J Yamate


Affiliation: Osaka Prefecture University
Country: Japan


  1. Atarashi M, Izawa T, Mori M, Inai Y, Kuwamura M, Yamate J. Dietary Iron Overload Abrogates Chemically-Induced Liver Cirrhosis in Rats. Nutrients. 2018;10: pubmed publisher
    ..Our results suggested that dietary hepatic iron overload abrogates chemically-induced liver cirrhosis in rats, which could partly involve decreased hepatocellular apoptosis. ..
  2. Terada N, Karim M, Izawa T, Kuwamura M, Yamate J. Expression of β-catenin in regenerating renal tubules of cisplatin-induced kidney failure in rats. Clin Exp Nephrol. 2018;22:1240-1250 pubmed publisher
    ..The presence or absence of β-catenin expression would become a marker for the EMT phenomenon in progressive renal fibrosis. ..
  3. Golbar H, Izawa T, Wijesundera K, Tennakoon A, Katou Ichikawa C, Tanaka M, et al. Expression of nestin in remodelling of ?-naphthylisothiocyanate-induced acute bile duct injury in rats. J Comp Pathol. 2014;151:255-63 pubmed publisher
    ..Nestin expression may serve as an indicator for cellular remodelling and behaviour of injured and repopulating bile ducts. ..
  4. Tennakoon A, Izawa T, Wijesundera K, Katou Ichikawa C, Tanaka M, Golbar H, et al. Analysis of glial fibrillary acidic protein (GFAP)-expressing ductular cells in a rat liver cirrhosis model induced by repeated injections of thioacetamide (TAA). Exp Mol Pathol. 2015;98:476-85 pubmed publisher
  5. Kotera T, Katou Ichikawa C, Tennakoon A, Tanaka M, Tanaka N, Izawa T, et al. Rat malignant fibrous histiocytoma (MFH)-derived cloned cell lines (MT-8 and MT-9) show different differentiation in mesenchymal stem cell lineage. Exp Toxicol Pathol. 2015;67:499-507 pubmed publisher
    ..In MFHs, collectively, MT-8 and MT-9 cells are regarded as "tumor stem cells" and "tumor precursors" in the stem cell lineage, respectively, according to the concept of "cancer stem cell theory". ..
  6. Kokoshima H, Yamada N, Doi T, Tsuchitani M, Yamate J. Histopathological and immunohistochemical characterization of spontaneous pituitary tumors in dwarfs derived from Wistar Hannover GALAS rats. Exp Toxicol Pathol. 2016;68:191-6 pubmed publisher
  7. Tennakoon A, Izawa T, Wijesundera K, Murakami H, Katou Ichikawa C, Tanaka M, et al. Immunohistochemical characterization of glial fibrillary acidic protein (GFAP)-expressing cells in a rat liver cirrhosis model induced by repeated injections of thioacetamide (TAA). Exp Toxicol Pathol. 2015;67:53-63 pubmed publisher
    ..These findings, which were shown for the first time in detail, would be useful to understand the role of GFAP-expressing myofibroblasts in the pathogenesis of chemically induced liver cirrhosis. ..
  8. Pervin M, Golbar H, Bondoc A, Izawa T, Kuwamura M, Yamate J. Immunophenotypical characterization and influence on liver homeostasis of depleting and repopulating hepatic macrophages in rats injected with clodronate. Exp Toxicol Pathol. 2016;68:113-24 pubmed publisher
    ..The present study confirmed importance of hepatic macrophages in liver homeostasis. The condition of hepatic macrophages should be taken into consideration when chemicals capable of inhibiting macrophage functions are evaluated. ..
  9. Atarashi M, Izawa T, Miyagi R, Ohji S, Hashimoto A, Kuwamura M, et al. Dietary Iron Supplementation Alters Hepatic Inflammation in a Rat Model of Nonalcoholic Steatohepatitis. Nutrients. 2018;10: pubmed publisher
    ..Iron-laden macrophages can play an important role in the enhancement of hepatic inflammation. ..

More Information


  1. Golbar H, Izawa T, Wijesundera K, Bondoc A, Tennakoon A, Kuwamura M, et al. Depletion of Hepatic Macrophages Aggravates Liver Lesions Induced in Rats by Thioacetamide (TAA). Toxicol Pathol. 2016;44:246-58 pubmed publisher
    ..It was clearly demonstrated that hepatic macrophages have important roles in tissue damage and remodeling in hepatotoxicity. ..
  2. Kuramochi M, Izawa T, Pervin M, Bondoc A, Kuwamura M, Yamate J. The kinetics of damage-associated molecular patterns (DAMPs) and toll-like receptors during thioacetamide-induced acute liver injury in rats. Exp Toxicol Pathol. 2016;68:471-7 pubmed publisher
    ..Our data would contribute to the elucidation of the mechanism of DILI. ..
  3. Karim M, Izawa T, Pervin M, Sasai H, Kuwamura M, Yamate J. Cutaneous Histiocytic Sarcoma with Regional Lymph Node Metastasis in a Netherland Dwarf Rabbit (Oryctolagus cuniculus). J Comp Pathol. 2017;156:169-172 pubmed publisher
    ..To the authors' knowledge cutaneous histiocytic disease has not been reported previously in lagomorphs. ..
  4. Golbar H, Izawa T, Bondoc A, Wijesundera K, Tennakoon A, Kuwamura M, et al. Attenuation of alpha-naphthylisothiocyanate (ANIT)-induced biliary fibrosis by depletion of hepatic macrophages in rats. Exp Toxicol Pathol. 2017;69:221-230 pubmed publisher
    ..The present results indicated clearly importance of macrophage functions in the pathogenesis of biliary fibrosis. ..
  5. Bondoc A, Katou Ichikawa C, Golbar H, Tanaka M, Izawa T, Kuwamura M, et al. Establishment and characterization of a transplantable tumor line (RMM) and cell line (RMM-C) from a malignant amelanotic melanoma in the F344 rat, with particular reference to galectin-3 expression in vivo and in vitro. Histol Histopathol. 2016;31:1195-207 pubmed publisher
    ..These tools are the first tumor lines of amelanotic melanomas in the rat. ..
  6. Bondoc A, Golbar H, Pervin M, Katou Ichikawa C, Tanaka M, Izawa T, et al. Participation of Tumor-Associated Myeloid Cells in Progression of Amelanotic Melanoma (RMM Tumor Line) in F344 Rats, with Particular Reference to MHC Class II- and CD163-Expressing Cells. Cancer Microenviron. 2017;10:9-24 pubmed publisher
    ..Our results provide novel information on tumor-associated myeloid cells in amelanotic melanoma, and may become useful in further research on melanoma immunity. ..
  7. Kuramochi M, Izawa T, Pervin M, Bondoc A, Kuwamura M, LaMarre J, et al. Attenuation of thioacetamide-induced hepatocellular injury by short-term repeated injections associated with down-regulation of metabolic enzymes and relationship with MHC class II-presenting cells. Exp Toxicol Pathol. 2017;69:589-597 pubmed publisher
  8. Tennakoon A, Izawa T, Kuwamura M, Yamate J. Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in Renal and Hepatic Fibrosis. J Clin Med. 2015;5: pubmed publisher
    ..Possible pathogenesis of type 2 EMT and its differences between renal and hepatic fibrosis are reviewed based on our experimental data. ..
  9. Yamate J, Sakamori M, Kuwamura M, Kotani T. Neoplastic and non-neoplastic cell lines from a malignant peripheral nerve sheath tumour of the cervix of a rat. J Comp Pathol. 2007;137:9-21 pubmed publisher
    ..LY-PPB6 and LY-H12 may prove useful for studies on the pathobiological nature of neoplastic cells and interactions between neoplastic and stromal cells in PNSTs. ..
  10. Yano R, Golbar H, Izawa T, Sawamoto O, Kuwamura M, Yamate J. Participation of bone morphogenetic protein (BMP)-6 and osteopontin in cisplatin (CDDP)-induced rat renal fibrosis. Exp Toxicol Pathol. 2015;67:99-107 pubmed publisher
    ..Collectively, it was found that BMP-6 and OPN considerably participate in progressive renal fibrosis through development of myofibroblasts, in relation with TGF-β1. ..
  11. Wijesundera K, Izawa T, Tennakoon A, Golbar H, Tanaka M, Kuwamura M, et al. M1-/M2-macrophage polarization in pseudolobules consisting of adipohilin-rich hepatocytes in thioacetamide (TAA)-induced rat hepatic cirrhosis. Exp Mol Pathol. 2016;101:133-42 pubmed publisher
    ..MHC class II cells may be responsible for steatosis at early stages, suggesting different functions from the above M1-/M2-macropahges. ..
  12. Yamate J, Ishimine S, Izawa T, Kumagai D, Kuwamura M. Macrophage populations and expressions of regulatory proinflammatory factors in the rat meninx under lipopolysaccharide treatment in vivo and in vitro. Histol Histopathol. 2009;24:13-24 pubmed publisher