Akihiro Tamori

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. ncbi request reprint HBV DNA integration and HBV-transcript expression in non-B, non-C hepatocellular carcinoma in Japan
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Med Virol 71:492-8. 2003
  2. pmc Expression of connective tissue growth factor in the human liver with idiopathic portal hypertension
    Hiroyasu Morikawa
    Department of Hepatology, Osaka City University Graduate School of Medicine, Asahimachi, Osaka, Japan
    Mol Med 13:240-5. 2007
  3. ncbi request reprint Sequencing of human-viral DNA junctions in hepatocellular carcinoma from patients with HCV and occult HBV infection
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Japan
    J Med Virol 69:475-81. 2003
  4. ncbi request reprint Hepatitis B virus DNA integration in hepatocellular carcinoma after interferon-induced disappearance of hepatitis C virus
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Gastroenterol 100:1748-53. 2005
  5. ncbi request reprint Alteration of gene expression in human hepatocellular carcinoma with integrated hepatitis B virus DNA
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 11:5821-6. 2005
  6. pmc The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis
    Yoshiki Murakami
    Department of Hepatology, Graduate School of Medicine Osaka City University, Osaka 545 8585, Japan
    BMC Cancer 13:99. 2013
  7. doi request reprint Frequent detection of hepatitis B virus DNA in hepatocellular carcinoma of patients with sustained virologic response for hepatitis C virus
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Med Virol 81:1009-14. 2009
  8. doi request reprint Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy: evaluation of both HBsAg-positive and HBsAg-negative cohorts
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 46:556-64. 2011
  9. ncbi request reprint Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Liver Int 27:95-100. 2007
  10. doi request reprint Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus
    A Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    J Viral Hepat 17:123-9. 2010

Detail Information

Publications77

  1. ncbi request reprint HBV DNA integration and HBV-transcript expression in non-B, non-C hepatocellular carcinoma in Japan
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Med Virol 71:492-8. 2003
    ..These results suggested that occult HBV infection might play an important role in hepatocarcinogenesis in non-B, non-C patients with anti-HBc and that excessive alcohol intake might be related to HCC in non-B, non-C patients in Japan...
  2. pmc Expression of connective tissue growth factor in the human liver with idiopathic portal hypertension
    Hiroyasu Morikawa
    Department of Hepatology, Osaka City University Graduate School of Medicine, Asahimachi, Osaka, Japan
    Mol Med 13:240-5. 2007
    ..Six (8%) of the 76 patients with IPH had serum CTGF levels greater than 80 ng/mL, far exceeding the level of any patient with cirrhosis. In conclusion, overexpression of CTGF is one of the most important features of IPH...
  3. ncbi request reprint Sequencing of human-viral DNA junctions in hepatocellular carcinoma from patients with HCV and occult HBV infection
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Japan
    J Med Virol 69:475-81. 2003
    ..In conclusion, integrated HBV was detected in some patients with HCV infection; in these patients, the integrated DNA was associated with accelerated hepatocarcinogenesis...
  4. ncbi request reprint Hepatitis B virus DNA integration in hepatocellular carcinoma after interferon-induced disappearance of hepatitis C virus
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Gastroenterol 100:1748-53. 2005
    ..Hepatocellular carcinoma (HCC) has been reported in patients in whom hepatitis C virus (HCV) was eliminated by interferon (IFN) therapy. We examined the pathogenesis of HCC in patients with sustained viral response...
  5. ncbi request reprint Alteration of gene expression in human hepatocellular carcinoma with integrated hepatitis B virus DNA
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 11:5821-6. 2005
    ..This study attempted to find the link between HBV DNA, the adjoining cellular sequence, and altered gene expression in hepatocellular carcinoma (HCC) with integrated HBV DNA...
  6. pmc The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis
    Yoshiki Murakami
    Department of Hepatology, Graduate School of Medicine Osaka City University, Osaka 545 8585, Japan
    BMC Cancer 13:99. 2013
    ..In hepatocellular carcinoma (HCC), malignancy level is related to the degree of histological differentiation...
  7. doi request reprint Frequent detection of hepatitis B virus DNA in hepatocellular carcinoma of patients with sustained virologic response for hepatitis C virus
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Med Virol 81:1009-14. 2009
    ..Mutation in 'a' determinant of HBsAg was found in three HCC of group A. Occult HBV infection may be one of the most important risk factors in hepatocarcinogenesis of Japanese patients with sustained virologic response...
  8. doi request reprint Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy: evaluation of both HBsAg-positive and HBsAg-negative cohorts
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 46:556-64. 2011
    ..This study also evaluated guidelines for determining HBV reactivation in patients with RA...
  9. ncbi request reprint Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Liver Int 27:95-100. 2007
    ..We investigated the genotypic status of TPMT to evaluate the risk of azathioprine-related adverse effects in Japanese patients with different liver diseases, including autoimmune hepatitis (AIH)...
  10. doi request reprint Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus
    A Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    J Viral Hepat 17:123-9. 2010
    ..However, the dosing interval of ADV should be adjusted according to renal function and serum phosphate levels in patients receiving long-term treatment...
  11. doi request reprint Differences in molecular alterations of hepatocellular carcinoma between patients with a sustained virological response and those with hepatitis C virus infection
    Takehiro Hayashi
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Liver Int 29:126-32. 2009
    ..We compared molecular alterations in hepatocellular carcinoma (HCC) between patients with a sustained virological response (SVR) to IFN and patients with HCV...
  12. ncbi request reprint Chemiluminescence enzyme immunoassay for monitoring hepatitis C virus core protein during interferon-alpha2b and ribavirin therapy in patients with genotype 1 and high viral loads
    Masaru Enomoto
    Department of Hepatology, Osaka City University Medical School, Osaka, Japan
    J Med Virol 77:77-82. 2005
    ..13 log10/day) than in 13 patients with no response (0.028 log10/day, P = 0.042). The wide linear range of the HCV core protein assay is appropriate for measuring viral loads during therapy with IFN-alpha and ribavirin...
  13. ncbi request reprint Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug-resistant variants during lamivudine therapy: analyses of the polymerase gene and full-length sequences
    Masaru Enomoto
    Department of Hepatology, Osaka City University Medical School, Asahimachi, Abeno Ku, Osaka, Japan
    J Med Virol 79:1664-70. 2007
    ..In conclusion, mutational patterns of HBV DNA at the time of emergence of YMDD variants were apparently unrelated to the clinical outcomes in Japanese patients with chronic hepatitis B during lamivudine therapy...
  14. ncbi request reprint Quantitative detection of hepatitis B surface antigen by chemiluminescent microparticle immunoassay during lamivudine treatment of chronic hepatitis B virus carriers
    Madoka Kohmoto
    Department of Hepatology, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    J Med Virol 75:235-9. 2005
    ....
  15. ncbi request reprint Real-time PCR assays for hepatitis C virus RNA (genotype 1) is useful for evaluating virological response to the treatment with peginterferon-alpha2b and ribavirin
    Mika Nakaya
    Department of Hepatology, Osaka City University, Graduate School of Medicine, Japan
    Osaka City Med J 59:79-89. 2013
    ..However, 'response-guided therapy' to use on-treatment response for tailoring the duration of treatment with peginterferon-alpha and ribavirin has not been fully evaluated for real-time PCR...
  16. ncbi request reprint Clinical role of FDG-PET for HCC: relationship of glucose metabolic indicator to Japan Integrated Staging (JIS) score
    Etsushi Kawamura
    Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Hepatogastroenterology 55:582-6. 2008
    ....
  17. ncbi request reprint Usefulness of per-rectal portal scintigraphy with technetium-99m pertechnetate for prognosis of primary biliary cirrhosis
    Shuhei Nishiguchi
    Department of Hepatology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, 545 8585 Osaka, Japan
    Hepatogastroenterology 50:1783-6. 2003
    ..Portal circulation can be evaluated in a relatively noninvasive manner by per-rectal portal scintigraphy. We used this method to evaluate portal hemodynamics and assess prognosis in patients with primary biliary cirrhosis...
  18. doi request reprint Effect of mosapride citrate on gastric emptying in interferon-induced gastroparesis
    Etsushi Kawamura
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Dig Dis Sci 57:1510-6. 2012
    ..Current therapeutic options are limited. We evaluated the efficacy of mosapride for IFN-induced gastroparesis...
  19. ncbi request reprint Dynamics of hepatitis C virus monitored by real-time quantitative polymerase chain reaction during first 2 weeks of IFN-beta treatment are predictive of long-term therapeutic response
    Masaru Enomoto
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    J Interferon Cytokine Res 22:389-95. 2002
    ..09 log10/day in nonresponders. We conclude that during the first 2 weeks of therapy, changes in serum HCV RNA levels as monitored by real-time quantitative PCR can be used to predict the long-term response to treatment with IFN-beta...
  20. ncbi request reprint p16 promoter hypermethylation in human hepatocellular carcinoma with or without hepatitis virus infection
    Takashi Narimatsu
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Intervirology 47:26-31. 2004
    ..Epigenetic alteration through methylation is one of the most important steps in carcinogenesis. However, the relation between hepatitis virus infection and epigenetic alterations is poorly understood...
  21. ncbi request reprint Accurate prediction of response to interferon therapy by repeated measurement of hepatitis C virus core protein in patients with chronic hepatitis C
    Shuhei Nishiguchi
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Intervirology 45:105-10. 2002
    ..0-4.5 months before and just before the start of IFN therapy, and were tested for HCV core protein by a fluorescent enzyme immunoassay...
  22. ncbi request reprint Previous or occult hepatitis B virus infection in hepatitis B surface antigen-negative and anti-hepatitis C-negative patients with hepatocellular carcinoma
    Kazuki Ohba
    Second Department of Surgery, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Surg Today 34:842-8. 2004
    ....
  23. ncbi request reprint Lamivudine and IFN-beta sequential therapy in HBe antigen-positive patients with chronic hepatitis B virus genotype C infection
    Masaru Enomoto
    Department of Hepatology, Osaka City University Medical School, Osaka 545 8585, Japan
    J Interferon Cytokine Res 27:201-7. 2007
    ..Patients who were young or who had a favorable virologic response to lamivudine were more likely to have a sustained response...
  24. doi request reprint Real-time tissue elastography as a tool for the noninvasive assessment of liver stiffness in patients with chronic hepatitis C
    Hiroyasu Morikawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    J Gastroenterol 46:350-8. 2011
    ....
  25. ncbi request reprint Effect of long-term postoperative interferon therapy on intrahepatic recurrence and survival rate after resection of hepatitis C virus-related hepatocellular carcinoma
    Shuhei Nishiguchi
    Department of Hepatology, Osaka City University Medical School, Osaka, Japan
    Intervirology 48:71-5. 2005
    ..This study was aimed at evaluating the effects of interferon (IFN)-alpha on survival rate after resection of hepatocellular carcinoma...
  26. doi request reprint Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver
    Hiroyuki Motoyama
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Lab Invest 94:192-207. 2014
    ..When activated, they also become α-SMA positive; however, they are negative for Thy-1 and FBLN2. Thus, CYGB is a useful marker with which to distinguish stellate cells from portal myofibroblasts in the damaged human liver. ..
  27. ncbi request reprint Hepatocellular carcinoma (HCC) recurring 10 years after clearance of hepatitis B surface antigen and 20 years after resection of hepatitis B virus-related HCC
    Hiroji Shinkawa
    Department of Hepato Biliary Pancreatic Surgery, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, 545 8585, Japan
    Int J Clin Oncol 13:562-6. 2008
    ..Cassette-ligation-mediated PCR showed that HBV DNA was integrated into the telomerase reverse transcriptase gene located on chromosome 5p15...
  28. doi request reprint Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are also useful in patients with non-alcoholic steatohepatitis
    Hideki Fujii
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 44:608-14. 2009
    ..We assessed whether noninvasive laboratory tests designed to predict the risk of cirrhosis in patients with chronic hepatitis C virus (HCV) infection could be used in patients with NASH...
  29. ncbi request reprint Comparison of the effect of BCAA granules on between decompensated and compensated cirrhosis
    Daiki Habu
    Department of Hepatology, Graduate School of Medicine, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Hepatogastroenterology 56:1719-23. 2009
    ....
  30. ncbi request reprint A complete response induced by 21-day sorafenib therapy in a patient with advanced hepatocellular carcinoma
    Atsushi Hagihara
    Department of Hepatology, Osaka City University Hospital, Japan
    Intern Med 52:1589-92. 2013
    ..There was no clinical evidence of recurrence without the administration of anticancer treatment. It is unique that short-term sorafenib treatment achieved a complete response. ..
  31. ncbi request reprint Portal hemodynamics in primary biliary cirrhosis as evaluated by per-rectal portal scintigraphy with Tc-99m pertechnetate
    Shuhei Nishiguchi
    Third Department of Internal Medicine, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Hepatogastroenterology 50:1535-8. 2003
    ..We did the procedures simultaneously in some patients to examine the relation between portal circulation and hepatic functional reserve in these diseases...
  32. ncbi request reprint Cimetidine reduces impairment of cellular immunity after transcatheter arterial embolization in patients with hepatocellular carcinoma
    Shuhei Nishiguchi
    Department of Hepatology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Hepatogastroenterology 50:460-2. 2003
    ..Therefore, we investigated whether cimetidine could improve cellular immunity after transcatheter arterial embolization, especially in relation to natural killer activity...
  33. ncbi request reprint Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver
    Daiki Habu
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    JAMA 292:358-61. 2004
    ..Previous findings indicate that vitamin K2 (menaquinone) may play a role in controlling cell growth...
  34. ncbi request reprint Polyamine metabolism and recurrence after resection for hepatocellular carcinoma
    Shoji Kubo
    Department of Gastroenterological and Hepato Biliary Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatogastroenterology 51:208-10. 2004
    ..We investigated the relationship between polyamine metabolism in hepatocellular carcinoma tissues and the recurrence after resection of hepatocellular carcinoma...
  35. ncbi request reprint Hepatitis B virus genotypes and response to antiviral therapy
    Masaru Enomoto
    Department of Hepatology, Osaka City University Medical School, Osaka, Japan
    Clin Lab 52:43-7. 2006
    ..Determining the genotype could be helpful for predicting the outcome of antiviral therapy in patients with chronic hepatitis B...
  36. doi request reprint Entecavir and interferon-α sequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B
    Masaru Enomoto
    Department of Hepatology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka, 545 8585, Japan
    J Gastroenterol 48:397-404. 2013
    ..However, the efficacy of sequential therapy with entecavir and interferon remains unclear...
  37. doi request reprint Benefits of artificially induced pleural effusion and/or ascites for percutaneous radiofrequency ablation of hepatocellular carcinoma located on the liver surface and in the hepatic dome
    Shuji Iwai
    Department of Hepatology, Osaka City University, Osaka, Japan
    Hepatogastroenterology 59:546-50. 2012
    ..However, the indication of this technique is unclear and its therapeutic efficacy is undetermined...
  38. ncbi request reprint Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver
    Susumu Shiomi
    Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Am J Gastroenterol 97:978-81. 2002
    ..The effects of therapy for osteoporosis associated with cirrhosis of the liver are still controversial. We evaluated the effects of vitamin K2 on osteopenia in women with cirrhosis...
  39. ncbi request reprint Does a late evening meal reduce the risk of hepatocellular carcinoma among patients with chronic hepatitis C?
    Satoko Ohfuji
    Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatol Res 38:860-8. 2008
    ..Further studies with larger study sizes are needed to corroborate these findings...
  40. ncbi request reprint Optimal duration of additional therapy after biochemical and virological responses to lamivudine in patients with HBeAg-negative chronic hepatitis B: a randomized trial
    Masaru Enomoto
    Department of Hepatology, Graduate School of Medicine, Osaka City University Medical School, Osaka, Japan
    Hepatol Res 38:954-9. 2008
    ....
  41. ncbi request reprint A randomized pilot trial of oral branched-chain amino acids in early cirrhosis: validation using prognostic markers for pre-liver transplant status
    Etsushi Kawamura
    Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Liver Transpl 15:790-7. 2009
    ..4% (7 of 23 patients) at 3 years, P = 0.043]; only ascites was significant individually. In conclusion, early interventional oral BCAAs might prolong the liver transplant waiting period by preserving hepatic reserve in cirrhosis...
  42. ncbi request reprint Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients
    Satoko Ohfuji
    Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan
    Liver Int 34:700-6. 2014
    ..The aim of this study was to examine the effectiveness of monovalent inactivated influenza A(H1N1)pdm09 vaccine and other characteristics associated with hospitalization in patients with chronic hepatitis C...
  43. ncbi request reprint [Tumor lysis syndrome after transarterial embolization for hepatocellular carcinoma]
    Yu Nishida
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Nihon Shokakibyo Gakkai Zasshi 110:441-8. 2013
    ..Generally it is rare in the treatment of solid tumors. In the case of TAE for huge HCC, we should keep the possibility of TLS in mind...
  44. doi request reprint Pretreatment prediction of anemia progression by pegylated interferon alpha-2b plus ribavirin combination therapy in chronic hepatitis C infection: decision-tree analysis
    Naoki Hiramatsu
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol 46:1111-9. 2011
    ..This study aimed to develop a model to predict the development of severe anemia during pegylated interferon alpha-2b plus ribavirin combination therapy...
  45. doi request reprint Relationship between inosine triphosphate genotype and outcome of extended therapy in hepatitis C virus patients with a late viral response to pegylated-interferon and ribavirin
    Hoang Hai
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol 29:201-7. 2014
    ..It is not yet clear which factors are associated with the outcome of 72-week treatment with pegylated-interferon and ribavirin (RBV) in patients with chronic hepatitis C virus (HCV) infection...
  46. ncbi request reprint Emerging antiviral drugs for hepatitis C virus
    Masaru Enomoto
    Department of Hepatology, Osaka City University Medical School, Osaka, Japan
    Rev Recent Clin Trials 4:179-84. 2009
    ..Herein we review recent progress in the development of new treatments under investigation in clinical trials, including specifically targeted antiviral therapy for HCV such as NS3/4A protease and NS5B polymerase inhibitors...
  47. ncbi request reprint Correlation between clinical characteristics and mitochondrial D-loop DNA mutations in hepatocellular carcinoma
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, 545 8585, Osaka, Japan
    J Gastroenterol 39:1063-8. 2004
    ..Mitochondrial DNA (mtDNA) mutations are found in many kinds of human cancer. The aim of this study was to evaluate the relationship between mtDNA mutations in the liver and human hepatocarcinogenesis...
  48. ncbi request reprint [Epidemiology of HBV related hepatocellular carcinoma in Japan]
    Shuhei Nishiguchi
    Department of Hepatology, Osaka City University Graduate School of Medicine
    Nihon Rinsho 62:377-80. 2004
  49. doi request reprint Close correlation of liver stiffness with collagen deposition and presence of myofibroblasts in non-alcoholic fatty liver disease
    Mami Mori
    Department of Hepatology, Graduate School of Medicine, Osaka City University Central Clinical Laboratory, Osaka City University Medical School Hospital, Osaka, Japan
    Hepatol Res 41:897-903. 2011
    ..390, P = 0.0184) and α-smooth muscle actin-positive area (r = 0.333, P = 0.0471). Conclusions:  Liver stiffness measurement by transient elastography is valuable for evaluating fibrotic progression in NAFLD...
  50. ncbi request reprint GB virus C and TT virus infections in Japanese patients with autoimmune hepatitis
    Shuhei Nishiguchi
    Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    J Med Virol 66:258-62. 2002
    ..These findings provide no compelling evidence that GBV-C or TTV has a pathogenic role in autoimmune hepatitis...
  51. doi request reprint Combination therapy with a nucleos(t)ide analogue and interferon for chronic hepatitis B: simultaneous or sequential
    Masaru Enomoto
    Department of Hepatology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka, 545 8585, Japan
    J Gastroenterol 48:999-1005. 2013
    ..The efficacy of IFN in combination with a more potent NA, such as entecavir or tenofovir, remains to be comprehensively evaluated. ..
  52. pmc Effect of caffeine-containing beverage consumption on serum alanine aminotransferase levels in patients with chronic hepatitis C virus infection: a hospital-based cohort study
    Yachiyo Sasaki
    Department of Gerontological Nursing, Graduate School of Nursing, Osaka City University, Osaka, Japan Department of Public Health, Graduate School of Medicine, Osaka City University, Osaka, Japan
    PLoS ONE 8:e83382. 2013
    ..We conducted a hospital-based cohort study among patients with chronic HCV infection to assess an association between baseline coffee consumption and subsequent ALT levels for 12 months...
  53. ncbi request reprint [Interferon]
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine
    Nihon Rinsho 70:620-4. 2012
    ..Maintenance therapy with low dose of PEG-IFN or IFN can improve the prognosis of patients with advanced hepatic fibrosis...
  54. doi request reprint Response-guided therapy for patients with chronic hepatitis who have high viral loads of hepatitis C virus genotype 2
    Yasunori Yamaguchi
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatol Res 42:549-57. 2012
    ..Conclusions:  16 weeks of combination therapy could achieve an adequate antiviral effect for RVR patients. Extending therapy could not significantly improve SVR rate in non-RVR patients...
  55. pmc A case of primary small cell carcinoma of the liver that was treated with chemotherapy
    Hiroyasu Morikawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka, 545 8585, Japan
    Hepatol Int 2:500-4. 2008
    ..We discuss the clinical course and therapy of extra-pulmonary SCC and review the literature of the cases previously reported...
  56. ncbi request reprint Portal vein thrombosis following percutaneous ethanol injection therapy for hepatocellular carcinoma
    Daiki Habu
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Indian J Gastroenterol 21:162-3. 2002
    ..She developed portal vein thrombosis that on color Doppler revealed no tumor vascular signal, and so was diagnosed as non-tumor thrombus. The thrombus resolved over 3 months...
  57. ncbi request reprint Effects of lamivudine on outcome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus
    Shoji Kubo
    Departments of Hepato Biliary Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatol Res 37:94-100. 2007
    ....
  58. ncbi request reprint Usefulness of transient elastography for assessment of liver fibrosis in chronic hepatitis B: Regression of liver stiffness during entecavir therapy
    Masaru Enomoto
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatol Res 40:853-61. 2010
    ..7) to 3.9 (3.2-4.4) ng/mL (P = 0.015), respectively. Conclusion:  Liver stiffness measurement can be useful for monitoring regression of liver fibrosis during entecavir treatment in patients with chronic hepatitis B virus infection...
  59. ncbi request reprint Ultrasonographic diagnosis of degree of chronic type C liver disease
    Daiki Habu
    Department of Hepatology, Graduate School of Medicine, Osaka City University Medical School, Japan
    Hepatogastroenterology 52:1820-4. 2005
    ..We propose a method, named US score, for semi-quantitative determination of the stage of chronic type C liver disease by ultrasonography...
  60. doi request reprint Changes in sequences of core region, interferon sensitivity-determining region and interferon and ribavirin resistance-determining region of hepatitis C virus genotype 1 during interferon-alpha and ribavirin therapy, and efficacy of retreatment
    Ritsuzo Kozuka
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka Center for the Advancement of Higher Education, Faculty of Engineering, Kinki University, Hiroshima, Japan
    Hepatol Res 42:1157-67. 2012
    ..Conclusion:  Sequences of the core region and ISDR sometimes change during anti-HCV therapy, potentially affecting the outcomes of retreatment...
  61. ncbi request reprint [Drug-induced liver injury caused by an herbal medicine, bofu-tsu-sho-san]
    Hiroyuki Motoyama
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan
    Nihon Shokakibyo Gakkai Zasshi 105:1234-9. 2008
    ..The liver biopsy specimen revealed features of acute hepatitis. Physicians should be aware that bofu-tsu-sho-san can cause liver injury, as this drug is commonly used as an over-the-counter medicine...
  62. doi request reprint Favorable factors for re-treatment with pegylated interferon α2a plus ribavirin in patients with high viral loads of genotype 1 hepatitis C virus
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine Department of Hepatology Osaka City General Hospital Department of Gastroenterology and Hepatology, Osaka City Juso Hospital, Osaka Internal Medicine, Izumi Municipal Hospital, Izumi Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatol Res 41:1169-77. 2011
    ..Re-treatment is a particularly useful option for patients who achieve early viral clearance during previous therapy...
  63. pmc Two cases of hepatocellular adenomatosis treated with transcatheter arterial embolization
    Sawako Kobayashi
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka, 545 8585, Japan
    Hepatol Int 3:416-20. 2009
    ..After TAE, most parts of the adenomas showed necrotic change. These cases suggest that TAE is an effective treatment of hepatocellular adenomatosis...
  64. pmc Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant: Report of a case
    Hirotoshi Okazaki
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3, Asahimachi, Abeno Ku, Osaka, Japan
    World J Gastroenterol 12:5408-11. 2006
    ..After the patient received this therapy, her condition of rectal varices was markedly improved...
  65. doi request reprint High prevalence of hepatitis C virus infection in Airin district, Osaka, Japan: A hospital-based study of 1162 patients
    Yasunori Yamaguchi
    Departments of Hepatology Gastroenterology, Graduate School of Medicine, Osaka City University Department of Internal Medicine, Osaka Socio Medical Center Hospital Izumi Municipal Hospital, Izumi, Osaka, Japan
    Hepatol Res 41:731-7. 2011
    ..Patient education and strict action against illegal drug use are indispensable to prevent the spread of HCV infection from the district...
  66. ncbi request reprint [Prevalence and clinical course in HBV and HCV dual chronic infection]
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine
    Nihon Rinsho 62:667-70. 2004
  67. ncbi request reprint A case of sclerosing cholangitis with autoimmune pancreatitis evaluated by FDG-PET
    Etsushi Kawamura
    Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Ann Nucl Med 21:223-8. 2007
    ....
  68. ncbi request reprint Erythrocyte-binding polyamine as a tumor growth marker for human hepatocellular carcinoma
    Shuhei Nishiguchi
    Third Department of Internal Medicine, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Hepatogastroenterology 49:504-7. 2002
    ..Concentrations of polyamines are higher in some cancer tissue than in normal tissue. We examined erythrocyte-binding polyamines to evaluate the usefulness of polyamines as pathophysiological markers for hepatocellular carcinoma...
  69. ncbi request reprint Randomized trial assessing gastric emptying in patients with chronic hepatitis C during interferon-alpha or -beta therapy and effect of cisapride
    Shuhei Nishiguchi
    Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Dig Dis Sci 47:73-8. 2002
    ..Interferon-alpha is associated with a greater delay in gastric emptying and a higher symptom score than is interferon-beta. Administration of cisapride corrects the delayed gastric emptying and relieves associated digestive symptoms...
  70. ncbi request reprint Potential role of vitamin K(2) as a chemopreventive agent against hepatocellular carcinoma
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatol Res 37:S303-7. 2007
    ..This article reviews the potential role of vitamin K(2) as a chemopreventive agent against HCC and discusses future directions for clinical trials...
  71. doi request reprint Immunogenicity of influenza A(H1N1)pdm09 vaccine and the associated factors on lowered immune response in patients with hepatitis C
    Satoko Ohfuji
    Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan
    Influenza Other Respir Viruses 7:456-65. 2013
    ..Patients with underlying disease represent a high-risk group for influenza-associated complications and hospitalization. However, few studies investigated the immunogenicity of influenza vaccine in patients with liver disease...
  72. ncbi request reprint Esophagogastric varices due to arterioportal shunt in a serous cystadenoma of the pancreas in von Hippel-Lindau disease
    Masatsugu Okuyama
    Department of Gastroenterology, Osaka City University Medical School, Osaka, Japan
    Dig Dis Sci 48:1948-54. 2003
    ..Rupture of esophageal varices was successfully treated with endoscopic injection sclerotherapy...
  73. pmc Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients
    Yoshiyuki Takahara
    Exploratory and Applied Pharmaceutical Research Department, Pharmaceutical Company, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    World J Gastroenterol 14:2010-22. 2008
    ....
  74. ncbi request reprint Changes in serum levels of hepatitis C virus genotype 1b monitored by real-time quantitative polymerase chain reaction as a predictor of long term response to interferon-alpha treatment
    Masaru Enomoto
    Third Department of Internal Medicine and Second Department of Biochemistry, Osaka City University Medical School, Japan
    Am J Gastroenterol 97:420-6. 2002
    ..The aim of this study was to find whether there is a relationship between the changes in the amounts of hepatitis C virus (HCV) at the start of interferon treatment and the long term response to therapy...
  75. ncbi request reprint Disease associations and altered immune function in CD45 138G variant carriers
    Sally Boxall
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Hum Mol Genet 13:2377-84. 2004
    ..These data suggest that the 138G variant allele strongly influences these diseases by modulation of immune mechanisms and may have achieved its high frequency as a result of a natural selection probably related to pathogen resistance...
  76. ncbi request reprint [Present status of community-based HCV screening in Osaka City and evaluation of the utility of follow-up programs on hepatitis]
    Kenji Matsumoto
    Asahi Ward Health and Welfare Center, Osaka City
    Nihon Koshu Eisei Zasshi 55:75-82. 2008
    ..The present status of community-based HCV screening in Osaka City and the utility of follow-up programs on hepatitis were examined...
  77. ncbi request reprint Geographical distribution and disease associations of the CD45 exon 6 138G variant
    Victoria Ward
    Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Cancer Research UK, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Immunogenetics 58:235-9. 2006
    ..The allele is widely distributed in the Far East and India, indicating that it may have a significant effect on disease burden in a large part of the human population...