Shinjiro Yamaguchi

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. doi request reprint Dendritic cell-based vaccines suppress metastatic liver tumor via activation of local innate and acquired immunity
    Shinjiro Yamaguchi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Cancer Immunol Immunother 57:1861-9. 2008
  2. doi request reprint Mutations associated with the therapeutic efficacy of adefovir dipivoxil added to lamivudine in patients resistant to lamivudine with type B chronic hepatitis
    Kazuyoshi Ohkawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
    J Med Virol 81:798-806. 2009
  3. doi request reprint Decreased expressions of CD1d molecule on liver dendritic cells in subcutaneous tumor bearing mice
    Tomohide Tatsumi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Hepatol 49:779-86. 2008
  4. pmc Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities
    Masahisa Jinushi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    Immunology 120:73-82. 2007
  5. doi request reprint Activated liver dendritic cells generate strong acquired immunity in alpha-galactosylceramide treatment
    Akira Sasakawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Hepatol 50:1155-62. 2009
  6. doi request reprint Fatal exacerbation of type B chronic hepatitis triggered by changes in relaxed circular viral DNA synthesis and virion secretion
    Kazuyoshi Ohkawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Biochem Biophys Res Commun 394:87-93. 2010
  7. ncbi request reprint Intrahepatic delivery of alpha-galactosylceramide-pulsed dendritic cells suppresses liver tumor
    Tomohide Tatsumi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hepatology 45:22-30. 2007
  8. doi request reprint EphA2-derived peptide vaccine with amphiphilic poly(gamma-glutamic acid) nanoparticles elicits an anti-tumor effect against mouse liver tumor
    Shinjiro Yamaguchi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    Cancer Immunol Immunother 59:759-67. 2010
  9. doi request reprint Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus
    Kazuyoshi Ohkawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Infect Dis 198:1150-8. 2008
  10. ncbi request reprint Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell vaccines
    Shinjiro Yamaguchi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer 110:1469-77. 2007

Collaborators

Detail Information

Publications14

  1. doi request reprint Dendritic cell-based vaccines suppress metastatic liver tumor via activation of local innate and acquired immunity
    Shinjiro Yamaguchi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Cancer Immunol Immunother 57:1861-9. 2008
    ..In this study, we investigated whether preventive vaccination with unpulsed DCs or peptide-pulsed DCs could offer anti-tumor effects against MC38 or BL6 liver tumors...
  2. doi request reprint Mutations associated with the therapeutic efficacy of adefovir dipivoxil added to lamivudine in patients resistant to lamivudine with type B chronic hepatitis
    Kazuyoshi Ohkawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
    J Med Virol 81:798-806. 2009
    ....
  3. doi request reprint Decreased expressions of CD1d molecule on liver dendritic cells in subcutaneous tumor bearing mice
    Tomohide Tatsumi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Hepatol 49:779-86. 2008
    ..However, the activation of liver innate immunity by alpha-GalCer should be examined because clinical trials of alpha-GalCer resulted in limited clinical responses...
  4. pmc Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities
    Masahisa Jinushi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    Immunology 120:73-82. 2007
    ..These findings provide new insight into the role of NK receptor signals in the DC-mediated induction of regulatory T cells...
  5. doi request reprint Activated liver dendritic cells generate strong acquired immunity in alpha-galactosylceramide treatment
    Akira Sasakawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Hepatol 50:1155-62. 2009
    ..Alpha-galactosylceramide (alpha-GalCer) presented by dendritic cells (DCs) activates NKT cells that in turn drive DC maturation. However, the potential of generating acquired immunity of liver DCs in alpha-GalCer treatment remains unclear...
  6. doi request reprint Fatal exacerbation of type B chronic hepatitis triggered by changes in relaxed circular viral DNA synthesis and virion secretion
    Kazuyoshi Ohkawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Biochem Biophys Res Commun 394:87-93. 2010
    ..This may have been responsible for disease deterioration in the patient. This is a novel type of HBV genomic variation associated with the development of fulminant liver disease...
  7. ncbi request reprint Intrahepatic delivery of alpha-galactosylceramide-pulsed dendritic cells suppresses liver tumor
    Tomohide Tatsumi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hepatology 45:22-30. 2007
    ..CONCLUSION: These results demonstrate that alphaGCDC injection into the liver can efficiently activate NK cells that in turn reject liver tumors to establish potent acquired immunity against the original tumor...
  8. doi request reprint EphA2-derived peptide vaccine with amphiphilic poly(gamma-glutamic acid) nanoparticles elicits an anti-tumor effect against mouse liver tumor
    Shinjiro Yamaguchi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    Cancer Immunol Immunother 59:759-67. 2010
    ....
  9. doi request reprint Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus
    Kazuyoshi Ohkawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Infect Dis 198:1150-8. 2008
    ..To elucidate the differences between viruses with and those without rtL180M, we conducted full-length sequencing analysis of HBV derived from patients with type B chronic hepatitis showing lamivudine resistance...
  10. ncbi request reprint Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell vaccines
    Shinjiro Yamaguchi
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer 110:1469-77. 2007
    ....
  11. ncbi request reprint Early emergence of entecavir-resistant hepatitis B virus in a patient with hepatitis B virus/human immunodeficiency virus coinfection
    Aimi Kanada
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan
    Hepatol Res 38:622-8. 2008
    ..In entecavir therapy for patients infected with both viruses, great care should be taken with respect to the emergence of entecavir-resistant hepatitis B virus, especially in patients with pre-existing lamivudine-resistant virus...
  12. ncbi request reprint Type B fulminant hepatitis is closely associated with a highly mutated hepatitis B virus strain
    Aimi Kanada
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
    Intervirology 50:394-401. 2007
    ..We carried out full-length sequencing analysis of viral strains derived from patients with type B acute liver injury...
  13. ncbi request reprint Suppressive effect on hepatocyte differentiation of hepatitis C virus core protein
    Atsushi Hosui
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Biochem Biophys Res Commun 346:1125-30. 2006
    ..In conclusion, the HCV core may suppress differentiation into hepatocytes via inhibition of the JAK-STAT pathway and OSMRbeta expression...
  14. ncbi request reprint Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas
    Masahisa Jinushi
    Department of Molecular Therapeutics, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Hepatol 43:1013-20. 2005
    ..Earlier research demonstrated that the soluble form of MICA (sMICA) is released from some types of tumors, but its presence and role in HCC was not determined...