Toshihide Yamashita

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia
    Atsushi Yamaguchi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 277:623-9. 2002
  2. ncbi request reprint EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway
    Miwa Aoki
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Biol Chem 279:32643-50. 2004
  3. pmc The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho
    Toshihide Yamashita
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Cell Biol 157:565-70. 2002
  4. ncbi request reprint P311 accelerates nerve regeneration of the axotomized facial nerve
    Masashi Fujitani
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Neurochem 91:737-44. 2004
  5. doi request reprint The p75 receptor is associated with inflammatory thermal hypersensitivity
    Tomoko Watanabe
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurosci Res 86:3566-74. 2008
  6. ncbi request reprint Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule
    Takekazu Kubo
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan, and BioClues Inc, Nihonbashi, Chuo Ku, Tokyo, Japan
    J Neurochem 105:113-26. 2008
  7. ncbi request reprint Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis
    Toshinori Ito
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 32:2070-5. 2007
  8. doi request reprint Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse
    Mitsuharu Endo
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Neurosci 29:6649-62. 2009
  9. ncbi request reprint Chimaerins act downstream from neurotrophins in overcoming the inhibition of neurite outgrowth produced by myelin-associated glycoprotein
    Tatsunori Mizuno
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Neurochem 91:395-403. 2004
  10. doi request reprint Transfection of rat cells with proopiomeranocortin gene, precursor of endogenous endorphin, using radial shock waves suppresses inflammatory pain
    Masaomi Yamashita
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 34:2270-7. 2009

Detail Information

Publications92

  1. ncbi request reprint Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia
    Atsushi Yamaguchi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 277:623-9. 2002
    ..These results suggest that Peg3/Pw1 is involved in the p53-mediated cell death pathway as a downstream effector of p53 in brain ischemia/hypoxia...
  2. ncbi request reprint EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway
    Miwa Aoki
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Biol Chem 279:32643-50. 2004
    ..Our results identify EphA receptors as positive regulators of the mitogen-activated protein kinase pathway that exerts neurogenesis of neural precursor cells from the developing central nervous system...
  3. pmc The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho
    Toshihide Yamashita
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Cell Biol 157:565-70. 2002
    ..Ganglioside GT1b, which is one of the binding partners of MAG, specifically associates with p75(NTR). Thus, p75(NTR) and GT1b may form a receptor complex for MAG to transmit the inhibitory signals in neurons...
  4. ncbi request reprint P311 accelerates nerve regeneration of the axotomized facial nerve
    Masashi Fujitani
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Neurochem 91:737-44. 2004
    ..Our data provide evidence that genes involved in the differentiation process contribute to the regeneration of injured mature neurons, and may provide a practical molecular target...
  5. doi request reprint The p75 receptor is associated with inflammatory thermal hypersensitivity
    Tomoko Watanabe
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurosci Res 86:3566-74. 2008
    ..Interference in the binding may provide a therapeutic approach for the treatment of inflammatory pain...
  6. ncbi request reprint Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule
    Takekazu Kubo
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan, and BioClues Inc, Nihonbashi, Chuo Ku, Tokyo, Japan
    J Neurochem 105:113-26. 2008
    ..We conclude that Rho-kinase-dependent activation of MIIA via MLC phosphorylation induces F-actin reduction and growth cone collapse and the subsequent neurite retraction/outgrowth inhibition triggered by RGMa...
  7. ncbi request reprint Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis
    Toshinori Ito
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 32:2070-5. 2007
    ..Immunohistochemical and behavioral study using a rat cauda equina compression model...
  8. doi request reprint Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse
    Mitsuharu Endo
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Neurosci 29:6649-62. 2009
    ....
  9. ncbi request reprint Chimaerins act downstream from neurotrophins in overcoming the inhibition of neurite outgrowth produced by myelin-associated glycoprotein
    Tatsunori Mizuno
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Neurochem 91:395-403. 2004
    ..These results suggest that up-regulated expression of chimaerin counteracts the activation of RhoA, which is a key molecule in transducing inhibitory signals in neurons...
  10. doi request reprint Transfection of rat cells with proopiomeranocortin gene, precursor of endogenous endorphin, using radial shock waves suppresses inflammatory pain
    Masaomi Yamashita
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 34:2270-7. 2009
    ..The effect of proopiomelanocortin (POMC) gene transfer with radial shock waves (RSW) was investigated in vitro and in vivo rat pain models...
  11. pmc RGMa inhibition promotes axonal growth and recovery after spinal cord injury
    Katsuhiko Hata
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    J Cell Biol 173:47-58. 2006
    ..Thus, RGMa plays an important role in limiting axonal regeneration after CNS injury and the RGMa antibody offers a possible therapeutic agent in clinical conditions characterized by a failure of CNS regeneration...
  12. ncbi request reprint Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats
    Yutaka Nishio
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Exp Neurol 200:392-7. 2006
    ..Our findings suggest that RhoA/Rho-kinase alone may not account for the irreversible arrest of axon outgrowth in the chronic stage of injury in the central nervous system...
  13. pmc Identification of the neogenin-binding site on the repulsive guidance molecule A
    Takahide Itokazu
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 7:e32791. 2012
    ..Thus, we propose that this peptide is a promising lead in finding reagents capable of inhibiting RGMa signaling...
  14. ncbi request reprint Multiple signals regulate axon regeneration through the Nogo receptor complex
    Toshihide Yamashita
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Mol Neurobiol 32:105-11. 2005
    ..Possible crosstalk downstream of these signals should be explored to clarify all the inhibitory signals and may provide an efficient molecular target against injuries to the CNS...
  15. ncbi request reprint Induction of repulsive guidance molecule in neurons following sciatic nerve injury
    Hideo Doya
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Japan
    J Chem Neuroanat 32:74-7. 2006
    ..Our present study demonstrates that induction of RGMa is associated with the peripheral nerve injury...
  16. ncbi request reprint FLRT3, a cell surface molecule containing LRR repeats and a FNIII domain, promotes neurite outgrowth
    Lyuji Tsuji
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Osaka, Japan
    Biochem Biophys Res Commun 313:1086-91. 2004
    ..FLRT3 mRNA was especially abundant in the basal ganglia, the granular layer of cerebellum, and the hippocampus, except the CA1 region in the adult rat brain. Thus, FLRT3 may contribute to regeneration following axonal injury...
  17. pmc Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury
    Yuka Nakamura
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 286:1876-83. 2011
    ..These results indicate that PIR-B knock-out is not sufficient to induce extensive axonal regeneration after spinal cord injury...
  18. doi request reprint Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury
    Tomohiro Miyashita
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurotrauma 26:955-64. 2009
    ..Thus, reexpression of the embryonic repulsive cues in adult tissues contributes to the failure of axon regeneration in the central nervous system...
  19. doi request reprint RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis
    Rieko Muramatsu
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Med 17:488-94. 2011
    ..These results demonstrate that an RGMa-specific antibody suppresses T cell responses, and suggest that RGMa could be a promising molecular target for the treatment of multiple sclerosis...
  20. doi request reprint Layer V cortical neurons require microglial support for survival during postnatal development
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Neurosci 16:543-51. 2013
    ..Our results highlight a neuron-glia interaction that is indispensable for network formation during a specific period in the developing brain...
  21. ncbi request reprint Wallerian degeneration involves Rho/Rho-kinase signaling
    Satoru Yamagishi
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Biol Chem 280:20384-8. 2005
    ..Our findings suggest that inhibiting the signaling pathway may retard axon degeneration in pathological conditions...
  22. ncbi request reprint Role of Clast1 in development of cerebellar granule cells
    Yukiteru Maeda
    Department of Developmental Genetics H2, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Brain Res 1104:18-26. 2006
    ..Histopathological analysis of the developing Clast1-KO cerebellum demonstrated the reduced number of cells in the external germinal layer. Thus, Clast1 is required for development of cerebellar granule cells...
  23. ncbi request reprint Neogenin and repulsive guidance molecule signaling in the central nervous system
    Toshihide Yamashita
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Curr Opin Neurobiol 17:29-34. 2007
    ..Thus, re-expression of embryonic repulsive cues in adult tissues contributes to failure of axon regeneration in the central nervous system...
  24. pmc Unc5B associates with LARG to mediate the action of repulsive guidance molecule
    Katsuhiko Hata
    Department of Molecular Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Cell Biol 184:737-50. 2009
    ..Focal adhesion kinase (FAK) is involved in RGMa-induced tyrosine phosphorylation of LARG as well as RhoA activation. These findings uncover the molecular basis for diverse functions mediated by RGMa...
  25. ncbi request reprint Changes in mRNA of Slit-Robo GTPase-activating protein 2 following facial nerve transection
    Tomas Madura
    Department of Plastic Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 123:76-80. 2004
    ..The upregulation was found mostly in the neuronal cells and only to a small extent in the glial cells. Our results suggest that srGAP2, as a part of Slit-Robo pathway, plays an important role in the axonal regeneration after axotomy...
  26. doi request reprint Corticospinal tract fibers cross the ephrin-B3-negative part of the midline of the spinal cord after brain injury
    Shusaku Omoto
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Neurosci Res 69:187-95. 2011
    ..Our results suggest that ephrin-B3 is not expressed along the entire midline of the spinal cord, and sprouting axons can cross the midline at ephrin-B3-negative areas...
  27. doi request reprint Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Brain 135:1253-67. 2012
    ..Our findings establish the anatomical, functional and molecular basis for the intrinsic capacity of neurons to form compensatory neural network following injury...
  28. ncbi request reprint Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury
    Akihiro Kyoto
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Brain Res 1186:74-86. 2007
    ..These findings suggest that the suppression of synaptic rearrangements as well as axon growth inhibition in the adult spinal cord may contribute to the limitation of functional recovery after SCI...
  29. doi request reprint Role of RhoA in activity-dependent cortical axon branching
    Soichiro Ohnami
    Laboratory of Cellular and Molecular Neurobiology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Neurosci 28:9117-21. 2008
    ..These findings suggest that RhoA signaling acts as a positive regulator for activity-dependent axon branching in cortical neurons...
  30. ncbi request reprint [Molecular mechanism that inhibits axon regeneration]
    Toshihide Yamashita
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
    Seikagaku 77:1475-80. 2005
  31. ncbi request reprint Repulsion of cerebellar granule neurons by chondroitin sulfate proteoglycans is mediated by MAPK pathway
    Meika Kaneko
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Neurosci Lett 423:62-7. 2007
    ..The MAPK pathway was activated in the neurons treated with CSPGs, and this activation was dependent on EGFR. Thus, CSPGs triggered the inhibition of CGNs through the activation of the EGFR-mediated MAPK pathway...
  32. doi request reprint BMP inhibition enhances axonal growth and functional recovery after spinal cord injury
    Iichiro Matsuura
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    J Neurochem 105:1471-9. 2008
    ..Thus, BMPs play a role in inhibiting axonal regeneration and limiting functional recovery following injury to the CNS...
  33. doi request reprint Nerve growth factor of cultured medium extracted from human degenerative nucleus pulposus promotes sensory nerve growth and induces substance p in vitro
    Kazuyo Yamauchi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 34:2263-9. 2009
    ..We investigated the mechanism of discogenic low back pain using an in vitro model...
  34. doi request reprint Chronic inflammatory demyelinating polyneuropathy sera inhibit axonal growth of mouse dorsal root ganglion neurons by activation of Rho-kinase
    Junko Taniguchi
    Department of Neurology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Ann Neurol 66:694-7. 2009
    ..These findings suggest that CIDP sera inhibit axonal elongation by Rho-kinase activation, and some serum factors may be responsible for development of axonal degeneration in CIDP...
  35. ncbi request reprint Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G
    Yuiko Hasegawa
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    J Neurosci 24:6826-32. 2004
    ..Activation of RhoA is independent of PKC. Thus, a balance between PKC and IP3 is important for bidirectional regulation of axon regeneration by the myelin-derived proteins...
  36. doi request reprint Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury
    Shusaku Omoto
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita Shi, Osaka 565 0871, Japan
    J Neurosci 30:13045-52. 2010
    ..Our results suggest that blocking the function of PirB is not sufficient to promote axonal reorganization or functional recovery after cortical injury...
  37. ncbi request reprint A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling
    Tateki Kubo
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    J Neurosci 22:8504-13. 2002
    ..These results suggest that FIR may regulate neurite remodeling by mediating the signaling pathways from membrane proteins to Rac...
  38. pmc Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice
    Xuemei Jin
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita Shi, Osaka, Japan
    PLoS ONE 7:e41892. 2012
    ..In contrast, some immune responses have neuroprotective effects. However, detailed information regarding the dynamics of immune responses after traumatic CNS injury is still unavailable...
  39. doi request reprint TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule
    Yusuke Okamura
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Res 71:63-70. 2011
    ..Conversely, exogenous expression of TACE abolishes the effect of RGMa. Therefore, TACE may play a role in modulating the RGM-induced repulsive behavior of neurons by regulating the expression of neogenin on the cell surface...
  40. ncbi request reprint Functional inhibition of the p75 receptor using a small interfering RNA
    Haruhisa Higuchi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Biochem Biophys Res Commun 301:804-9. 2003
    ..Inhibition of p75(NTR) in specific pathological conditions by the siRNA may provide a potential therapeutic agent...
  41. ncbi request reprint [Repair strategies for the injured central nervous system]
    Toshihide Yamashita
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    No Shinkei Geka 35:733-9. 2007
  42. doi request reprint miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression
    Rikako Sanuki
    Department of Developmental Biology, Osaka Bioscience Institute, Suita, Osaka, Japan
    Nat Neurosci 14:1125-34. 2011
    ..These results suggest that miR-124a is essential for the maturation and survival of dentate gyrus neurons and retinal cones, as it represses Lhx2 translation...
  43. doi request reprint Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury
    Xiaoxiang Liu
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Biochem Biophys Res Commun 382:795-800. 2009
    ..These findings suggest that RGMb is a myelin-derived inhibitor of axon growth in the CNS. Inhibition of RGMb may provide an alternative approach for the treatment of spinal injuries...
  44. ncbi request reprint Expression of FERM domain including guanine nucleotide exchange factor mRNA in adult rat brain
    Tomas Madura
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 114:163-7. 2003
    ..The expression was found all throughout the brain with the most intensive signals in hippocampus, piriform cortex, red nucleus and nuclei of cranial nerves. The signal was predominantly localized in the neuronal cells...
  45. ncbi request reprint Extracellular signal-regulated kinase mitogen-activated protein kinase activation in the dorsal root ganglion (DRG) and spinal cord after DRG injury in rats
    Hideo Doya
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 30:2252-6. 2005
    ..We investigated the extracellular signal-regulated kinase (ERK) activation by immunohistochemically detecting phosphorylated ERK (pERK) in the dorsal root ganglion (DRG) and spinal cord...
  46. ncbi request reprint Adenoviral gene transfer in the peripheral nervous system
    Tomoko Saito Watanabe
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    J Orthop Sci 11:64-9. 2006
    ..There are no data showing efficiency of protein transduction in the PNS, which consists of a variety of cell types, many of which are postmitotic...
  47. ncbi request reprint Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts
    Masashi Fujitani
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 327:150-4. 2005
    ..Proper recruitment of activated Rac1 to lipid rafts, structures that represent specialized signaling organelles, is of fundamental importance in determining neurotrophins' bioactivity...
  48. ncbi request reprint Progressive hearing loss in mice carrying a mutation in the p75 gene
    Takashi Sato
    Department of Otolaryngology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res 1091:224-34. 2006
    ....
  49. pmc Neogenin, a receptor for bone morphogenetic proteins
    Meiko Hagihara
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 286:5157-65. 2011
    ..Taken together, our findings suggest that neogenin negatively regulates the functions of BMP and that this effect of neogenin is mediated by the activation of RhoA...
  50. pmc Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity
    Yuki Fujita
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    EMBO J 30:1389-401. 2011
    ..Moreover, in vivo transfection of small interfering RNA (siRNA) for SHP-1 or SHP-2 induced axonal regeneration after optic nerve injury in mice. Our results thus identify a new molecular target to enhance regeneration of the injured CNS...
  51. ncbi request reprint Identification and characterization of a novel mitochondrial tricarboxylate carrier
    Shin ichi Miyake
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 295:463-8. 2002
    ..In contrast, the expression of TCC is rather ubiquitous and strong in neuronal cells in the brain. This new family of proteins may contribute to biosynthesis and bioenergetics in the brain...
  52. doi request reprint Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin
    Rieko Muramatsu
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Nat Med 18:1658-64. 2012
    ..These findings reveal an important function of angiogenesis in neuronal rewiring and suggest that prostacyclin is a promising molecule for enhancing functional recovery from CNS disease...
  53. doi request reprint c-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice
    Kazuhiro Yoshimura
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita Shi, Osaka, Japan
    Neurosci Res 71:266-77. 2011
    ..These results indicate that both JNK1 and JNK3 induce axonal degeneration and limit motor recovery after SCI. Thus, a JNK inhibitor may be a suitable therapeutic agent for SCI...
  54. doi request reprint Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins
    Hiroshi Ishii
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 402:168-72. 2010
    ..These results demonstrate that Sema4A and IFN-γ expressed in Th1 cells play a critical role in enhancing neurite outgrowth from cortical neurons...
  55. pmc Zyxin is a novel interacting partner for SIRT1
    Yuki Fujita
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    BMC Cell Biol 10:6. 2009
    ..Recent studies have revealed SIRT1 protects neurons from axonal degeneration or neurodegeneration. Further, SIRT1 null mice exhibit growth retardation and developmental defects, suggesting its critical roles in neurons and development...
  56. pmc PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts
    Haruhisa Higuchi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 087, Japan
    EMBO J 22:1790-800. 2003
    ..Proper recruitment of activated p75(NTR) to lipid rafts, structures that represent specialized signaling organelles, is of fundamental importance in determining p75(NTR) bioactivity...
  57. ncbi request reprint The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
    Toshihide Yamashita
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nat Neurosci 6:461-7. 2003
    ..This peptide has potential as a therapeutic agent against the inhibitory cues that block regeneration in the central nervous system...
  58. ncbi request reprint Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction
    Masashi Fujitani
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Japan
    J Neurochem 94:15-21. 2005
    ..These findings establish gangliosides as functional binding partners for soluble MAG. Gangliosides may play a role in translocation of p75(NTR.) to lipid rafts for initiation of the signal transduction...
  59. doi request reprint Inhibition of branching and spine maturation by repulsive guidance molecule in cultured cortical neurons
    Junko Yoshida
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Japan
    Biochem Biophys Res Commun 372:725-9. 2008
    ..This RGMa-mediated inhibition of the assembly of presynaptic and postsynaptic components suggests a role of RGMa in inhibiting mature synapse formation. Thus, RGMa may negatively regulate neuronal network formation in cortical neurons...
  60. ncbi request reprint p75 neurotrophin receptor signaling in the nervous system
    Yuiko Hasegawa
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Biotechnol Annu Rev 10:123-49. 2004
    ..p75(NTR) is a key receptor for myelin-derived inhibitory cues that contribute to the lack of regeneration of the central nervous system...
  61. pmc Chondroitin sulfate proteoglycans down-regulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB) protein
    Dai Kurihara
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    J Biol Chem 287:13822-8. 2012
    ..These results suggest that the inhibitory activity of CSPGs on dendritic spine formation operates through the targeting of neurotrophins at the receptor level...
  62. ncbi request reprint Diverse functions of the p75 neurotrophin receptor
    Toshihide Yamashita
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Anat Sci Int 80:37-41. 2005
    ..This diversity can be explained by the complex formation of p75NTR with other receptors and multiple signaling molecules that interact with the intracellular domain of p75NTR...
  63. doi request reprint Expression of galectin-1 in immune cells and glial cells after spinal cord injury
    Dai Kurihara
    Department of Molecular Neuroscience, Osaka University, Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Res 66:265-70. 2010
    ..These results suggest that galectin-1 may be associated with the pathogenesis of spinal cord injury...
  64. doi request reprint Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin β
    Ryo Ohara
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 405:697-702. 2011
    ..Taken together, these results suggest that retrograde transport of injury-induced signals in injured axons play key roles in the axotomy-induced axonogenesis of hippocampal neurons...
  65. ncbi request reprint c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity
    Hideo Doya
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 335:132-8. 2005
    ..These findings demonstrate that JNK is a therapeutic target for treating inflammation-induced pain hypersensitivity...
  66. ncbi request reprint Intrinsic regenerative mechanisms of central nervous system neurons
    Rieko Muramatsu
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    Biosci Trends 3:179-83. 2009
    ..Enhancing the intrinsic regenerative machinery of injured axons in the adult CNS is a potentially powerful strategy for treating patients with a CNS injury...
  67. doi request reprint Kinematic analyses reveal impaired locomotion following injury of the motor cortex in mice
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Exp Neurol 230:280-90. 2011
    ..Our findings provide practical parameters to assess motor deficits and recovery following cortical injury in mice...
  68. doi request reprint Peptides derived from repulsive guidance molecule act as antagonists
    Masayoshi Suda
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Japan
    Biochem Biophys Res Commun 371:501-4. 2008
    ..The peptides studied in vitro dose-dependently suppressed the neurite growth inhibition and growth cone collapse induced by RGMa. Thus, these peptides are promising reagents to treat injuries of the central nervous system...
  69. ncbi request reprint Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays
    Tateki Kubo
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Japan
    J Neurochem 82:1129-36. 2002
    ..In addition to unknown genes, there seemed to be a lot of annotated genes whose role in nerve regeneration remains unknown...
  70. ncbi request reprint Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration
    Takekazu Kubo
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Curr Pharm Des 13:2493-9. 2007
    ..Therefore, the Rho-ROCK inhibitors have a therapeutic potential against injuries to the human CNS, such as spinal cord injuries...
  71. pmc Activation of Rho in the injured axons following spinal cord injury
    Tomas Madura
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    EMBO Rep 5:412-7. 2004
    ..Following spinal cord injury in vivo, massive activation of Rho is observed in the injured neurites. Spatial regulation of Rho activity may be necessary for axonal regulation by the inhibitory cues...
  72. ncbi request reprint Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain
    Akihiro Kawakita
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Dev Brain Res 144:181-9. 2003
    ..These results suggest that FIR may play a role not only in neurogenesis, but also in the asymmetrical cell division and migration of neurons...
  73. ncbi request reprint Changes in mRNA for choline transporter-like protein following facial nerve transection
    Yong Ho Che
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 101:122-5. 2002
    ..These results suggest that rCTL1 is involved in activated choline uptake for membrane synthesis in motoneurons following nerve transection...
  74. pmc Engulfment of axon debris by microglia requires p38 MAPK activity
    Tatsuhide Tanaka
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 284:21626-36. 2009
    ..We observed regrowth of the severed neurites after axon debris was removed. This finding suggests that axon debris, in addition to myelin debris, is an inhibitory factor for axon regeneration...
  75. ncbi request reprint The p75 receptor is required for BDNF-induced differentiation of neural precursor cells
    Sanae Hosomi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 301:1011-5. 2003
    ..These findings suggest that the p75NTR is required for proper neuronal fate decision as well as the differentiation of the neural precursor cells...
  76. ncbi request reprint Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain
    Shin ichi Miyake
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 100:67-73. 2002
    ..Our results suggest that this tricarboxylate carrier protein may contribute to biosynthesis and bioenergetics in neuronal cells in brain...
  77. pmc Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity
    Hiroyuki Tanaka
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Cell Biol 158:321-9. 2002
    ..These results suggest that cytoplasmic p21(Cip1/WAF1) may contribute to the developmental process of the newborn neurons that extend axons and dendrites into target regions...
  78. ncbi request reprint [Molecular mechanism and regulation of axon growth inhibition]
    Toshihide Yamashita
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Brain Nerve 59:1347-53. 2007
    ..The molecular mechanism of this phenomenon is poorly understood, and elucidation of this will contribute to enhancement of functional recovery after incomplete injury to the CNS. I will summarize recent findings regarding these issues...
  79. ncbi request reprint BMP inhibits neurite growth by a mechanism dependent on LIM-kinase
    Iichiro Matsuura
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 360:868-73. 2007
    ..Thus, BMP-2 inhibits neurite outgrowth by a LIM-kinase 1-dependent mechanism, and our findings add a new member to the group of neurite growth inhibitors...
  80. doi request reprint Endothelin promotes neurite elongation by a mechanism dependent on c-Jun N-terminal kinase
    Noriko Uesugi
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 383:509-12. 2009
    ..Thus, endothelin induces cortical neurite elongation through the endothelin A receptor by a mechanism dependent on JNK...
  81. pmc Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance
    Mitsuru Shinohara
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 285:22091-102. 2010
    ..These results have important implications for the development of disease-modifying therapy for Alzheimer disease as well as understanding of Abeta metabolism...
  82. ncbi request reprint Rho-ROCK inhibitors for the treatment of CNS injury
    Takekazu Kubo
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Recent Pat CNS Drug Discov 2:173-9. 2007
    ..This review also discusses recent patents and future developments which are useful in the treatment of human CNS injuries...
  83. doi request reprint Inhibition of TGF-beta1 promotes functional recovery after spinal cord injury
    Masaaki Kohta
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Res 65:393-401. 2009
    ..These results support the possibility of using TGF-beta1 inhibitors in the treatment of human spinal cord injuries...
  84. ncbi request reprint Changes in mRNA for VAMPs following facial nerve transection
    Yong Ho Che
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, Japan
    J Chem Neuroanat 24:147-52. 2002
    ..On the contrary, VAMP1 mRNA, which was abundantly expressed in the control facial nucleus, was transiently decreased from 3 to 21 days after axotomy. Differential regulation of VAMPs may reflect distinct roles in nerve regeneration...
  85. ncbi request reprint Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism
    Harald Neumann
    Departments of Neuroimmunology and Neurobiochemistry, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Neurosci 22:854-62. 2002
    ..These results suggest that glia-derived TNF, as part of an injury or inflammatory process, can inhibit neurite elongation and branching during development and regeneration...
  86. ncbi request reprint [Regeneration and plasticity of the injured central nervous system]
    Toshihide Yamashita
    Tanpakushitsu Kakusan Koso 52:11-7. 2007
  87. pmc The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system
    Bernhard K Mueller
    Neuroscience Discovery Research, Abbott GmbH and Co KG, Knollstrasse 50, 67061 Ludwigshafen, Germany
    Philos Trans R Soc Lond B Biol Sci 361:1513-29. 2006
    ..An example for embryonic repulsive directional cues re-expressed at lesion sites in both the rat and human CNS is provided with repulsive guidance molecules, a new family of directional guidance cues...
  88. ncbi request reprint Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury
    Akiyuki Hiraga
    Department of Neurobiology, Chiba University Graduate School of Medicine, Chiba, Japan
    J Peripher Nerv Syst 11:217-24. 2006
    ..In addition, fasudil does not suppress the myelination of regenerating axons. These findings suggest that RhoA/Rho-kinase may be a practical molecular target to enhance axonal regeneration in human peripheral neuropathies...
  89. ncbi request reprint [Therapeutic strategy to promote regeneration of the injured central nervous system]
    Toshihide Yamashita
    Department of Neurobiology, Graduate School of Medicine, Chiba University
    Nihon Rinsho 64:1553-60. 2006
    ..In addition, it is noted that synaptic plasticity in pre-existing pathways and the formation of new circuits through collateral sprouting of lesioned and unlesioned fibers are important components of the recovery process...
  90. ncbi request reprint Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism
    Fumiaki Mimura
    Department of Neurobiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670
    J Biol Chem 281:15970-9. 2006
    ..Our data suggest the important roles of CRMP-2 and microtubules in the inhibition of the axon regeneration by the myelin-derived inhibitors...
  91. ncbi request reprint [Inhibition of axon regeneration by myelin inhibitors]
    Toshihide Yamashita
    Tanpakushitsu Kakusan Koso 50:403-9. 2005
  92. ncbi request reprint Induction of mRNAs and proteins for Na/K ATPase alpha1 and beta1 subunits following hypoxia/reoxygenation in astrocytes
    Kosuke Kasai
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 110:38-44. 2003
    ..These findings suggest that Na/K ATPases may contribute to maintain the cellular environment of astrocytes subjected to hypoxia/reoxygenation...