Satoshi Uematsu

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Cell type-specific involvement of RIG-I in antiviral response
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Immunity 23:19-28. 2005
  2. ncbi request reprint [Innate immune recognition of viral infection]
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Uirusu 56:1-8. 2006
  3. ncbi request reprint [Innate immunity and tuberculosis]
    Satoshi Uematsu
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan
    Kekkaku 83:101-9. 2008
  4. ncbi request reprint [TLR family and viral infection]
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, 565 0871, Japan
    Uirusu 54:145-51. 2004
  5. doi request reprint Immune responses of TLR5(+) lamina propria dendritic cells in enterobacterial infection
    Satoshi Uematsu
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
    J Gastroenterol 44:803-11. 2009
  6. doi request reprint The innate immune system in the intestine
    Satoshi Uematsu
    Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka, 565 0871, Japan
    Microbiol Immunol 54:645-57. 2010
  7. pmc Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    J Exp Med 201:915-23. 2005
  8. doi request reprint Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
    Tatsuya Saitoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Immunity 34:352-63. 2011
  9. pmc Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
    Cevayir Coban
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST, Osaka, Japan
    J Exp Med 201:19-25. 2005
  10. ncbi request reprint A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    Ken J Ishii
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:40-8. 2006

Detail Information

Publications47

  1. ncbi request reprint Cell type-specific involvement of RIG-I in antiviral response
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Immunity 23:19-28. 2005
    ..In contrast, plasmacytoid DCs, which produce large amounts of IFN-alpha, use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner...
  2. ncbi request reprint [Innate immune recognition of viral infection]
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Uirusu 56:1-8. 2006
    ..Recent reports have shown that hosts also have a mechanism to detect replicating viruses in the cytoplasm in a TLR-independent manner. In this review, we focus on the viral recognition by innate immunity and the signaling pathways...
  3. ncbi request reprint [Innate immunity and tuberculosis]
    Satoshi Uematsu
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan
    Kekkaku 83:101-9. 2008
    ..TLRs are critically involved in the induction of host defense to M. tuberculosis...
  4. ncbi request reprint [TLR family and viral infection]
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, 565 0871, Japan
    Uirusu 54:145-51. 2004
    ..A subset of TLRs recognize viral components and induce antiviral responses by producing type I interferons. Recent accumulating evidence has clarified signaling pathways triggered by TLRs in viral infection...
  5. doi request reprint Immune responses of TLR5(+) lamina propria dendritic cells in enterobacterial infection
    Satoshi Uematsu
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
    J Gastroenterol 44:803-11. 2009
    ..These LPDCs have unique properties in that they can induce acquired immunity as well as innate immunity via TLR5 in the intestine...
  6. doi request reprint The innate immune system in the intestine
    Satoshi Uematsu
    Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka, 565 0871, Japan
    Microbiol Immunol 54:645-57. 2010
    ..One of the NLR, NOD2, is thought to be involved in the pathogenesis of Crohn's disease. This review focuses on the innate immune responses triggered by PRR in the intestine...
  7. pmc Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    J Exp Med 201:915-23. 2005
    ..These results indicated that IRAK-1 is a specific regulator for TLR7- and TLR9-mediated IFN-alpha induction in pDCs...
  8. doi request reprint Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
    Tatsuya Saitoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Immunity 34:352-63. 2011
    ..However, Viperin was dispensable for the production of type I IFN induced by intracellular nucleic acids. Thus, Viperin mediates its antiviral function via the regulation of the TLR7 and TLR9-IRAK1 signaling axis in pDCs...
  9. pmc Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
    Cevayir Coban
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST, Osaka, Japan
    J Exp Med 201:19-25. 2005
    ..These data suggest that TLR9-mediated, MyD88-dependent, and CQ-sensitive innate immune activation by HZ may play an important role in malaria parasite-host interactions...
  10. ncbi request reprint A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    Ken J Ishii
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:40-8. 2006
    ..These results suggest that both TBK1 and IKKi are required for innate immune activation by B-DNA, which might be important in antiviral innate immunity and other DNA-associated immune disorders...
  11. pmc Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling
    Tatsukata Kawagoe
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Exp Med 204:1013-24. 2007
    ..R. Elford, et al. 2006. Science. 311:1927-1932), the TCR signaling was not impaired in IRAK-4(-/-) and IRAK-4(KN/KN) mice. Thus, the kinase activity of IRAK-4 is essential for the regulation of TLR-mediated innate immune responses...
  12. ncbi request reprint Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells
    Kosuke Matsui
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Immunol 177:5785-9. 2006
    ..Thus, these two kinases are essential and compensate each other for the regulation of IFN responses in innate immune cells except plasmacytoid DCs...
  13. ncbi request reprint Pathological role of Toll-like receptor signaling in cerebral malaria
    Cevayir Coban
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Int Immunol 19:67-79. 2007
    ..These results strongly suggest that TLR2- and/or TLR9-mediated, MyD88-dependent brain pathogenesis may play a critical role in CM, the lethal complication during PbA infection...
  14. ncbi request reprint Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0851, Japan
    J Immunol 177:7520-4. 2006
    ..Thus, Ubc13 plays an important role in thymocyte TCR-mediated signaling and immune responses...
  15. ncbi request reprint Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
    Satoshi Uematsu
    Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 9:769-76. 2008
    ..Our findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine...
  16. ncbi request reprint TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Nat Immunol 4:1144-50. 2003
    ..TLR4- but not TLR3-mediated MyD88-independent interferon-beta production and activation of signaling cascades were abolished in TRAM-deficient cells. Thus, TRAM provides specificity for the MyD88-independent component of TLR4 signaling...
  17. ncbi request reprint Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Nature 441:101-5. 2006
    ..Together, our data show that RIG-I and MDA5 distinguish different RNA viruses and are critical for host antiviral responses...
  18. ncbi request reprint Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination
    Shohei Koyama
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka, Japan
    J Immunol 179:4711-20. 2007
    ..These results strongly suggest that either the MyD88 or IPS-1 signaling pathway is sufficient for initial antiviral responses, whereas the protective adaptive immune responses to influenza A virus are governed by the TLR7-MyD88 pathway...
  19. pmc Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency
    Masahiro Yamamoto
    Department of Host Defense and Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 204:2233-9. 2007
    ..These results demonstrate that Trib1 is a negative regulator of NF-IL6 protein expression and modulates NF-IL6-dependent gene expression in TLR-mediated signaling...
  20. ncbi request reprint Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    Nat Immunol 7:868-74. 2006
    ..These data suggest that CD11c+ LPCs, via TLR5, detect and are used by pathogenic bacteria in the intestinal lumen...
  21. ncbi request reprint Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
    Nature 430:218-22. 2004
    ....
  22. pmc Essential role of IPS-1 in innate immune responses against RNA viruses
    Himanshu Kumar
    Department of Host Defense, Japan Science and Technology Agency, Osaka 565 0871, Japan
    J Exp Med 203:1795-803. 2006
    ..IPS-1, however, was not essential for the responses to either DNA virus or double-stranded B-DNA. Thus, IPS-1 is the sole adapter in both RIG-I and Mda5 signaling that mediates effective responses against a variety of RNA viruses...
  23. ncbi request reprint Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest
    Rabindra N Bhattacharjee
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    FEBS Lett 579:6604-10. 2005
    ..We therefore suggest that GADD proteins might play an important role in VT1 induced S phase arrest and programmed cell death in HCT116 cells...
  24. doi request reprint Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation
    Masahiro Fukasaka
    Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
    J Immunol 190:5702-11. 2013
    ..Taken together, AZI2 expression is critical for the generation of cDCs by GM-CSF and can potentially be used to increase the efficiency of immunization by cDCs...
  25. doi request reprint A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity
    Kosuke Fujimoto
    Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan
    J Immunol 186:6287-95. 2011
    ..Accordingly, CD103(+)CD8α(+) LPDCs exhibit a different function from CD103(+)CD8α(-) LPDCs in active immunity. This is the first analysis, to our knowledge, of CD8α(+) DCs in the LP of the small intestine...
  26. ncbi request reprint Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta
    Tomonori Hirotani
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 328:383-92. 2005
    ..Genes known to be induced by type I interferons were simply dependent on TRIF for their expression. Taken together, MyD88 and TRIF play both redundant and distinct roles in LPS-induced gene expression...
  27. ncbi request reprint The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    J Immunol 179:5378-86. 2007
    ..Collectively, we demonstrated that 34-kDa LAP is responsible for NF-IL6-mediated gene induction, but not essential for intracellular bacteria killing in activated macrophages...
  28. ncbi request reprint Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:962-70. 2006
    ..Ubc13-induced activation of mitogen-activated protein kinase required, at least in part, ubiquitination of the adaptor protein IKKgamma. These results show that Ubc13 is key in the mammalian immune response...
  29. pmc Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP
    Kenta Maruyama
    Laboratory of Host Defense, WPI Immunology Frontier Research Center IFReC, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 210:1947-60. 2013
    ..Thus, Sbno2 plays a pivotal role in bone homeostasis in vivo by fine-tuning osteoclast fusion. ..
  30. doi request reprint Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    Tatsuya Saitoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 456:264-8. 2008
    ..These results demonstrate that Atg16L1 is an essential component of the autophagic machinery responsible for control of the endotoxin-induced inflammatory immune response...
  31. pmc Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner
    Takayuki Abe
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Virol 83:7629-40. 2009
    ..These results suggest that a novel signaling pathway(s) other than TLR- and IPS-1-dependent pathways participates in the production of type I IFN in response to AcNPV infection...
  32. ncbi request reprint Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    Taro Kawai
    ERATO, Akira Innate Immunity Program, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 5:1061-8. 2004
    ..These results indicate that TLR-mediated IFN-alpha induction requires the formation of a complex consisting of MyD88, TRAF6 and IRF7 as well as TRAF6-dependent ubiquitination...
  33. ncbi request reprint Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan Science and Technology Corporation, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 420:324-9. 2002
    ..Instead, TIRAP has a crucial role in the MyD88-dependent signalling pathway shared by TLR2 and TLR4...
  34. pmc NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection
    Hisako Kayama
    Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS Pathog 5:e1000514. 2009
    ..T. cruzi-infected Nfatc1(-/-) fetal liver DCs were impaired in IFN-gamma production and DC maturation. These results demonstrate that NFATc1 mediates TLR-independent innate immune responses in T. cruzi infection...
  35. ncbi request reprint Toll-like receptors and Type I interferons
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and ERATO, Japan Science and Technology Corporation, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    J Biol Chem 282:15319-23. 2007
    ..After ligand recognition, these members activate their intrinsic signaling pathways and induce type I interferon. In this review, we discuss the recent findings of the viral recognition by TLRs and their signaling pathways...
  36. ncbi request reprint Pathogen recognition and innate immunity
    Shizuo Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Cell 124:783-801. 2006
    ..New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity...
  37. doi request reprint Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
    Etsushi Kuroda
    Department of Immunology and Parasitology, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807 8555, Japan
    Immunity 34:514-26. 2011
    ..Our results indicate that silica and alum regulate the production of PGE₂ and that the induction of PGE₂ by particulates controls the immune response in vivo...
  38. doi request reprint Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease
    Takayuki Ogino
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Gastroenterology 145:1380-91.e1. 2013
    ..We investigated whether human intestinal lamina propria cells (LPCs) induce development of Th17 cells and whether these have a role in the pathogenesis of CD...
  39. doi request reprint Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance
    Nagatoshi Fujiwara
    Department of Bacteriology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Biochim Biophys Acta 1831:1177-84. 2013
    ..The results indicate that activation of the TLR4-dependent pathway of BMMs by SPLs induced an innate immune response and contributed to bacterial clearance...
  40. ncbi request reprint Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus
    Rabindra N Bhattacharjee
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 335:328-34. 2005
    ..Our results strongly suggest that apoptosis requires functional TTSS1 and TTSS1-dependent translocation factor(s) to be associated with the host cell death, and thus pathogenesis of V. parahaemolyticus...
  41. ncbi request reprint [Toll-like receptor and innate immunity]
    Satoshi Uematsu
    Department of Host Defense Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka, 565 0871, Japan
    Seikagaku 79:769-76. 2007
  42. ncbi request reprint Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice
    Atsushi Kumanogoh
    Department of Molecular Immunology and CREST Program of JST, Research Institute for Microbial DiseasesOsaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Immunity 22:305-16. 2005
    ..Collectively, these results indicate a nonredundant role of Sema4A not only in T cell priming, but also in the regulation of Th1/Th2 responses...
  43. doi request reprint TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    Ken J Ishii
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST
    Nature 451:725-9. 2008
    ..These data suggest that TBK1 is a key signalling molecule for DNA-vaccine-induced immunogenicity, by differentially controlling DNA-activated innate immune signalling through haematopoietic and non-haematopoietic cells...
  44. ncbi request reprint Toll-like receptors and innate immunity
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka, 565 0851, Japan
    J Mol Med (Berl) 84:712-25. 2006
    ..Recently, cytoplasmic PRRs have been identified to detect pathogens that have invaded cytosols. In this review, we focus on the functions of PRRs in innate immunity and their downstream signaling cascades...
  45. ncbi request reprint 'Toll' gates for future immunotherapy
    Ken J Ishii
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST, Suita, Osaka 565 0871, Japan
    Curr Pharm Des 12:4135-42. 2006
    ..The manipulation or intervention of TLR-mediated immune responses is a possible multiple 'Toll' gate for future developments of immunotherapies...
  46. ncbi request reprint Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Immunol 168:5811-6. 2002
    ..Thus, mPGES is critically involved in the biosynthesis of PGE(2) induced by LPS, but is dispensable for the modulation of inflammatory responses...
  47. ncbi request reprint The role of Toll-like receptors in immune disorders
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0851, Japan
    Expert Opin Biol Ther 6:203-14. 2006
    ..This review looks at the role of TLRs in various immune disorders, and discusses the pathogenesis of diseases...