Research Topics
Genomes and Genes | S ToyosawaSummaryAffiliation: Osaka University Country: Japan Publications
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Publications
Cloning and characterization of the human ameloblastin geneS Toyosawa
Department of Oral Pathology, Osaka University Faculty of Dentistry, 1 8 Yamadaoka, Suita, 565 0871, Osaka, Japan
Gene 256:1-11. 2000..By DNA analysis of a human genomic clones, the AMBN gene was shown to consist of 13 exons and a novel 78bp segment, which proved to comprise two small exons. Human ameloblastomas express AMBN transcripts that contain some mutations...- mRNA expression and protein localization of dentin matrix protein 1 during dental root formationS Toyosawa
Department of Oral Pathology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565 0871, Japan
Bone 34:124-33. 2004..The localization of DMP1 mRNA and protein in dentin and cementum was related to their mineralization, suggesting that one of the functions of DMP1 may be involved in the mineralization of dentin and cementum during root formation... - Small cell undifferentiated carcinoma of the submandibular gland: immunohistochemical evidence of myoepithelial, basal and luminal cell featuresS Toyosawa
Department of Oral Pathology, Osaka University Faculty of Dentistry, Japan
Pathol Int 49:887-92. 1999..Furthermore, it supports the hypothesis of multipotential stem cells as the origin for small cell undifferentiated carcinomas in salivary glands... - Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalaciaSatoru Toyosawa
Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
Mod Pathol 17:573-8. 2004..Paranuclear DMP1 staining in the tumor cells was also observed. These findings indicate that DMP1 immunohistochemistry is a useful tool for identifying PMTs... - Expression of dentin matrix protein 1 (DMP1) during fracture healingS Toyosawa
Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
Bone 35:553-61. 2004..Therefore, DMP1 is likely to play an important role in the mineralization of the bony callus... - Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterizationSatoru Toyosawa
Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
Mod Pathol 20:389-96. 2007..Furthermore, PCR analysis with PNA for GNAS mutations at the Arg(201) codon is a useful method to differentiate between fibrous dysplasia and ossifying fibroma... - Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblastsS Toyosawa
Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Japan
J Bone Miner Res 16:2017-26. 2001..These data show that DMP1 is a bone matrix protein specifically expressed in osteocytes and preosteocytes and suggest that DMP1 plays a role in bone homeostasis because of its high calcium ion-binding capacity... - Immunohistochemical localization of carbonic anhydrase isozyme II in rat incisor epithelial cells at various stages of amelogenesisS Toyosawa
Department of Oral Pathology, Osaka University Faculty of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565, Japan
Cell Tissue Res 285:217-25. 1996.... - Keratin 14 immunoreactive cells in pleomorphic adenomas and adenoid cystic carcinomas of salivary glandsY Ogawa
Department of Oral Pathology, Osaka University Faculty of Dentistry, Suita, Japan
Virchows Arch 437:58-68. 2000..MECs were observed only occasionally in the periphery. Solid and cribriform structures of adenoid cystic carcinomas were formed by proliferation of the luminal cells. MECs were observed in the periphery and around the pseudocyst... - A immunohistochemical study of the peripheral ameloblastomaM Kishino
Department of Oral Pathology, Osaka University Graduate School of Dentistry, Osaka, Japan
Oral Dis 13:575-80. 2007..In this study, we examined the immunohistochemical profiles of cytokeratins (CKs) and Ki-67 labeling index (LI) of PAs, and discuss the histogenesis and the biologic behavior of the PA... - Induction of adenocarcinoma containing myoepithelial cells in rat submandibular gland by 7,12-dimethylbenz(a)anthraceneY Ogawa
Department of Oral Pathology, Osaka University, Faculty of Dentistry, Suita, Japan
Virchows Arch 437:314-24. 2000.... 
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fracturesW Liu
Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
J Cell Biol 155:157-66. 2001....
Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storageY Ihara
Department of Biochemistry, Osaka University Medical School, 2 2 Yamadaoka, 1 8 Yamadaoka, Suita, Osaka 565, Japan
Proc Natl Acad Sci U S A 95:2526-30. 1998..This observation suggests a novel mechanism for the pathogenesis of fatty liver...- Intentional replantation of an immature permanent lower incisor because of a refractory peri-apical lesion: case report and 5-year follow-upS Shintani
Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan
Int J Paediatr Dent 14:218-22. 2004..Our results indicate that intentional replantation is a useful method for an immature tooth with refractory peri-apical problems... - Immunoelectron microscopy of carbonic anhydrase isozyme VI in human submandibular gland: comparison with isozymes I and IIY Ogawa
Department of Oral Pathology, Osaka University Faculty of Dentistry, Japan
J Histochem Cytochem 41:343-51. 1993..These results suggest that (a) serous acinar cells secrete 42 KD CA VI which functions in the oral cavity and that (b) serous acinar and duct epithelial cells possess cytosolic CA (30 KD CA VI and CA II) which functions in situ... - Studies on cytotoxicity of nickel ions using C3H10T1/2 fibroblast cellsM Taira
Department of Dental Materials Science and Technology, Osaka University Faculty of Dentistry, Osaka, Japan
J Oral Rehabil 27:1068-72. 2000..The dissolution of Ni ions from Ni-containing metallic restorations must be lower than these concentration levels so that oral tissues might not be damaged. No neoplastic transformation was found on all cells examined... - Identification and characterization of amelogenin genes in monotremes, reptiles, and amphibiansS Toyosawa
Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, D 72076 Tubingen, Germany
Proc Natl Acad Sci U S A 95:13056-61. 1998..Clones corresponding to one locus only were found in caiman, whereas the clawed toad possesses at least two amelogenin-encoding loci... - Origin of gene overlap: the case of TCP1 and ACAT2S Shintani
Max Planck Institut fur Biologie, D 72076 Tubingen, Germany
Genetics 152:743-54. 1999..One or both of the transposed genes found by chance signals that are necessary for the processing of their transcripts to be present on the noncoding strand of the partner gene... - Expression of the dentin matrix protein 1 gene in birdsS Toyosawa
Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Germany
J Mol Evol 50:31-8. 2000..The DMP1 gene may have been retained in birds because of its involvement in bone formation... - Biglycan-like extracellular matrix genes of agnathans and teleostsS Shintani
Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, D 72076, Tubingen, Germany
J Mol Evol 51:363-73. 2000..The BGL gene presumably turned into a typical biglycan only in the tetrapod lineages. The presumed acquisitions of new functions appear to have been accompanied by changes in the evolutionary rate... - Studies on osteogenic differentiation of rat bone marrow stromal cells cultured in type I collagen gel by RT-PCR analysisM Taira
Department of Dental Materials Science and Technology, Iwate Medical University School of Dentistry, Iwate, Japan
J Oral Rehabil 30:802-7. 2003..This study might contribute to tissue engineering therapy to fix bone and periodontal defects in the future...