicular cancer
    Rikio Yoshimura
    Department of Urology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Int J Mol Med 13:389-93. 2004
    ..The LOX inhibitors inhibited the growth of TC cells. LOX is induced in TC, and results may suggest that LOXs are essential for cell growth of TC cells...
  18. ncbi request reprint Overexpression of cysteinyl LT1 receptor in prostate cancer and CysLT1R antagonist inhibits prostate cancer cell growth through apoptosis
    Masahide Matsuyama
    Department of Urology, Osaka City University Hospital, Osaka 545 8585, Japan
    Oncol Rep 18:99-104. 2007
    ..In conclusion, CysLT1R is induced in PC, and the results suggest that CysLT1R antagonist may mediate potent anti-proliferative effects of PC cells. Thus, the target of CysLT1R may become a new therapy in the treatment of PC...
  19. ncbi request reprint Telmisartan is a potent target for prevention and treatment in human prostate cancer
    Kiyoaki Funao
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Oncol Rep 20:295-300. 2008
    ..Telmisartan may mediate potent antiproliferative effects against PC cells through PPAR-gamma. Thus, Telmisartan is a potent target for prevention and treatment in PC...
  20. ncbi request reprint Expression of peroxisome proliferator-activated receptor (PPAR) in human prostate cancer
    Yoshihiro Segawa
    Department of Urology, Osaka City University Medical School, 1 4 3 Asahi machi, Abenoku, Osaka 545 8585, Japan
    Prostate 51:108-16. 2002
    ..In this study, PPARs expression was investigated in human prostate cancer (PC), prostatic intraepithelial neoplasia (PIN), benign prostatic hyperplasia (BPH), and normal prostate (NP) tissues...
  21. ncbi request reprint Lipoxygenase inhibitors prevent urological cancer cell growth
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Int J Mol Med 13:665-8. 2004
    ..LOX inhibitor may mediate potent antiproliferative effects against RCC, BT and PC cells through differentiation. Thus, LOX inhibitor, especially 5-LOX inhibitor may become a new target in treatment of urological cancers...
  22. doi request reprint Relationship between cysteinyl-leukotriene-1 receptor and human transitional cell carcinoma in bladder
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Urology 73:916-21. 2009
    ..LTD(4) is a pro-inflammatory mediator derived from arachidonic acid through various enzymatic steps, and 5-lipoxygenase is an important factor in generating LTD(4)...
  23. ncbi request reprint Expression of nonmuscle myosin heavy chain B (SMemb) in rat allogeneic kidney transplantation
    Yoshihiro Watanabe
    Department of Urology, Osaka City University Medical School, Japan
    Nephron 91:316-23. 2002
    ..Therefore, we hypothesized that SMemb plays important roles in acute kidney rejection. To evaluate the role of SMemb in the development of kidney rejection, we examined its expression in rat kidney transplantation models...
  24. ncbi request reprint Echography of left ventricular end-diastolic diameter as a reliable tool for estimating "dry weight" in hemodialysis patients
    Rikio Yoshimura
    Department of Urology, Osaka City University Medical School, Abenoku, Osaka, Japan
    Ren Fail 25:31-41. 2003
    ..It is hard to decide an accurate value for the so-called dry weight (DW) in hemodialysis patients with cardiac disease. Our objective is to evaluate the efficacy of echocardiography to decide DW...
  25. ncbi request reprint Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells
    Tomoaki Tanaka
    Department of Urology, Osaka City University, Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Anticancer Res 29:1089-94. 2009
    ..This indirect inhibition of prostate cancer cells via bone cells could be beneficial in treating prostate cancer patients with bone metastases...
  26. ncbi request reprint Endotoxin adsorption of various dialysis membranes: in vitro study
    Yoshiaki Takemoto
    Department of Urology and Division of Artificial Kidney, Osaka City University Medical School, Osaka, Japan
    Artif Organs 27:1134-7. 2003
    ....
  27. ncbi request reprint Biological reactions resulting from endotoxin adsorbed on dialysis membrane: an in vitro study
    Kenji Tsuchida
    Department of Urology and Division of Artificial Kidney, Osaka City University Medical School, Osaka, Japan
    Artif Organs 28:231-4. 2004
    ..The ET adsorbed to the dialysis membrane may influence a living body even if it does not pass through the membrane. Accordingly, it is difficult to assume that the adsorption of ET to the membrane enhances its biocompatibility...
  28. ncbi request reprint The effect of neutrophil elastase inhibitor on acute tubular necrosis after renal ischemia-reperfusion injury
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Mol Med Report 1:489-92. 2008
    ..To conclude, ONO-5046.Na inhibits neutrophil elastase and reduces acute tubular necrosis. Thus, it is a potent therapeutic agent for the control of renal I/R injury in renal transplantation...
  29. doi request reprint Increased levels of serum matrix metalloproteinase-3 in haemodialysis patients with dialysis-related amyloidosis
    Toshihide Naganuma
    Department of Urology, Osaka City University Medical School, Osaka, Japan
    Nephrology (Carlton) 13:104-8. 2008
    ..Little is known about serum MMP-3 levels in haemodialysis (HD) patients, and thus, the association between serum MMP-3 and dialysis-related amyloidosis (DRA) has yet to be elucidated...
  30. ncbi request reprint A case of quadruple cancer including urinary bladder, oral cavity, stomach and lung
    Makoto Mitsuhashi
    Department of Urology, Osaka City University Medical School
    Hinyokika Kiyo 50:429-33. 2004
    ..Since then, the patient has been followed carefully...
  31. ncbi request reprint Overexpression of orotate phosphoribosyl transferase in hormone-refractory prostate cancer
    Tomoaki Tanaka
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Oncol Rep 21:33-7. 2009
    ..Thus, 5-FU may be an effective option for some HRPC patients...
  32. ncbi request reprint A case of renal cell carcinoma found after skin metastasis
    Makoto Mitsuhashi
    Department of Urology, Osaka City University Medical School
    Hinyokika Kiyo 50:239-43. 2004
    ..At that time, multiple metastases appeared in bilateral lung fields. The patient is currently receiving interferon-alpha therapy, without surgical treatment...
  33. ncbi request reprint [Relationship between cyclooxygenase (COX)-2 and malignant tumors]
    Rikio Yoshimura
    Department of Urology, Osaka City University Graduate School of Medicine
    Nihon Rinsho 63:1839-48. 2005
    ..In this review, we demonstrated the expression of COX-2 in urological cancer(renal cell carcinoma, bladder tumor, prostate cancer, and testicular tumor) tissues as well as the effects of COX inhibitors...
  34. doi request reprint Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis
    Masahide Matsuyama
    Department of Urology, Osaka City University Hospital, Osaka 545 8585, Japan
    Mol Med Report 2:163-7. 2009
    ..In conclusion, CysLT1R was induced in TC. The results suggest that the CysLT1R antagonist may mediate potent anti-proliferative effects against TC cells. Thus, CysLT1R may become a new therapeutic target for the treatment of TC...
  35. doi request reprint Telmisartan as a peroxisome proliferator-activated receptor-γ ligand is a new target in the treatment of human renal cell carcinoma
    Kiyoaki Funao
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Mol Med Report 2:193-8. 2009
    ..Telmisartan may mediate potent antiproliferative effects against RCC cells through PPAR-γ. Thus, Telmisartan is a potential target for prevention and treatment in RCC...
  36. ncbi request reprint The role of arachidonic acid in a rat renal ischemia-reperfusion injury model
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Mol Med Report 1:493-7. 2008
    ..Our results demonstrate that COX-2 and LOX can be induced in a rat renal I/R injury model, and that the arachidonic acid pathways play a very important role in renal I/R injury...
  37. ncbi request reprint Blood purification for critical illness: cytokines adsorption therapy
    Kenji Tsuchida
    Osaka City University Graduate School of Medicine, Division of Urology and Artificial Kidney, Osaka, Japan
    Ther Apher Dial 10:25-31. 2006
    ..9, 31.8, and 32.9%, respectively. Clinically, their blood pressure increased and they recovered from shock status. These results suggest that SIRS and sepsis with hypercytokinemia can be treated with the DHP using the Lixelle column...
  38. ncbi request reprint Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Mol Med Report 1:499-503. 2008
    ..PPAR-γ was induced in the endothelial cells, including the mesangial cells, interstitial cells and collecting ducts in a rat model of renal I/R injury...
  39. ncbi request reprint The cysteinylLT1 receptor in human renal cell carcinoma
    Kiyoaki Funao
    Department of Urology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Mol Med Report 1:185-9. 2008
    ..To conclude, CysLT1R was induced in RCC and the results suggest that the CysLT1R antagonist may mediate the potent anti-proliferative effects of RCC cells. Thus, CysLT1R may become a new target therapy in the treatment of RCC...
  40. doi request reprint Cysteinyl-leukotriene1 receptor antagonist prevents urological cancer cell growth through early apoptosis
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Mol Med Report 3:329-32. 2010
    ..In conclusion, the CysLT1R antagonist may mediate potent anti-proliferative effects against urological cancer cells through early apoptosis, and may therefore serve as a novel therapeutic target in the treatment of urological cancer...
  41. ncbi request reprint Plasma exchange therapy for the treatment of Escherichia coli O-157 associated hemolytic uremic syndrome
    Tatsuya Nakatani
    Department of Urology and Division of Artificial Kidney, Osaka City University Medical School, Osaka City, Japan
    Int J Mol Med 10:585-8. 2002
    ..PE therapy was an effective early phase treatment for Escherichia coli O-157 associated HUS...
  42. ncbi request reprint Results of cadaver kidney transplantation with right renal vein extension
    Tatsuya Nakatani
    Department of Urology, Osaka City University Medical School, Japan
    Urol Int 70:282-5. 2003
    ..Furthermore, its long- and short-term results have not been investigated. Therefore, we studied the results of this operative procedure to confirm the safety of the technique...
  43. ncbi request reprint Percutaneous transluminal angioplasty against arteriosclerosis obliterans in dialysis patients
    Kenji Tsuchida
    Department of Urology and Division of Artificial Kidney, Osaka City University Medical School, Abeno Ku, Osaka City 545 8586, Japan
    Int J Mol Med 11:365-8. 2003
    ..However, the method has a high risk of causing thrombus formation, vessel rupture and organ failure. In this regard, it is advisable to evaluate the systemic condition and conduct IV if the extent of stenosis is mild...
  44. ncbi request reprint Response of peripheral blood mononuclear cells in hemodialyzed patients against endotoxin and muramyldipeptide
    Tatsuya Nakatani
    Department of Urology and Devision of Artificial Kidney, Osaka City University Medical School, Abeno Ku, Osaka City 545 8586, Japan
    Int J Mol Med 10:469-72. 2002
    ..Response of PBMC in patients against ET+MDP stimulant decreased with duration of dialysis treatment. This suggested that chronic exposure to ET or MDP during hemodialysis treatment, might cause a tolerance against ET and ET+MDP in PBMC...
  45. ncbi request reprint The prevalence of metabolic syndrome in Japanese renal transplant recipients
    Toshihide Naganuma
    Department of Urology, Osaka City University Medical School, Osaka, Japan
    Nephrology (Carlton) 12:413-7. 2007
    ..The prevalence of metabolic syndrome (MS) after renal transplantation has yet to be elucidated. In the present study, we investigated the prevalence of MS in Japanese renal transplant recipients...
  46. ncbi request reprint Investigation of endotoxin adsorption with polyether polymer alloy dialysis membranes
    Tatsuya Nakatani
    Department of Urology, Osaka City University, Abeno Ku, Osaka 545 8585, Japan
    Int J Mol Med 11:195-7. 2003
    ....
  47. ncbi request reprint Study on autologous blood transfusion in hemodialysis patients
    Kenji Tsuchida
    Department of Urology and Division of Artificial Kidney, Osaka City University Medical School, Abeno Ku, Osaka City 545 8586, Japan
    Int J Mol Med 11:211-5. 2003
    ..It is assumed that the generally accepted storage period of 21-35 days in the case of autologous blood is not applicable in the case of HD patients...
  48. ncbi request reprint Direct hemoperfusion by using Lixelle column for the treatment of systemic inflammatory response syndrome
    Kenji Tsuchida
    Department of Urology and Division of Artificial Kidney, Osaka City University Medical School, Abeno Ku, Osaka City 545 8586, Japan
    Int J Mol Med 10:485-8. 2002
    ..With the use of this column, removal of inflammatory cytokine by adsorption can be expected. Thus, it can be applied to the treatment of hypercytokinemia...
  49. ncbi request reprint [Relationship between peroxisome proliferator activator-receptor (PPAR) and urological cancer]
    Rikio Yoshimura
    Department of Urology, Osaka City University Graduate School of Medicine
    Nihon Rinsho 63:672-8. 2005
    ..Cells treated with PPAR-gamma inhibitors showed typical redundant characteristics of apoptosis. PPAR-gamma ligands may mediate potent antiproliferative effects through differentiation...
  50. ncbi request reprint Hepatocyte growth factor (HGF) as a rapid diagnostic marker and its potential in the prevention of acute renal rejection
    Rikio Yoshimura
    Department of Urology, Osaka City University Hospital, 1 4 3 Asahi machi, Abenoku, Osaka 545 8585, Japan
    Transpl Int 15:156-62. 2002
    ..We suggest that recombinant HGF suppresses the onset of the pathological changes of acute rejection...
  51. ncbi request reprint Adsorption of endotoxin by beta2-microglobulin adsorbent column (Lixelle): the new approach for endotoxinemia
    Kenji Tsuchida
    Division of Urology and Artificial Kidney, Osaka City University Medical School, Osaka, Japan
    Ther Apher 6:116-8. 2002
    ..Thus, Lixelle beads can adsorb not only BMG but also microorganism components such as LPS and ET. These findings together with the ability of Lixelle to adsorb ET show the possibility of the application for treatment of endotoxinemia...
  52. doi request reprint Biocompatibility of the dialysis membrane
    Yoshiaki Takemoto
    Department of Urology, Osaka City University, Graduate School of Medicine, Osaka, Japan
    Contrib Nephrol 168:139-45. 2011
    ..In this paper, blood-membrane inter actions will be emphasized for evaluating the biocompatibility of dialysis membranes...
  53. ncbi request reprint Prospects of antisense oligodeoxynucleotides to alleviate renal ischaemia-reperfusion injury
    Masahide Matsuyama
    Osaka City University Graduate School of Medicine, Department of Urology, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Expert Opin Biol Ther 4:1931-7. 2004
    ..This review discusses the efficacy of AS-ODN/TF and AS-ODN/intercellular adhesion molecule-1 as existing targets, and the potential of AS-ODN/nuclear factor-kappaB, AS-ODN/cyclooxygenase and AS-ODN/5-lipoxygenase as prospective targets...
  54. doi request reprint Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Mol Med Report 3:245-51. 2010
    ..These results demonstrate that CysLT1R expressed in urological cancer may play a crucial role in carcinogenesis. CysLT1R may therefore be a novel target in the treatment of urological cancer...
  55. doi request reprint Arachidonic acid pathway: A molecular target in human testicular cancer (Review)
    Masahide Matsuyama
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Mol Med Report 2:527-31. 2009
    ..In this review, we report the expression of COX-2, LOX and PPAR-γ in human testicular cancer tissues, as well as the effects of COX-2 and LOX inhibitors and PPAR-γ ligands...