S Tsuji

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats
    S Tsuji
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Arzneimittelforschung 51:46-50. 2001
  2. ncbi request reprint Helicobacter pylori eradication to prevent gastric cancer: underlying molecular and cellular mechanisms
    Shingo Tsuji
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine K1, 2 2 Yamadaoka, Suita, 565 0871 Japan
    World J Gastroenterol 12:1671-80. 2006
  3. ncbi request reprint Lansoprazole induces mucosal protection through gastrin receptor-dependent up-regulation of cyclooxygenase-2 in rats
    Shingo Tsuji
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Pharmacol Exp Ther 303:1301-8. 2002
  4. ncbi request reprint Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis
    S Tsuji
    Dept of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    J Exp Clin Cancer Res 20:117-29. 2001
  5. ncbi request reprint Endoscope disinfection using acidic electrolytic water
    S Tsuji
    First Dept of Medicine, Osaka University School of Medicine, Suita, Japan
    Endoscopy 31:528-35. 1999
  6. ncbi request reprint Review article: inflammation-related promotion of gastrointestinal carcinogenesis--a perigenetic pathway
    S Tsuji
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Aliment Pharmacol Ther 18:82-9. 2003
  7. ncbi request reprint Two cases of autoimmune neutropenia possibly induced by beta-lactam antibiotics in infants
    S Taniuchi
    Department of Pediatrics, Kansai Medical University, Moriguchi, Osaka, Japan
    J Pediatr Hematol Oncol 22:533-8. 2000
  8. ncbi request reprint FcgammaRIII b and FcgammaRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy
    S Taniuchi
    Department of Pediatrics, Kansai Medical University, Osaka, Japan
    Hum Immunol 62:408-13. 2001
  9. ncbi request reprint Roles of hepatocyte growth factor and its receptor in gastric mucosa. A cell biological and molecular biological study
    S Tsuji
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Dig Dis Sci 40:1132-9. 1995
  10. ncbi request reprint Dizygotic twin sisters with myelokathexis: mechanism of its neutropenia
    S Taniuchi
    Department of Pediatrics, Kansai Medical University, Osaka, Japan
    Am J Hematol 62:106-11. 1999

Detail Information

Publications72

  1. ncbi request reprint Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats
    S Tsuji
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Arzneimittelforschung 51:46-50. 2001
    ..Thus racemic T-593 may protect the gastric mucosa by antagonizing H2-receptors and by enhancing gastric circulation in rats...
  2. ncbi request reprint Helicobacter pylori eradication to prevent gastric cancer: underlying molecular and cellular mechanisms
    Shingo Tsuji
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine K1, 2 2 Yamadaoka, Suita, 565 0871 Japan
    World J Gastroenterol 12:1671-80. 2006
    ..Efficiency of the cure of the infection in suppressing gastric cancer depends on the timing and the target population, and warrant further investigation...
  3. ncbi request reprint Lansoprazole induces mucosal protection through gastrin receptor-dependent up-regulation of cyclooxygenase-2 in rats
    Shingo Tsuji
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Pharmacol Exp Ther 303:1301-8. 2002
    ..Activation of gastrin receptors by endogenous gastrin has a pivotal role in the effects of lansoprazole on COX-2 up-regulation and mucosal protection in the rat stomach...
  4. ncbi request reprint Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis
    S Tsuji
    Dept of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    J Exp Clin Cancer Res 20:117-29. 2001
    ..This evidence supports the hypothesis that COX is an important perigenetic factor in the development of cancer growth, and offers a new strategy against cancer using COX inhibitors (nonsteroidal anti-inflammatory drugs)...
  5. ncbi request reprint Endoscope disinfection using acidic electrolytic water
    S Tsuji
    First Dept of Medicine, Osaka University School of Medicine, Suita, Japan
    Endoscopy 31:528-35. 1999
    ..The aim of the present study was to evaluate a new endoscope disinfector (WM-1) that uses acidic electrolytic water (AEW)...
  6. ncbi request reprint Review article: inflammation-related promotion of gastrointestinal carcinogenesis--a perigenetic pathway
    S Tsuji
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Aliment Pharmacol Ther 18:82-9. 2003
    ..Furthermore, certain radical scavengers suppressed the invasive phenotype of the cells. These results indicate that perigenetic alterations are an important target of pharmacological intervention of carcinogenesis...
  7. ncbi request reprint Two cases of autoimmune neutropenia possibly induced by beta-lactam antibiotics in infants
    S Taniuchi
    Department of Pediatrics, Kansai Medical University, Moriguchi, Osaka, Japan
    J Pediatr Hematol Oncol 22:533-8. 2000
    ....
  8. ncbi request reprint FcgammaRIII b and FcgammaRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy
    S Taniuchi
    Department of Pediatrics, Kansai Medical University, Osaka, Japan
    Hum Immunol 62:408-13. 2001
    ..The genotype of FcgammaRIIIb and FcgammaRIIa may affect the production of neutrophil specific auto-antibodies in AIN of infancy and influence its clinical course...
  9. ncbi request reprint Roles of hepatocyte growth factor and its receptor in gastric mucosa. A cell biological and molecular biological study
    S Tsuji
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Dig Dis Sci 40:1132-9. 1995
    ..These results indicate that HGF plays important roles in the morphogenesis of gastric mucosal cells and that the HGF receptor gene participates in the healing process of gastric mucosa...
  10. ncbi request reprint Dizygotic twin sisters with myelokathexis: mechanism of its neutropenia
    S Taniuchi
    Department of Pediatrics, Kansai Medical University, Osaka, Japan
    Am J Hematol 62:106-11. 1999
    ..Peripheral neutropenia and appearance of characteristic neutrophils in the bone marrow in myelokathexis are considered to be an expression of apoptosis of bone marrow neutrophils...
  11. ncbi request reprint Helicobacter bilis infection in biliary tract cancer
    H Murata
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Aliment Pharmacol Ther 20:90-4. 2004
    ..Biliary tract cancer is a highly fatal disease with poor prognosis, but the aetiology is poorly understood...
  12. ncbi request reprint Functional modulation of human macrophages through CD46 (measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHP-1 to CD46
    M Kurita-Taniguchi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka, Japan
    J Immunol 165:5143-52. 2000
    ....
  13. ncbi request reprint Role of mucosal blood flow: a conceptional review in gastric mucosal injury and protection
    S Kawano
    Department of Clinical Laboratory Science, School of Allied Health Sciences, Osaka University Graduate School of Medicine, Suita, Japan
    J Gastroenterol Hepatol 15:D1-6. 2000
    ..The endothelium-derived vasoactive substances ET and NO regulate gastric mucosal microcirculation and an imbalance of endothelium-derived factors may play an important pathophysiological role in the development of gastric lesions...
  14. ncbi request reprint Expressions of CCAAT/Enhancer-binding proteins beta and delta and their activities are intensified by cAMP signaling as well as Ca2+/calmodulin kinases activation in hippocampal neurons
    K Yukawa
    Department of Physiology II, Wakayama Medical College, 811 1 Kimiidera, Wakayama, Wakayama 641 0012, Japan
    J Biol Chem 273:31345-51. 1998
    ....
  15. ncbi request reprint Differential diagnosis and clinical course of autoimmune neutropenia in infancy: comparison with congenital neutropenia
    S Taniuchi
    Department of Paediatrics, Kansai Medical University, Moriguchi, Osaka, Japan
    Acta Paediatr 91:1179-82. 2002
    ..Clinical presentation and diagnosis have not been well studied, resulting in cumbersome diagnostic investigations and unnecessary treatment such as granulocyte colony-stimulating factor (G-CSF) therapy...
  16. ncbi request reprint Increased expression of c-met messenger RNA following acute gastric injury in rats
    M Tsujii
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 200:536-41. 1994
    ..Hepatocyte growth factor reportedly plays an important role in gastric cell proliferation. The increased c-met expression indicates that this gene may participate in the healing process of gastric mucosa after injury...
  17. pmc Role of reactive oxygen species in neutrophil apoptosis following ingestion of heat-killed Staphylococcus aureus
    A Yamamoto
    Department of Paediatrics, Kansai Medical University, Osaka, Japan
    Clin Exp Immunol 129:479-84. 2002
    ..On the other hand glutathione (GSH, an H2O2 scavenger) significantly inhibited both types of apoptosis. Our findings suggest that oxygen-independent pathways may mainly operate in the process of phagocytosis-induced apoptosis...
  18. ncbi request reprint Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by Toll-like receptor 2: role of N-terminal hydrophobic portion in its multiple functions
    M Nishiguchi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka, Japan
    J Immunol 166:2610-6. 2001
    ....
  19. ncbi request reprint Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens
    Y Ikehara
    Division of Cell Biology, Institute of Life Science, Soka University, 1 236 Tangi cho, Hachioji, Tokyo 192 8577, Japan
    Glycobiology 9:1213-24. 1999
    ..Thus, we determined that the long-form cDNA of the human ST6GalNAc I gene encodes the probable candidate for the human sTn synthase(s)...
  20. ncbi request reprint Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    M Tsujii
    Department of Medicine, Vanderbilt University Medical Center, VA Medical Center, Nashville, Tennessee 37232, USA
    Cell 93:705-16. 1998
    ..Cyclooxygenase regulates colon carcinoma-induced angiogenesis by two mechanisms: COX-2 can modulate production of angiogenic factors by colon cancer cells, while COX-1 regulates angiogenesis in endothelial cells...
  21. ncbi request reprint [Molecular mechanisms of neurodegeneration in dentatorubral-pallidoluysian atrophy (DRPLA)]
    S Tsuji
    Department of Neurology, Brain Research Institute, Niigata University
    Rinsho Shinkeigaku 41:1064-6. 2001
    ..Taken together, these findings suggest that the interference of CREB-dependent transcription by expanded polyglutamine stretches is involved in the neuronal dysfunction in polyglutamine diseases...
  22. ncbi request reprint Prolactin-releasing peptide is a potent mediator of stress responses in the brain through the hypothalamic paraventricular nucleus
    T Mera
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Neuroscience 141:1069-86. 2006
    ..These results suggest that prolactin-releasing peptide is a potent and important mediator of the stress response in the brain through the hypothalamic paraventricular nucleus...
  23. ncbi request reprint Interference of CREB-dependent transcriptional activation by expanded polyglutamine stretches--augmentation of transcriptional activation as a potential therapeutic strategy for polyglutamine diseases
    M Shimohata
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 93:654-63. 2005
    ....
  24. ncbi request reprint Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons
    S Niiyama
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Neurosci Res 53:271-8. 2005
    ..All the results suggest that the neuroprotective lidocaine action is due to the protection of the mitochondria to maintain the tissue ATP content during and after in vitro ischemia...
  25. pmc B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1
    S Tsuji
    Division of Molecular Biology, Research Institute for Biological Sciences, Science University of Tokyo, Chiba 278 0022, Japan
    J Exp Med 194:529-39. 2001
    ..These results reveal a novel BCR signaling pathway leading to the activation of HPK1 and subsequently IKKbeta, in which BASH recruits tyrosine-phosphorylated HPK1 into the BCR signaling complex...
  26. ncbi request reprint SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein
    K Nakamura
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hum Mol Genet 10:1441-8. 2001
    ..We therefore propose that this new disease be called SCA17 (TBP disease)...
  27. ncbi request reprint Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta
    C Zhao
    Department of Cell Biology and Anatomy, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    Cell 105:587-97. 2001
    ..We show that CMT2A patients contain a loss-of-function mutation in the motor domain of the KIF1B gene. This is clear indication that defects in axonal transport due to a mutated motor protein can underlie human peripheral neuropathy...
  28. ncbi request reprint Er81 is expressed in a subpopulation of layer 5 neurons in rodent and primate neocortices
    H Yoneshima
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Machikaneyama, Toyonaka, Osaka 560 8531, Japan
    Neuroscience 137:401-12. 2006
    ....
  29. ncbi request reprint Spinocerebellar ataxia type 1 in China: molecular analysis and genotype-phenotype correlation in 5 families
    Y X Zhou
    Genetics of Development and Disease Branch, Bldg 10/9N104, NIDDK, NIH, 10 Center Dr Bethesda, MD 20892, USA
    Arch Neurol 58:789-94. 2001
    ....
  30. ncbi request reprint Lithium, but not valproate, induces the serine/threonine phosphatase activity of protein phosphatase 2A in the rat brain, without affecting its expression
    S Tsuji
    Department of Psychiatry, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    J Neural Transm 110:413-25. 2003
    ..It is suggested that the changes in neuronal functions induced by PP2A may be, at least in part, associated with the therapeutic action of lithium...
  31. ncbi request reprint Sharing of polyglutamine localization by the neuronal nucleus and cytoplasm in CAG-repeat diseases
    M Yamada
    Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
    Neuropathol Appl Neurobiol 30:665-75. 2004
    ....
  32. ncbi request reprint Early-onset ataxia with ocular motor apraxia and hypoalbuminemia: the aprataxin gene mutations
    H Shimazaki
    Department of Neurology, Jichi Medical School, Tochigi, Japan
    Neurology 59:590-5. 2002
    ..A new clinical entity named early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) has been proposed to explain these two diseases...
  33. ncbi request reprint Prostaglandin E1 protects cultured spinal neurons against the effects of nitric oxide toxicity
    S Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Neuropharmacology 42:714-23. 2002
    ..Our data indicate that PGE(1) exerts a protective action against NO neurotoxicity in cultured spinal neurons, and suggests a therapeutic potential of PGE(1) against spinal cord disease, such as amyotrophic lateral sclerosis...
  34. ncbi request reprint A new cytochemical method for ultrastructural localization of Co2+ in rat hippocampal CA1 pyramidal neurons in vitro
    E Tanaka
    Department of Physiology, Kurume University School of Medicine, Japan
    J Neurosci Methods 135:1-8. 2004
    ..These results indicate that the Schaffer collaterals stimulation induces the binding of Co(2+) on CA1 pyramidal neuron membrane...
  35. ncbi request reprint Effects of angiotensin converting enzyme inhibitor and angiotensin II type 1 receptor blocker on cardiac dysfunction induced by isoproterenol in dogs
    T Ohta
    The First Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan
    J Cardiovasc Pharmacol 38:S63-7. 2001
    ..In conclusion, an ACE inhibitor and ARB prevent LV systolic and diastolic dysfunction as well as myocardial damage induced by excess beta-adrenergic stimulation...
  36. ncbi request reprint Reduction in levels of amphiphysin 1 mRNA in the hippocampus of aged rats subjected to repeated variable stress
    T Sawada
    Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, 734 8551, Hiroshima, Japan
    Neuroscience 126:461-6. 2004
    ....
  37. ncbi request reprint Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation
    K Nozaki
    Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8585, Japan
    Neuroreport 12:3357-64. 2001
    ..These results indicate that the amino acid sequences flanking the polyglutamine stretches significantly influence their aggregate formation potential...
  38. ncbi request reprint Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene
    H Date
    Department of Neurology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951, Japan
    Nat Genet 29:184-8. 2001
    ..We have called its product aprataxin; the gene symbol is APTX. Although many HIT proteins have been identified, aprataxin is the first to be linked to a distinct phenotype...
  39. ncbi request reprint Analysis of the expression level of alpha-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy
    T Ozawa
    Department of Neurology, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 102:188-90. 2001
    ..These results suggest that the transcriptional regulation of the alpha-synuclein gene is unlikely to be affected in MSA brains...
  40. pmc Pigmentary macular dystrophy in spinocerebellar ataxia type 1
    Y Saito
    J Neurol Neurosurg Psychiatry 77:1293. 2006
  41. pmc Beta-synuclein gene alterations in dementia with Lewy bodies
    H Ohtake
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Neurology 63:805-11. 2004
    ..To determine whether mutations in the genes for alpha-synuclein or beta-synuclein are responsible for dementia with Lewy bodies (DLB), a disorder closely related to Parkinson disease (PD)...
  42. ncbi request reprint Protection of outer hair cells from reperfusion injury by an iron chelator and a nitric oxide synthase inhibitor in the guinea pig cochlea
    K Tabuchi
    Department of Otolaryngology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
    Neurosci Lett 307:29-32. 2001
    ..These results suggest that cochlear reperfusion as well as ischemia injured the active process of the cochlea and that free radicals and nitric oxide play important roles in this injury...
  43. ncbi request reprint Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall
    S Tsuji
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    J Biol Chem 276:23456-63. 2001
    ..These results suggested that hIntL is a new type lectin recognizing galactofuranose, and that hIntL plays a role in the recognition of bacteria-specific components in the host...
  44. ncbi request reprint Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
    F C Nucifora
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Science 291:2423-8. 2001
    ..Thus, polyglutamine-mediated interference with CBP-regulated gene transcription may constitute a genetic gain of function, underlying the pathogenesis of polyglutamine disorders...
  45. ncbi request reprint Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system
    H Kobayashi
    Department of Neurology, Tokyo Medical and Dental University, Japan
    Brain Res Mol Brain Res 19:188-94. 1993
    ..These results indicate that transcriptional regulation of the rat GIF gene is quite different from that of MTs despite its strikingly high homology with MTs...
  46. ncbi request reprint Molecular cloning and expression of chick embryo Gal beta 1,4GlcNAc alpha 2,6-sialyltransferase. Comparison with the mammalian enzyme
    N Kurosawa
    Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Wako, Japan
    Eur J Biochem 219:375-81. 1994
    ..The expressed enzyme exhibited activity only towards the disaccharide moiety of Gal beta 1,4GlcNAc in glycoproteins...
  47. ncbi request reprint Molecular cloning and expression of GalNAc alpha 2,6-sialyltransferase
    N Kurosawa
    Glyco Molecular Biology, Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitamo, Japan
    J Biol Chem 269:1402-9. 1994
    ..Synthetic GalNAc-SerNAc also served as an acceptor for alpha 2,6-sialylation. These results clearly showed that the expressed enzyme is GalNAc alpha 2,6-sialyltransferase...
  48. ncbi request reprint Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase)
    K Sasaki
    Tokyo Research Laboratories, Kyowa Hakko Kogyo, CO, Ltd, Japan
    J Biol Chem 269:15950-6. 1994
    ..The deduced primary sequence also contains the "sialyl motif" conserved among all the sialyltransferases cloned to date. The polymerase chain reaction analysis reveals that this gene is located on chromosome 12...
  49. ncbi request reprint Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase
    Y C Lee
    Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    J Biol Chem 269:10028-33. 1994
    ..1, but showed a difference in acceptor substrate preference, i.e. asialo-GM1 and GM1 were much more suitable substrates for ST3GalA.2 than for ST3GalA.1...
  50. ncbi request reprint Cloning and expression of Gal beta 1,3GalNAc-specific GalNAc alpha 2,6-sialyltransferase
    N Kurosawa
    Department of Glyco Molecular Biology, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    J Biol Chem 269:19048-53. 1994
    ....
  51. pmc Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from Xenopus, pig, and rat
    S Tsuji
    Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 91:9392-6. 1994
    ..The mammalian LDH-C (testis) subunit appears to have diverged very early, prior to the divergence of vertebrate LDH-A and LDH-B subunits, as reported previously...
  52. ncbi request reprint Molecular cloning and expression of chick Gal beta 1,3GalNAc alpha 2,3-sialyltransferase
    N Kurosawa
    Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Biochim Biophys Acta 1244:216-22. 1995
    ..This enzyme expressed in COS-7 cells exhibited transferase activity similar to that of mouse ST3Gal I...
  53. ncbi request reprint Molecular cloning and expression of two types of rabbit beta-galactoside alpha 1,2-fucosyltransferase
    S Hitoshi
    Molecular Glycobiology, Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    J Biol Chem 270:8844-50. 1995
    ....
  54. ncbi request reprint Evidence for allelism of leaner and tottering in the mouse
    S Tsuji
    Genet Res 17:83-8. 1971
  55. ncbi request reprint Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a
    H Wada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Biochem Biophys Res Commun 165:533-8. 1989
    ..In a mouse neuroblast cell line, Neuro 2a, down modulation of mRNAs for both PKC alpha and nPKC epsilon was observed in association with in vitro differentiation...
  56. ncbi request reprint Molecular cloning of two species of cDNAs for human alpha-N-acetylgalactosaminidase and expression in mammalian cells
    T Yamauchi
    Department of Neurology, Niigata University, Japan
    Biochem Biophys Res Commun 170:231-7. 1990
    ..Analysis of mRNA species utilizing polymerase chain reaction revealed that the majority of the mRNA does not contain the 70 bp insertion, and the mRNA containing the 70 bp insertion is present only in a minor amount in human brain...
  57. ncbi request reprint Assignment of the human ST2 gene to chromosome 2 at q11.2
    S Tominaga
    Department of Biochemistry II, Jichi Medical School, Tochigi, Japan
    Hum Genet 97:561-3. 1996
    ..The locus is very tightly linked to the Il-1r1 locus. Together with the structural similarity of ST2 to IL-1RI, these data suggest functional relationships between these two genes...
  58. ncbi request reprint Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression
    M Kono
    Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Glycobiology 7:469-79. 1997
    ..The ST3Gal III and IV genes were expressed in a wide variety of tissues. These differences in tissue specific expression suggest the expression of each ST3Gal influences the distribution of sialyl-glycoconjugates in vivo...
  59. ncbi request reprint Polysialic acid synthase (ST8Sia II/STX) mRNA expression in the developing mouse central nervous system
    N Kurosawa
    Molecular Glycobiology, Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Wako Shi, Saitama, Japan
    J Neurochem 69:494-503. 1997
    ..The regional and transient expression of ST8Sia II mRNA coincides with that of PSA, suggesting that ST8Sia II is closely involved in the biosynthesis and expression of PSA in the developing mouse CNS...
  60. ncbi request reprint Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR
    S Takashima
    Frontier Research Program, The Institute of Physical and Chemical Research RIKEN, Saitama, Wako, 351 0198, Japan
    Biochem Biophys Res Commun 260:23-7. 1999
    ..Using this method, we can investigate the levels of gene expression of sialyltransferases in various cell lines and various tissues of mice, and can accurately determine their expression levels...
  61. ncbi request reprint Ganglioside GD3 and its mimetics induce cytochrome c release from mitochondria
    Y Inoki
    Research Institute of Life Science, Tochigi, 329 05, Japan
    Biochem Biophys Res Commun 276:1210-6. 2000
    ..In contrast, gangliosides GM1, GM2, and GM3 did not induce cytochrome c release. These results indicate that two sialo residues must play an important role in the induction of cytochrome c release by gangliosides...
  62. ncbi request reprint An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in the parkin gene
    S Hayashi
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Mov Disord 15:884-8. 2000
    ..Gene analysis revealed that this autopsied patient and his siblings had the parkin gene mutation (homozygous exon 4 deletion) that is responsible for the disease...
  63. ncbi request reprint Organization of the human synphilin-1 gene, a candidate for Parkinson's disease
    S Engelender
    Department of Psychiatry, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Room 618, Baltimore, Maryland 21205 2196, USA
    Mamm Genome 11:763-6. 2000
    ..Because of its association with alpha-synuclein, synphilin-1 may be a candidate for involvement in Parkinson's disease or other related disorders...
  64. pmc The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
    K Hayashi
    Research Institute for Biological Sciences, Science University of Tokyo, Japan
    Proc Natl Acad Sci U S A 97:2755-60. 2000
    ....
  65. ncbi request reprint Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase)
    M Kono
    Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Biochem Biophys Res Commun 253:170-5. 1998
    ..The gene expression seemed to be coincident with ganglioside expression in mouse. Thus, we conclude that mST3Gal V is the fifth-type alpha 2,3-sialyltransferase carrying GM3 synthetic activity...
  66. ncbi request reprint Hereditary dentatorubral-pallidoluysian atrophy: detection of widespread ubiquitinated neuronal and glial intranuclear inclusions in the brain
    Y Hayashi
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 96:547-52. 1998
    ....
  67. ncbi request reprint BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius
    R Goitsuka
    Inheritance and Variation Group, PREST, JST, Kyoto, Japan
    J Immunol 161:5804-8. 1998
    ..These findings suggest that BASH is involved in BCR-mediated signal transduction and could play a critical role in B cell development in the bursa...
  68. ncbi request reprint The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells
    P Good
    Feist Weiller Cancer Center, LSU Medical Center Shreveport, Shreveport, Louisiana 71130 3932, USA
    Genomics 52:382-4. 1998
  69. ncbi request reprint Genomic structure and promoter activity of the mouse polysialic acid synthase (mST8Sia IV/PST) gene
    S Takashima
    Department of Molecular Glycobiology, Frontier Research Program, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 01, Japan
    J Biol Chem 273:7675-83. 1998
    ....
  70. ncbi request reprint Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family
    T Saito
    Genome Research Group, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Biochem Biophys Res Commun 243:61-6. 1998
    ....
  71. ncbi request reprint Machado-Joseph disease gene products carrying different carboxyl termini
    J Goto
    Department of Neurology, Institute for Brain Research, Faculty of Medicine, University of Tokyo, Japan
    Neurosci Res 28:373-7. 1997
    ..Genetic analysis results suggest that Japanese MJD mutations are associated with allele A...
  72. pmc An unusual splicing mutation in the HEXB gene is associated with dramatically different phenotypes in patients from different racial backgrounds
    B McInnes
    Research Institute, Hospital for Sick Children, Montreal, Quebec, Canada
    J Clin Invest 90:306-14. 1992
    ..The biochemical basis of his mild phenotype is uncertain, but may result from genetic variations in the RNA splicing machinery...