Motokazu Tsujikawa

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. doi request reprint Age at onset curves of retinitis pigmentosa
    Motokazu Tsujikawa
    Department of Ophthalmology, Osaka University Medical School, O 2 2 Yamadaoka, Japan
    Arch Ophthalmol 126:337-40. 2008
  2. doi request reprint Chromosomal sharing in atypical cases of gelatinous drop-like corneal dystrophy
    Motokazu Tsujikawa
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    Jpn J Ophthalmol 54:494-8. 2010
  3. doi request reprint Gelatinous drop-like corneal dystrophy
    Motokazu Tsujikawa
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Cornea 31:S37-40. 2012
  4. doi request reprint Efficacy of intravitreal bevacizumab combined with photodynamic therapy for polypoidal choroidal vasculopathy
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Ophthalmol 150:48-54.e1. 2010
  5. doi request reprint Efficacy and safety of one intravitreal injection of bevacizumab in diabetic macular oedema
    Xiaoyun Fang
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Acta Ophthalmol 86:800-5. 2008
  6. doi request reprint Intravitreal bevacizumab for choroidal neovascularization attributable to pathological myopia: one-year results
    Yasushi Ikuno
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Am J Ophthalmol 147:94-100.e1. 2009
  7. doi request reprint Bevacizumab treatment for choroidal neovascularization due to age-related macular degeneration in Japanese patients
    Mihoko Suzuki
    Department of Ophthalmology, Osaka University Medical School, Yamadaoka, Suita, Japan
    Jpn J Ophthalmol 54:124-8. 2010
  8. doi request reprint Intravitreal bevacizumab for exudative branching vascular networks in polypoidal choroidal vasculopathy
    Taku Wakabayashi
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    Br J Ophthalmol 96:394-9. 2012
  9. doi request reprint One-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial detachment secondary to age-related macular degeneration
    Chiharu Shima
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Graefes Arch Clin Exp Ophthalmol 247:899-906. 2009
  10. doi request reprint Long-term results of intravitreal bevacizumab injection for choroidal neovascularization secondary to angioid streaks
    Miki Sawa
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Am J Ophthalmol 148:584-590.e2. 2009

Collaborators

Detail Information

Publications42

  1. doi request reprint Age at onset curves of retinitis pigmentosa
    Motokazu Tsujikawa
    Department of Ophthalmology, Osaka University Medical School, O 2 2 Yamadaoka, Japan
    Arch Ophthalmol 126:337-40. 2008
    ..Retinitis pigmentosa is a common hereditary retinal disease that leads to blindness. It is a slow-onset disease, and family members of patients sometimes develop RP later...
  2. doi request reprint Chromosomal sharing in atypical cases of gelatinous drop-like corneal dystrophy
    Motokazu Tsujikawa
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    Jpn J Ophthalmol 54:494-8. 2010
    ..To present the phenotypic variability both among and within families in Japanese gelatinous drop-like corneal dystrophy (GDLD), and to study the genetic background of the variability...
  3. doi request reprint Gelatinous drop-like corneal dystrophy
    Motokazu Tsujikawa
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Cornea 31:S37-40. 2012
    ..TACSTD2 deleterious mutations resulted in destabilized tight junction proteins, including claudins, ZO-1, and occludin. These findings may explain why the corneal epithelium barrier function is impaired in GDLD patients...
  4. doi request reprint Efficacy of intravitreal bevacizumab combined with photodynamic therapy for polypoidal choroidal vasculopathy
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Ophthalmol 150:48-54.e1. 2010
    ..To compare the efficacy of photodynamic therapy (PDT) with or without intravitreal bevacizumab injection for polypoidal choroidal vasculopathy...
  5. doi request reprint Efficacy and safety of one intravitreal injection of bevacizumab in diabetic macular oedema
    Xiaoyun Fang
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Acta Ophthalmol 86:800-5. 2008
    ..To assess the efficacy, duration of effect and safety of one intravitreal injection of bevacizumab in diabetic macular oedema (DMO)...
  6. doi request reprint Intravitreal bevacizumab for choroidal neovascularization attributable to pathological myopia: one-year results
    Yasushi Ikuno
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Am J Ophthalmol 147:94-100.e1. 2009
    ..To assess the potential effect of intravitreal bevacizumab (IVB) (Avastin) on retinal function and anatomic recovery in eyes with choroidal neovascularization attributable to pathological myopia (mCNV)...
  7. doi request reprint Bevacizumab treatment for choroidal neovascularization due to age-related macular degeneration in Japanese patients
    Mihoko Suzuki
    Department of Ophthalmology, Osaka University Medical School, Yamadaoka, Suita, Japan
    Jpn J Ophthalmol 54:124-8. 2010
    ..To assess intravitreal bevacizumab (IVB) for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) in Japanese patients...
  8. doi request reprint Intravitreal bevacizumab for exudative branching vascular networks in polypoidal choroidal vasculopathy
    Taku Wakabayashi
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    Br J Ophthalmol 96:394-9. 2012
    ..To assess the long-term efficacy of intravitreal bevacizumab for recurrent leakage owing to the residual branching vascular networks in polypoidal choroidal vasculopathy after photodynamic therapy...
  9. doi request reprint One-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial detachment secondary to age-related macular degeneration
    Chiharu Shima
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Graefes Arch Clin Exp Ophthalmol 247:899-906. 2009
    ..To evaluate the efficacy of combined photodynamic therapy (PDT) and intravitreal bevacizumab injection in eyes with a serous pigment epithelial detachment (PED) associated with age-related macular degeneration (AMD)...
  10. doi request reprint Long-term results of intravitreal bevacizumab injection for choroidal neovascularization secondary to angioid streaks
    Miki Sawa
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Am J Ophthalmol 148:584-590.e2. 2009
    ..To investigate the long-term efficacy of intravitreal injections of bevacizumab (Avastin; Genentech Inc, South San Francisco, California, USA) for choroidal neovascularization (CNV) secondary to angioid streaks...
  11. ncbi request reprint A spectrum of clinical manifestations of gelatinous drop-like corneal dystrophy in japan
    Takeshi Ide
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
    Am J Ophthalmol 137:1081-4. 2004
    ..Moreover, there have been no detailed reports about the various clinical presentations. The purpose of this study is to describe a clinical subclassification for GDLD...
  12. doi request reprint Choroidal thickness in central serous chorioretinopathy
    Sato Kuroda
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    Retina 33:302-8. 2013
    ..To study the choroidal thickness profile using high-penetration optical coherence tomography in central serous chorioretinopathy (CSC)...
  13. doi request reprint Foveal sparing in patients with Japanese Stargardt's disease and good visual acuity
    Takeshi Nakao
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Jpn J Ophthalmol 56:584-8. 2012
    ..The purpose of this study was to investigate the BCVA outcomes in Japanese patients with Stargardt's disease with foveal sparing...
  14. doi request reprint Lacquer crack formation and choroidal neovascularization in pathologic myopia
    Yasushi Ikuno
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Retina 28:1124-31. 2008
    ..To clarify the characteristics of choroidal neovascularization (CNV) due to myopic CNV (mCNV) and the relation to lacquer crack (LC) formation...
  15. doi request reprint Fundus autofluorescence after full macular translocation surgery for myopic choroidal neovascularization
    Miki Sawa
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Graefes Arch Clin Exp Ophthalmol 246:1087-95. 2008
    ..To investigate fundus autofluorescence (FAF) findings in patients who underwent full macular translocation surgery with 360-degree retinotomy (MT360) for myopic choroidal neovascularization (CNV)...
  16. ncbi request reprint Complications in patients after intravitreal injection of bevacizumab
    Chiharu Shima
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
    Acta Ophthalmol 86:372-6. 2008
    ..To report complications in patients after intravitreal injection of bevacizumab to treat ocular diseases associated with vascular endothelial growth factor...
  17. ncbi request reprint Allelic homogeneity in Avellino corneal dystrophy due to a founder effect
    Kaoru Tsujikawa
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamadaoka Suita, Osaka, Japan
    J Hum Genet 52:92-7. 2007
    ....
  18. ncbi request reprint A novel missense mutation in a Japanese patient with gelatinous droplike corneal dystrophy
    Yukiko Taniguchi
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Am J Ophthalmol 139:186-8. 2005
    ..To report a novel missense mutation in TACSTD2 gene, L186P, responsible for gelatinous droplike dystrophy (GDLD)...
  19. doi request reprint Macular pigment optical density in central serous chorioretinopathy
    Yuzuru Sasamoto
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Invest Ophthalmol Vis Sci 51:5219-25. 2010
    ..To evaluate macular pigment optical density (MPOD) in patients with central serous chorioretinopathy (CSC) and in normal subjects...
  20. doi request reprint Effect of cataract in evaluation of macular pigment optical density by autofluorescence spectrometry
    Yuzuru Sasamoto
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Invest Ophthalmol Vis Sci 52:927-32. 2011
    ..To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients...
  21. doi request reprint Macular autofluorescence in eyes with cystoid macula edema, detected with 488 nm-excitation but not with 580 nm-excitation
    Kenichiro Bessho
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Graefes Arch Clin Exp Ophthalmol 247:729-34. 2009
    ..Because lipofuscin is a by-product of phagocytosis of photoreceptors by RPE, AF imaging is expected to describe some functional aspect of the retina. In this study we report distribution of AF in patients showing macular edema...
  22. doi request reprint Effect of 1-year lutein supplementation on macular pigment optical density and visual function
    Yuzuru Sasamoto
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Graefes Arch Clin Exp Ophthalmol 249:1847-54. 2011
    ..Our aim was to assess the 1-year changes in MPOD and visual function in response to supplementation containing lutein...
  23. ncbi request reprint Topical bromfenac as an adjunctive treatment with intravitreal ranibizumab for exudative age-related macular degeneration
    Fumi Gomi
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    Retina 32:1804-10. 2012
    ..Its limitation is that most patients require repeated intravitreal injections to achieve and maintain the visual gain. We assessed the effectiveness of adjunctive topical bromfenac, a nonsteroidal antiinflammatory drug, with ranibizumab...
  24. ncbi request reprint Allelic homogeneity due to a founder mutation in Japanese patients with lattice corneal dystrophy type IIIA
    Kaoru Tsujikawa
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Med Genet 113:20-2. 2002
    ..003; chi-square test) was also observed between P501T and the G allele in the patients. These results suggest that allelic homogeneity seen in Japanese patients with LCDIIIA may result from a single founder mutation...
  25. pmc Low-dose lipopolysaccharide pretreatment suppresses choroidal neovascularization via IL-10 induction
    Nagakazu Matsumura
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e39890. 2012
    ..We concluded that CNV formation was suppressed by low-dose LPS pretreatment via IL-10 production by macrophages...
  26. doi request reprint Simultaneous intravitreal injection of triamcinolone acetonide and tissue plasminogen activator for central retinal vein occlusion: a pilot study
    Takuhiro Yamamoto
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    Br J Ophthalmol 95:69-73. 2011
    ..To evaluate the efficacy and safety of simultaneous intravitreal injection of triamcinolone acetonide (TA) and tissue plasminogen activator (tPA) for macular oedema associated with central retinal vein occlusion (CRVO)...
  27. doi request reprint Correlation of fundus autofluorescence with photoreceptor morphology and functional changes in eyes with retinitis pigmentosa
    Taku Wakabayashi
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Acta Ophthalmol 88:e177-83. 2010
    ..To assess and correlate fundus autofluorescence (FAF) characteristics with photoreceptor morphology and functional features in eyes with retinitis pigmentosa (RP)...
  28. doi request reprint Association between the efficacy of photodynamic therapy and indocyanine green angiography findings for central serous chorioretinopathy
    Ryo Inoue
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Am J Ophthalmol 149:441-6.e1-2. 2010
    ..To determine the efficacy of photodynamic therapy (PDT) and indocyanine green angiography (ICGA) findings for treating chronic central serous chorioretinopathy (CSC)...
  29. doi request reprint Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography
    Hisataka Fujimoto
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 115:1494-500, 1500.e1-2. 2008
    ..To investigate morphologic alterations around fluorescein leakage sites using Fourier-domain optical coherence tomography (FD OCT) in acute central serous chorioretinopathy (CSC)...
  30. doi request reprint Effectiveness of 1.25 % povidone-iodine combined with topical levofloxacin against conjunctival flora in intravitreal injection
    Yasushi Ikuno
    Department of Ophthalmology E7, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 5650871, Japan
    Jpn J Ophthalmol 56:497-501. 2012
    ..25 %) of povidone-iodine (PI) eye drops, combined with 0.5 % topical levofloxacin (LVFX), with that of the standard of care (5 % PI) on conjunctival flora before intravitreal injections (IVT)...
  31. doi request reprint Effect of instillation of eyedrops for dry eye on optical quality
    Shizuka Koh
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Invest Ophthalmol Vis Sci 54:4927-33. 2013
    ..3% sodium hyaluronate ophthalmic solution, 3% diquafosol ophthalmic solution, and 2% rebamipide ophthalmic suspension) on ocular higher-order aberrations (HOAs) and forward light scatter...
  32. pmc Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy
    Mina Nakatsukasa
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Pathol 177:1344-55. 2010
    ..These results indicate that loss of function of the TACSTD2 gene impairs epithelial barrier function through decreased expression and altered subcellular localization of tight junction-related proteins in GDLD corneas...
  33. ncbi request reprint Angiographic lesion of polypoidal choroidal vasculopathy on indocyanine green and fluorescein angiography
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Yamadaoka, Suita, Japan
    Graefes Arch Clin Exp Ophthalmol 245:1421-7. 2007
    ..The purpose of this study was to evaluate angiographic findings and compare the lesion sizes of PCV on ICGA and FA using confocal scanning laser ophthalmoscopy (SLO) and fundus camera...
  34. pmc Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration
    Mihoko Suzuki
    Department of Ophthalmology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Cell Sci 125:2407-15. 2012
    ..These findings add to the current understanding of AMD pathology and suggest protection from oxidative stress or suppression of the subsequent inflammation as new potential therapeutic targets for AMD...
  35. ncbi request reprint Intravitreal bevacizumab for idiopathic choroidal neovascularization after previous injection with posterior subtenon triamcinolone
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Am J Ophthalmol 143:507-10. 2007
    ..To assess short-term efficacy and safety of intravitreal bevacizumab injections for idiopathic choroidal neovascularization (CNV) refractory to posterior subtenon triamcinolone injections...
  36. ncbi request reprint Micro serial analysis of gene expression in normal human choroid and retinal pigment epithelial transcriptomes
    Michiyo Kobashi-Hashida
    Department of Biomaterial Science, Graduate School of Dentistry, Osaka University, Osaka, Japan
    Jpn J Ophthalmol 49:15-22. 2005
    ..To investigate the gene expression profile of the normal human choroid/retinal pigment epithelium(RPE) tissues...
  37. doi request reprint Development of methicillin-resistant Staphylococcus aureus keratitis in a dry eye patient with a therapeutic contact lens
    Shizuka Koh
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
    Eye Contact Lens 38:200-2. 2012
    ..The aim was to report a case of methicillin-resistant Staphylococcus aureus (MRSA) keratitis possibly associated with the use of a silicone hydrogel soft contact lens in a patient with dry eye...
  38. ncbi request reprint ABCA4 gene mutations in Japanese patients with Stargardt disease and retinitis pigmentosa
    Takehiro Fukui
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    Invest Ophthalmol Vis Sci 43:2819-24. 2002
    ..To evaluate photoreceptor cell-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) gene mutations in Japanese patients with Stargardt disease (STGD) and the correlation of these mutations to clinical phenotypes...
  39. pmc The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa
    Takeshi Nakao
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    PLoS ONE 7:e32472. 2012
    ..In short, our study indicates that in some RP, adenylyl cyclase is involved in photoreceptor cell death pathway; its inhibition is potentially a logical approach for a novel RP therapy...
  40. ncbi request reprint Effects of RGD peptides on cells derived from the human eye
    Yoshiko Imoto
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Jpn J Ophthalmol 47:444-53. 2003
    ..To investigate the effects of Arg-Gly-Asp (RGD) peptides on cells derived from the human eye...
  41. ncbi request reprint [Regenerative medicine in cornea]
    Motokazu Tsujikawa
    Department of Ophthalmology, Osaka University Graduate School of Medicine
    Nihon Rinsho 69:2235-40. 2011
    ..We have auto transplantation of this epithelial sheet to severe corneal deficiency patients and obtained good clinical results. According to endothelium, we are trying to make the sheet from various stem sells including iPS cells...
  42. pmc Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium
    Ryuhei Hayashi
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    PLoS ONE 7:e45435. 2012
    ....