Shizuya Yamashita

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint High concentration of glucose induces the expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells
    S Takami
    Second Department of Internal Medicine, Osaka University Medical School, Suita, Japan
    Atherosclerosis 138:35-41. 1998
  2. doi request reprint Differential reactivities of four homogeneous assays for LDL-cholesterol in serum to intermediate-density lipoproteins and small dense LDL: comparisons with the Friedewald equation
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Clin Chim Acta 410:31-8. 2009
  3. ncbi request reprint Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients
    Shizuya Yamashita
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Mol Cell Biochem 299:19-22. 2007
  4. doi request reprint Where are we with probucol: a new life for an old drug?
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Atherosclerosis 207:16-23. 2009
  5. ncbi request reprint Molecular mechanisms of HDL-cholesterol elevation by statins and its effects on HDL functions
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    J Atheroscler Thromb 17:436-51. 2010
  6. ncbi request reprint Roles of plasma lipid transfer proteins in reverse cholesterol transport
    S Yamashita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Front Biosci 6:D366-87. 2001
  7. ncbi request reprint Molecular biology and pathophysiological aspects of plasma cholesteryl ester transfer protein
    S Yamashita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochim Biophys Acta 1529:257-75. 2000
  8. pmc Fasting remnant lipoproteins can predict postprandial hyperlipidemia
    Tomoki Nagata
    Division of Clinical Nutrition, Faculty of Nutrition, Kobe Gakuin University, 518 Arise, Ikawadani cho, Nishi ku, Kobe, 651 2180, Japan
    Lipids Health Dis 11:146. 2012
  9. ncbi request reprint Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations
    Masahiro Koseki
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Atheroscler Thromb 16:292-6. 2009
  10. doi request reprint Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages
    Kazumi Tsubakio-Yamamoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamamdaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 375:390-4. 2008

Collaborators

Detail Information

Publications57

  1. ncbi request reprint High concentration of glucose induces the expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells
    S Takami
    Second Department of Internal Medicine, Osaka University Medical School, Suita, Japan
    Atherosclerosis 138:35-41. 1998
    ..6 mM). We conclude that a high concentration of glucose can induce ICAM-1 in endothelial cells and that this effect may play an important role in atherogenesis in patients with diabetes mellitus...
  2. doi request reprint Differential reactivities of four homogeneous assays for LDL-cholesterol in serum to intermediate-density lipoproteins and small dense LDL: comparisons with the Friedewald equation
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Clin Chim Acta 410:31-8. 2009
    ..We investigated the relationship between the Friedewald equation and 4 homogeneous assays for LDL-C...
  3. ncbi request reprint Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients
    Shizuya Yamashita
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Mol Cell Biochem 299:19-22. 2007
    ....
  4. doi request reprint Where are we with probucol: a new life for an old drug?
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Atherosclerosis 207:16-23. 2009
    ..Therefore, probucol could be a more common therapeutic drug for the treatment of patients with FH as well. There is more than enough reason to believe that this old drug has much more to offer than hitherto known...
  5. ncbi request reprint Molecular mechanisms of HDL-cholesterol elevation by statins and its effects on HDL functions
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    J Atheroscler Thromb 17:436-51. 2010
    ..In the future, it may be necessary to assess the functions of HDL elevated by statins, and select statins based on differences in their effects in clinical practice...
  6. ncbi request reprint Roles of plasma lipid transfer proteins in reverse cholesterol transport
    S Yamashita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Front Biosci 6:D366-87. 2001
    ..The current review will also focus on the molecular genetics and function of plasma lipid transfer proteins, including CETP and PLTP...
  7. ncbi request reprint Molecular biology and pathophysiological aspects of plasma cholesteryl ester transfer protein
    S Yamashita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochim Biophys Acta 1529:257-75. 2000
    ..The current review will focus on the recent findings on the molecular biology and pathophysiological aspects of plasma CETP, a key protein in reverse cholesterol transport...
  8. pmc Fasting remnant lipoproteins can predict postprandial hyperlipidemia
    Tomoki Nagata
    Division of Clinical Nutrition, Faculty of Nutrition, Kobe Gakuin University, 518 Arise, Ikawadani cho, Nishi ku, Kobe, 651 2180, Japan
    Lipids Health Dis 11:146. 2012
    ..Hypertriglyceridemia and postprandial hyperlipidemia is thought to play an important role in atherosclerosis, but to select patients at high-risk for cardiovascular diseases is difficult with triglycerides (TG) alone in these patients...
  9. ncbi request reprint Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations
    Masahiro Koseki
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Atheroscler Thromb 16:292-6. 2009
    ..The aim of the current study was to confirm these findings by the oral glucose tolerance test (OGTT) in human subjects with ABCA1 deficiency...
  10. doi request reprint Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages
    Kazumi Tsubakio-Yamamoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamamdaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 375:390-4. 2008
    ..In summary, APN might protect against atherosclerosis by increasing apoA-I-mediated cholesterol efflux from macrophages through ABCA1-dependent pathway by the activation of LXRalpha and PPARgamma...
  11. ncbi request reprint Guidelines for the management of familial hypercholesterolemia
    Mariko Harada-Shiba
    Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    J Atheroscler Thromb 19:1043-60. 2012
    ..The treatment cost of homozygous FH is authorized to be covered under the program of Research on Measures against Intractable Diseases by the Japanese Ministry of Health, Labour, and Welfare...
  12. ncbi request reprint Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver
    Hiroyuki Oku
    Department of Cardiovascular Medicine, Osaka University, Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    FEBS Lett 581:5029-33. 2007
    ..The ABCA1 expression in liver was also decreased in APN-KO mice. APN deficiency might cause the impaired HDL assembly by decreasing ABCA1 expression and apoA-I synthesis in the liver...
  13. ncbi request reprint Fenofibrate reduces postprandial hypertriglyceridemia in CD36 knockout mice
    Jose C Sandoval
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Atheroscler Thromb 17:610-8. 2010
    ..Fenofibrate was reported to reduce fasting and postprandial triglyceride (TG) levels in hypertriglyceridemic subjects with MetS. To define its mechanism, we investigated the effect of fenofibrate on PHTG in CD36KO...
  14. ncbi request reprint Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism
    Ken ichi Hirano
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Arterioscler Thromb Vasc Biol 25:2422-7. 2005
    ..The aim of the present study was to know the effect of probucol on the expression of SR-BI and the underlying mechanism...
  15. ncbi request reprint Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver
    Fumihiko Matsuura
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 358:1091-5. 2007
    ..Taken together, the current study demonstrates that APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver...
  16. doi request reprint Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography
    Kazumi Tsubakio-Yamamoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Metabolism 61:1763-70. 2012
    ..It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism...
  17. ncbi request reprint Molecular mechanisms of ezetimibe-induced attenuation of postprandial hypertriglyceridemia
    Jose C Sandoval
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 17:914-24. 2010
    ..In the current study, we investigated the effect of ezetimibe on PHTG in this mouse model of metabolic syndrome...
  18. ncbi request reprint Familial massive tendon xanthomatosis with decreased high-density lipoprotein-mediated cholesterol efflux
    Fumihiko Matsuura
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Metabolism 54:1095-101. 2005
    ....
  19. ncbi request reprint Atorvastatin markedly improves type III hyperlipoproteinemia in association with reduction of both exogenous and endogenous apolipoprotein B-containing lipoproteins
    Masato Ishigami
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 168:359-66. 2003
    ..Taken together, atorvastatin improves remnant lipoprotein metabolism in type III HLP both in quality and in quantity. Atorvastatin can be one of the optimal options for the treatment of patients with type III HLP...
  20. pmc Chylomicron remnants are increased in the postprandial state in CD36 deficiency
    Daisaku Masuda
    Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Lipid Res 50:999-1011. 2009
    ..These results suggest that CD36-D might increase atherosclerotic risk by enhancing plasma level of CM remnants due to the increased synthesis of lipoproteins smaller than CM in size in the intestine...
  21. doi request reprint Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence
    Daisaku Masuda
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Eur J Clin Invest 42:992-9. 2012
    ..We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD)...
  22. ncbi request reprint Effect of probucol on antioxidant properties of HDL in patients with heterozygous familial hypercholesterolemia
    Miwako Inagaki
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Atheroscler Thromb 19:643-56. 2012
    ..To elucidate the effect of probucol on antioxidant properties of HDL, we investigated the function of HDL derived from patients with heterozygous familial hypercholesterolemia (FH) who have been treated with probucol...
  23. ncbi request reprint Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands
    Tohru Ohama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 296:625-30. 2002
    ....
  24. ncbi request reprint Apolipoprotein B-48 to triglyceride ratio is a novel and useful marker for detection of type III hyperlipidemia after antihyperlipidemic intervention
    Miyako Yuasa-Kawase
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 19:862-71. 2012
    ....
  25. ncbi request reprint Senescent phenotypes of skin fibroblasts from patients with Tangier disease
    Fumihiko Matsuura
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 357:493-8. 2007
    ..Taken together, the current study demonstrates that the late-passaged TD fibroblasts showed senescent phenotype in vitro, which might be related to the increased cardiovascular manifestations in TD patients...
  26. ncbi request reprint RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation
    Hanjun Zhao
    Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Circ J 70:615-24. 2006
    ..The present study was designed to assess whether RECS1 KO mice have altered gelatinase (matrix metalloproteinase (MMP)-2 and MMP-9) levels and whether they are prone to aortic dilation...
  27. ncbi request reprint Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases
    Miyako Yuasa-Kawase
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 19:263-75. 2012
    ..The current study aimed to investigate the morbidity and severity of cardiovascular diseases in CD36-D patients...
  28. ncbi request reprint Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia
    Daisaku Masuda
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 18:1062-70. 2011
    ....
  29. doi request reprint Serum apolipoprotein B-48 levels are correlated with carotid intima-media thickness in subjects with normal serum triglyceride levels
    Kazuhiro Nakatani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 218:226-32. 2011
    ....
  30. ncbi request reprint Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages
    Masahiro Koseki
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Lipid Res 48:299-306. 2007
    ..We report here that Abca1-KO macrophages with defective lipid efflux exhibited increased lipid rafts on the cell surface and accelerated TNF-alpha secretion...
  31. ncbi request reprint Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease
    Satomi Mugii
    Division of Laboratory for Clinical Investigation, Department of Medical Technology, Osaka University Hospital, Osaka, Japan
    J Atheroscler Thromb 19:890-6. 2012
    ..To clarify the clinical significance of apoB-48 measurement in patients with thyroid disease, we investigated the correlations between the serum apoB-48 level and thyroid hormones...
  32. ncbi request reprint Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase
    Zhongyan Zhang
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Exp Gerontol 40:286-94. 2005
    ..These data indicated that the reduced expression of Cdc42 may be responsible for the abnormal lipid transport, which in turn might be related to the cardiovascular manifestations in WS...
  33. ncbi request reprint Human scavenger receptor class B type I is expressed with cell-specific fashion in both initial and terminal site of reverse cholesterol transport
    Yumiko Nakagawa-Toyama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 183:75-83. 2005
    ..These data clearly demonstrated that SR-BI was expressed with cell-specific fashions in both the initial and terminal step of RCT in humans. Thus, SR-BI might be physiologically relevant and have distinct tissue-specific functions...
  34. ncbi request reprint Evaluation of a homogeneous assay for measuring LDL-cholesterol in hyperlipidemic serum specimens
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    J Atheroscler Thromb 15:82-6. 2008
    ..In this study, we examined the reactivity of a homogeneous assay, Cholestest LDL (R) (CT-LDL), with hyperlipemic sera that were classified according to the WHO system...
  35. ncbi request reprint Current therapy for patients with sitosterolemia--effect of ezetimibe on plant sterol metabolism
    Kazumi Tsubakio-Yamamoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Atheroscler Thromb 17:891-900. 2010
    ..3% and 48.9%, respectively, in the two patients, demonstrating ezetimibe as a novel and potent treatment agent for sitosterolemia that could work additively with conventional drug therapy...
  36. ncbi request reprint Distal protection during primary coronary intervention can preserve the index of microcirculatory resistance in patients with acute anterior ST-segment elevation myocardial infarction
    Noritoshi Ito
    Senri Critical Care Medical Center, Critical and Cardiovascular Care Unit, Osaka Saiseikai Senri Hospital, Suita, Japan
    Circ J 75:94-8. 2011
    ....
  37. ncbi request reprint Comparison of eight- versus 16-slice multidetector-row computed tomography for visibility and image quality of coronary segments
    Takao Maruyama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Am J Cardiol 94:1539-43. 2004
    ....
  38. ncbi request reprint Retarded intracellular lipid transport associated with reduced expression of Cdc42, a member of Rho-GTPases, in human aged skin fibroblasts: a possible function of Cdc42 in mediating intracellular lipid transport
    Kosuke Tsukamoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 22:1899-904. 2002
    ..Recently, we raised the hypothesis that Cdc42, which is a member of the Rho-GTPase family and is known to play an important role in actin dynamics, might be important in cellular lipid transport...
  39. pmc Establishment of a novel murine model of ischemic cardiomyopathy with multiple diffuse coronary lesions
    Hajime Nakaoka
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    PLoS ONE 8:e70755. 2013
    ..Therefore, we aimed to modify the HypoE mouse model to establish a novel model for ischemic cardiomyopathy caused by atherosclerotic lesions, which the ligation model does not exhibit...
  40. doi request reprint Remnant lipoprotein-cholesterol is a predictive biomarker for large artery atherosclerosis in apparently healthy women: usefulness as a parameter for annual health examinations
    Mikiyasu Taguchi
    Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka
    Ann Clin Biochem 48:332-7. 2011
    ..It should be emphasized that conventional risk factors are still strong predictors for large artery atherosclerosis in the whole group...
  41. ncbi request reprint Pathophysiology of human genetic CD36 deficiency
    Ken ichi Hirano
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Trends Cardiovasc Med 13:136-41. 2003
    ..It also has been reported that CD36 deficiency might be linked with cardiomyopathy. These data raised the possibility that CD36 deficiency might be an important genetic background for these life-threatening human cardiovascular diseases...
  42. ncbi request reprint Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 15:292-303. 2008
    ..a potent anti-oxidant and cholesteryl ester transfer protein (CETP) activator is associated with a lowered risk of cardiovascular events in a very high-risk population: familial hypercholesterolemia (FH)...
  43. ncbi request reprint Decreased microsomal triglyceride transfer protein activity contributes to initiation of alcoholic liver steatosis in rats
    Taizo Sugimoto
    Department of Internal Medicine and Molecular Science, B5, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Hepatol 36:157-62. 2002
    ..To elucidate the role of microsomal triglyceride transfer protein (MTP) in the pathogenesis of alcoholic fatty liver, the effects of ethanol on MTP activity and gene expression were investigated...
  44. ncbi request reprint Prevalence and phenotypic spectrum of cholesteryl ester transfer protein gene mutations in Japanese hyperalphalipoproteinemia
    Takao Maruyama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, B5, Suita, Osaka 565 0871, Japan
    Atherosclerosis 166:177-85. 2003
    ..Some cases with In14 (5.7%) or Ex15 (7.2%) mutation showed low HDL-C levels. We conclude that CETP deficiency is a major cause of HALP; nevertheless CETP deficiency is not necessarily HALP...
  45. doi request reprint Establishment of chemiluminescence enzyme immunoassay for apolipoprotein B-48 and its clinical applications for evaluation of impaired chylomicron remnant metabolism
    Hiroyuki Hanada
    Division of Laboratory for Clinical Investigation, Department of Medical Technology, Osaka University Hospital, Suita, Osaka, Japan
    Clin Chim Acta 413:160-5. 2012
    ..The serum concentration of apoB-48 at fasting has been reported to be a marker of postprandial hyperlipidemia, a presumed risk factor for atherosclerosis...
  46. ncbi request reprint Matrix metalloproteinases as novel disease markers in Takayasu arteritis
    Akifumi Matsuyama
    Department of Internal Medicine and Molecular Science, B5, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Circulation 108:1469-73. 2003
    ..Given the histological findings characterized by destruction of elastic fibers, we hypothesized that matrix metalloproteinases (MMPs) could be useful as markers of disease activity in TA...
  47. ncbi request reprint Mutations in Japanese subjects with primary hyperlipidemia--results from the Research Committee of the Ministry of Health and Welfare of Japan since 1996--
    Takao Maruyama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
    J Atheroscler Thromb 11:131-45. 2004
    ..defect of familial combined hyperlipidemia (FCHL) is still unknown although FCHL is speculated to be the most prevalent genetic hyperlipidemia, and further investigations should be performed to elucidate the molecular mechanisms of FCHL..
  48. ncbi request reprint RECS1 deficiency in mice induces susceptibility to cystic medial degeneration
    Hanjun Zhao
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Genes Genet Syst 81:41-50. 2006
    ..Taken together, we conclude that RECS1 is an endosomal/lysosomal membrane protein which plays protective roles in vascular remodeling...
  49. ncbi request reprint Measurement of fasting serum apoB-48 levels in normolipidemic and hyperlipidemic subjects by ELISA
    Naohiko Sakai
    Department of Internal Medicine, Osaka University Graduate School of Medicine, B5, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Lipid Res 44:1256-62. 2003
    ..On the other hand, in patients with dysbetalipoproteinemia, serum apoB-48 levels did not change considerably. Our results indicate that serum apoB-48 is a very useful parameter for evaluating lipoprotein metabolism in exogenous pathways...
  50. ncbi request reprint Risk stratification based on metabolic syndrome as well as non- metabolic risk factors in the assessment of carotid atherosclerosis
    Hiroyuki Noda
    Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, Japan
    J Atheroscler Thromb 18:504-12. 2011
    ..We aimed to develop a new approach to risk stratification using metabolic syndrome as well as traditional non-metabolic risk factors, and to examine its validity in carotid atherosclerosis...
  51. ncbi request reprint Multicenter study to determine the diagnosis criteria of heterozygous familial hypercholesterolemia in Japan
    Mariko Harada-Shiba
    Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    J Atheroscler Thromb 19:1019-26. 2012
    ..Early diagnosis and prompt treatment are necessary to prevent their CAD. In this study we tried to amend the Japanese diagnostic criteria of FH for general practitioners by examining each component of the current criteria...
  52. ncbi request reprint Visfatin: a protein secreted by visceral fat that mimics the effects of insulin
    Atsunori Fukuhara
    Department of Medicine and Pathophysiology, Graduate School of Medicine, and Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Science 307:426-30. 2005
    ..Surprisingly, visfatin binds to and activates the insulin receptor. Further study of visfatin's physiological role may lead to new insights into glucose homeostasis and/or new therapies for metabolic disorders such as diabetes...
  53. ncbi request reprint [Trends toward development of other novel antihyperlipidemic drugs]
    Shizuya Yamashita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
    Nihon Rinsho 60:984-92. 2002
    ....
  54. ncbi request reprint Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase
    Mitsuru Shimamura
    Department of Medicine and Pathophysiology, Graduate School of Frontier Bioscience, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 27:366-72. 2007
    ..Current studies aim to reveal the contribution of angiopoietin-like protein3 (angptl3), previously known as a plasma suppressor of lipoprotein lipase, to HDL metabolism...
  55. ncbi request reprint Comparison of visibility and diagnostic capability of noninvasive coronary angiography by eight-slice multidetector-row computed tomography versus conventional coronary angiography
    Takao Maruyama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Am J Cardiol 93:537-42. 2004
    ..1% (226 of 228 segments), and 98.1% (253 of 258 segments), respectively. Low visibilities in the left circumflex artery and distal and small segments are limitations of 8-slice MDCT-CA because of limited spatial resolution...
  56. ncbi request reprint Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency
    Yoshiharu Nishida
    Department of Internal Medicine and Molecular Science, Osaka University, Osaka, Japan
    Biochem Biophys Res Commun 290:713-21. 2002
    ..These data indicated that, in the three patients investigated, the abnormalities and dysfunction of ABCA1 occurred at the different levels, providing important information about the expression, regulation, and function of ABCA1...
  57. ncbi request reprint High index of microcirculatory resistance level after successful primary percutaneous coronary intervention can be improved by intracoronary administration of nicorandil
    Noritoshi Ito
    Critical and Cardiovascular Care Unit, Osaka Saiseikai Senri Hospital, Suita, Japan
    Circ J 74:909-15. 2010
    ..We hypothesized that intracoronary administration of nicorandil can improve IMR after successful primary PCI in patients with ST-segment elevation myocardial infarction (STEMI)...