P L Wang

Summary

Affiliation: Osaka Dental University
Country: Japan

Publications

  1. ncbi request reprint Involvement of CD14 on human gingival fibroblasts in Porphyromonas gingivalis lipopolysaccharide-mediated interleukin-6 secretion
    P L Wang
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Arch Oral Biol 43:687-94. 1998
  2. ncbi request reprint Purification and characterization of a trypsin-like protease from the culture supernatant of Actinobacillus actinomycetemcomitans Y4
    P L Wang
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Eur J Oral Sci 107:147-53. 1999
  3. ncbi request reprint IL-10 inhibits Porphyromonas gingivalis LPS-stimulated human gingival fibroblasts production of IL-6
    P L Wang
    Department of Pharmacology, Department of Pediatric Dentistry, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Japan
    Biochem Biophys Res Commun 263:372-7. 1999
  4. ncbi request reprint Heterogeneous expression of Toll-like receptor 4 and downregulation of Toll-like receptor 4 expression on human gingival fibroblasts by Porphyromonas gingivalis lipopolysaccharide
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Japan
    Biochem Biophys Res Commun 288:863-7. 2001
  5. ncbi request reprint Toll-like receptor 4-mediated signal pathway induced by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho Hirakata, Osaka, 573 1121, Japan
    Biochem Biophys Res Commun 273:1161-7. 2000
  6. ncbi request reprint Effect of Actinobacillus actinomycetemcomitans protease on the proliferation of gingival epithelial cells
    P L Wang
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Oral Dis 7:233-7. 2001
  7. ncbi request reprint Streptococcus mutans lipoteichoic acid-induced apoptosis in cultured dental pulp cells from human deciduous teeth
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka, 573 1121, Japan
    Biochem Biophys Res Commun 281:957-61. 2001
  8. ncbi request reprint Comparison of inhibitory effects of local anesthetics on immune functions of neutrophils
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Osaka, Japan
    Int J Immunopharmacol 22:789-96. 2000
  9. doi request reprint Dental caries area of rat molar expanded by cigarette smoke exposure
    Y Fujinami
    Department of Pharmacology, Graduate School of Oral Medicine, Matsumoto Dental University, Shiojiri, Japan
    Caries Res 45:561-7. 2011
  10. ncbi request reprint 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-10 and IL-12 production by macrophages
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Osaka, Hirakata, 573 1121, Japan
    Biochem Biophys Res Commun 283:344-6. 2001

Detail Information

Publications23

  1. ncbi request reprint Involvement of CD14 on human gingival fibroblasts in Porphyromonas gingivalis lipopolysaccharide-mediated interleukin-6 secretion
    P L Wang
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Arch Oral Biol 43:687-94. 1998
    ..These results suggest that CD14 is a cell surface binding site for LPS and is involved in the LPS-mediated activation of HGF...
  2. ncbi request reprint Purification and characterization of a trypsin-like protease from the culture supernatant of Actinobacillus actinomycetemcomitans Y4
    P L Wang
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Eur J Oral Sci 107:147-53. 1999
    ..These data suggest that this protease is a serine protease or metallo protease. This enzyme extensively degraded collagen type I and fibronectin...
  3. ncbi request reprint IL-10 inhibits Porphyromonas gingivalis LPS-stimulated human gingival fibroblasts production of IL-6
    P L Wang
    Department of Pharmacology, Department of Pediatric Dentistry, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Japan
    Biochem Biophys Res Commun 263:372-7. 1999
    ..These results suggest that IL-10 inhibits the inflammatory response via the IL-10 receptor in P. gingivalis LPS-initiated periodontal diseases...
  4. ncbi request reprint Heterogeneous expression of Toll-like receptor 4 and downregulation of Toll-like receptor 4 expression on human gingival fibroblasts by Porphyromonas gingivalis lipopolysaccharide
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Japan
    Biochem Biophys Res Commun 288:863-7. 2001
    ..gingivalis LPS downregulates TLR4 expression on HGFs. These findings may be used to control inflammatory and immune responses in periodontal disease...
  5. ncbi request reprint Toll-like receptor 4-mediated signal pathway induced by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho Hirakata, Osaka, 573 1121, Japan
    Biochem Biophys Res Commun 273:1161-7. 2000
    ..Our findings suggest that the binding of P. gingivalis LPS to TLR4 on HGFs activates various second messenger systems...
  6. ncbi request reprint Effect of Actinobacillus actinomycetemcomitans protease on the proliferation of gingival epithelial cells
    P L Wang
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Oral Dis 7:233-7. 2001
    ..The aim of this report is to examine the effect of in vitro application of A. actinomycetemcomitans protease on the cell growth, DNA synthesis, and fibronectin level of human gingival epithelial cells...
  7. ncbi request reprint Streptococcus mutans lipoteichoic acid-induced apoptosis in cultured dental pulp cells from human deciduous teeth
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka, 573 1121, Japan
    Biochem Biophys Res Commun 281:957-61. 2001
    ..Collectively, these findings suggest that Streptococcus mutans lipoteichoic acids may cause apoptosis in human dental pulp cells, and serve as an important factor in pulpitis...
  8. ncbi request reprint Comparison of inhibitory effects of local anesthetics on immune functions of neutrophils
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Osaka, Japan
    Int J Immunopharmacol 22:789-96. 2000
    ..These results suggest that the local anesthetics may affect adhesion, phagocytosis, and the production of superoxide anion and hydrogen peroxide by neutrophils...
  9. doi request reprint Dental caries area of rat molar expanded by cigarette smoke exposure
    Y Fujinami
    Department of Pharmacology, Graduate School of Oral Medicine, Matsumoto Dental University, Shiojiri, Japan
    Caries Res 45:561-7. 2011
    ..Passive smoking is the involuntary inhalation of cigarette smoke (CS) and has an adverse impact on oral health. We examined the effect of CS exposure on caries risk and experimental dental caries...
  10. ncbi request reprint 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-10 and IL-12 production by macrophages
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Osaka, Hirakata, 573 1121, Japan
    Biochem Biophys Res Commun 283:344-6. 2001
    ..Further, dPGJ(2) did not appear to act through the PGD(2) receptor. These results suggest that dPGJ(2) may inhibit LPS-induced IL-10 and IL-12 production by macrophages through PPARgamma...
  11. ncbi request reprint Comparative studies of modulatory effect to the function of rat peritoneal neutrophils treated with new quinolones
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Immunol Lett 69:321-7. 1999
    ..These results suggest that the new quinolones at a therapeutic concentration may affect functions such as phagocytosis, and production of superoxide anion in neutrophils...
  12. ncbi request reprint Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka 573 1121, Japan
    Crit Rev Oral Biol Med 13:132-42. 2002
    ..In this article, we review recent findings on the signaling pathways induced by the binding of P. gingivalis LPS to CD14 and Toll-like receptors (TLRs) in gingival fibroblasts...
  13. ncbi request reprint Differentiation by in vitro treatment of lidocaine-epinephrine and prilocaine-felypressine in neutrophils
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Osaka, Japan
    Immunol Lett 77:151-8. 2001
    ....
  14. ncbi request reprint Quinolones alter defense reactions mediated by macrophages
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 1:179-87. 2001
    ..These results suggest that the quinolones at a therapeutic concentration differentially affect phagocytosis, adhesion, and the production of hydrogen peroxide by macrophages...
  15. ncbi request reprint Endomorphins 1 and 2 modulate chemotaxis, phagocytosis and superoxide anion production by microglia
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Osaka 573 1121, Hirakata, Japan
    J Neuroimmunol 119:51-6. 2001
    ..These results suggest that endomorphins 1 and 2 modulate phagocytosis, chemotaxis and superoxide anion production by microglia...
  16. ncbi request reprint Immunomodulation of the neutrophil respiratory burst by endomorphins 1 and 2
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Immunol Lett 75:55-9. 2000
    ..These results suggest that the endogenous opioid peptides endomorphins 1 and 2 may modulate the production of superoxide anions in neutrophils via mu-opioid receptors...
  17. ncbi request reprint Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-receptors
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 1:1867-75. 2001
    ..These results suggest that histamine and dimaprit may inhibit chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-histamine receptors. reserved...
  18. ncbi request reprint 15-Deoxy-delta(12,14)-prostaglandin J2 is a negative regulator of macrophage functions
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 1:2101-8. 2001
    ..Similarly, dPGJ2 inhibited the production of hydrogen peroxide when macrophages were stimulated with either PMA or OPZ. These studies suggest that dPGJ2 may be a negative regulator of macrophage functions...
  19. ncbi request reprint The effects of antibiotics on in vitro biofilm model of periodontal disease
    A Tamura
    Department of Pharmacology, Matsumoto Dental University, Hirooka, Shiojiri, Nagano, Japan
    Eur J Med Res 13:439-45. 2008
    ..Periodontal disease is considered to be a bio?film infectious disease. The effects of macrolide and tetracycline on biofilm were examined in in vitro biofilm model made of periodontal disease-associated bacteria...
  20. doi request reprint The effects of cigarette exposure on rat salivary proteins and salivary glands
    Y Fujinami
    Department of Pharmacology, Graduate School of Oral Medicine, Matsumoto Dental University, Shiojiri, Nagano 399 0781, Japan
    Oral Dis 15:466-71. 2009
    ..Passive smoking is the involuntary inhalation of cigarette smoke (CS) and has an adverse impact on oral health. We examined the effect of CS exposure on saliva and salivary glands (SGs)...
  21. pmc Porphyromonas gingivalis gingipain-R enhances interleukin-8 but decreases gamma interferon-inducible protein 10 production by human gingival fibroblasts in response to T-cell contact
    M Oido-Mori
    Department of Preventive Dentistry, School of Dental Medicine, University of Geneva, 1211 Geneva 14, Switzerland
    Infect Immun 69:4493-501. 2001
    ....
  22. ncbi request reprint Calcium antagonist isradipine-induced calcium influx through nonselective cation channels in human gingival fibroblasts
    T Hattori
    Department of Dental Pharmacology, Matsumoto Dental University, Shiojiri, Japan
    Eur J Med Res 11:93-6. 2006
    ..The results obtained here play an important role in the development of drugs for etiologic therapy of gingival overgrowth...
  23. ncbi request reprint The 'wildtype' conformation of p53: epitope mapping using hybrid proteins
    P L Wang
    Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK
    Oncogene 20:2318-24. 2001
    ..These epitope locations may help in dissecting the interactions of p53, including those with E6/E6-AP and in its DNA-bound state...