Fuminori Tokunaga

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. ncbi [Hereditary deficiencies of blood coagulation factors: from the viewpoints of intracellular transport and quality control]
    Fuminori Tokunaga
    Tanpakushitsu Kakusan Koso 49:1135. 2004
  2. ncbi [E2 ubiquitin-conjugating enzymes: structures and functions]
    Fuminori Tokunaga
    Tanpakushitsu Kakusan Koso 51:1150-6. 2006
  3. ncbi E3 ubiquitin ligase that recognizes sugar chains
    Yukiko Yoshida
    Department of Tumor Immunology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Nature 418:438-42. 2002
  4. ncbi Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains
    Yukiko Yoshida
    Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 278:43877-84. 2003
  5. ncbi [Quality control of secretory pathway proteins by a ubiquitin ligase that recognizes sugar chains]
    Yukiko Yoshida
    Tanpakushitsu Kakusan Koso 47:1924-30. 2002
  6. ncbi Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2
    Koji Yamanaka
    Department of Molecular and System Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Cell Biol 5:336-40. 2003
  7. ncbi N-linked oligosaccharide processing, but not association with calnexin/calreticulin is highly correlated with endoplasmic reticulum-associated degradation of antithrombin Glu313-deleted mutant
    Fuminori Tokunaga
    Department of Life Science, Graduate School of Science, Himeji Institute of Technology, Harima Science Garden City, Hyogo 678-1297, Japan
    Arch Biochem Biophys 411:235-42. 2003
  8. ncbi Characterization of endoplasmic reticulum-associated degradation of a protein S mutant identified in a family of quantitative protein S deficiency
    Hiroko Tsuda
    Department of Nutritional Sciences, Nakamura Gakuen University, 5 7 1 Befu, Johnan ku, Fukuoka 814 0198, Japan
    Thromb Res 117:323-31. 2006
  9. ncbi Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2
    Haruto Ishikawa
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan
    Mol Cell 19:171-81. 2005
  10. ncbi Proline-rich cell surface antigens of horseshoe crab hemocytes are substrates for protein cross-linking with a clotting protein coagulin
    Tsukasa Osaki
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan
    J Biol Chem 277:40084-90. 2002

Collaborators

  • Keiji Tanaka
  • Yukiko Yoshida
  • Michiko Kato
  • Kazuhiro Iwai
  • Shigeo Murata
  • Takayoshi Kirisako
  • Haruto Ishikawa
  • Yasuhiro Miyauchi
  • Munehiro Nakamura
  • Hiroko Tsuda
  • Masato Kanie
  • Koichiro Ishimori
  • Koji Yamanaka
  • Tsukasa Osaki
  • Shin ichi Sakata
  • Takehiko Koide
  • Hiromi Fukumoto
  • Soichi Sano
  • Hiroshi Nagamitsu
  • Shin-ichi Sakata
  • Kiyoko Kamei
  • Hiroshi Hori
  • Isao Morishima
  • Nagahiro Minato
  • Tracey A Rouault
  • Yuzuru Megumi
  • Sadaaki Iwanaga
  • Shun-ichiro Kawabata
  • Nozomu Okino

Detail Information

Publications13

  1. ncbi [Hereditary deficiencies of blood coagulation factors: from the viewpoints of intracellular transport and quality control]
    Fuminori Tokunaga
    Tanpakushitsu Kakusan Koso 49:1135. 2004
  2. ncbi [E2 ubiquitin-conjugating enzymes: structures and functions]
    Fuminori Tokunaga
    Tanpakushitsu Kakusan Koso 51:1150-6. 2006
  3. ncbi E3 ubiquitin ligase that recognizes sugar chains
    Yukiko Yoshida
    Department of Tumor Immunology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Nature 418:438-42. 2002
    ..Our results indicate that SCF(Fbx2) ubiquitinates N-glycosylated proteins that are translocated from the ER to the cytosol by the quality control mechanism...
  4. ncbi Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains
    Yukiko Yoshida
    Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 278:43877-84. 2003
    ..Thus, Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD...
  5. ncbi [Quality control of secretory pathway proteins by a ubiquitin ligase that recognizes sugar chains]
    Yukiko Yoshida
    Tanpakushitsu Kakusan Koso 47:1924-30. 2002
  6. ncbi Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2
    Koji Yamanaka
    Department of Molecular and System Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Cell Biol 5:336-40. 2003
    ..The oxidation of IRP2 is generated by haem, which binds to IRP2 in iron-rich cells, and by oxygen, indicating that the iron sensing of IRP2 depends on the synthesis and availability of haem...
  7. ncbi N-linked oligosaccharide processing, but not association with calnexin/calreticulin is highly correlated with endoplasmic reticulum-associated degradation of antithrombin Glu313-deleted mutant
    Fuminori Tokunaga
    Department of Life Science, Graduate School of Science, Himeji Institute of Technology, Harima Science Garden City, Hyogo 678-1297, Japan
    Arch Biochem Biophys 411:235-42. 2003
    ....
  8. ncbi Characterization of endoplasmic reticulum-associated degradation of a protein S mutant identified in a family of quantitative protein S deficiency
    Hiroko Tsuda
    Department of Nutritional Sciences, Nakamura Gakuen University, 5 7 1 Befu, Johnan ku, Fukuoka 814 0198, Japan
    Thromb Res 117:323-31. 2006
    ..The mutation causes intracellular degradation and decreased secretion of the Y595C mutant PS. The aim of the present study was to further characterize the molecular basis of the intracellular degradation of the mutant...
  9. ncbi Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2
    Haruto Ishikawa
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan
    Mol Cell 19:171-81. 2005
    ....
  10. ncbi Proline-rich cell surface antigens of horseshoe crab hemocytes are substrates for protein cross-linking with a clotting protein coagulin
    Tsukasa Osaki
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan
    J Biol Chem 277:40084-90. 2002
    ..We named them proxins-1 and -2 after proline-rich proteins for protein cross-linking. Proxins may form a stable physical barrier against invading pathogens in cooperation with hemolymph coagulation at injured sites...
  11. ncbi A ubiquitin ligase complex assembles linear polyubiquitin chains
    Takayoshi Kirisako
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    EMBO J 25:4877-87. 2006
    ..Moreover, the complex regulates the stability of Ub-GFP (a GFP fusion protein with an N-terminal ubiquitin). The linear polyubiquitin chain generated post-translationally may function as a new modulator of proteins...
  12. ncbi Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex
    Munehiro Nakamura
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 351:340-7. 2006
    ..These results indicate that LUBAC is an E3 for activated conventional PKC, and that PKC and LUBAC regulate each other for proper PKC signaling...
  13. ncbi The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination
    Yasuhiro Miyauchi
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Abeno Ku, Osaka 545 8585, Japan
    J Biol Chem 283:16622-31. 2008
    ....