Eiji Yamato

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic β cell line MIN6
    Eiji Yamato
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    PLoS ONE 8:e61211. 2013
  2. ncbi request reprint Protection against CCl4-induced injury in liver by adenovirally introduced thioredoxin gene
    Katsuhiro Isoda
    Laboratory of Bio Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 350:157-61. 2006
  3. ncbi request reprint Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPbeta gene
    Katsuhiro Isoda
    Laboratory of Bio Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 329:182-7. 2005
  4. ncbi request reprint Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus
    Mayu Yamamoto
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Osaka, Japan
    Antioxid Redox Signal 10:43-9. 2008
  5. doi request reprint Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia
    Shuichi Toyoda
    Division of Stem Cell Regulation Research G6, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Dev Biol 325:238-48. 2009
  6. ncbi request reprint Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes
    Takuji Yoshimura
    Supply Center of Inbred Animals of Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Dev Biol 335:216-27. 2009
  7. pmc Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells
    Satsuki Miyazaki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes 59:2854-61. 2010
  8. ncbi request reprint Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells
    Satsuki Miyazaki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Suita, Japan
    Diabetes 53:1030-7. 2004
  9. ncbi request reprint Development of a single-cassette system for spatiotemporal gene regulation in mice
    Satsuki Miyazaki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 338:1083-8. 2005
  10. doi request reprint Analysis of Foxo1-regulated genes using Foxo1-deficient pancreatic β cells
    Satsuki Miyazaki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    Genes Cells 17:758-67. 2012

Collaborators

Detail Information

Publications22

  1. pmc Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic β cell line MIN6
    Eiji Yamato
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    PLoS ONE 8:e61211. 2013
    ..Our findings suggest that the global expression profiling of GSIS-competent and GSIS-incompetent MIN6 cells will help delineate the gene regulatory networks for insulin secretion...
  2. ncbi request reprint Protection against CCl4-induced injury in liver by adenovirally introduced thioredoxin gene
    Katsuhiro Isoda
    Laboratory of Bio Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 350:157-61. 2006
    ..The gene delivery of TRX, which plays a central role in intracellular redox control, was shown to be effective in protecting the liver against oxidative stress-induced injury...
  3. ncbi request reprint Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPbeta gene
    Katsuhiro Isoda
    Laboratory of Bio Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 329:182-7. 2005
    ..These results indicate that C/EBPbeta appears to be a survival factor under stressful conditions, and the introduction of the gene has therapeutic function against liver injury...
  4. ncbi request reprint Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus
    Mayu Yamamoto
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Osaka, Japan
    Antioxid Redox Signal 10:43-9. 2008
    ....
  5. doi request reprint Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia
    Shuichi Toyoda
    Division of Stem Cell Regulation Research G6, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Dev Biol 325:238-48. 2009
    ..This study lays the foundation for further dissection of the bHLH network that regulates early spermatogenesis and oogenesis...
  6. ncbi request reprint Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes
    Takuji Yoshimura
    Supply Center of Inbred Animals of Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Dev Biol 335:216-27. 2009
    ..These observations indicate that Gtsf1/Cue110 is required for spermatogenesis and involved in retrotransposon suppression in male germ cells...
  7. pmc Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells
    Satsuki Miyazaki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes 59:2854-61. 2010
    ..Although several experiments using pancreatic β-cell lines have shown that the ligands of nuclear hormone receptors modulate insulin secretion, it is not clear whether RXRs have any role in insulin secretion...
  8. ncbi request reprint Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells
    Satsuki Miyazaki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Suita, Japan
    Diabetes 53:1030-7. 2004
    ..Thus, exogenous expression of pdx-1 should provide a promising approach for efficiently producing insulin-secreting cells from human ES cells for future therapeutic use in diabetic patients...
  9. ncbi request reprint Development of a single-cassette system for spatiotemporal gene regulation in mice
    Satsuki Miyazaki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 338:1083-8. 2005
    ..This Tet-off system should serve as an efficient tool to analyze the roles of genes in complex biological systems, such as embryogenesis, metabolism, immune system, etc...
  10. doi request reprint Analysis of Foxo1-regulated genes using Foxo1-deficient pancreatic β cells
    Satsuki Miyazaki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    Genes Cells 17:758-67. 2012
    ..These cells should be useful for further studies on Foxo1's roles in β-cells and may lead to novel strategies for treating the impaired insulin secretion in type 2 diabetes mellitus...
  11. ncbi request reprint Both Pdx-1 and NeuroD1 genes are requisite for the maintenance of insulin gene expression in ES-derived differentiated cells
    Koichi Saitoh
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes Res Clin Pract 77:S138-42. 2007
    ..These results suggested that maintenance of the property of insulin-producing cells derived from ES cells could be achieved by synergistic expression of Pdx-1 and NeuroD1...
  12. ncbi request reprint Needleless in vivo gene transfer into muscles by jet injection in combination with electroporation
    Mayumi Horiki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Gene Med 6:1134-8. 2004
    ..Thus the jet-injection method provides a useful means of gene delivery into large muscles, which is essential for future use in human gene therapy...
  13. pmc Acinar-to-ductal metaplasia induced by adenovirus-mediated pancreatic expression of Isl1
    Satsuki Miyazaki
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    PLoS ONE 7:e47536. 2012
    ..Considering the regenerative potential of TCs, a strategy that efficiently induces TC formation may lead to novel therapies for diabetes...
  14. doi request reprint Maternal-effect gene Ces5/Ooep/Moep19/Floped is essential for oocyte cytoplasmic lattice formation and embryonic development at the maternal-zygotic stage transition
    Fumi Tashiro
    Division of Stem Cell Regulation Research, G6, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Genes Cells 15:813-28. 2010
    ..Further analysis showed that CES5/OOEP was directly associated with the CPLs. These results indicate that CES5/OOEP is an essential component of the CPLs and is required for embryonic development at the maternal-zygotic stage transition...
  15. ncbi request reprint Protective effect of montmorillonite on plasmid DNA in oral gene delivery into small intestine
    Masaya Kawase
    Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Biol Pharm Bull 27:2049-51. 2004
    ..These results indicate that montmorillonite protected the plasmid DNA from the acidic environment in the stomach and DNA-degrading enzymes in the intestine, and successfully delivered it into cells of the small intestine...
  16. ncbi request reprint Gene expression pattern of Cue110: a member of the uncharacterized UPF0224 gene family preferentially expressed in germ cells
    Takuji Yoshimura
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Gene Expr Patterns 8:27-35. 2007
    ..Thus, the Cue110 gene is expressed predominantly in male germ cells at stages from the pachytene spermatocytes to round spermatids...
  17. ncbi request reprint Treatment of dilated cardiomyopathy with electroporation of hepatocyte growth factor gene into skeletal muscle
    Kazuo Komamura
    Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Hypertension 44:365-71. 2004
    ..Systemic delivery of gene products with in vivo electroporation into skeletal muscle seemed to be an alternative means of direct gene delivery...
  18. ncbi request reprint Long-term control of food intake and body weight by hydrodynamics-based delivery of plasmid DNA encoding leptin or CNTF
    Jingjing Jiang
    Division of Stem Cell Regulation Research G6, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Gene Med 5:977-83. 2003
    ....
  19. ncbi request reprint Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells
    Yusuke Moritoh
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes 52:1163-8. 2003
    ..These results suggest that ES cells can differentiate not only into endocrine cells but also into exocrine cells of the pancreas, without the initiation of pdx-1 expression...
  20. doi request reprint Molecular scanning of the gene for thioredoxin, an antioxidative and antiapoptotic protein, and genetic susceptibility to type 1 diabetes
    Hiroshi Ikegami
    Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, Osaka, Japan
    Ann N Y Acad Sci 1150:103-5. 2008
    ..4%), followed by type 2 diabetes (6.8%), and the lowest in the controls (5.9%), suggesting the contribution of TXN polymorphism to susceptibility to T1D...
  21. ncbi request reprint Adenoviral transfection of hepatocytes with the thioredoxin gene confers protection against apoptosis and necrosis
    Toshio Tsutsui
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 307:765-70. 2003
    ..These findings provide important information for the development of bioartificial liver support systems and gene therapy for liver diseases...
  22. ncbi request reprint Sustained expression of Fc-fusion cytokine following in vivo electroporation and mouse strain differences in expression levels
    Jingjing Jiang
    Division of Stem Cell Regulation Research G6, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871
    J Biochem 133:423-7. 2003
    ....