Affiliation: Osaka Medical College
Ikushiro H, Nagami A, Takai T, Sawai T, Shimeno Y, Hori H, et al
. Heme-dependent Inactivation of 5-Aminolevulinate Synthase from Caulobacter crescentus. Sci Rep. 2018;8:14228 pubmed publisher
..ALAS expressed in C. crescentus was also found to bind heme, suggesting that heme-mediated feedback inhibition of ALAS is physiologically relevant in C. crescentus. ..
Fukui K, Baba S, Kumasaka T, Yano T. Structural Features and Functional Dependency on ?-Clamp Define Distinct Subfamilies of Bacterial Mismatch Repair Endonuclease MutL. J Biol Chem. 2016;291:16990-7000 pubmed publisher
..We propose that MutL endonucleases are divided into three subfamilies on the basis of their structural features and dependence on ?-clamp. ..
Nakai Y, Nakai M, Yano T. Sulfur Modifications of the Wobble U34 in tRNAs and their Intracellular Localization in Eukaryotic Cells. Biomolecules. 2017;7: pubmed publisher
..This review addresses presumed sulfur delivery pathways for the s²U34 formation in distinct intracellular locations, especially that for cy-tRNAs in comparison with that for mt-tRNAs. ..
Ishii S, Fukui K, Yokoshima S, Kumagai K, Beniyama Y, Kodama T, et al
. High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway. Sci Rep. 2017;7:4029 pubmed publisher
..These compounds inhibit PEP activity by binding to and suppressing the structural changes of this site. These results showed that PEP is a good target for inhibitors of the Streptococcus quorum-sensing system. ..
Fukui K, Iino H, Baba S, Kumasaka T, Kuramitsu S, Yano T. Crystal structure and DNA-binding property of the ATPase domain of bacterial mismatch repair endonuclease MutL from Aquifex aeolicus. Biochim Biophys Acta Proteins Proteom. 2017;1865:1178-1187 pubmed publisher
..On the basis of the model structure and further experimental results, we concluded that the two separate DNA-binding sites in the full-length A. aeolicus MutL simultaneously bind a dsDNA molecule. ..