Masakazu Yashiro

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. pmc Prognostic predictive values of gemcitabine sensitivity-related gene products for unresectable or recurrent biliary tract cancer treated with gemcitabine alone
    Akihiro Murata
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    World J Surg Oncol 11:117. 2013
  2. pmc IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer
    Toshiki Hirakawa
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Osaka, Abeno Ku, Japan
    BMC Cancer 13:392. 2013
  3. pmc An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells
    M Yashiro
    Oncology Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Br J Cancer 105:1522-32. 2011
  4. pmc Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line
    Yasumichi Yagi
    Department of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Ishikawa 920 8641, Japan
    J Exp Clin Cancer Res 29:149. 2010
  5. ncbi request reprint ICAM-1 (intercellular adhesion molecule-1) gene transfection inhibits lymph node metastasis by human gastric cancer cells
    T Sunami
    First Department of Surgery, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
    Jpn J Cancer Res 91:925-33. 2000
  6. pmc Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Ann Surg Oncol 16:2926-35. 2009
  7. ncbi request reprint K-ras mutation influences macroscopic features of gastric carcinoma
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Surg Res 124:74-8. 2005
  8. ncbi request reprint Effect of organ-specific fibroblasts on proliferation and differentiation of breast cancer cells
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Breast Cancer Res Treat 90:307-13. 2005
  9. ncbi request reprint Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Int J Oncol 35:997-1003. 2009
  10. pmc Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model
    M Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Br J Cancer 101:1100-6. 2009

Collaborators

Detail Information

Publications86

  1. pmc Prognostic predictive values of gemcitabine sensitivity-related gene products for unresectable or recurrent biliary tract cancer treated with gemcitabine alone
    Akihiro Murata
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    World J Surg Oncol 11:117. 2013
    ..The aim of this study is to clarify which biomarker is the most reliable among hENT1, dCK, and RRM1 to predict survival in patients with advanced BTC treated with gemcitabine alone...
  2. pmc IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer
    Toshiki Hirakawa
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Osaka, Abeno Ku, Japan
    BMC Cancer 13:392. 2013
    ..In this study, IGF1R and IGFBP3 expression was examined, and their potential roles as prognostic markers in patients with pancreatic cancer were evaluated...
  3. pmc An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells
    M Yashiro
    Oncology Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Br J Cancer 105:1522-32. 2011
    ..This study was performed to clarify the effect of epidermal growth factor receptor (EGFR) inhibitors in combination with SN38, an active metabolite of irinotecan, on the proliferation of irinotecan-refractory gastric cancer...
  4. pmc Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line
    Yasumichi Yagi
    Department of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Ishikawa 920 8641, Japan
    J Exp Clin Cancer Res 29:149. 2010
    ..This study was performed to investigate the inhibitory effects of valproic acid (VPA) on a highly peritoneal-seeding cell line of human scirrhous gastric cancer, OCUM-2MD3, and to explore the mechanism and the potential of VPA...
  5. ncbi request reprint ICAM-1 (intercellular adhesion molecule-1) gene transfection inhibits lymph node metastasis by human gastric cancer cells
    T Sunami
    First Department of Surgery, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
    Jpn J Cancer Res 91:925-33. 2000
    ..The above findings indicate that ICAM-1 gene transduction could prove to be an effective gene therapy for lymph node metastasis of gastric cancer...
  6. pmc Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Ann Surg Oncol 16:2926-35. 2009
    ..However, it is ineffective in half of all patients. This study tests the hypothesis that genetic markers might identify those patients with gastric cancer who would respond to neoadjuvant FP chemotherapy...
  7. ncbi request reprint K-ras mutation influences macroscopic features of gastric carcinoma
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Surg Res 124:74-8. 2005
    ..This morphological classification is important because biological characteristics differ between the four morphological types, but little is known about genetic differences between them...
  8. ncbi request reprint Effect of organ-specific fibroblasts on proliferation and differentiation of breast cancer cells
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Breast Cancer Res Treat 90:307-13. 2005
    ..Structural and functional interactions between organ-specific fibroblasts and breast cancer cells may importantly regulate breast cancer growth and progression...
  9. ncbi request reprint Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Int J Oncol 35:997-1003. 2009
    ..Loss of methylation in the promoter of ERas might be one of mechanisms responsible for the re-expression of an embryonic oncogene in gastric cancer...
  10. pmc Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model
    M Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Br J Cancer 101:1100-6. 2009
    ..The aim of this study is to clarify the benefit of a VEGFR-3 inhibitor Ki23057 for LN metastasis...
  11. ncbi request reprint CD54 expression is predictive for lymphatic spread in human gastric carcinoma
    Masakazu Yashiro
    The Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Dig Dis Sci 50:2224-30. 2005
    ..The CD54-negative group had a significantly worse prognosis than the CD54-positive group. These findings suggested that CD54 expression is predictive for lymphatic spread and prognosis in human gastric carcinoma...
  12. doi request reprint Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, Japan
    Int J Cancer 126:1004-16. 2010
    ..These findings suggested that the combined treatment with 5-FU and Ki23057 produced synergistic antitumor effects and is therapeutically promising for SGC treatment...
  13. ncbi request reprint Decreased expression of the adhesion molecule desmoglein-2 is associated with diffuse-type gastric carcinoma
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University, Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Eur J Cancer 42:2397-403. 2006
    ..These findings suggest that decreased expression of Dsg2 is associated with diffuse-type gastric cancers and poor prognosis in gastric carcinoma...
  14. ncbi request reprint Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 120:686-93. 2007
    ....
  15. pmc Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    BMC Cancer 10:303. 2010
    ..In this study, early stage CRCs were examined for frameshift mutations in these target genes, and compared with late stage tumors and CRC cell lines...
  16. ncbi request reprint Cronkhite-Canada syndrome containing colon cancer and serrated adenoma lesions
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Digestion 69:57-62. 2004
    ..Thus, genetic alterations between the serrated adenoma and the colorectal cancer was correlated in this case. These findings suggested the possibility of a serrated adenoma-carcinoma sequence in this case of Cronkhite-Canada syndrome...
  17. ncbi request reprint Tranilast (N-3,4-dimethoxycinamoyl anthranilic acid): a novel inhibitor of invasion-stimulating interaction between gastric cancer cells and orthotopic fibroblasts
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Anticancer Res 23:3899-904. 2003
    ..Tranilast is a clinical drug for inhibition of fibroblast growth. To develop a drug for cancer invasion, the effect of Tranilast on the invasion-stimulating interaction was examined...
  18. pmc Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling
    Akiyoshi Komuro
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
    J Natl Cancer Inst 101:592-604. 2009
    ..However, the association of TGF-beta signaling with diffuse-type gastric carcinoma has not been investigated in detail...
  19. doi request reprint A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma
    Hidemi Kawajiri
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 14:2850-60. 2008
    ..The aim of the current study is to clarify the possibility of molecular target therapy with a TGFbeta-R inhibitor, A-77, for the treatment of peritoneal dissemination of scirrhous gastric cancer...
  20. doi request reprint c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma
    Kunihiko Kiyono
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 100:1809-16. 2009
    ..These findings suggest that c-Ski overexpression promotes the growth of diffuse-type gastric carcinoma through induction of angiogenesis...
  21. ncbi request reprint Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma
    Yasuo Nakagawa
    Department of Surgical Oncology, Graduate School of Medicine, Osaka City University 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Anticancer Res 33:5023-9. 2013
    ..However, to our knowledge, no previous reports on the prediction of nodal metastasis determined by evaluating primary tumor specimens of patients with ESCC are available...
  22. ncbi request reprint Usefulness of inhibiting the lymph node metastasis in human gastric carcinoma by B7-1 gene transfection
    Yoji Sakate
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Surg Res 122:89-95. 2004
    ..In this study, we investigated the inhibitory effect of B7-1 on lymph node metastasis by B7-1 gene transfection into gastric cancer cells...
  23. ncbi request reprint A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells
    Masashige Tendo
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cancer Lett 244:247-51. 2006
    ..These findings suggested that combining S-1 and COX-2 inhibitor administration obtain a synergistic inhibitory-effect on the peritoneal metastasis of scirrhous gastric carcinoma...
  24. pmc Phosphorylated smad2 in advanced stage gastric carcinoma
    Osamu Shinto
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, Japan
    BMC Cancer 10:652. 2010
    ..The aim of the current study is to clarify the role of phosphorylated Smad2 (p-Smad2) in gastric adenocarcinomas at advanced stages...
  25. ncbi request reprint Up regulation of ICAM-1 gene expression inhibits tumour growth and liver metastasis in colorectal carcinoma
    Akiko Tachimori
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Eur J Cancer 41:1802-10. 2005
    ..In conclusion ICAM-1 gene transfection using adenovirus vector might be an effective therapy for liver metastasis of colorectal carcinoma...
  26. doi request reprint In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer
    Masahiro Komoto
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 101:468-73. 2010
    ..Both lapatinib monotherapy and combined treatment with S-1 may be promising treatments for patients with pancreatic cancers; the majority these cancers express lapatinib target molecules...
  27. doi request reprint Predictive value of expression of ERCC 1 and GST-p for 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer
    Eiji Noda
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatogastroenterology 59:130-3. 2012
    ....
  28. ncbi request reprint Very low incidence of microsatellite instability in intraductal papillary-mucinous neoplasm of the pancreas
    Bunzo Nakata
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 102:655-9. 2002
    ..All IPMCs and IPMAs showed normal expression of both hMLH1 and hMSH2. MSI-H and loss of hMLH1 and hMSH2 are very rare events in both IPMCs and IPMAs. We conclude that a good prognosis for patients with IPMC is not associated with MSI-H...
  29. ncbi request reprint CD80 gene therapy for lymph node involvement by gastric carcinoma
    Kinshi Kosaka
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Int J Oncol 25:1319-25. 2004
    ..Histopathologic findings revealed CD80-positive cells around the tumor. These results suggest that CD80 gene transfer into cancer cells using an adenovirus vector might be a promising approach for in vivo cancer therapy...
  30. ncbi request reprint Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity
    Hiroaki Tanaka
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Oncol Rep 24:1637-43. 2010
    ..In conclusion, TGFβ receptor I kinase inhibitor such as SB-431542 might induce anti-tumor immune response in immuno-tolerant patients associated with TGFβ activity...
  31. ncbi request reprint Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis
    Masafumi Inoue
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Oncol Rep 14:1445-51. 2005
    ..These findings suggested that PAI-1 gene transfection might have the ability to prevent the liver metastasis of pancreatic cancer by modulating angiogenesis...
  32. ncbi request reprint Association of MHC class I expression and lymph node metastasis of gastric carcinoma
    Mami Yoshii
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatogastroenterology 60:611-5. 2013
    ..Loss of HLA class I expression has been considered to be an important prognostic factor in many malignancies. We investigated the impact of HLA class I expression on lymph node metastasis in gastric carcinoma...
  33. ncbi request reprint Inhibitory effect of a selective cyclooxygenase inhibitor on the invasion-stimulating activity of orthotopic fibroblasts for scirrhous gastric cancer cells
    Masashige Tendo
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Japan
    Cancer Sci 96:451-5. 2005
    ....
  34. ncbi request reprint [A case of advanced esophageal cancer with para-aortic lymph node metastasis with complete response (CR) to combination chemotherapy including nedaplatin]
    Satoru Noda
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
    Gan To Kagaku Ryoho 36:2451-3. 2009
    ..After ten courses, the tumor marker was decreased, and the patient is still in a stable disease state. We concluded that FGP therapy and DGP therapy were a very effective treatment for advanced esophageal SCC...
  35. ncbi request reprint Negative hMSH2 protein expression in pancreatic carcinoma may predict a better prognosis of patients
    Bunzo Nakata
    Department of Surgical Oncology First Department of Surgery, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Oncol Rep 10:997-1000. 2003
    ..The patients with hMSH2-negative tumors may have better prognoses than those with hMSH2-positive tumors. To clarify these findings, further large number of pancreatic carcinomas must be investigated...
  36. ncbi request reprint [Results of neo-adjuvant chemotherapy by FOLFOX and FOLFIRI for colorectal liver metastasis]
    Ryosuke Amano
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
    Gan To Kagaku Ryoho 36:2003-5. 2009
    ..Now, 9 patients are alive with no recurrence. NAC by FOLFOX for liver metastasis of colorectal cancer showed a high reduction rate, and there was a little influence to hepatectomy indicating that FOLFOX could be an effective therapy...
  37. doi request reprint Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer
    Taro Matsuzaki
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Cancer Sci 100:2402-10. 2009
    ..Therefore, mTOR inhibitor is a promising therapeutic agent in combination with 5FU in scirrhous gastric cancer...
  38. ncbi request reprint Efficacy of S-1 for gastric cancer patients with positive peritoneal lavage cytology
    Eiji Ako
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Hepatogastroenterology 55:1939-42. 2008
    ..We examined the clinical efficacy of S-1 chemotherapy against gastric cancer with positive PLC after macroscopically curative resection...
  39. ncbi request reprint Significance of keratinocyte growth factor receptor in the proliferation of biliary tract cancer
    Ryosuke Amano
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Anticancer Res 30:4115-21. 2010
    ..Biliary tract carcinoma (BTC) has extremely poor prognosis because of rapid cancer cell proliferation. The aim of this study was to clarify the significance of keratinocyte growth factor receptor (KGFR) in the proliferation of BTC...
  40. ncbi request reprint [Concurrent chemoradiotherapy with nedaplatin and 5-fluorouracil (5-fu) for locally advanced squamous cell carcinoma of the esophagus]
    Naoshi Kubo
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, and Department of Digestive Surgery, Osaka City General Hospital
    Gan To Kagaku Ryoho 36:1997-9. 2009
    ..We reported the efficacy and safety of CRT using CDGP and 5-FU for locally advanced squamous cell carcinoma of the esopahagus...
  41. ncbi request reprint A novel angiogenesis inhibitor, Ki23057, is useful for preventing the progression of colon cancer and the spreading of cancer cells to the liver
    Katsunobu Sakurai
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Eur J Cancer 43:2612-20. 2007
    ..Anti-CD31 antibody stained significantly fewer microvessels in the xenografted tumours treated with Ki23057 compared with controls. Ki23057 may be a promising new antiangiogenic agent for colon cancer...
  42. ncbi request reprint A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer
    Kazunori Nakamura
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Gastroenterology 131:1530-41. 2006
    ..The aim of the current study is to clarify the possibility of molecular target therapy with Ki23057 for treating scirrhous gastric cancer...
  43. ncbi request reprint Expression of ERas oncogene in gastric carcinoma
    Ryoji Kaizaki
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Anticancer Res 29:2189-93. 2009
    ..Embryonic stem cell expressed Ras (ERas) oncogene is associated with the tumorigenicity of embryonic stem cells. The aim of this study was to clarify the significance of ERas expression in clinical samples of gastric carcinomas...
  44. doi request reprint Cancer stem cell-like SP cells have a high adhesion ability to the peritoneum in gastric carcinoma
    Takafumi Nishii
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Cancer Sci 100:1397-402. 2009
    ..Oct3/4 and Sox2 may be associated with CSC in gastric cancer...
  45. doi request reprint Combination effect of a TGF-beta receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice
    Osamu Shinto
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 101:1846-52. 2010
    ..These findings suggested that the TbetaR-I kinase inhibitor with S1 is useful for the treatment of scirrhous gastric carcinoma with LN metastasis. (Cancer Sci 2010)...
  46. ncbi request reprint Vitamin D receptor expression is associated with colon cancer in ulcerative colitis
    Koji Wada
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Oncol Rep 22:1021-5. 2009
    ..These findings suggested that correlation seems to exist between the level of VDR expression and carcinogenesis in UC. VDR could be a possible marker to detect dysplasia and cancer in ulcerative colitis...
  47. ncbi request reprint Establishment and characterization of multidrug-resistant gastric cancer cell lines
    Xiaotian Zhang
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Anticancer Res 30:915-21. 2010
    ..Aim: The aim of this study was to establish drug-resistant cell lines and to elucidate mechanisms leading to multi-drug resistance in gastric cancer...
  48. doi request reprint Borrmann's macroscopic criteria and p-Smad2 expression are useful predictive prognostic markers for cytology-positive gastric cancer patients without overt peritoneal metastasis
    Satoru Noda
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Ann Surg Oncol 18:3718-25. 2011
    ..The goal of this study was to identify characteristic features of peritoneal-free cancer cells that could develop into peritoneal recurrence...
  49. ncbi request reprint Frequent microsatellite instability in primary esophageal carcinoma associated with extraesophageal primary carcinoma
    Naoshi Kubo
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Int J Cancer 114:166-73. 2005
    ..Our findings suggested that carcinogenesis in ECOPC was closely associated with the MSI pathway because of mismatch repair protein deficiency...
  50. ncbi request reprint ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma
    Hiroaki Tanaka
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 10:4885-92. 2004
    ..In the present study, we examined whether ICAM-2 transfection using adenovirus vector is effective gene therapy for peritoneal metastasis of gastric cancer...
  51. doi request reprint A FGFR2 inhibitor, Ki23057, enhances the chemosensitivity of drug-resistant gastric cancer cells
    Hong Qiu
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Japan
    Cancer Lett 307:47-52. 2011
    ..The aim of this study was to clarify the ability of a FGFR2 inhibitor, Ki23057, to enhance the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs...
  52. pmc Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells
    O Shinto
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka, Japan
    Br J Cancer 102:844-51. 2010
    ..The aim of this study was to clarify the effect of a TGF-beta receptor (TbetaR) phosphorylation inhibitor on the invasiveness of gastric cancer cells...
  53. pmc Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFβ signaling
    Junko Matsuoka
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    PLoS ONE 8:e62310. 2013
    ..These findings might suggest that hypoxia stimulates the EMT of gastric cancer cells via autocrine TGFβ/TGFβR signaling...
  54. pmc CD133 is a useful surrogate marker for predicting chemosensitivity to neoadjuvant chemotherapy in breast cancer
    Naoki Aomatsu
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e45865. 2012
    ..The aim of this study was to find a surrogate maker to predict chemosensitivity of NAC for breast cancer...
  55. doi request reprint VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells
    Yosuke Doi
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Ann Surg Oncol 19:2733-43. 2012
    ..VEGFRs might play an important role for the development of pancreatic cancer cells. The purpose of this study was to evaluate the efficacy of VEGF/VEGFR-2-targeted therapy in pancreatic carcinoma...
  56. doi request reprint Concurrent biological targeting therapy of squamous cell carcinoma of the esophagus with cetuximab and trastuzumab
    Masanao Yamazaki
    Department of Surgical Oncology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Oncol Rep 28:49-54. 2012
    ..The antitumor effect may be induced by the inhibition of the phosphorylation of Akt. These findings suggest that combination therapy including cetuximab and trastuzumab may be a promising strategy to treat SCC...
  57. doi request reprint Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells
    Yuhiko Fuyuhiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 103:797-805. 2012
    ....
  58. doi request reprint Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway
    Ichiro Fujiwara
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Dis Colon Rectum 51:1387-94. 2008
    ..To understand the molecular mechanisms of the carcinogenesis process of ulcerative colitis-associated colorectal cancer, the genetic alterations in inflamed or neoplastic colon epithelium in ulcerative colitis were analyzed...
  59. ncbi request reprint Clinical significance of vimentin-positive gastric cancer cells
    Yuhiko Fuyuhiro
    Department of Surgical Oncology, Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, Osaka, Japan
    Anticancer Res 30:5239-43. 2010
    ..However, the clinical significance of vimentin expression in carcinomas is not well understood. The aim of this study was to clarify the significance of vimentin-positive gastric cancer (GC)...
  60. doi request reprint Identification of HLA-A*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer
    Takehiko Iwauchi
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 102:683-9. 2011
    ..Our results suggest that ERas is a novel tumor-associated antigen with the potential application to be a vaccine against scirrhous gastric cancer...
  61. doi request reprint Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer
    Yosuke Doi
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 101:1529-35. 2010
    ..The expression of pVEGFR-2 might be a novel predictive prognostic marker for patients with pancreatic cancers, especially at clinical stage IIA...
  62. ncbi request reprint Novel models for human scirrhous gastric carcinoma in vivo
    Satoru Takemura
    The Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545 8585
    Cancer Sci 95:893-900. 2004
    ..Our orthotopic models should contribute to the elucidation of disease progression in situ and to the development of therapy for scirrhous gastric cancer...
  63. doi request reprint Expression of a hypoxia-associated protein, carbonic anhydrase-9, correlates with malignant phenotypes of gastric carcinoma
    Yukihiro Kato
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Digestion 82:246-51. 2010
    ..The purpose of our study was to clarify the significance of hypoxia in gastric carcinoma by evaluating the expression of a hypoxic marker, namely carbonic anhydrase-9 (CA-9)...
  64. ncbi request reprint Prognostic value of microsatellite instability in resectable pancreatic cancer
    Bunzo Nakata
    Department of Surgical Oncology, Osaka City University Medical School, Osaka 545 8585, Japan
    Clin Cancer Res 8:2536-40. 2002
    ..In conclusion, a patient with MSI-positive pancreatic cancer may have a comparatively better prognosis after resection, possibly due to intensive immunoreaction to the tumor...
  65. pmc Advantages of adjuvant chemotherapy for patients with triple-negative breast cancer at Stage II: usefulness of prognostic markers E-cadherin and Ki67
    Shinichiro Kashiwagi
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, Japan
    Breast Cancer Res 13:R122. 2011
    ..Chemotherapy is, therefore, the primary systemic modality used in the treatment of this disease, but reliable parameters to predict the chemosensitivity of TNBC have not been clinically available...
  66. ncbi request reprint ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells
    Koichi Yasuda
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Anticancer Res 27:4071-5. 2007
    ..Up-regulation of ERas by histone acetylation might be one of the mechanisms reversing/overcoming the epigenetic transcriptional silencing of the ERas oncogenes...
  67. ncbi request reprint Successful resection of esophageal carcinoma associated with double aortic arch: a case report
    Naoshi Kubo
    Department of Surgical Oncology, Osaka City University, Graduate School of Medicine, 1 4 3 Asahimachi, Osaka 545 8585, Japan
    Anticancer Res 32:3351-5. 2012
    ..Moreover, this is the first reported case of symptomatic DAA with esophageal carcinoma. Spiral computed tomography and three-dimensional reconstruction was very useful for preoperative assessment of the abnormal vessels...
  68. ncbi request reprint Lipid-mediated gene transfection of intercellular adhesion molecule-1 suppresses the peritoneal metastasis of gastric carcinoma
    Hiroaki Tanaka
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Int J Mol Med 10:613-7. 2002
    ..These findings revealed that ICAM-1 gene transfection to cancer cells could be a useful immuno-gene therapy for the peritoneal metastasis of gastric carcinoma...
  69. ncbi request reprint Frequent p16 CpG island hypermethylation in primary remnant gastric cancer suggesting an independent carcinogenic pathway
    Aya Mino
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Oncol Rep 15:615-20. 2006
    ..Silencing of the p16 gene by methylation of its promoter CpG island was suggested as a unique molecular mechanism in the carcinogenesis of PRC compared with MRC or PC...
  70. ncbi request reprint Carcinogenesis in the remnant stomach following distal gastrectomy with billroth II reconstruction is associated with high-level microsatellite instability
    Makoto Aya
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Anticancer Res 26:1403-11. 2006
    ..Carcinogenesis in the remnant stomach following distal gastrectomy with gastrojejunostomy was found to be associated with the MSI pathway due to inactivation of the DNA mismatch repair system...
  71. doi request reprint Hypoxia upregulates adhesion ability to peritoneum through a transforming growth factor-beta-dependent mechanism in diffuse-type gastric cancer cells
    Satoru Noda
    Department of Surgical Oncology, Osaka City University, Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, Japan
    Eur J Cancer 46:995-1005. 2010
    ..The upregulation of alpha2-, alpha3- and alpha5-integrin by TGF-beta under hypoxic conditions may be one of the mechanisms responsible for the high metastatic potential of hypoxic DGC cells to the peritoneum...
  72. ncbi request reprint Establishment of a new scirrhous gastric carcinoma cell line with microsatellite instability
    Tsuyoshi Koyama
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Oncol Rep 12:317-21. 2004
    ..OCUM-7 might be beneficial for analyzing the mechanisms of MSI in scirrhous gastric carcinoma...
  73. ncbi request reprint A synergistic antitumor effect of interleukin-2 addition with CD80 immunogene therapy for peritoneal metastasis of gastric carcinoma
    Kinshi Kosaka
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Dig Dis Sci 52:1946-53. 2007
    ..These results suggest that interleukin-2 addition might contribute to improving the observed outcome of CD80 immunogene therapy in peritoneal metastasis of gastric carcinoma...
  74. doi request reprint Role of the stemness factors sox2, oct3/4, and nanog in gastric carcinoma
    Junko Matsuoka
    Department of Surgical Oncology, Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Surg Res 174:130-5. 2012
    ..We therefore investigated the role of stemness factors in the tumorigenesis of human gastric cancer...
  75. ncbi request reprint Genetic alterations in adenoma-carcinoma sequencing of intraductal papillary-mucinous neoplasm of the pancreas
    Bunzo Nakata
    Department of Surgical Oncology First Department of Surgery, Osaka City University Graduate Shool of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Int J Oncol 21:1067-72. 2002
    ..Taken together, genetic changes such as K-ras, p53, APC and DCC mutations may not be associated with adenoma-carcinoma sequence in intraductal papillary-mucinous neoplasm of pancreas...
  76. doi request reprint HER2 overexpression correlates with survival after curative resection of pancreatic cancer
    Masahiro Komoto
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 100:1243-7. 2009
    ..These results should encourage further investigation of treatments using new molecular targeting agents against HER2 protein to improve the survival of pancreatic cancer patients...
  77. ncbi request reprint 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells
    Yumiko Matsumura
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, 545 8585 Osaka, Japan
    Anticancer Res 25:3271-8. 2005
    ..These findings indicated that 5-FU stimulated IFN pathways in esophageal SCC cells following up-regulation of the IFN type I receptor. A combination of 5-FU and an IFN, therefore, may be particularly efficacious in esophageal cancer...
  78. ncbi request reprint Correlation between vascular endothelial growth factor C expression and lymph node metastasis in T1 carcinoma of the colon and rectum
    Kiyoshi Maeda
    Department of Surgical Oncology First Department of Surgery, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Surg Today 33:736-9. 2003
    ..In this study, we investigated the correlation between VEGF-C expression and lymph node metastasis in early carcinoma of the colon and rectum...
  79. ncbi request reprint [Impacts of PSK and TbetaR inhibitor on immune response in immunosuppressive status associated with cancer]
    Hiroaki Tanaka
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
    Gan To Kagaku Ryoho 36:1969-71. 2009
    ..These results suggested that PSK with TGF-beta receptor I kinase inhibitor should be able to induce antitumor immune response in immune-tolerant patients associated with TGF-beta activity...
  80. ncbi request reprint A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa
    Shinobu Yamada
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abenoku, Osaka, Japan
    Int J Cancer 113:1015-21. 2005
    ..008). The specificity of the MASA-PCR method for colorectal neoplasms was thus 100%. We conclude that detection of K-ras mutations in normal colonic mucosa might serve as a high-specificity approach to colorectal cancer...
  81. pmc Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12/Hypo, derived from a scirrhous gastric carcinoma
    Y Kato
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, Japan
    Br J Cancer 102:898-907. 2010
    ..However, the mechanisms by which hypoxia affects the aggressive phenotypes remain unclear...
  82. pmc Plasma pharmacokinetics after combined therapy of gemcitabine and oral S-1 for unresectable pancreatic cancer
    Bunzo Nakata
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    J Exp Clin Cancer Res 29:15. 2010
    ..The combination of gemcitabine (GEM) and S-1, an oral 5-fluorouracil (5-FU) derivative, has been shown to be a promising regimen for patients with unresectable pancreatic cancer...
  83. doi request reprint DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells
    Hong Qiu
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 100:181-8. 2009
    ..The arrest at G2-M phase and increased apoptotic rate might be partly mediated by enhanced expression of the p53, RASSF1, or DAPK gene families by 5-aza-CdR...
  84. ncbi request reprint Effects of acute and chronic hypoxia on the radiosensitivity of gastric and esophageal cancer cells
    Yukihiro Kato
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Anticancer Res 31:3369-75. 2011
    ..The aim of this study was to examine the effects of hypoxia on radiosensitivity and to analyze the mechanisms responsible for radiation resistance in gastric and esophageal cancer...
  85. ncbi request reprint Primary leiomyosarcoma of the breast: report of a case
    Osamu Shinto
    Department of Surgical Oncology First Department of Surgery, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Japan
    Surg Today 32:716-9. 2002
    ..A review of the literature on this unusual tumor of the breast is presented...
  86. ncbi request reprint [Efficacy of m-FOLFOX6 therapy for colorectal cancer in elderly patients]
    Woo Young Kim
    Dept of Surgical Oncology, Attached Hospital in Ambulatory Chemotherapy Center, Osaka City University
    Gan To Kagaku Ryoho 34:1833-6. 2007
    ..We concluded that m-FOLFOX6 may bring about the same response rate in older and younger elderly patients. Moreover, m-FOLFOX6 may be given safely regardless of patient age...