A Tsujimura

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi Low serum free testosterone level is associated with carotid intima-media thickness in middle-aged Japanese men
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Endocr J 59:809-15. 2012
  2. ncbi Survey of overactive bladder symptoms influencing bother before and after treatment with tamsulosin hydrochloride in Japanese patients with benign prostatic hyperplasia
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Urology 78:1058-62. 2011
  3. ncbi Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study
    Olaf Sunnotel
    Transcriptional Regulation and Epigenetics, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Reprod Biol Endocrinol 8:22. 2010
  4. ncbi Salvage microdissection testicular sperm extraction after failed conventional testicular sperm extraction in patients with nonobstructive azoospermia
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Urol 175:1446-9; discussion 1449. 2006
  5. ncbi Clinical trial of treatment with saikokaryukotsuboreito for eugonadal patients with late-inset hypogonadism-related symptoms
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Aging Male 11:95-9. 2008
  6. ncbi Is discontinuation of hormone replacement therapy possible for patients with late-onset hypogonadism?
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 15:625-9. 2008
  7. ncbi Microdissection testicular sperm extraction: prediction, outcome, and complications
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 14:883-9. 2007
  8. ncbi Comparative study on evaluation methods for serum testosterone level for PADAM diagnosis
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Impot Res 17:259-63. 2005
  9. ncbi Expression of inhibin alpha, glial cell line-derived neurotrophic factor and stem cell factor in Sertoli cell-only syndrome: relation to successful sperm retrieval by microdissection testicular sperm extraction
    K Fujita
    Department of Urology and Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Osaka 565 0871, Japan
    Hum Reprod 20:2289-94. 2005
  10. ncbi Brain processing of audiovisual sexual stimuli inducing penile erection: a positron emission tomography study
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka University, Suita, Japan
    J Urol 176:679-83. 2006

Collaborators

Detail Information

Publications90

  1. ncbi Low serum free testosterone level is associated with carotid intima-media thickness in middle-aged Japanese men
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Endocr J 59:809-15. 2012
    ....
  2. ncbi Survey of overactive bladder symptoms influencing bother before and after treatment with tamsulosin hydrochloride in Japanese patients with benign prostatic hyperplasia
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Urology 78:1058-62. 2011
    ..Annoyance from BPH usually provides the basis for a patient's decision to seek medical treatment. However, a study investigating the bother caused by OAB symptoms in patients with BPH and OAB has not been fully conducted...
  3. ncbi Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study
    Olaf Sunnotel
    Transcriptional Regulation and Epigenetics, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Reprod Biol Endocrinol 8:22. 2010
    ..In infertile men, no mutations of FKBP52 or FKBP6 have been found so far, but the gene for FKBP-like (FKBPL) maps to chromosome 6p21.3, an area linked to azoospermia in a group of Japanese patients...
  4. ncbi Salvage microdissection testicular sperm extraction after failed conventional testicular sperm extraction in patients with nonobstructive azoospermia
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Urol 175:1446-9; discussion 1449. 2006
    ..We also evaluated relations between the outcome of salvage microdissection TESE and the characteristics of previous conventional TESE...
  5. ncbi Clinical trial of treatment with saikokaryukotsuboreito for eugonadal patients with late-inset hypogonadism-related symptoms
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Aging Male 11:95-9. 2008
    ..Laboratory values did not change, and no adverse effects were identified after treatment. We conclude that SKRBT may be considered for treatment of patients with LOH-related symptoms for eugonadal patients...
  6. ncbi Is discontinuation of hormone replacement therapy possible for patients with late-onset hypogonadism?
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 15:625-9. 2008
    ..However, whether lifetime HRT is necessary has not been settled. We evaluated LOH-related symptoms and endocrinologic values after discontinuation of HRT in patients with LOH who had benefited from it...
  7. ncbi Microdissection testicular sperm extraction: prediction, outcome, and complications
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 14:883-9. 2007
    ..The present review considers the surgical procedure, outcome, prediction for spermatozoa retrieval, and postoperative complications of microdissection TESE...
  8. ncbi Comparative study on evaluation methods for serum testosterone level for PADAM diagnosis
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Impot Res 17:259-63. 2005
    ..PADAM symptoms are not related to testosterone level and it is still obscure whether ISSAM's criterion can be adopted for Japanese patients with PADAM. Other pathology needs to be addressed for evaluation and diagnosis of PADAM in Japan...
  9. ncbi Expression of inhibin alpha, glial cell line-derived neurotrophic factor and stem cell factor in Sertoli cell-only syndrome: relation to successful sperm retrieval by microdissection testicular sperm extraction
    K Fujita
    Department of Urology and Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Osaka 565 0871, Japan
    Hum Reprod 20:2289-94. 2005
    ....
  10. ncbi Brain processing of audiovisual sexual stimuli inducing penile erection: a positron emission tomography study
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka University, Suita, Japan
    J Urol 176:679-83. 2006
    ....
  11. ncbi Significance of electrostimulation in detecting neurovascular bundle during radical prostatectomy
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:926-31. 2006
    ....
  12. ncbi Treatment with human chorionic gonadotropin for PADAM: a preliminary report
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Aging Male 8:175-9. 2005
    ..No adverse effect was identified after treatment. We conclude that hCG injection may be considered as a treatment for PADAM...
  13. ncbi Associations of homologous RNA-binding motif gene on the X chromosome (RBMX) and its like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia
    Akira Tsujimura
    Department of Urology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Asian J Androl 8:213-8. 2006
    ....
  14. ncbi Sex differences in visual attention to sexually explicit videos: a preliminary study
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Sex Med 6:1011-7. 2009
    ..Eye-tracking technology has been used to investigate visual attention to still sexual images; however, it has not been applied to moving sexual images...
  15. ncbi The relation between sexual interest and personality characteristics in men: an eye-tracking study
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Int J Impot Res 22:185-9. 2010
    ..This is the first report showing that subjects with a high degree of paranoia, psychasthenia and particularly social introversion have a tendency to view the sexual region for a shorter duration...
  16. ncbi Recent topics related to testosterone deficiency syndrome in Japan
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Asian J Androl 13:558-62. 2011
    ..The increase in the levels of several cytokines, such as IL-8, IL-13, interferon-γ and tumor necrosis factor-α, after herbal medicine treatment may be the reason for this efficacy...
  17. ncbi Urgency is an independent factor for sleep disturbance in men with obstructive sleep apnea
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Urology 76:967-70. 2010
    ....
  18. ncbi Change in cytokine levels after administration of saikokaryuukotsuboreito or testosterone in patients with symptoms of late-onset hypogonadism
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Aging Male 14:76-81. 2011
    ..We conclude that SKRBT might improve LOH-related symptoms in eugonadal patients through the beneficial effect of cytokines, a mechanism that is quite different from ART...
  19. ncbi Conventional multiple or microdissection testicular sperm extraction: a comparative study
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan
    Hum Reprod 17:2924-9. 2002
    ..CONCLUSIONS: Microsurgical technique is safe and may improve SRR for TESE in a variety of patients with NOA, especially patients with heterogeneous testicular tubules...
  20. ncbi Serial follow-up study of serum testosterone and antisperm antibodies in patients with non-obstructive azoospermia after conventional or microdissection testicular sperm extraction
    K Komori
    Department of Urology, Osaka Police Hospital, Osaka, Japan
    Int J Androl 27:32-6. 2004
    ..Therefore, microdissection TESE is safe with respect to testicular damage, particularly for patients with hypogonadism...
  21. ncbi Effect of lifestyle factors on infertility in men
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka Central Hospital, Osaka, Japan
    Arch Androl 50:15-7. 2004
    ..05). Alcohol use was significantly more common in infertile men (92%) than in controls (80%; P < 0.01). Satisfaction with sexual life was greater in controls (85%) than in infertile men (77%; P < 0.05). Other factors had no effect...
  22. ncbi Outcome of surgical treatment for obstructive azoospermia
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Arch Androl 48:29-36. 2002
    ..Although mailed questionnaires and telephone interviews indicated occurrence of natural pregnancy in only 4 affected couples, postoperative sperm counts were relatively satisfactory as in previous reports...
  23. ncbi Effects of hepatocyte growth factor on E-cadherin-mediated cell-cell adhesion in DU145 prostate cancer cells
    H Miura
    Department of Specific Organ Regulation (Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Urology 58:1064-9. 2001
    ..CONCLUSIONS: These results indicate that HGF induces scattering by decreasing the expression of E-cadherin and causes its translocation to the cytoplasm of DU145 cells...
  24. ncbi Effect of renal transplantation on sexual function
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Arch Androl 48:467-74. 2002
    ..It is concluded that renal transplantation cannot improve sexual function in all patients, although hormonal profiles were largely normalized, and that renal transplantation should be encouraged at a younger age...
  25. ncbi Single nucleotide polymorphisms: discovery of the genetic causes of male infertility
    H Tanaka
    TANAKA Project, Center for Advanced Science and Innovation, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Soc Reprod Fertil Suppl 65:531-4. 2007
    ..These findings strongly support the hypothesis that dysfunction of germ cell-specific genes causes idiopathic human male infertility...
  26. ncbi Genomic analysis of idiopathic infertile patients with sperm-specific depletion of CD46
    M Nomura
    Department of Immunology, Osaka Medical Center for Cancer, Osaka, Japan
    Exp Clin Immunogenet 18:42-50. 2001
    ..Other unknown factors outside the known regulatory regions would play a role in the regulation of sperm-specific CD46 expression...
  27. ncbi Decreased immunostaining for macrophage scavenger receptor is associated with poor prognosis of prostate cancer
    Hitoshi Takayama
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    BJU Int 103:470-4. 2009
    ....
  28. ncbi Association of selenoprotein P with testosterone production in cultured Leydig cells
    K Nishimura
    Department of Specific Organ Regulation Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Arch Androl 47:67-76. 2001
    ..Testosterone concentration in the medium also increased, becoming maximal at 15 h. Selenoprotein P induced in Leydig cells following cAMP stimulation may counteract O2 toxicity from cAMP-mediated increases in testosterone production...
  29. ncbi Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer
    N Nonomura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Br J Cancer 97:952-6. 2007
    ..Multivariate analysis revealed that mast cell count was a significant prognostic factor (P<0.005). The number of mast cells infiltrating around cancer foci in prostate biopsy specimens can be a significant prognostic factor of PCa...
  30. ncbi Retrospective analysis of an oral combination of dexamethasone, uracil plus tegafur and cyclophosphamide for hormone-refractory prostate cancer
    Koji Hatano
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Jpn J Clin Oncol 41:253-9. 2011
    ..To evaluate the clinical utility of an oral combination of dexamethasone, uracil plus tegafur and cyclophosphamide as a treatment for patients with hormone-refractory prostate cancer...
  31. ncbi Successful superselective arterial embolization for post-traumatic high-flow priapism
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita, Osaka 565 0871, Japan
    Int J Urol 14:254-6. 2007
    ..In our review of the literature, superselective arterial embolization could be an alternative treatment after more than 3 weeks of conservative treatment...
  32. ncbi Prostatic stem cell marker identified by cDNA microarray in mouse
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita and Osaka Police Hospital, Osaka, Japan
    J Urol 178:686-91. 2007
    ..We recently reported that the proximal region of the mouse prostate contains a population of stem cells. However, to our knowledge the specific marker of stem cells in the proximal region remains unknown...
  33. ncbi Atorvastatin inhibits renal crystal retention in a rat stone forming model
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 180:2212-7. 2008
    ..Atorvastatin is also reported to control transforming growth factor-beta1 expression. We investigated whether atorvastatin can prevent renal tubular cell injury by oxalate and inhibit renal crystal retention...
  34. ncbi Laparoscopic adrenalectomy for primary hyperaldosteronism: clinical experience with 60 cases
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Endourol 20:262-5. 2006
    ..To assess the long-term outcome of patients with primary hyperaldosteronism who underwent laparoscopic adrenalectomy and to study hormone dynamics and differences between postoperative and preoperative blood pressure...
  35. ncbi Clinical experience with laparoscopic radical nephrectomy for renal cell carcinoma
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Urol Int 81:301-5. 2008
    ....
  36. ncbi Effect of 1,25-dihydroxyvitamin d on testicular morphology and gene expression in experimental cryptorchid mouse: testis specific cDNA microarray analysis and potential implication in male infertility
    Toshiaki Hirai
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Urol 181:1487-92. 2009
    ..We evaluated the morphological effect and alterations in gene expression caused by 1,25-dihydroxyvitamin D treatment in the mouse testis undergoing experimental cryptorchidism and subsequent orchiopexy...
  37. ncbi Decreased infiltration of macrophage scavenger receptor-positive cells in initial negative biopsy specimens is correlated with positive repeat biopsies of the prostate
    Norio Nonomura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 101:1570-3. 2010
    ..Decreased infiltration of MSR-positive cells in negative first biopsy specimens was correlated with positive findings in the repeat biopsy. The MSR count might be a good indicator for avoiding unnecessary repeat biopsies...
  38. ncbi Laparoscopic nephroureterectomy for upper tract transitional cell carcinoma: comparison of laparoscopic and open surgery
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita Japan
    Eur Urol 49:332-6. 2006
    ..We made a comparative study of laparoscopic nephroureterectomy (LNU) and standard open surgery (ONU) for upper urinary tract transitional cell carcinoma...
  39. ncbi Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein
    Hiromitsu Tanaka
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Int J Androl 29:353-9. 2006
    ..h-HANP1 is expressed in the testes and its genomic construct also intronless as mouse Hanp1. We found that the h-HANP1 coding region have 5 single-nucleotide polymorphisms in Japanese men...
  40. ncbi Susceptibility gene for non-obstructive azoospermia located near HLA-DR and -DQ loci in the HLA class II region
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
    Hum Genet 110:192-7. 2002
    ..Taken together, our previous and present data suggest that the critical region for development of non-obstructive azoospermia is near the HLA-DRB1 and -DQB1 segments in the HLA class II region...
  41. ncbi Clinical analysis of patients with azoospermia factor deletions by microdissection testicular sperm extraction
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
    Int J Androl 27:76-81. 2004
    ..Sperm retrieval rates were not significantly different between the groups. In conclusion, AZF deletions do not appear to confer specific characteristics to NOA patients...
  42. ncbi Lower urinary tract symptoms after hormone replacement therapy in Japanese patients with late-onset hypogonadism: a preliminary report
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 16:212-4. 2009
    ..91 +/- 1.13 after 3 months. There were no significant differences in any of the nine categories of KHQ. In this preliminary study, the results suggested that HRT for LOH had no short-term effects on patients with lower urinary symptoms...
  43. ncbi Prediction of successful outcome of microdissection testicular sperm extraction in men with idiopathic nonobstructive azoospermia
    Akira Tsujimura
    From the Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 172:1944-7. 2004
    ....
  44. ncbi Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation
    Hiroshi Kiuchi
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 181:2339-48. 2009
    ..Moreover, we determined the molecular mechanisms of parthenolide on the inhibitory action of nuclear factor-kappaB in inflammatory human benign urothelial cells...
  45. ncbi Clinical comparison of successful and failed microdissection testicular sperm extraction in patients with nonmosaic Klinefelter syndrome
    Minoru Koga
    Department of Urology, Osaka Central Hospital, Osaka, Japan
    Urology 70:341-5. 2007
    ..However, predicting successful microdissection TESE for patients with KS remains controversial. Thus, we conducted a study to determine whether the prediction of successful microdissection TESE is possible in patients with nonmosaic KS...
  46. ncbi Androgen decline in patients with nonobstructive azoospemia after microdissection testicular sperm extraction
    Shingo Takada
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Urology 72:114-8. 2008
    ..However, few studies of the postoperative endocrinologic course have been reported. We evaluated the endocrinologic course for 1 year after microdissection TESE and compared the results with the testicular histologic findings...
  47. ncbi Differential brain processing of audiovisual sexual stimuli in men: comparative positron emission tomography study of the initiation and maintenance of penile erection during sexual arousal
    Yasushi Miyagawa
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Neuroimage 36:830-42. 2007
    ....
  48. ncbi Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at university affiliated male infertility centers: a 30-year retrospective study
    Yasushi Miyagawa
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Urol 173:2072-5. 2005
    ..CONCLUSIONS: Initial TV values provide insight into phenotypic variables such as time of onset and severity in patients with primary or secondary HH, and may predict sperm output in response to hCG/hMG therapy...
  49. ncbi Isolation of germ cells from leukemia and lymphoma cells in a human in vitro model: potential clinical application for restoring human fertility after anticancer therapy
    Kazutoshi Fujita
    Department of Urology, Osaka University Graduate School of Medicine, Suita Osaka, Japan
    Cancer Res 66:11166-71. 2006
    ..Immunophenotyping for each patient will be necessary before isolation and induction of surface marker will be clinically applicable...
  50. ncbi A case of renal cell carcinoma with multiple lung metastases refractory to interferon-alpha showing complete remission by interleukin-2 monotherapy
    Tetsuya Hayashi
    Department of Urology, Division of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:805-8. 2006
    ..Resection of this residual lung mass was performed and pathological examination revealed no viable cancer cells...
  51. ncbi Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia
    Kazutoshi Fujita
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan. Laboratory for Genomic Reprogramming, Center for Developmental Biology, Institute of Physical and Chemical Research (RIKEN, Kobe, Japan
    J Clin Invest 115:1855-61. 2005
    ....
  52. ncbi [Testicular dysfunction]
    Shingo Takada
    Department of Urology, Osaka University Graduate School of Medicine
    Nippon Rinsho 64:484-8. 2006
  53. ncbi Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations
    Yasushi Miyagawa
    Department of Urology, Osaka University Graduate School of Medicine, Suita City, Osaka 565 0871, Japan
    J Androl 26:779-86. 2005
    ..This deletion reduces TNP1 expression and may cause human male infertility...
  54. ncbi Isolation and characterization of the spermatid-specific Smrp1 gene encoding a novel manchette protein
    Yasuhiro Matsuoka
    Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Mol Reprod Dev 75:967-75. 2008
    ..This localization pattern coincided with that of the manchette. SMRP1 may play an important role as a functional protein that co-operates with manchette proteins...
  55. ncbi Association of the shrinkage of uterine leiomyoma treated with GnRH agonist and deletion of long arm of chromosome 7
    K Takahashi
    Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Int J Oncol 18:1259-63. 2001
    ....
  56. ncbi Relation between erectile dysfunction and urinary incontinence after nerve-sparing and non-nerve-sparing radical prostatectomy
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Urol Int 73:31-5. 2004
    ..CONCLUSION: No relation between the status of urinary continence and erectile function was shown, regardless of the nerve-sparing nature of the prostatectomy...
  57. ncbi Effects of hepatocyte growth factor on urokinase-type plasminogen activator (uPA) and uPA receptor in DU145 prostate cancer cells
    Kenji Nishimura
    Department of Specific Organ Regulation (Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Androl 26:175-9. 2003
    ..HGF stimulated a uPA/uPAR proteolytic network in DU145 cells, which may be important for acquisition invasive potential by prostate cancer...
  58. ncbi Increased vascular endothelial growth factor expression in patients with bladder pain syndrome/interstitial cystitis: its association with pain severity and glomerulations
    Hiroshi Kiuchi
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    BJU Int 104:826-31; discussion 831. 2009
    ....
  59. ncbi Bioavailable testosterone with age and erectile dysfunction
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 170:2345-7. 2003
    ..We emphasize that measuring serum testosterone is necessary in aging males...
  60. ncbi Type-I interferon receptor expression: its circadian rhythm and downregulation after interferon-alpha administration in peripheral blood cells from renal cancer patients
    Masahiro Shiba
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 16:356-9. 2009
    ..To investigate the regulation of interferon-alpha (IFN-alpha) receptor expression in metastatic renal cell carcinoma (RCC) after IFN-alpha administration...
  61. ncbi [Leydig cell tumor of the testis presenting male infertility: a case report]
    Toyofumi Abe
    Department of Urology, Osaka University Graduate School of Medicine
    Hinyokika Kiyo 49:39-42. 2003
    ..Histologically, this testicular mass was a Leydig cell tumor. We reviewed 55 cases of Leydig cell tumor of the testis previously reported in Japan, and reported the hormonal profile in our case before and after surgery...
  62. ncbi Adiponectin and testosterone in patients with symptoms of late-onset hypogonadism: is there a link?
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 16:830-5. 2009
    ..To examine the correlation between testosterone and adiponectin in symptomatic late-onset hypogonadism (LOH) patients...
  63. ncbi Ketone bodies could support the motility but not the acrosome reaction of mouse sperm
    Hiromitsu Tanaka
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan
    Int J Androl 27:172-7. 2004
    ....
  64. ncbi [Testicular dysfunction]
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine
    Nippon Rinsho 60:344-7. 2002
  65. ncbi Prostate stem cells: the niche and cell markers
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 15:289-94. 2008
    ..Several candidate prostate stem cell markers are currently under investigation. In this review, we summarize the historical approaches and recent evidence regarding the niche and prostate-specific stem cell markers...
  66. ncbi The clinical studies of sildenafil for the ageing male
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Androl 25:28-33. 2002
    ..Sildenafil can be used safely and it is still effective for ageing male, because nearly two-thirds of our older subjects had a good response to the drug and no adverse effect was specific to older patients...
  67. ncbi [Bone and Men's Health. Testosterone and lifestyle disease]
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine
    Clin Calcium 20:217-23. 2010
    ..However, no inverse correlation exists between them in patients with LOH. Testosterone replacement treatment is expected to be one of treatments for metabolic syndrome...
  68. ncbi Relationship between substances in seminal plasma and Acrobeads Test results
    Kazuhiko Komori
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Fertil Steril 91:179-84. 2009
    ..To asses the effects of seminal plasma on sperm function...
  69. ncbi Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations
    Hiromitsu Tanaka
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita City, Japan
    Mol Hum Reprod 9:69-73. 2003
    ..Although the PRM1 and PRM2 genes are highly conserved, the single SNP in the PRM2 gene that induces translation termination may result in male infertility due to haploinsufficiency of PRM2...
  70. ncbi Mechanism underlying the low prevalence of pediatric calcium oxalate urolithiasis
    Chikahiro Momohara
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 182:1201-9. 2009
    ..To investigate the mechanism of Ca oxalate urolithiasis we evaluated the differences in inhibitory activity against oxalate induced renal cell injury between adults and children...
  71. ncbi [Clinical efficacy of tolterodine for patients with overactive bladder after insufficient efficacy by monotherapy with alpha1-adrenoceptor antagonist]
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine
    Nihon Hinyokika Gakkai Zasshi 100:686-92. 2009
    ..The adverse event of this combined therapy was also assessed...
  72. ncbi Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis
    Sompol Permpongkosol
    Department of Urology, Osaka University Medical School, Suita-city, Osaka, Japan
    Int J Cancer 98:167-72. 2002
    ..FTY720 may exert anticarcinogenic effects against prostate cancer cells possibly involving modulation of mitogenic signaling, cell-cycle regulators, induction of G(1) arrest and apoptotic death in DU145 cells...
  73. ncbi Effect of human leukemia cells in testicular tissues grafted into immunodeficient mice
    Kazutoshi Fujita
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Urol 15:733-8. 2008
    ..However, malignant cells present in the testicular tissue may disturb spermatogenesis in the xenografts. Here we examined the effect of human leukemia cells on ectopic xenografts in immunodeficient mice...
  74. ncbi Testicular epidermoid cyst in Klinefelter's syndrome
    Takahiro Yoshida
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:478-80. 2006
    ..Histological examination revealed an epidermoid cyst of the right testis. Epidermoid cysts in cases of KFS are rare. To our knowledge, only seven cases, including ours, have been reported in the literature...
  75. ncbi Nitric oxide synthesis leads to vascular endothelial growth factor synthesis via the NO/cyclic guanosine 3',5'-monophosphate (cGMP) pathway in human corpus cavernosal smooth muscle cells
    Kazuhiko Komori
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Sex Med 5:1623-35. 2008
    ..Expression of eNOS in corpus cavernosal smooth muscle has also been reported. However, it is unclear whether CCSMCs can generate NO...
  76. ncbi [Hormone replacement Up-to-date. The effect of androgen replacement therapy on bone metabolism]
    Yasushi Miyagawa
    Osaka University Graduate School of Medicine, Department of Urology, Japan
    Clin Calcium 17:1372-7. 2007
    ..A well-controlled larger clinical study to test androgen replacement therapy for aging male is expected also in Japan...
  77. ncbi Brain responses during the first desire to void: a positron emission tomography study
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 15:724-8. 2008
    ..First desire to void (FDV) is defined as the first feeling that would lead the patient to pass urine. The aim of the present study is to identify the brain regions activated during FDV...
  78. ncbi Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein
    Tomohiro Ueda
    TANAKA Project, Center for Advanced Science and Innovation, Osaka University, Suita, Osaka, Japan
    Int J Urol 16:639-46. 2009
    ..To examine the expression profiles of the proteins translated from Acpin1 mRNA in germ cells...
  79. ncbi Susceptibility gene for non-obstructive azoospermia in the HLA class II region: correlations with Y chromosome microdeletion and spermatogenesis
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Androl 27:37-41. 2004
    ..In either case, this haplotype showed association with severe spermatogenic impairment...
  80. ncbi Urological surgery in patients aged 80 years and older: a 30-year retrospective clinical study
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 15:789-93. 2008
    ..To investigate changes in the management of cases over time, we undertook a retrospective analysis of urological surgeries carried out in patients aged 80 years and older in a single institution over the last 30 years...
  81. ncbi Clinical practice manual for late-onset hypogonadism syndrome
    Mikio Namiki
    Int J Urol 15:377-88. 2008
  82. ncbi Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
    Akira Tsujimura
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 157:1257-65. 2002
    ..This model can account for many biological differences between cells of the proximal and distal regions, and has implications for prostatic disease formation...
  83. ncbi Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats
    Masaki Yamanaka
    Department of Urology, Veterans Affairs Medical Center, University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Urol 170:291-7. 2003
    ..To our knowledge this is the first report demonstrating that the relief of diabetes associated erectile dysfunction by insulin treatment is due to alterations in the protein expression of apoptotic factors in rat crura...
  84. ncbi Androgens modulate the balance between VEGF and angiopoietin expression in prostate epithelial and smooth muscle cells
    Christian Richard
    Department of Cell Biology and the Kaplan Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Prostate 50:83-91. 2002
    ..Synthesis of the angiopoietins did not respond to androgen treatment. CONCLUSIONS: Prostate smooth muscle may play an important role in regulating vascular responses to androgen...
  85. ncbi Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura
    Masaki Yamanaka
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Urol 173:318-23. 2005
    ..We hypothesized that intracavernous administration of VEGF would recover erectile dysfunction due to diabetes by protection from apoptosis in the penile cavernosum...
  86. ncbi Inter/intra investigator variation in orchidometric measurements of testicular volume by ten investigators from five institutions
    Shinobu Tatsunami
    Unit of Medical Statistics, Faculty of Medical Education and Culture, St. Marianna University School of Medicine, Kawasaki, Japan
    Asian J Androl 8:373-8. 2006
    ..Improved training and proper standardization of the measurement will be necessary before starting a multi-center study based on an andrological examination...
  87. ncbi [Predictive factors associated with successful varicocele repair a study of 139 infertile men with valicocele]
    Hiroshi Kiuchi
    Department of Urology, Osaka Central Hospital
    Nippon Hinyokika Gakkai Zasshi 96:480-6. 2005
    ..Our data suggest that patients with grade 3 varicocele, low serum FSH level and high sperm motility are more likely to benefit from varicocele repair in sperm concentration...
  88. ncbi Stromal/epithelial interactions of murine prostatic cell lines in vivo: a model for benign prostatic hyperplasia and the effect of doxazosin on tissue size
    Tetsuya Takao
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Prostate 54:17-24. 2003
    ....
  89. ncbi Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis
    Keizo Tokuhiro
    TANAKA Project, Center for Advanced Science and Innovation, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 283:19039-48. 2008
    ..Our results suggest that MCA is essential for sperm flagellum formation and the production of functional sperm...
  90. ncbi Differentiation and stromal-induced growth promotion of murine prostatic tumors
    Sarah N Salm
    Department of Cell Biology, MSB 634, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Prostate 51:175-88. 2002
    ....