Research Topics
Genomes and Genes
| Kenji TatematsuSummaryAffiliation: Osaka University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase CbetaKenji Tatematsu
Department of Structural Molecular Biology, The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
J Biol Chem 283:11575-85. 2008..It is possible that other RING proteins, such as Parkin, BRCA1, and RNF8, having the E3 activity, are also down-regulated by interaction with their RING-lacking splice variants and/or phosphorylation by protein kinases...
Cytoplasmic tethering of a RING protein RBCK1 by its splice variant lacking the RING domainNobuo Yoshimoto
Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, 8 1 Mihogaoka, Ibaraki, Osaka 567 0047, Japan
Biochem Biophys Res Commun 335:550-7. 2005..We propose a novel and general function of RING-lacking splice variants of RING proteins to control the intracellular localization and functions of the parental RING proteins by forming a hetero-oligomeric complex...- Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteinsKenji Tatematsu
Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Japan
J Biol Chem 280:22937-44. 2005..Taken together, our data demonstrate that RBCK1 is involved in transcriptional machinery in the nuclear bodies, and its transcriptional activity is regulated by nucleocytoplasmic shuttling... - Expression of squamous cell carcinoma antigen-1 in liver enhances the uptake of hepatitis B virus envelope-derived bio-nanocapsules in transgenic ratsTakeshi Kasuya
Department of Structural Molecular Biology, The Institute of Scientific and Industrial Research, Osaka University, Japan
FEBS J 275:5714-24. 2008..Therefore, this animal model is expected to be useful for the development of bio-nanocapsule-based medicines... - Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cellsToshitsugu Fujita
Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
Biochem Biophys Res Commun 361:605-10. 2007..Thus, our results suggest that the FEZ1/kinesin complex functions for the transport of mitochondria along microtubules toward the extending neurites in differentiating PC12 cells... - Efficient and rapid purification of drug- and gene-carrying bio-nanocapsules, hepatitis B virus surface antigen L particles, from Saccharomyces cerevisiaeJoohee Jung
Institute of Scientific and Industrial Research, Osaka University, 8 1 Mihogaoka, Ibaraki, Osaka 567 0047, Japan
Protein Expr Purif 78:149-55. 2011..This new process will significantly contribute to the development of forthcoming BNC-based nanomedicines as well as hepatitis B vaccines... - Accumulation of polyubiquitinated proteins by overexpression of RBCC protein interacting with protein kinase C2, a splice variant of ubiquitin ligase RBCC protein interacting with protein kinase C1Nobuo Yoshimoto
Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Japan
FEBS J 276:6375-85. 2009.... - LIM domains regulate protein kinase C activity: a novel molecular functionAndrés D Maturana
Department of Structural Molecular Biology, The Institute of Scientific and Industrial Research, Osaka University, Osaka 567 0047, Japan
Cell Signal 23:928-34. 2011..Thus, LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner... - In vivo delivery of bionanocapsules displaying Phaseolus vulgaris agglutinin-L4 isolectin to malignant tumors overexpressing N-acetylglucosaminyltransferase VTakeshi Kasuya
Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
Hum Gene Ther 19:887-95. 2008..These results open up the possibility of using L(4)-PHA lectin as a targeting molecule in a drug delivery system, and of using PHA-BNCs as a novel nanodevice for malignant tumor-specific bioimaging and drug delivery... - Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motilityJunko Ikuta
Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
Biochem Biophys Res Commun 353:127-32. 2007..Therefore, our results strongly suggest that FEZ1 participates in the establishment of neuronal polarity by controlling the mitochondrial motility along axon... - Bio-nanocapsule conjugated with liposomes for in vivo pinpoint delivery of various materialsJoohee Jung
Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
J Control Release 126:255-64. 2008..These results indicated that BNC confers the tissue- and cell-specificity on the conventional liposomes and raises new possibilities for drug delivery systems, gene delivery systems, and bio-imaging systems in vivo... - In vivo protein delivery to human liver-derived cells using hepatitis B virus envelope pre-S regionTakeshi Kasuya
Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, 8 1 Mihogaoka, Ibaraki, Osaka 567 0047, Japan
J Biosci Bioeng 106:99-102. 2008..The entire pre-S region would be useful for human liver-specific delivery of therapeutic proteins and bio-imaging fluoroproteins in biomedical field... 
Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiationNobuyuki Bokui
Department of Structural Molecular Biology, The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan
FEBS Lett 582:365-71. 2008..These findings suggest that upon binding to a specific receptor NELL1 transduces an osteogenic signal through activation of certain Tyr-kinases associated with the Ras-MAPK cascade, and finally leads to the osteogenic differentiation...- PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonistsMiki Iwata
Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
Biochem Biophys Res Commun 327:1105-13. 2005..Taken together, the PKCepsilon-PKD1 complex at Z-discs could play a pivotal role in the cardiac hypertrophy induced by GPCR agonists, at least alpha-adrenergic receptor agonist... - Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1Toshitsugu Fujita
Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
Biochem Biophys Res Commun 313:738-44. 2004..These results suggest that FEZ2 plays an important role in the morphological changes of various cells by associating with PKCzeta in a tissue-non-specific manner... - Yeast-based fluorescence reporter assay of G protein-coupled receptor signalling for flow cytometric screening: FAR1-disruption recovers loss of episomal plasmid caused by signalling in yeastJun Ishii
Department of Molecular Science and Material Engineering, Graduate School of Science and Technology, Graduate School of Engineering, Kobe University, Japan
J Biochem 143:667-74. 2008..Our system will be a powerful tool for the quantitative and high-throughput GPCR screening of yeast-based combinatorial libraries using FCM... - Optimal surface chemistry for peptide immobilization in on-chip phosphorylation analysisKazuki Inamori
Biotechnology Frontier Project, Toyobo Co, Ltd, 10 24 Toyo Cho, Tsuruga, Fukui 914 0047, Japan
Anal Chem 80:643-50. 2008..However, PEG linker also did not suppress the phosphorylation in protein kinase A. Thus, we concluded that SSMCC and PEGylated peptide will be a good combination for the surface chemistry of on-chip phosphorylation in peptide array... - Phosphorylation of Rho-associated kinase (Rho-kinase/ROCK/ROK) substrates by protein kinases A and CJeong Hun Kang
CREST, Japan Science and Technology Corporation, Japan
Biochimie 89:39-47. 2007..Kinetic parameters (K(m) and k(cat)) showed that two of these peptides could be useful as substrates specific to Rho-kinase phosphorylation...