Koichiro Wada

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease
    Masato Yoneda
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    BMC Gastroenterol 12:16. 2012
  2. ncbi [Role of PPARgamma in the development of the central nervous system]
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Japan
    Nihon Yakurigaku Zasshi 122:301-8. 2003
  3. ncbi Life style-related diseases of the digestive system: endocrine disruptors stimulate lipid accumulation in target cells related to metabolic syndrome
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan
    J Pharmacol Sci 105:133-7. 2007
  4. ncbi Roles of oral bacteria in cardiovascular diseases--from molecular mechanisms to clinical cases: Involvement of Porphyromonas gingivalis in the development of human aortic aneurysm
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan
    J Pharmacol Sci 113:115-9. 2010
  5. ncbi Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:12673-81. 2006
  6. ncbi Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway
    Toshio Fujisawa
    Division of Gastroenterology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    J Pharmacol Sci 106:627-38. 2008
  7. ncbi Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility
    Atsushi Nakajima
    Division of Gastroenterology, Yokohama City University School of Medicine, Yokohama, Japan
    Cancer Sci 99:1892-900. 2008
  8. ncbi Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model
    Koji Fujita
    From the Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Alcohol Clin Exp Res 34:S18-24. 2010
  9. ncbi Telmisartan, an angiotensin II type 1 receptor blocker, controls progress of nonalcoholic steatohepatitis in rats
    Koji Fujita
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama, Japan
    Dig Dis Sci 52:3455-64. 2007
  10. ncbi Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease
    Masato Yoneda
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama City University Hospital, Yokohama, Japan
    Liver Int 29:1078-85. 2009

Collaborators

Detail Information

Publications65

  1. ncbi Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease
    Masato Yoneda
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    BMC Gastroenterol 12:16. 2012
    ..gingivalis), a major causative agent of periodontitis...
  2. ncbi [Role of PPARgamma in the development of the central nervous system]
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Japan
    Nihon Yakurigaku Zasshi 122:301-8. 2003
    ..These results may indicate that PPARgamma plays an important role during the early stage of the development of the central nervous system...
  3. ncbi Life style-related diseases of the digestive system: endocrine disruptors stimulate lipid accumulation in target cells related to metabolic syndrome
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan
    J Pharmacol Sci 105:133-7. 2007
    ..These observations indicate that exposure to EDs stimulates the lipid accumulation in target cells involved in the metabolic syndrome and may cause the dysfunction of those cells, resulting in induction of metabolic syndrome...
  4. ncbi Roles of oral bacteria in cardiovascular diseases--from molecular mechanisms to clinical cases: Involvement of Porphyromonas gingivalis in the development of human aortic aneurysm
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan
    J Pharmacol Sci 113:115-9. 2010
    ..gingivalis infection are different from those present in non-infected patients. The major characteristic of P. gingivalis infection associated with aneurysms is smooth muscle cell proliferation in the distal aorta...
  5. ncbi Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:12673-81. 2006
    ..The inhibition of differentiation was associated with an activation of STAT3. These data indicate that PPARgamma regulates the development of the central nervous system during early embryogenesis via control of NSC proliferation...
  6. ncbi Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway
    Toshio Fujisawa
    Division of Gastroenterology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    J Pharmacol Sci 106:627-38. 2008
    ..Our findings suggest that PPARgamma plays a role as a physiological regulator of colonic epithelial cell turnover and consequently predisposition to the development of colon cancer in early stage...
  7. ncbi Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility
    Atsushi Nakajima
    Division of Gastroenterology, Yokohama City University School of Medicine, Yokohama, Japan
    Cancer Sci 99:1892-900. 2008
    ..Based on these findings, PPARgamma could function as a novel target for the therapeutic control of cancer cell invasion or metastasis...
  8. ncbi Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model
    Koji Fujita
    From the Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Alcohol Clin Exp Res 34:S18-24. 2010
    ..Recently, the 2-hit hypothesis was proposed, in which nitric oxide production, representing oxidative stress, was proposed as a very important candidate for the second hit...
  9. ncbi Telmisartan, an angiotensin II type 1 receptor blocker, controls progress of nonalcoholic steatohepatitis in rats
    Koji Fujita
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama, Japan
    Dig Dis Sci 52:3455-64. 2007
    ..However, telmisartan, but not pioglitazone, dramatically decreased both subcutaneous and visceral fat. In conclusion, these results indicated that telmisartan should be the drug of first choice for the treatment of patients with NASH...
  10. ncbi Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease
    Masato Yoneda
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama City University Hospital, Yokohama, Japan
    Liver Int 29:1078-85. 2009
    ..Genetic factors are important for the development of NAFLD, as well as environmental factors. Recently an angiotensin II type 1 receptor (AGTR1) has been recognized as important in the aetiology of fibrosis in the liver...
  11. ncbi Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: clinical significance of measurement for nitrate/nitrite
    Koji Fujita
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Kanazawa Ku, Yokohama, Japan
    Med Sci Monit 17:CR123-31. 2011
    ..We evaluated the usefulness of measurement of the serum levels of nitric oxide (NO), instead of CT and the waist circumference, as a marker of abdominal visceral fat accumulation...
  12. ncbi Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease
    Yuichi Nozaki
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Hepatol 51:548-56. 2009
    ..In this study, we propose a novel combination therapy for NAFLD comprising ezetimibe (EZ), a cholesterol absorption inhibitor, and acarbose (AC), an alpha-glucosidase inhibitor...
  13. ncbi Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue
    Kyoko Yoneda
    Gastroenterology Division, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama, Japan
    Oncol Rep 20:479-83. 2008
    ..Further studies are required to elucidate the function of the AdipoRs activated by adiponectin and the downstream mechanisms of AdipoRs in colon cancer cells...
  14. ncbi Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression
    Takashi Uchiyama
    Division of Gastroenterology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    Int J Oncol 39:935-40. 2011
    ..STAT3 signaling in colorectal cancer may be mediated not only by leptin but by other factors...
  15. ncbi Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway
    Michiko Sugiyama
    Division of Gastroenterology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    Int J Oncol 34:339-44. 2009
    ..Our results clearly demonstrate the novel findings that adiponectin inhibits colorectal cancer cell growth via activation of AMPK, thereby down-regulating the mTOR pathway...
  16. ncbi Nonylphenol induces the death of neural stem cells due to activation of the caspase cascade and regulation of the cell cycle
    Chiho Kudo
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Japan
    J Neurochem 88:1416-23. 2004
    ....
  17. ncbi RNA interfering approach for clarifying the PPARgamma pathway using lentiviral vector expressing short hairpin RNA
    Kazufumi Katayama
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Science, Osaka University, Osaka 565 0871, Japan
    FEBS Lett 560:178-82. 2004
    ..Our PPARgamma-knockdown method will serve to clarify the PPARgamma pathway in various cell types in vivo and in vitro, and will facilitate the development of therapeutic applications for a variety of diseases...
  18. ncbi Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies
    Masato Yoneda
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Pharmacol Sci 105:151-6. 2007
    ..In conclusion, the results confirmed involvement of the PPARgamma pathway in NASH and the therapeutic utility of a PPARgamma ligand...
  19. ncbi Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma
    Morio Kusayama
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan
    Cancer Sci 102:1128-36. 2011
    ..These results imply a potentially important and novel role for the inhibition of AQP3 function via the use of specific siRNA in the treatment of SCC...
  20. ncbi Critical role of estrogen receptor on anoikis and invasion of squamous cell carcinoma
    Hiroyuki Ishida
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Sci 98:636-43. 2007
    ..In addition, tamoxifen strongly inhibited invasion of SCC. These results imply a potentially important role for ER, whose inhibition may be effective for the treatment of SCC and the prevention of invasion and metastasis...
  21. ncbi Novel findings for the development of drug therapy for various liver diseases: Liver microsomal triglyceride transfer protein activator may be a possible therapeutic agent in non-alcoholic steatohepatitis
    Koji Fujita
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Japan
    J Pharmacol Sci 115:270-3. 2011
    ..A growing body of literature suggests that the measurement of hepatic MTP expression may be helpful for diagnosis; and moreover, hepatic MTP activator may be a possible therapeutic agent for the treatment of NASH...
  22. ncbi Inhibition of peroxisome proliferator-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties
    Hirokazu Takahashi
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan
    Cancer Sci 97:854-60. 2006
    ..These results suggested that PPARgamma plays an important role in cancer cell invasion and that it might be a novel target for therapy of esophageal cancer...
  23. ncbi 5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model
    Ikuko Ikeda
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Clin Cancer Res 13:6527-31. 2007
    ..We therefore investigated the possible inhibition by peroxisome proliferator-activated receptor-gamma (PPARgamma) ligands and 5-ASA of colitis-associated colon carcinogenesis in a mouse model...
  24. ncbi Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis
    Hiroki Endo
    Division of Gastroenterology, Yokohama City University School of Medicine, Yokohama, Japan
    Gut 60:1363-71. 2011
    ..We explored the hypothesis that leptin signalling regulates the growth of CRC, by examining the effects of leptin deficiency on murine colon tumour growth...
  25. ncbi Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma
    Shunsuke Ishimoto
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka 565 0871, Japan
    Int J Oncol 41:67-75. 2012
    ..AQPs play important roles in cell growth in SCC rather than ACC...
  26. ncbi Leptin receptor is involved in STAT3 activation in human colorectal adenoma
    Takashi Uchiyama
    Gastroenterology Division, School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan
    Cancer Sci 102:367-72. 2011
    ..These results indicate STAT3-mediated leptin receptor signaling pathways may be activated in human colorectal adenomas...
  27. ncbi Role of myeloid cell leukemia-1 in cell growth of squamous cell carcinoma
    Masahide Nagata
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Japan
    J Pharmacol Sci 110:344-53. 2009
    ..These results imply a potentially important and novel role of the inhibition of Mcl-1 function by the use of specific siRNA in the treatment of SCC...
  28. ncbi A novel therapy for acute hepatitis utilizing dehydroepiandrosterone in the murine model of hepatitis
    Masato Yoneda
    The Third Department of Internal Medicine, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa, Yokohama, Japan
    Biochem Pharmacol 68:2283-9. 2004
    ..DHEA should, thus, be considered as a novel candidate for the therapy of liver injury...
  29. ncbi Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer
    Aya Ihara
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Pharmacol Sci 103:24-32. 2007
    ..These results indicate that the blockade of the LTB(4)-signaling pathway induces apoptosis via the inhibition of ERK activation in colon cancer cells. The LTB(4)-signaling pathway might be a new therapeutic target for colon cancer...
  30. ncbi Metformin suppresses intestinal polyp growth in ApcMin/+ mice
    Ayako Tomimoto
    Division of Gastroenterology, Yokohama City School of Medicine, Kanazawa, Yokohama, Japan
    Cancer Sci 99:2136-41. 2008
    ..Metformin suppressed the polyp growth in Apc(Min/+) mice, suggesting that it may be a novel candidate as a chemopreventive agent for colorectal cancer...
  31. ncbi Critical role of peroxisome proliferator-activated receptor gamma on anoikis and invasion of squamous cell carcinoma
    Tomotake Masuda
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan
    Clin Cancer Res 11:4012-21. 2005
    ..These results imply a potentially important and novel role for the inhibition of PPARgamma function via the use of specific antagonists in the treatment of squamous cell carcinoma and the prevention of tumor invasion and metastasis...
  32. ncbi Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    FASEB J 20:1785-92. 2006
    ..These results indicate for the first time that LTB(4) and LXA(4) directly regulate proliferation and differentiation of NSCs, suggesting these new pathways may be useful in restoring stem cells...
  33. ncbi Nitration of PPARgamma inhibits ligand-dependent translocation into the nucleus in a macrophage-like cell line, RAW 264
    Atsuhito Shibuya
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, 565 0871, Osaka, Japan
    FEBS Lett 525:43-7. 2002
    ....
  34. ncbi Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis
    Koji Fujita
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Hepatology 50:772-80. 2009
    ..Therefore, dysfunctional VLDL synthesis and release may be a key factor in progression to NASH...
  35. ncbi Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population
    Hirokazu Takahashi
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236 0004, Japan
    Cancer Sci 100:29-32. 2009
    ....
  36. ncbi Nuclear receptors as targets for drug development: the role of nuclear receptors during neural stem cell proliferation and differentiation
    Kazufumi Katayama
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Science, Osaka University, Japan
    J Pharmacol Sci 97:171-6. 2005
    ..In this review, recent findings on stem cell biology, especially focusing on nuclear receptors in NSCs, including our current study, will be discussed...
  37. ncbi Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis
    Ayuchi Kojima
    Department of Pediatric Dentistry, Graduate School of Dentistry, Osaka University, Osaka, 565 0871, Japan
    Sci Rep 2:332. 2012
    ..Administration of the specific strains of S. mutans isolated from patients caused aggravation of colitis. Infection with highly-virulent specific types of S. mutans might be a potential risk factor in the aggravation of UC...
  38. ncbi Role of endothelin receptor signalling in squamous cell carcinoma
    Shunsuke Ishimoto
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Oncol 40:1011-9. 2012
    ..These results indicate that endothelin signalling may, in part, play important roles in cell growth in SCCs through the MAP kinase pathway...
  39. ncbi Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)
    Masato Yoneda
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Yokohama, Japan
    BMC Gastroenterol 8:27. 2008
    ....
  40. ncbi A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model
    Kazufumi Katayama
    Department of Biopharmaceutics, Graduate School of Biopharmaceutical Science, Osaka University, Japan
    Gastroenterology 124:1315-24. 2003
    ..CONCLUSIONS: Our results suggest that gene delivery of PPAR gamma can be used to restore and/or enhance endogenous anti-inflammatory processes that are normally operative in mammalian tissues such as in the colon...
  41. ncbi Diclofenac inhibits proliferation and differentiation of neural stem cells
    Chiho Kudo
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan
    Biochem Pharmacol 66:289-95. 2003
    ..These results suggest that diclofenac may affect the development of the central nervous system...
  42. ncbi Upregulation of S100 calcium-binding protein A9 is required for induction of smooth muscle cell proliferation by a periodontal pathogen
    Hiroaki Inaba
    Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, Suita 565 0871, Japan
    FEBS Lett 583:128-34. 2009
    ..gingivalis on transformation and proliferation of hAOSMCs. Our data suggested that upregulation of S100A9 mediated by P. gingivalis is an important event in the development of aortic intimal hyperplasia...
  43. ncbi Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver disease
    Masato Yoneda
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Hepatol Res 39:963-71. 2009
    ..Conclusion: This is the first study to identify genetic variations in iNOS that may influence the risk of NAFLD and liver fibrosis in NAFLD...
  44. ncbi Hypoadiponectinemia plays a crucial role in the development of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue
    Masato Yoneda
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Alcohol Clin Exp Res 31:S15-21. 2007
    ..Recent evidence has indicated that hypoadiponectinemia is involved in hepatic steatosis and NASH...
  45. ncbi Gene expression profiling of non-alcoholic steatohepatitis using gene set enrichment analysis
    Masato Yoneda
    Divisions of Gastroenterology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    Hepatol Res 38:1204-12. 2008
    ..genome.rcast.u-tokyo.ac.jp/___/NASH/NASH_GSEA2/). Conclusion: Our data revealed differences in expression of many gene sets that are involved in the pathogenesis of NASH...
  46. ncbi PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice
    Tomoko Shiojiri
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan
    Eur J Pharmacol 448:231-8. 2002
    ..These results indicate that PPARgamma ligands may possess anti-inflammatory activity against adjuvant-induced arthritis via the inhibition of NF-kappaB pathway...
  47. ncbi Serum ferritin is associated with visceral fat area and subcutaneous fat area
    Tomoyuki Iwasaki
    Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    Diabetes Care 28:2486-91. 2005
    ..The results of this study suggest that the serum ferritin concentration may be a useful indicator of systemic fat content and degree of insulin resistance...
  48. ncbi Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling
    Kento Imajo
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Yokohama, Japan
    Cell Metab 16:44-54. 2012
    ..Our results indicate that obesity-induced leptin plays a crucial role in NASH progression via enhanced responsivity to endotoxin, and we propose a mechanism of bacteria-mediated progression of NASH...
  49. ncbi Role of leukotriene Bâ‚„ receptor signaling in human preadipocyte differentiation
    Kae Hirata
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 429:197-203. 2012
    ..The LTB(4)-BLT signaling pathway may negatively regulate preadipocyte differentiation via induction of TGFBI expression as a rate-limiting system to control adipocyte differentiation...
  50. ncbi The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke
    Kazuhiko Nakano
    Department of Pediatric Dentistry, Graduate School of Dentistry, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Commun 2:485. 2011
    ..Administration of recombinant CBP causes aggravation of haemorrhage. Our data suggest that CBP of S. mutans is directly involved in haemorrhagic stroke...
  51. ncbi Plasma free choline is a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis: A multi-center validation study
    Kento Imajo
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama Skylight Biotech Inc, Akita Center for Digestive and Liver Diseases, Nara City Hospital, Nara Division of Gastroenterology, National Kyusyu Medical Center Hospital, Fukuoka Division of Gastroenterology, NTT Medical Center, Tokyo Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan
    Hepatol Res 42:757-66. 2012
    ..Conclusion:  Plasma fCh levels are closely related to the grade of liver steatosis and fibrosis, and predict NASH severity. Plasma fCh levels are therefore a potential diagnostic marker for early-stage NASH in clinical practice...
  52. ncbi Liver abscess caused by periodontal bacterial infection with Fusobacterium necrophorum
    Masato Yoneda
    Division of Gastroenterology Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama Department of Pharmacology, Osaka University, Graduate School of Dentistry, Suita, Osaka, Japan
    Hepatol Res 41:194-6. 2011
    ..A systemic survey including periodontitis may be required for the exact diagnosis of the source of infection...
  53. ncbi [Anti-inflammatory effect of PPARgamma agonists: basics and clinical applications]
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University
    Nihon Rinsho 68:278-83. 2010
    ..Further clinical applications for the therapy of intractable or chronic inflammatory diseases will be progressed...
  54. ncbi Distribution of oral streptococci highly resistant to amoxicillin in dental plaque specimens from Japanese children and adolescents
    Hirotoshi Nemoto
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    J Med Microbiol 60:1853-9. 2011
    ....
  55. ncbi Chemoprevention of precursors to colon cancer by dehydroepiandrosterone (DHEA)
    Emi Osawa
    The Third Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Life Sci 70:2623-30. 2002
    ..These data strongly suggest that DHEA might be a potential chemopreventative agent against human colon cancer...
  56. ncbi Life style-related diseases of the digestive system: from molecular mechanisms to therapeutic strategies: preface
    Atsushi Nakajima
    Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Japan
    J Pharmacol Sci 105:127-8. 2007
  57. ncbi Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice
    Emi Osawa
    The Third Department of Internal Medicine, Yokohama City University School of Medicine, Japan
    Gastroenterology 124:361-7. 2003
    ..CONCLUSIONS: Our findings indicate that PPARgamma ligands are indeed potential chemopreventive agents for colon carcinogenesis...
  58. ncbi Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion
    Koichiro Wada
    Gastroenterology Division, Thorn 1419, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 287:G452-8. 2004
    ..These data indicate that an endogenous pathway associated with PPARgamma plays an important role in the pathogenesis of I/R-associated injury in the stomach...
  59. ncbi Gene expression profile after peroxisome proliferator activator receptor-gamma ligand administration in dextran sodium sulfate mice
    Atsushi Nakajima
    Third Department of Internal Medicine, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    J Gastroenterol 37:62-6. 2002
    ..CONCLUSIONS: This is the first demonstration of global gene expression analysis using the DSS colitis mouse model with a PPARgamma ligand, and these results provide new insight for finding novel target genes for treating IBD...
  60. ncbi Marked attenuation of production of collagen type I from cardiac fibroblasts by dehydroepiandrosterone
    Tomoyuki Iwasaki
    Division of Endocrinology and Metabolism, Yokohama City Univ. Graduate School of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama 236-0004, Japan
    Am J Physiol Endocrinol Metab 288:E1222-8. 2005
    ..These results strongly indicate that DHEA can directly attenuate collagen type I synthesis at the transcriptional level in vivo and in vitro in cardiac fibroblasts...
  61. ncbi Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis
    Lawrence J Saubermann
    Inflamm Bowel Dis 8:330-9. 2002
    ..These results indicate that the protective effects exhibited by PPARgamma ligands in intestinal inflammation may be due to immune deviation away from Th1 and towards Th2 cytokine production...
  62. ncbi Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms
    Katherine L Schaefer
    Section of Gastroenterology, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Inflamm Bowel Dis 11:244-52. 2005
    ..These findings imply the existence of a novel posttranscriptional regulatory antiinflammatory mechanism by TZDs that is not associated with reductions in nuclear factor-kappaB activation...
  63. ncbi Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells
    Katherine L Schaefer
    Section of Gastroenterology, Boston Medical Center, Boston, MA 02118, USA
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    ..Inhibition of PPARgamma function causes HCC cell death by preventing adhesion and inducing anoikis-mediated apoptosis. PPARgamma inhibitors represent a potential novel treatment approach to HCC...
  64. ncbi [PPAR gamma ligand pioglitazone as a therapeutic strategy in nonalcoholic steatohepatitis (NASH)]
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    Nippon Yakurigaku Zasshi 128:235-8. 2006
  65. ncbi Different effect of acute treatment with rosiglitazone on rat myocardial ischemia/reperfusion injury by administration method
    Masahiro Abe
    Department of Clinical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Eur J Pharmacol 589:215-9. 2008
    ..However, acute treatment with rosiglitazone is harmful if its concentration is high during ischemia...