Affiliation: Osaka University
Suzuki K, Sentani K, Tanaka H, Yano T, Suzuki K, Oshima M, et al
. Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H. Pylori Infection. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
Tsukita S, Tanaka H, Tamura A. The Claudins: From Tight Junctions to Biological Systems. Trends Biochem Sci. 2019;44:141-152 pubmed publisher
..Meanwhile, ongoing studies at the cell and tissue levels are clarifying how the paracellular barrier and/or channel functions of claudin-based TJs, which are both robust and flexible, organize various biological systems. ..
Yano T, Torisawa T, Oiwa K, Tsukita S. AMPK-dependent phosphorylation of cingulin reversibly regulates its binding to actin filaments and microtubules. Sci Rep. 2018;8:15550 pubmed publisher
..We propose that the cellular metabolic state, which involves AMPK, can contribute to the organization and maintenance of epithelial tissues through cingulin's tight junction/cytoskeleton regulation. ..
Tanaka H, Imasato M, Yamazaki Y, Matsumoto K, Kunimoto K, Delpierre J, et al
. Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice. J Hepatol. 2018;69:1308-1316 pubmed publisher
..Thus, altered phosphate ion metabolism under cholesterol overdose plays a major role in the lifestyle- and age-related risks of developing cholesterol gallstone disease. ..
Tamura A, Tsukita S. Paracellular barrier and channel functions of TJ claudins in organizing biological systems: advances in the field of barriology revealed in knockout mice. Semin Cell Dev Biol. 2014;36:177-85 pubmed publisher
Tamura A, Kitano Y, Hata M, Katsuno T, Moriwaki K, Sasaki H, et al
. Megaintestine in claudin-15-deficient mice. Gastroenterology. 2008;134:523-34 pubmed publisher
Tsukita S, Katsuno T, Yamazaki Y, Umeda K, Tamura A, Tsukita S. Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function. Ann N Y Acad Sci. 2009;1165:44-52 pubmed publisher
Matsumoto K, Imasato M, Yamazaki Y, Tanaka H, Watanabe M, Eguchi H, et al
. Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice. Gastroenterology. 2014;147:1134-45.e10 pubmed publisher
..Dysregulation of this process increases susceptibility to cholesterol gallstone disease in mice. ..
Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, et al
. Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. Proc Natl Acad Sci U S A. 2016;113:E4061-8 pubmed publisher
..Furthermore, we revealed a relationship between macrophage recruitment and CLDN1 levels in human AD patients. Our findings collectively suggest that CLDN1 regulates the pathogenesis, severity, and natural course of human AD. ..