Research Topics
Genomes and Genes | Shigeo TakenakaSummaryAffiliation: Osaka Prefecture University Country: Japan Publications
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Detail Information
Publications
Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 statusS Takenaka
Laboratory of Nutrition and Food Science, Hagoromo gakuen College, Sakai 592 8344, Japan
Br J Nutr 85:699-703. 2001..These results indicate that vitamin B12 in dried purple laver is bioavailable to rats...- Occurrence of coenzyme forms of vitamin B12 in a cultured purple laver (Porphyla yezoensis)Shigeo Takenaka
Department of Veterinary Sciences, Osaka Prefecture University, Sakai, Japan
Biosci Biotechnol Biochem 67:2480-2. 2003..Coenzyme forms of vitamin B(12) (about 60% of the total vitamin B(12)) were found in the cultured purple laver aseptically, which may have the ability to biosynthesize the coenzymes... 
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivativesTsutomu Shimada
Laboratory of Cellular and Molecular Biology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 58 Rinku Orai Kita, Izumisano, Osaka 598 8531, Japan
Chem Res Toxicol 23:1921-35. 2010....- Expression patterns of the BRCA1 splicing variants in canine normal tissues and mammary gland tumorsTakaaki Sugiura
Laboratory of Veterinary Radiology, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
J Vet Med Sci 69:587-92. 2007..Especially, the relative amounts of the exon11-defecting products were remarkably decreased in most of the tumors (11/16)... - Expression patterns of the slit subfamily mRNA in canine malignant mammary tumorsToshihiko Tanno
Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan
J Vet Med Sci 68:1173-7. 2006..These results suggest that the expression of slit2 plays an important role in tumor angiogenesis in canine mammary gland tumors and that slit2 can be a putative marker for malignancy diagnosis of these tumors... 
Urinary metabolic fingerprinting for alpha-naphthylisothiocyanate-induced intrahepatic cholestasis in rats using Fourier transform-ion cyclotron resonance mass spectrometryMina Hasegawa
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
Toxicol Pathol 36:818-26. 2008..In conclusion, it is possible to monitor the progression of and recovery from drug-induced hepatotoxicity by urinary metabolic fingerprinting with FT-ICR MS and to search for potential biomarkers involved in intrahepatic cholestasis...- Participation of functionally different macrophage populations and monocyte chemoattractant protein-1 in early stages of thioacetamide-induced rat hepatic injuryYoko Mori
Laboratories of Veterinary Pathology and Molecular Science, Life and Environmental Sciences, Osaka Prefecture University, Nakaku, Sakai, Osaka, Japan
Toxicol Pathol 37:463-73. 2009..Collectively, macrophages in acute hepatic necrosis may express different properties such as phagocytosis, MHC class II expression, and TGF-beta1 production; such expression may be influenced by MCP-1 produced by HSCs... - Molecular characterization of a bifunctional glyoxylate cycle enzyme, malate synthase/isocitrate lyase, in Euglena gracilisMasami Nakazawa
Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
Comp Biochem Physiol B Biochem Mol Biol 141:445-52. 2005..We discussed the physiological roles of the bifunctional glyoxylate cycle enzyme in these organisms as well as its molecular evolution... - Alternations of phospholipid profile in placenta of streptozotocin-induced diabetic ratMina Hasegawa
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan
Congenit Anom (Kyoto) 51:174-6. 2011..We suggest that these changes in phospholipids in the diabetic placenta might be involved in development of fetal malformation in a type 1 diabetic pregnancy... - Slit3 regulates cell motility through Rac/Cdc42 activation in lipopolysaccharide-stimulated macrophagesToshihiko Tanno
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
FEBS Lett 581:1022-6. 2007..These results suggest that slit3 functions as an intracellular signaling molecule for cell motility as part of the LPS-induced signaling cascade... - Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compoundsTsutomu Shimada
Laboratory of Cellular and Molecular Biology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 58 Rinku Orai Kita, Izumisano, Osaka 598 8531, Japan
Chem Res Toxicol 24:1327-37. 2011.... - Urinary metabolic fingerprinting for thioacetamide-induced rat acute hepatic injury using fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS), with reference to detection of potential biomarkers for hepatotoxicityMina Hasegawa
Department of Veterinary Science, Graduate School of Life and Environmenal Science, Osaka Prefecture University, Sakai, Osaka, Japan
Toxicol Pathol 35:570-5. 2007..dCty might be a biomarker for the acute hepatotoxicity in rats... - Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MSMina Hasegawa
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
Exp Toxicol Pathol 59:115-20. 2007..These results indicate that PAG, IDN and HA are biomarkers for AMD-induced PLD in urinary metabolic fingerprinting using FT-ICR MS. These markers may be useful for evaluation of chemicals, which have the potential to induce PLD... - Expression of a chemorepellent factor, Slit2, in peripheral nerve regenerationToshihiko Tanno
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan
Biosci Biotechnol Biochem 69:2431-4. 2005..These results suggest that disruption of the continuity of basal lamina tubes induces the expression of slit2 in Schwann cells during peripheral nerve regeneration... - Cellular responses in the spinal cord during development of hypomyelination in the mv ratTakeshi Izawa
Department of Veterinary Sciences, Osaka Prefecture University, Gakuencho 1 1, Nakaku, Sakai, Osaka 599 8531, Japan
Brain Res 1195:120-9. 2008..The data suggest that attractin may be directly involved in the function of oligodendrocytes in CNS myelination... - Metabolic fingerprinting of amniotic fluid from the streptozotocin-induced diabetic pregnant rat using Fourier transform-ion cyclotron resonance mass spectrometryMina Hasegawa
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
Congenit Anom (Kyoto) 48:137-9. 2008..The alteration of biochemical composition in the diabetic amniotic fluid suggests the presence of potential biomarkers to indicate progression of malformation under the diabetic pregnancy... - Rat hair follicle-constituting cells labeled by a newly-developed somatic stem cell-recognizing antibody: a possible marker of hair follicle developmentChisa Ichikawa
Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano shi, Osaka, Japan
Histol Histopathol 28:257-68. 2013..A3 would become a useful antibody to know the kinetics of rat hair follicle-constituting cells... - Detection of chromogranin A in the adrenal gland extracts of different animal species by an enzyme-linked immunosorbent assay using Thomsen-Friedenreich antigen-specific Amaranthus caudatus lectinHideo Akiyoshi
Laboratory of Veterinary Surgery, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan
Vet Immunol Immunopathol 144:255-8. 2011..Thus, ACA is concluded to be a valuable reagent for CgA detection in crude extracts from different animal species, and for CgA isolation/purification... - Expression and function of Slit1alpha, a novel alternative splicing product for slit1Toshihiko Tanno
Department of Veterinary Science, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
J Biochem 136:575-81. 2004..These findings suggest that Slit1alpha is an active Slit1 protein specific in the vertebrate nervous system... - Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship studyTsutomu Shimada
Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1 58 Rinku Orai Kita, Izumisano, Osaka 598 8531, USA
Chem Res Toxicol 22:1325-33. 2009..Substitutions on the compounds with various acetylenic groups and propargyl ethers cause an increase or decrease of their affinities to P450 1B1, depending on the parent compound used... - Hypoxia-induced megaloblastosis in vitamin B12-deficient ratsShuhei Ebara
Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka, Japan
Br J Nutr 89:441-4. 2003..These results indicate that a megaloblastic anaemia-like symptom is induced when the vitamin B12-deficient rats are exposed to hypoxia... - Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1beta in hypoxiaKaori Nagao
Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599-8531
J Biochem (Tokyo) 133:501-5. 2003..In addition, the IL-1beta-induced synthesis of tetrahydrobiopterin, a cofactor for iNOS, was also greatly stimulated by hypoxia in VSMC... - Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cellsJyoji Yamate
Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, Gakuencho 1 1, Sakai, Osaka 599 8531, Japan
Eur J Cancer 43:2747-56. 2007..c-kit mRNA expression was seen in bone marrows and MT-9. Collectively, progenitors of MFH should be sought in lineage of marrow stem cells capable of differentiating into mesenchymal cells... - Amelioration of the progression of an atopic dermatitis-like skin lesion by silk peptide and identification of functional peptidesYasuhira Ikegawa
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka, Japan
Biosci Biotechnol Biochem 76:473-7. 2012..Our findings indicate that silk peptide exerts an effect on atopic dermatitis by modulating the Th1/Th2 balance... - Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes)Madoka Inui
Department of Applied Biological Chemistry, Osaka Prefecture University, Osaka 599-8531, Japan
Toxicology 194:43-50. 2003..In this study, we showed that 4-MBC, OMC, and PP have estrogenic activity in fish... - Identification and molecular characterization of mitochondrial ferredoxins and ferredoxin reductase from ArabidopsisKeiko Takubo
Graduate School of Agriculture and Biosciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai 599-8531, Japan
Plant Mol Biol 52:817-30. 2003..Possible physiological roles of these mitochondrial electron transfer components are discussed in relation to redox dependent metabolic pathways in plants... - Production and characterization of a novel monoclonal antibody against Vibrio parahaemolyticus F0F1 ATP synthase's delta subunit and its application for rapid identification of the pathogenJunko Sakata
Division of Bacteriology, Osaka Prefectural Institute of Public Health, 1 3 69, Nakamichi, Higashinari ku, Osaka 537 0025, Japan
J Microbiol Methods 88:77-82. 2012..parahaemolyticus colonies as compared with the conventional biochemical test... - Mutation at the Lmx1a locus provokes aberrant brain development in the ratMitsuru Kuwamura
Laboratory of Veterinary Pathology, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
Brain Res Dev Brain Res 155:99-106. 2005..These findings suggest that the qc mutation is involved in development of the ventricular system and dorsal migration of neurons... - Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activityTsutomu Shimada
Laboratory of Cellular and Molecular Biology, Department of Veterinary Science, Osaka Prefecture University, 1 1 Gakuen cho, Naka ku, Sakai, Osaka 599 8531, Japan
Chem Res Toxicol 21:2313-23. 2008.... - Determination of unique amino acid substitutions in protein variants by peptide mass mapping with FT-ICR MSKatsuhiro Tanaka
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan
J Am Soc Mass Spectrom 17:508-13. 2006..Therefore, FTICR MS is capable of identifying all 53 types of substitutions, each of which is associated with a unique mass difference, except for the Leu and Ile isomers... - Pyruvate:NADP+ oxidoreductase is stabilized by its cofactor, thiamin pyrophosphate, in mitochondria of Euglena gracilisMasami Nakazawa
Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan
Arch Biochem Biophys 411:183-8. 2003..These findings suggest that PNO is readily degraded when TPP is not provided in mitochondria, and consequently the PNO protein level is greatly reduced by thiamin deficiency in E. gracilis... - Characterization and bioavailability of vitamin B12-compounds from edible algaeFumio Watanabe
Department of Health Science, Kochi Women s University, Kochi 780 8515, Japan
J Nutr Sci Vitaminol (Tokyo) 48:325-31. 2002..Pseudovitamin B12 (an inactive corrinoid) predominated in the spirulina tablets, which are not suitable for use as a vitamin B12 source, especially for vegetarians. algal health food, bioavailability, cobalamin, edible algae, vitamin B12..