Research Topics
Genomes and Genes
| Hirokazu YamagamiSummaryAffiliation: Osaka City University Country: Japan Publications
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Detail Information
Publications
Trehalose 6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis induces foreign-body- and hypersensitivity-type granulomas in miceH Yamagami
Department of Host Defense, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
Infect Immun 69:810-5. 2001..Taken together with a previous report, this study shows that TDM is a pleiotropic molecule against the host and plays an important role in the pathogenesis of tuberculosis...
Usefulness of double-balloon endoscopy in the diagnosis of malignant small-bowel tumorsHirokazu Yamagami
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
Clin Gastroenterol Hepatol 6:1202-5. 2008..This study examined the clinical features of patients with MSBT and evaluated the usefulness of DBE in the diagnosis of MSBT...
Signet-ring cell carcinoma of the jejunum diagnosed by double balloon enteroscopyHirokazu Yamagami
Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
Hepatogastroenterology 55:1246-8. 2008..The endoscopic findings are important in diagnosing such lesions, and are useful in distinguishing them from other diseases...- Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's diseaseShuhei Hosomi
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Inflamm Bowel Dis 14:1205-13. 2008..The aim of this study was to investigate the expression of ghrelin and GHSR and the function of ghrelin in inflammatory bowel disease (IBD)... - Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's diseaseKenichi Morimoto
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
Scand J Gastroenterol 46:701-9. 2011..We investigated TIM-3 and galectin-9 expression in inflammatory bowel disease (IBD) patients and in healthy controls, and evaluated the immune role of the TIM-3 pathway in Crohn's disease (CD) pathogenesis... - Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritisKoji Otani
Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Osaka 545 8585, Japan
Biochem Biophys Res Commun 426:342-9. 2012..Our findings suggest that TLR9 signaling plays important roles in the suppression of H. pylori-induced gastritis in the early phase via downregulation of Th1-type cytokines modulated by IFN-α... - Dislocation of Rab13 and vasodilator-stimulated phosphoprotein in inactive colon epithelium in patients with Crohn's diseaseMizuki Ohira
Department of Gastroenterology, Osaka City University, Graduate School of Medicine, Osaka, Japan
Int J Mol Med 24:829-35. 2009..Latent dislocation of tight junction proteins in the inactive mucosa of patients with Crohn's disease may permit the invasion of gut antigens to initiate and perpetuate altered immune response... - High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4Yuji Nadatani
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Am J Pathol 181:98-110. 2012..Exogenous HMGB1 aggravated the damage in TLR2- and RAGE-KO mice but did not affect the damage in TLR4-KO mice. Thus, our results suggest that HMGB1 promotes NSAID-induced small intestinal damage through TLR4-dependent signaling pathways... - Cigarette smoking and its association with overlapping gastroesophageal reflux disease, functional dyspepsia, or irritable bowel syndromeYasuhiro Fujiwara
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
Intern Med 50:2443-7. 2011..Several studies have shown a significant occurrence of overlap among these 3 diseases. The purpose of this study was to examine the factors associated with such disease overlap in Japanese adults... - Gastrointestinal bleeding after percutaneous coronary interventionTetsuya Tanigawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka City, Japan
Digestion 83:153-60. 2011..Further extensive studies are required to ascertain the beneficial effect of prophylactic agents for dual antiplatelet therapy following PCI... - Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acidToshio Watanabe
Dept of Gastroenterology, Osaka City Univ Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
Am J Physiol Gastrointest Liver Physiol 297:G506-13. 2009..These findings suggest that LcS exhibits a prophylactic effect on indomethacin-induced enteropathy by suppressing the LPS/TLR4 signaling pathway and that this probiotic effect of LcS may be mediated by L-lactic acid... - Pathogenesis of proton-pump inhibitor-refractory non-erosive reflux disease according to multichannel intraluminal impedance-pH monitoringYukie Kohata
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
J Gastroenterol Hepatol 27:58-62. 2012..The purpose of this study was to clarify the usefulness of multichannel intraluminal impedance-pH (MII-pH) monitoring for PPI-refractory NERD patients and examine the pathogenesis... - Association between left-handedness and gastrointestinal symptomsYasuhiro Fujiwara
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Digestion 84:114-8. 2011..The aim of this study was to determine the association between left-handedness and GI symptoms or diseases... - Evaluation of small bowel injury in patients with rheumatoid arthritis by capsule endoscopy: effects of anti-rheumatoid arthritis drugsSatoshi Sugimori
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
Digestion 78:208-13. 2008..We evaluated the incidence of small bowel injury in RA patients who were taking anti-RA drugs with or without concomitant NSAIDs by capsule endoscopy... - Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinomaHiroshi Tatsuwaki
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Cancer Sci 101:550-8. 2010..These findings suggest that reduction of 15-PGDH is an independent predictor of poor survival associated with enhancement of cell proliferation in gastric adenocarcinoma... - Proliferation of immature plasma cells in pouchitis mucosa in patients with ulcerative colitisNaoto Hirata
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Inflamm Bowel Dis 14:1084-90. 2008..We have previously reported the specific and significant proliferation of immature plasma lineage cells in the ulcer bases and inflamed mucosa of UC. In the present study we report the results of a phenotypic study of ileal pouch mucosa... - Leptin promotes gastric ulcer healing via upregulation of vascular endothelial growth factorTetsuya Tanigawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan ttanigawa med osaka cu ac jp
Digestion 81:86-95. 2010..Its role in gastric ulcer healing is unclear. In this study, we investigated the role of leptin in gastric ulcer healing... - The usefulness of double-balloon enteroscopy in gastrointestinal stromal tumors of the small bowel with obscure gastrointestinal bleedingMasami Nakatani
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
Intern Med 51:2675-82. 2012..The aim of the present study was to analyze the clinical characteristics of small bowel GISTs and the usefulness of DBE, CE and computed tomography (CT)... - Internal hypoechoic feature by EUS as a possible predictive marker for the enlargement potential of gastric GI stromal tumorsMiho Onishi
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Gastrointest Endosc 75:731-8. 2012..There is no clinical predictor for the enlargement potential of gastric GI stromal tumors (GISTs) during the follow-up observation period... - Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritisKoji Otani
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Biochem Biophys Res Commun 382:252-8. 2009..In conclusion, IL-17A exerts anti-inflammatory effects on H. pylori-induced gastritis through suppression of Th1 differentiation... - Role of Th-2 cytokines in the development of Barrett's esophagus in ratsYukie Kohata
Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 7 Asahimachi, Abenoku, Osaka, 545 8585, Japan
J Gastroenterol 46:883-93. 2011..The aim of this study was to examine the role of Th-2 cytokines during the development of Barrett's esophagus, using a rat model... - Evaluation of deep small bowel involvement by double-balloon enteroscopy in Crohn's diseaseNobuhide Oshitani
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Am J Gastroenterol 101:1484-9. 2006.... - Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of lifeMakiko Kaji
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
J Gastroenterol Hepatol 25:1151-6. 2010..The purpose of this study was to examine the prevalence of GERD, FD, and IBS, their overlap rates, and HR-QOL for each disease and each overlap compared with healthy controls in the Japanese general population... - High prevalence of gastroesophageal reflux symptoms in patients with non-alcoholic fatty liver disease associated with serum levels of triglyceride and cholesterol but not simple visceral obesityYoshiko Fujikawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Digestion 86:228-37. 2012..However, other characteristic factors different from visceral obesity are associated with the pathogenesis of NAFLD. We investigated the prevalence of GERD symptoms in patients with NAFLD and its associated risk factors... - Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damageToshio Watanabe
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan Electronic address
Dig Liver Dis 45:390-5. 2013..Few studies have assessed the risk factors associated with nonsteroidal anti-inflammatory drugs (NSAIDs)-induced small intestinal damage... - Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5Tetsuya Tanigawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka City, Osaka 545 8585, Japan Electronic address
Eur J Pharmacol 704:64-9. 2013..In conclusion, our study results suggest that rebamipide inhibits indomethacin-induced small intestinal injuries, possibly by modulating microbiota in the small intestine by upregulation of α-defensin 5... - [Gastric ulcer in the elderly: general concept and clinical features]Makiko Kubo
Department of Gastroenterology, Osaka City University Graduate School of Medicine
Nihon Rinsho 68:1967-72. 2010..Even recently, there have been no changes in the mortality of patients with severe gastric ulcers. Management based on pathological conditions of gastric ulcers in the elderly persons is required... - Mitochondrial disorders in NSAIDs-induced small bowel injuryToshio Watanabe
Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
J Clin Biochem Nutr 48:117-21. 2011.... - Prevalence of mid-gastrointestinal bleeding in patients with acute overt gastrointestinal bleeding: multi-center experience with 1,044 consecutive patientsHirotoshi Okazaki
Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abenoku, Osaka 545 8585, Japan
J Gastroenterol 44:550-5. 2009..Video capsule endoscopy (VCE) and double-balloon enteroscopy (DBE) enable the detection of small intestinal lesions... - Mycobacterial trehalose 6,6'-dimycolate preferentially induces type 1 helper T cell responses through signal transducer and activator of transcription 4 proteinRyuta Oiso
Department of Host Defense, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
Microb Pathog 39:35-43. 2005..These results shed light on the molecular pathogenesis of mycobacterial disease. Taken together with previous studies, TDM is a pleiotropic molecule against the host and participates in the pathogenesis... - Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-alpha and Interleukin-1beta Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear FTetsuya Tanigawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
J Clin Biochem Nutr 45:86-92. 2009..These findings suggest that LANSO exerts anti-inflammatory effects by suppressing induction of TNF-alpha and IL-1beta via inhibition of nuclear factor (NF)-kappaB and ERK activation... - Endoscopic radial incision and cutting method for refractory esophageal stricture after endoscopic submucosal dissection of superficial esophageal carcinomaHiroaki Minamino
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Dig Endosc 25:200-3. 2013..ERIC is a safe and efficient method for treating refractory strictures after EBD caused by ESD for SEC... - Incidence and risk factors of gastrointestinal bleeding in patients on low-dose aspirin therapy after percutaneous coronary intervention in JapanYuji Nadatani
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Scand J Gastroenterol 48:320-5. 2013..Long-term treatment with LDA has serious adverse effects, including gastrointestinal (GI) hemorrhage. Most studies have focused only on upper GI bleeding and few studies have evaluated the effect of LDA on total GI bleeding... - Precise endoscopic and pathologic features in a crohn's disease case with two fistula-associated small bowel adenocarcinomas complicated by an anal canal adenocarcinomaMitsue Sogawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
Intern Med 52:445-9. 2013..Accumulating endoscopic findings of CD-associated cancer and precise pathologic diagnostic findings will help to establish a suitable surveillance method... - Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestineToshio Watanabe
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka Japan
Am J Physiol Gastrointest Liver Physiol 303:G324-34. 2012..These findings suggest that the MyD88 signaling pathway may inhibit I/R injury in the small intestine by inducing COX-2 expression... - Usefulness of magnetic resonance imaging for detection of asymptomatic osteonecrosis of the femoral head in patients with inflammatory bowel disease on long-term corticosteroid treatmentNoriko Kamata
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Scand J Gastroenterol 43:308-13. 2008..The aim of this study was to assess the usefulness of magnetic resonance imaging in diagnosing early osteonecrotic change and to determine whether corticosteroid administration is related to the development of osteonecrosis... - A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleedingNatsuhiko Kameda
Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
J Gastroenterol 43:434-40. 2008..However, which of the two is superior is unclear. We therefore prospectively compared the clinical efficacy of CE and DBE... - Bile acids induce cdx2 expression through the farnesoid x receptor in gastric epithelial cellsYingji Xu
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
J Clin Biochem Nutr 46:81-6. 2010..The effects of CDCA and GW4064 on expression of Cdx2 and MUC2 were abolished by guggulsterone. These findings suggest that bile acids may induce gastric intestinal metaplasia and carcinogenesis through the FXR... - Rebamipide, a mucoprotective drug, inhibits NSAIDs-induced gastric mucosal injury: possible involvement of the downregulation of 15-hydroxyprostaglandin dehydrogenaseTetsuya Tanigawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka City, Osaka 545 8585, Japan
J Clin Biochem Nutr 48:149-53. 2011.... - Differential expression of vasoactive intestinal peptide receptor 1 expression in inflammatory bowel diseaseTomomi Yukawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
Int J Mol Med 20:161-7. 2007..The differential expression of VIPR1 in ulcerative colitis and Crohn's disease mucosa suggests that the VIP system plays different roles in the pathogenesis of IBD... - [Portal venous gas complicated with Crohn's disease. A report of a case]Kyoko Fujii
Department of Gastroenterology, Osaka City University Graduate School of Medicine
Nippon Shokakibyo Gakkai Zasshi 100:42-7. 2003 - Endoscopic differential diagnosis between ulcerative colitis-associated neoplasia and sporadic neoplasia in surveillance colonoscopy using narrow band imagingKenji Watanabe
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
Dig Endosc 23:143-9. 2011..Optimization of surveillance colonoscopy, including development of novel methods, should be addressed in the near future... - [Post infectious irritable bowel syndrome experimental model]Nobuhide Oshitani
Department of Gastroenterology, Osaka City University Graduate School of Medicine
Nippon Rinsho 64:1437-40. 2006..Pathogenesis of irritable bowel syndrome may be further subdivided by the results of experimental models, and a novel therapeutic approach is expected from such experimental models... - The production of interferon-gamma-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activityAtsushi Noguchi
Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
J Gastroenterol 42:947-56. 2007..To clarify which types of cells produce interferon-gamma-inducible protein 10 (IP-10) and whether IP-10 is associated with the development of ulcerative colitis (UC), we investigated IP-10 production in UC patients... - [Rumination syndrome in an adult with normal intelligence]Takashi Sugawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine
Nippon Shokakibyo Gakkai Zasshi 103:631-5. 2006..Since patients with rumination syndrome are often misdiagnosed and receive unnecessary treatment, awareness of it by physicians is important... - A murine model of granulomatous colitis with mesenteric lymphadenitis induced by mycobacterial cord factorMitsue Sogawa
Department of Anatomy, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
Virchows Arch 442:151-8. 2003..The CF-induced colonic granulomas associated with mesenteric lymphadenitis will be useful for investigating human granulomatous colitis... - A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in East Asian countries in 2007Tetsuo Arakawa
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abenoku, Osaka, Japan
Digestion 79:177-85. 2009..Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are widely used clinically but increase the risk of gastrointestinal (GI) complications...