A Tsujimura

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. doi request reprint Is low testosterone concentration a risk factor for metabolic syndrome in healthy middle-aged men?
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan Electronic address
    Urology 82:814-9. 2013
  2. ncbi request reprint Low serum free testosterone level is associated with carotid intima-media thickness in middle-aged Japanese men
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Endocr J 59:809-15. 2012
  3. doi request reprint Survey of overactive bladder symptoms influencing bother before and after treatment with tamsulosin hydrochloride in Japanese patients with benign prostatic hyperplasia
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Urology 78:1058-62. 2011
  4. pmc Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study
    Olaf Sunnotel
    Transcriptional Regulation and Epigenetics, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Reprod Biol Endocrinol 8:22. 2010
  5. doi request reprint Urgency is an independent factor for sleep disturbance in men with obstructive sleep apnea
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Urology 76:967-70. 2010
  6. doi request reprint The relation between sexual interest and personality characteristics in men: an eye-tracking study
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Int J Impot Res 22:185-9. 2010
  7. ncbi request reprint Associations of homologous RNA-binding motif gene on the X chromosome (RBMX) and its like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia
    Akira Tsujimura
    Department of Urology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Asian J Androl 8:213-8. 2006
  8. doi request reprint Sex differences in visual attention to sexually explicit videos: a preliminary study
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Sex Med 6:1011-7. 2009
  9. ncbi request reprint Treatment with human chorionic gonadotropin for PADAM: a preliminary report
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Aging Male 8:175-9. 2005
  10. doi request reprint Is discontinuation of hormone replacement therapy possible for patients with late-onset hypogonadism?
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 15:625-9. 2008

Collaborators

Detail Information

Publications92

  1. doi request reprint Is low testosterone concentration a risk factor for metabolic syndrome in healthy middle-aged men?
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan Electronic address
    Urology 82:814-9. 2013
    ....
  2. ncbi request reprint Low serum free testosterone level is associated with carotid intima-media thickness in middle-aged Japanese men
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Endocr J 59:809-15. 2012
    ....
  3. doi request reprint Survey of overactive bladder symptoms influencing bother before and after treatment with tamsulosin hydrochloride in Japanese patients with benign prostatic hyperplasia
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Urology 78:1058-62. 2011
    ..Annoyance from BPH usually provides the basis for a patient's decision to seek medical treatment. However, a study investigating the bother caused by OAB symptoms in patients with BPH and OAB has not been fully conducted...
  4. pmc Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study
    Olaf Sunnotel
    Transcriptional Regulation and Epigenetics, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Reprod Biol Endocrinol 8:22. 2010
    ..In infertile men, no mutations of FKBP52 or FKBP6 have been found so far, but the gene for FKBP-like (FKBPL) maps to chromosome 6p21.3, an area linked to azoospermia in a group of Japanese patients...
  5. doi request reprint Urgency is an independent factor for sleep disturbance in men with obstructive sleep apnea
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Urology 76:967-70. 2010
    ....
  6. doi request reprint The relation between sexual interest and personality characteristics in men: an eye-tracking study
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Int J Impot Res 22:185-9. 2010
    ..This is the first report showing that subjects with a high degree of paranoia, psychasthenia and particularly social introversion have a tendency to view the sexual region for a shorter duration...
  7. ncbi request reprint Associations of homologous RNA-binding motif gene on the X chromosome (RBMX) and its like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia
    Akira Tsujimura
    Department of Urology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Asian J Androl 8:213-8. 2006
    ....
  8. doi request reprint Sex differences in visual attention to sexually explicit videos: a preliminary study
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Sex Med 6:1011-7. 2009
    ..Eye-tracking technology has been used to investigate visual attention to still sexual images; however, it has not been applied to moving sexual images...
  9. ncbi request reprint Treatment with human chorionic gonadotropin for PADAM: a preliminary report
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Aging Male 8:175-9. 2005
    ..No adverse effect was identified after treatment. We conclude that hCG injection may be considered as a treatment for PADAM...
  10. doi request reprint Is discontinuation of hormone replacement therapy possible for patients with late-onset hypogonadism?
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 15:625-9. 2008
    ..However, whether lifetime HRT is necessary has not been settled. We evaluated LOH-related symptoms and endocrinologic values after discontinuation of HRT in patients with LOH who had benefited from it...
  11. ncbi request reprint Clinical trial of treatment with saikokaryukotsuboreito for eugonadal patients with late-inset hypogonadism-related symptoms
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Aging Male 11:95-9. 2008
    ..Laboratory values did not change, and no adverse effects were identified after treatment. We conclude that SKRBT may be considered for treatment of patients with LOH-related symptoms for eugonadal patients...
  12. ncbi request reprint Expression of inhibin alpha, glial cell line-derived neurotrophic factor and stem cell factor in Sertoli cell-only syndrome: relation to successful sperm retrieval by microdissection testicular sperm extraction
    K Fujita
    Department of Urology and Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Osaka 565 0871, Japan
    Hum Reprod 20:2289-94. 2005
    ....
  13. ncbi request reprint Salvage microdissection testicular sperm extraction after failed conventional testicular sperm extraction in patients with nonobstructive azoospermia
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Urol 175:1446-9; discussion 1449. 2006
    ..We also evaluated relations between the outcome of salvage microdissection TESE and the characteristics of previous conventional TESE...
  14. ncbi request reprint Comparative study on evaluation methods for serum testosterone level for PADAM diagnosis
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Impot Res 17:259-63. 2005
    ..PADAM symptoms are not related to testosterone level and it is still obscure whether ISSAM's criterion can be adopted for Japanese patients with PADAM. Other pathology needs to be addressed for evaluation and diagnosis of PADAM in Japan...
  15. ncbi request reprint Microdissection testicular sperm extraction: prediction, outcome, and complications
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 14:883-9. 2007
    ..The present review considers the surgical procedure, outcome, prediction for spermatozoa retrieval, and postoperative complications of microdissection TESE...
  16. doi request reprint Change in cytokine levels after administration of saikokaryuukotsuboreito or testosterone in patients with symptoms of late-onset hypogonadism
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Aging Male 14:76-81. 2011
    ..We conclude that SKRBT might improve LOH-related symptoms in eugonadal patients through the beneficial effect of cytokines, a mechanism that is quite different from ART...
  17. pmc Recent topics related to testosterone deficiency syndrome in Japan
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Asian J Androl 13:558-62. 2011
    ..The increase in the levels of several cytokines, such as IL-8, IL-13, interferon-γ and tumor necrosis factor-α, after herbal medicine treatment may be the reason for this efficacy...
  18. ncbi request reprint Brain processing of audiovisual sexual stimuli inducing penile erection: a positron emission tomography study
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka University, Suita, Japan
    J Urol 176:679-83. 2006
    ....
  19. ncbi request reprint Significance of electrostimulation in detecting neurovascular bundle during radical prostatectomy
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:926-31. 2006
    ....
  20. ncbi request reprint Conventional multiple or microdissection testicular sperm extraction: a comparative study
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871, Japan
    Hum Reprod 17:2924-9. 2002
    ..However, a comprehensive comparison between multiple and microdissection TESE patients including histological findings has not been reported...
  21. ncbi request reprint Effect of lifestyle factors on infertility in men
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka Central Hospital, Osaka, Japan
    Arch Androl 50:15-7. 2004
    ..05). Alcohol use was significantly more common in infertile men (92%) than in controls (80%; P < 0.01). Satisfaction with sexual life was greater in controls (85%) than in infertile men (77%; P < 0.05). Other factors had no effect...
  22. ncbi request reprint Serial follow-up study of serum testosterone and antisperm antibodies in patients with non-obstructive azoospermia after conventional or microdissection testicular sperm extraction
    K Komori
    Department of Urology, Osaka Police Hospital, Osaka, Japan
    Int J Androl 27:32-6. 2004
    ..Therefore, microdissection TESE is safe with respect to testicular damage, particularly for patients with hypogonadism...
  23. ncbi request reprint Outcome of surgical treatment for obstructive azoospermia
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Arch Androl 48:29-36. 2002
    ..Although mailed questionnaires and telephone interviews indicated occurrence of natural pregnancy in only 4 affected couples, postoperative sperm counts were relatively satisfactory as in previous reports...
  24. ncbi request reprint Effects of hepatocyte growth factor on E-cadherin-mediated cell-cell adhesion in DU145 prostate cancer cells
    H Miura
    Department of Specific Organ Regulation (Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Urology 58:1064-9. 2001
    ..CONCLUSIONS: These results indicate that HGF induces scattering by decreasing the expression of E-cadherin and causes its translocation to the cytoplasm of DU145 cells...
  25. ncbi request reprint Genomic analysis of idiopathic infertile patients with sperm-specific depletion of CD46
    M Nomura
    Department of Immunology, Osaka Medical Center for Cancer, Osaka, Japan
    Exp Clin Immunogenet 18:42-50. 2001
    ..Other unknown factors outside the known regulatory regions would play a role in the regulation of sperm-specific CD46 expression...
  26. ncbi request reprint Single nucleotide polymorphisms: discovery of the genetic causes of male infertility
    H Tanaka
    TANAKA Project, Center for Advanced Science and Innovation, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Soc Reprod Fertil Suppl 65:531-4. 2007
    ..These findings strongly support the hypothesis that dysfunction of germ cell-specific genes causes idiopathic human male infertility...
  27. ncbi request reprint Effect of renal transplantation on sexual function
    A Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Arch Androl 48:467-74. 2002
    ..It is concluded that renal transplantation cannot improve sexual function in all patients, although hormonal profiles were largely normalized, and that renal transplantation should be encouraged at a younger age...
  28. doi request reprint Decreased immunostaining for macrophage scavenger receptor is associated with poor prognosis of prostate cancer
    Hitoshi Takayama
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    BJU Int 103:470-4. 2009
    ....
  29. ncbi request reprint Association of selenoprotein P with testosterone production in cultured Leydig cells
    K Nishimura
    Department of Specific Organ Regulation Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Arch Androl 47:67-76. 2001
    ..Testosterone concentration in the medium also increased, becoming maximal at 15 h. Selenoprotein P induced in Leydig cells following cAMP stimulation may counteract O2 toxicity from cAMP-mediated increases in testosterone production...
  30. pmc Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer
    N Nonomura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Br J Cancer 97:952-6. 2007
    ..Multivariate analysis revealed that mast cell count was a significant prognostic factor (P<0.005). The number of mast cells infiltrating around cancer foci in prostate biopsy specimens can be a significant prognostic factor of PCa...
  31. doi request reprint Atorvastatin inhibits renal crystal retention in a rat stone forming model
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 180:2212-7. 2008
    ..Atorvastatin is also reported to control transforming growth factor-beta1 expression. We investigated whether atorvastatin can prevent renal tubular cell injury by oxalate and inhibit renal crystal retention...
  32. ncbi request reprint Successful superselective arterial embolization for post-traumatic high-flow priapism
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita, Osaka 565 0871, Japan
    Int J Urol 14:254-6. 2007
    ..In our review of the literature, superselective arterial embolization could be an alternative treatment after more than 3 weeks of conservative treatment...
  33. ncbi request reprint Susceptibility gene for non-obstructive azoospermia located near HLA-DR and -DQ loci in the HLA class II region
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Hum Genet 110:192-7. 2002
    ..Taken together, our previous and present data suggest that the critical region for development of non-obstructive azoospermia is near the HLA-DRB1 and -DQB1 segments in the HLA class II region...
  34. doi request reprint Retrospective analysis of an oral combination of dexamethasone, uracil plus tegafur and cyclophosphamide for hormone-refractory prostate cancer
    Koji Hatano
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Jpn J Clin Oncol 41:253-9. 2011
    ..To evaluate the clinical utility of an oral combination of dexamethasone, uracil plus tegafur and cyclophosphamide as a treatment for patients with hormone-refractory prostate cancer...
  35. doi request reprint Clinical experience with laparoscopic radical nephrectomy for renal cell carcinoma
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Urol Int 81:301-5. 2008
    ....
  36. ncbi request reprint Laparoscopic adrenalectomy for primary hyperaldosteronism: clinical experience with 60 cases
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Endourol 20:262-5. 2006
    ..To assess the long-term outcome of patients with primary hyperaldosteronism who underwent laparoscopic adrenalectomy and to study hormone dynamics and differences between postoperative and preoperative blood pressure...
  37. ncbi request reprint Prostatic stem cell marker identified by cDNA microarray in mouse
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita and Osaka Police Hospital, Osaka, Japan
    J Urol 178:686-91. 2007
    ..We recently reported that the proximal region of the mouse prostate contains a population of stem cells. However, to our knowledge the specific marker of stem cells in the proximal region remains unknown...
  38. ncbi request reprint Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein
    Hiromitsu Tanaka
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Int J Androl 29:353-9. 2006
    ..h-HANP1 is expressed in the testes and its genomic construct also intronless as mouse Hanp1. We found that the h-HANP1 coding region have 5 single-nucleotide polymorphisms in Japanese men...
  39. doi request reprint Decreased infiltration of macrophage scavenger receptor-positive cells in initial negative biopsy specimens is correlated with positive repeat biopsies of the prostate
    Norio Nonomura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 101:1570-3. 2010
    ..Decreased infiltration of MSR-positive cells in negative first biopsy specimens was correlated with positive findings in the repeat biopsy. The MSR count might be a good indicator for avoiding unnecessary repeat biopsies...
  40. ncbi request reprint Effect of 1,25-dihydroxyvitamin d on testicular morphology and gene expression in experimental cryptorchid mouse: testis specific cDNA microarray analysis and potential implication in male infertility
    Toshiaki Hirai
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Urol 181:1487-92. 2009
    ..We evaluated the morphological effect and alterations in gene expression caused by 1,25-dihydroxyvitamin D treatment in the mouse testis undergoing experimental cryptorchidism and subsequent orchiopexy...
  41. ncbi request reprint Laparoscopic nephroureterectomy for upper tract transitional cell carcinoma: comparison of laparoscopic and open surgery
    Masao Tsujihata
    Department of Urology, Osaka University Graduate School of Medicine, Suita Japan
    Eur Urol 49:332-6. 2006
    ..We made a comparative study of laparoscopic nephroureterectomy (LNU) and standard open surgery (ONU) for upper urinary tract transitional cell carcinoma...
  42. doi request reprint Lower urinary tract symptoms after hormone replacement therapy in Japanese patients with late-onset hypogonadism: a preliminary report
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 16:212-4. 2009
    ..91 +/- 1.13 after 3 months. There were no significant differences in any of the nine categories of KHQ. In this preliminary study, the results suggested that HRT for LOH had no short-term effects on patients with lower urinary symptoms...
  43. ncbi request reprint Clinical analysis of patients with azoospermia factor deletions by microdissection testicular sperm extraction
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Int J Androl 27:76-81. 2004
    ..Sperm retrieval rates were not significantly different between the groups. In conclusion, AZF deletions do not appear to confer specific characteristics to NOA patients...
  44. doi request reprint Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation
    Hiroshi Kiuchi
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 181:2339-48. 2009
    ..Moreover, we determined the molecular mechanisms of parthenolide on the inhibitory action of nuclear factor-kappaB in inflammatory human benign urothelial cells...
  45. ncbi request reprint Prediction of successful outcome of microdissection testicular sperm extraction in men with idiopathic nonobstructive azoospermia
    Akira Tsujimura
    From the Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 172:1944-7. 2004
    ..In this retrospective study we determined the diagnostic and predictive values of noninvasive parameters used in the treatment of patients with NOA...
  46. doi request reprint Androgen decline in patients with nonobstructive azoospemia after microdissection testicular sperm extraction
    Shingo Takada
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Urology 72:114-8. 2008
    ..However, few studies of the postoperative endocrinologic course have been reported. We evaluated the endocrinologic course for 1 year after microdissection TESE and compared the results with the testicular histologic findings...
  47. ncbi request reprint Clinical comparison of successful and failed microdissection testicular sperm extraction in patients with nonmosaic Klinefelter syndrome
    Minoru Koga
    Department of Urology, Osaka Central Hospital, Osaka, Japan
    Urology 70:341-5. 2007
    ..However, predicting successful microdissection TESE for patients with KS remains controversial. Thus, we conducted a study to determine whether the prediction of successful microdissection TESE is possible in patients with nonmosaic KS...
  48. doi request reprint Isolation and characterization of the spermatid-specific Smrp1 gene encoding a novel manchette protein
    Yasuhiro Matsuoka
    Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Mol Reprod Dev 75:967-75. 2008
    ..This localization pattern coincided with that of the manchette. SMRP1 may play an important role as a functional protein that co-operates with manchette proteins...
  49. ncbi request reprint Differential brain processing of audiovisual sexual stimuli in men: comparative positron emission tomography study of the initiation and maintenance of penile erection during sexual arousal
    Yasushi Miyagawa
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Neuroimage 36:830-42. 2007
    ....
  50. pmc Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia
    Kazutoshi Fujita
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan Laboratory for Genomic Reprogramming, Center for Developmental Biology, Institute of Physical and Chemical Research RIKEN, Kobe, Japan
    J Clin Invest 115:1855-61. 2005
    ....
  51. ncbi request reprint Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations
    Yasushi Miyagawa
    Department of Urology, Osaka University Graduate School of Medicine, Suita City, Osaka 565 0871, Japan
    J Androl 26:779-86. 2005
    ..This deletion reduces TNP1 expression and may cause human male infertility...
  52. ncbi request reprint [Testicular dysfunction]
    Shingo Takada
    Department of Urology, Osaka University Graduate School of Medicine
    Nihon Rinsho 64:484-8. 2006
  53. ncbi request reprint Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at university affiliated male infertility centers: a 30-year retrospective study
    Yasushi Miyagawa
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Urol 173:2072-5. 2005
    ..Even specialized centers see small numbers of patients and have little experience in restoring fertility in these patients. To explore the phenotypic heterogeneity and treatment outcome of HH, we summarized our 30-year experience...
  54. ncbi request reprint A case of renal cell carcinoma with multiple lung metastases refractory to interferon-alpha showing complete remission by interleukin-2 monotherapy
    Tetsuya Hayashi
    Department of Urology, Division of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:805-8. 2006
    ..Resection of this residual lung mass was performed and pathological examination revealed no viable cancer cells...
  55. ncbi request reprint Isolation of germ cells from leukemia and lymphoma cells in a human in vitro model: potential clinical application for restoring human fertility after anticancer therapy
    Kazutoshi Fujita
    Department of Urology, Osaka University Graduate School of Medicine, Suita Osaka, Japan
    Cancer Res 66:11166-71. 2006
    ..Immunophenotyping for each patient will be necessary before isolation and induction of surface marker will be clinically applicable...
  56. ncbi request reprint Association of the shrinkage of uterine leiomyoma treated with GnRH agonist and deletion of long arm of chromosome 7
    K Takahashi
    Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Int J Oncol 18:1259-63. 2001
    ....
  57. ncbi request reprint Relation between erectile dysfunction and urinary incontinence after nerve-sparing and non-nerve-sparing radical prostatectomy
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Urol Int 73:31-5. 2004
    ....
  58. doi request reprint [Bone and Men's Health. Testosterone and lifestyle disease]
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine
    Clin Calcium 20:217-23. 2010
    ..However, no inverse correlation exists between them in patients with LOH. Testosterone replacement treatment is expected to be one of treatments for metabolic syndrome...
  59. ncbi request reprint Bioavailable testosterone with age and erectile dysfunction
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 170:2345-7. 2003
    ..Currently bioavailable testosterone (BT) is considered the most reliable marker for establishing the presence of hypogonadism. We clarified the relationship between BT and other hormones with respect to patient age and PADAM symptoms...
  60. doi request reprint Increased vascular endothelial growth factor expression in patients with bladder pain syndrome/interstitial cystitis: its association with pain severity and glomerulations
    Hiroshi Kiuchi
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    BJU Int 104:826-31; discussion 831. 2009
    ....
  61. doi request reprint Type-I interferon receptor expression: its circadian rhythm and downregulation after interferon-alpha administration in peripheral blood cells from renal cancer patients
    Masahiro Shiba
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 16:356-9. 2009
    ..To investigate the regulation of interferon-alpha (IFN-alpha) receptor expression in metastatic renal cell carcinoma (RCC) after IFN-alpha administration...
  62. doi request reprint Adiponectin and testosterone in patients with symptoms of late-onset hypogonadism: is there a link?
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 16:830-5. 2009
    ..To examine the correlation between testosterone and adiponectin in symptomatic late-onset hypogonadism (LOH) patients...
  63. ncbi request reprint [Testicular dysfunction]
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine
    Nihon Rinsho 60:344-7. 2002
  64. ncbi request reprint Effects of hepatocyte growth factor on urokinase-type plasminogen activator (uPA) and uPA receptor in DU145 prostate cancer cells
    Kenji Nishimura
    Department of Specific Organ Regulation Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Androl 26:175-9. 2003
    ..HGF stimulated a uPA/uPAR proteolytic network in DU145 cells, which may be important for acquisition invasive potential by prostate cancer...
  65. ncbi request reprint [Leydig cell tumor of the testis presenting male infertility: a case report]
    Toyofumi Abe
    Department of Urology, Osaka University Graduate School of Medicine
    Hinyokika Kiyo 49:39-42. 2003
    ..Histologically, this testicular mass was a Leydig cell tumor. We reviewed 55 cases of Leydig cell tumor of the testis previously reported in Japan, and reported the hormonal profile in our case before and after surgery...
  66. ncbi request reprint Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations
    Hiromitsu Tanaka
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita City, Japan
    Mol Hum Reprod 9:69-73. 2003
    ..Although the PRM1 and PRM2 genes are highly conserved, the single SNP in the PRM2 gene that induces translation termination may result in male infertility due to haploinsufficiency of PRM2...
  67. ncbi request reprint The clinical studies of sildenafil for the ageing male
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Androl 25:28-33. 2002
    ..Sildenafil can be used safely and it is still effective for ageing male, because nearly two-thirds of our older subjects had a good response to the drug and no adverse effect was specific to older patients...
  68. doi request reprint Prostate stem cells: the niche and cell markers
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 15:289-94. 2008
    ..Several candidate prostate stem cell markers are currently under investigation. In this review, we summarize the historical approaches and recent evidence regarding the niche and prostate-specific stem cell markers...
  69. ncbi request reprint Ketone bodies could support the motility but not the acrosome reaction of mouse sperm
    Hiromitsu Tanaka
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Androl 27:172-7. 2004
    ....
  70. doi request reprint Relationship between substances in seminal plasma and Acrobeads Test results
    Kazuhiko Komori
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Fertil Steril 91:179-84. 2009
    ..To asses the effects of seminal plasma on sperm function...
  71. ncbi request reprint Testicular epidermoid cyst in Klinefelter's syndrome
    Takahiro Yoshida
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:478-80. 2006
    ..Histological examination revealed an epidermoid cyst of the right testis. Epidermoid cysts in cases of KFS are rare. To our knowledge, only seven cases, including ours, have been reported in the literature...
  72. doi request reprint Nitric oxide synthesis leads to vascular endothelial growth factor synthesis via the NO/cyclic guanosine 3',5'-monophosphate (cGMP) pathway in human corpus cavernosal smooth muscle cells
    Kazuhiko Komori
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Sex Med 5:1623-35. 2008
    ..Expression of eNOS in corpus cavernosal smooth muscle has also been reported. However, it is unclear whether CCSMCs can generate NO...
  73. ncbi request reprint Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis
    Sompol Permpongkosol
    Department of Urology, Osaka University Medical School, Suita City, Osaka, Japan
    Int J Cancer 98:167-72. 2002
    ..FTY720 may exert anticarcinogenic effects against prostate cancer cells possibly involving modulation of mitogenic signaling, cell-cycle regulators, induction of G(1) arrest and apoptotic death in DU145 cells...
  74. ncbi request reprint [Clinical efficacy of tolterodine for patients with overactive bladder after insufficient efficacy by monotherapy with alpha1-adrenoceptor antagonist]
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine
    Nihon Hinyokika Gakkai Zasshi 100:686-92. 2009
    ..The adverse event of this combined therapy was also assessed...
  75. doi request reprint Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein
    Tomohiro Ueda
    TANAKA Project, Center for Advanced Science and Innovation, Osaka University, Suita, Osaka, Japan
    Int J Urol 16:639-46. 2009
    ..To examine the expression profiles of the proteins translated from Acpin1 mRNA in germ cells...
  76. doi request reprint Mechanism underlying the low prevalence of pediatric calcium oxalate urolithiasis
    Chikahiro Momohara
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 182:1201-9. 2009
    ..To investigate the mechanism of Ca oxalate urolithiasis we evaluated the differences in inhibitory activity against oxalate induced renal cell injury between adults and children...
  77. ncbi request reprint [Hormone replacement Up-to-date. The effect of androgen replacement therapy on bone metabolism]
    Yasushi Miyagawa
    Osaka University Graduate School of Medicine, Department of Urology, Japan
    Clin Calcium 17:1372-7. 2007
    ..A well-controlled larger clinical study to test androgen replacement therapy for aging male is expected also in Japan...
  78. doi request reprint Brain responses during the first desire to void: a positron emission tomography study
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 15:724-8. 2008
    ..First desire to void (FDV) is defined as the first feeling that would lead the patient to pass urine. The aim of the present study is to identify the brain regions activated during FDV...
  79. doi request reprint Effect of human leukemia cells in testicular tissues grafted into immunodeficient mice
    Kazutoshi Fujita
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Urol 15:733-8. 2008
    ..However, malignant cells present in the testicular tissue may disturb spermatogenesis in the xenografts. Here we examined the effect of human leukemia cells on ectopic xenografts in immunodeficient mice...
  80. ncbi request reprint Susceptibility gene for non-obstructive azoospermia in the HLA class II region: correlations with Y chromosome microdeletion and spermatogenesis
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Androl 27:37-41. 2004
    ..In either case, this haplotype showed association with severe spermatogenic impairment...
  81. doi request reprint Urological surgery in patients aged 80 years and older: a 30-year retrospective clinical study
    Tetsuya Takao
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Urol 15:789-93. 2008
    ..To investigate changes in the management of cases over time, we undertook a retrospective analysis of urological surgeries carried out in patients aged 80 years and older in a single institution over the last 30 years...
  82. doi request reprint Clinical practice manual for late-onset hypogonadism syndrome
    Mikio Namiki
    Int J Urol 15:377-88. 2008
  83. ncbi request reprint Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats
    Masaki Yamanaka
    Department of Urology, Veterans Affairs Medical Center, University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Urol 170:291-7. 2003
    ..Molecular and immunohistochemical analyses for apoptosis were then performed in rat crura to assess their role in diabetes induced erectile dysfunction and insulin treatment...
  84. pmc Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
    Akira Tsujimura
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 157:1257-65. 2002
    ..This model can account for many biological differences between cells of the proximal and distal regions, and has implications for prostatic disease formation...
  85. ncbi request reprint Androgens modulate the balance between VEGF and angiopoietin expression in prostate epithelial and smooth muscle cells
    Christian Richard
    Department of Cell Biology and the Kaplan Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Prostate 50:83-91. 2002
    ..Here we examine the effects of androgen on production of three angiogenic factors, vascular endothelial growth factor (VEGF), angiopoietin-1, and angiopoietin-2, by the three major cell types in the prostate...
  86. ncbi request reprint Stromal/epithelial interactions of murine prostatic cell lines in vivo: a model for benign prostatic hyperplasia and the effect of doxazosin on tissue size
    Tetsuya Takao
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Prostate 54:17-24. 2003
    ..To address this issue, we have used murine prostatic cell lines to establish a novel in vivo model for studying prostatic cell interactions...
  87. ncbi request reprint Inter/intra investigator variation in orchidometric measurements of testicular volume by ten investigators from five institutions
    Shinobu Tatsunami
    Unit of Medical Statistics, Faculty of Medical Education and Culture, St Marianna University School of Medicine, Kawasaki, Japan
    Asian J Androl 8:373-8. 2006
    ..To perform quality control studies on testicular volume measurements for a multi-center epidemiological study of male reproductive function...
  88. ncbi request reprint Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura
    Masaki Yamanaka
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Urol 173:318-23. 2005
    ..We hypothesized that intracavernous administration of VEGF would recover erectile dysfunction due to diabetes by protection from apoptosis in the penile cavernosum...
  89. ncbi request reprint [Predictive factors associated with successful varicocele repair a study of 139 infertile men with valicocele]
    Hiroshi Kiuchi
    Department of Urology, Osaka Central Hospital
    Nihon Hinyokika Gakkai Zasshi 96:480-6. 2005
    ..To determine pretreatment parameters which predict improvements following varicocele repaire in semen quality...
  90. doi request reprint Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis
    Keizo Tokuhiro
    TANAKA Project, Center for Advanced Science and Innovation, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 283:19039-48. 2008
    ..Our results suggest that MCA is essential for sperm flagellum formation and the production of functional sperm...
  91. ncbi request reprint Differentiation and stromal-induced growth promotion of murine prostatic tumors
    Sarah N Salm
    Department of Cell Biology, MSB 634, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Prostate 51:175-88. 2002
    ..We have derived a panel of p53-null prostatic "basal" and "luminal" epithelial cell lines and their ras transformed counterparts to study stromal/epithelial interactions and the properties of tumors arising from "basal" and "luminal" cells...