Yoshitsugu Takabatake

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine B6, Suita, Japan
    J Am Soc Nephrol 20:1714-23. 2009
  2. pmc A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology B6, Osaka University Graduate School of Medicine, Suita, Japan
    Mol Med 17:686-96. 2011
  3. doi request reprint Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy
    Hiroki Omori
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 16:549-56. 2012
  4. doi request reprint Autophagy guards against cisplatin-induced acute kidney injury
    Atsushi Takahashi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Pathol 180:517-25. 2012
  5. doi request reprint Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3
    Kazunori Inoue
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Japan
    Lab Invest 92:1686-97. 2012
  6. doi request reprint Negative effects of anemia on quality of life and its improvement by complete correction of anemia by administration of recombinant human erythropoietin in posttransplant patients
    Noritaka Kawada
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Exp Nephrol 13:355-60. 2009
  7. doi request reprint Renal artery injection for delivery of biological materials to the glomerulus
    Yoshitsugu Takabatake
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephrology (Carlton) 13:23-6. 2008
  8. doi request reprint Urinary type IV collagen in nondiabetic kidney disease
    Yoshiyuki Furumatsu
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephron Clin Pract 117:c160-6. 2011
  9. ncbi request reprint Targeting of interstitial cells using a simple gene-transfer strategy
    Naohiko Fujii
    Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Nephrol Dial Transplant 21:2745-53. 2006
  10. doi request reprint Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats
    Isao Matsui
    1Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephrol Dial Transplant 24:2354-61. 2009

Collaborators

Detail Information

Publications25

  1. pmc The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine B6, Suita, Japan
    J Am Soc Nephrol 20:1714-23. 2009
    ..We conclude that CXCL12 secreted from stromal cells or podocytes acts on endothelial cells to regulate vascular development in the kidney. These findings suggest new potential therapeutic targets for remodeling the injured kidney...
  2. pmc A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology B6, Osaka University Graduate School of Medicine, Suita, Japan
    Mol Med 17:686-96. 2011
    ..In conclusion, we demonstrated that treatment with JJ316 has a dramatic therapeutic effect on an experimental crescentic glomerulonephritis, possibly due to expansion and activation of Treg cells...
  3. doi request reprint Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy
    Hiroki Omori
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 16:549-56. 2012
    ..While some reports suggest a relationship between hyperuricemia and chronic kidney disease (CKD), the renoprotective mechanism of an XO inhibitor in CKD remains unknown. Recent reports have focused on XO as a source of oxidative stress...
  4. doi request reprint Autophagy guards against cisplatin-induced acute kidney injury
    Atsushi Takahashi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Pathol 180:517-25. 2012
    ..Enhancing autophagy may provide a novel therapeutic option to minimize AKI...
  5. doi request reprint Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3
    Kazunori Inoue
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Japan
    Lab Invest 92:1686-97. 2012
    ..This recruitment promoted the dephosphorylation of pSmad3 and attenuated the pSmad3-dependent production of TGF-β1. Our findings provide a novel approach to inhibit the TGF-β pathway in fibrotic diseases...
  6. doi request reprint Negative effects of anemia on quality of life and its improvement by complete correction of anemia by administration of recombinant human erythropoietin in posttransplant patients
    Noritaka Kawada
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Exp Nephrol 13:355-60. 2009
    ..We tested the hypothesis that targeting hemoglobin (Hb) over 13.3 g/dl by administration of recombinant human erythropoietin (rHuEPO-ad) has positive impact on quality of life (QOL)...
  7. doi request reprint Renal artery injection for delivery of biological materials to the glomerulus
    Yoshitsugu Takabatake
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephrology (Carlton) 13:23-6. 2008
    ..We investigated whether injection of synthetic small interfering siRNAs via renal artery followed by electroporation could be effective in silencing specific genes in glomerulus...
  8. doi request reprint Urinary type IV collagen in nondiabetic kidney disease
    Yoshiyuki Furumatsu
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephron Clin Pract 117:c160-6. 2011
    ..However, in nondiabetic kidney disease, urinary type IV collagen (u-IVc) levels have not been extensively investigated. The aim of this study was to evaluate u-IVc levels in various nephropathies except diabetic nephropathy...
  9. ncbi request reprint Targeting of interstitial cells using a simple gene-transfer strategy
    Naohiko Fujii
    Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Nephrol Dial Transplant 21:2745-53. 2006
    ..We examined the efficiency of a new gene transfer method that targets interstitial cells by using parenchymal injection of DNA followed by electroporation...
  10. doi request reprint Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats
    Isao Matsui
    1Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephrol Dial Transplant 24:2354-61. 2009
    ....
  11. doi request reprint CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats
    Kenro Miyasato
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 15:50-7. 2011
    ..Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of Treg in rats...
  12. doi request reprint Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats
    Isao Matsui
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Physiol Renal Physiol 304:F751-60. 2013
    ..Our findings suggest that tubular luminal fetuin-A works as a natural inhibitor against calcification in the proximal tubules under PTH-loaded condition...
  13. doi request reprint Towards developing new strategies to reduce the adverse side-effects of nonsteroidal anti-inflammatory drugs
    Noritaka Kawada
    Department of Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 16:25-9. 2012
    ....
  14. doi request reprint Fully phosphorylated fetuin-A forms a mineral complex in the serum of rats with adenine-induced renal failure
    Isao Matsui
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 75:915-28. 2009
    ..Our results suggest that the measurement of serum fetuin-mineral complex rather than fetuin-A alone might provide a better indication of extra-osseous calcification propensity...
  15. ncbi request reprint Electroporation-mediated HGF gene transfer ameliorated cyclosporine nephrotoxicity
    Masayuki Mizui
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Kidney Int 65:2041-53. 2004
    ..Here, we investigated protective effects of HGF gene therapy on rat CsA-induced nephrotoxicity using electroporation-mediated gene transfer...
  16. pmc Autophagy protects the proximal tubule from degeneration and acute ischemic injury
    Tomonori Kimura
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Am Soc Nephrol 22:902-13. 2011
    ..These data suggest that autophagy maintains proximal tubule cell homeostasis and protects against ischemic injury. Enhancing autophagy may provide a novel therapeutic approach to minimize acute kidney injury and slow CKD progression...
  17. ncbi request reprint Bcl-2 protects tubular epithelial cells from ischemia reperfusion injury by inhibiting apoptosis
    Chigure Suzuki
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cell Transplant 17:223-9. 2008
    ..In conclusion, Bcl-2 augmentation protected renal tubular epithelial cells from I/R, and subsequent interstitial injury by inhibiting tubular apoptosis...
  18. doi request reprint In vivo transfer of small interfering RNA or small hairpin RNA targeting glomeruli
    Yoshitsugu Takabatake
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Methods Mol Biol 466:251-63. 2009
    ..In addition, we describe the application of vector-based RNA interference (RNAi) (small hairpin RNA [shRNA]), which also inhibits TGF-beta1 expression in vivo...
  19. ncbi request reprint DNAzyme for TGF-beta suppressed extracellular matrix accumulation in experimental glomerulonephritis
    Yoshitaka Isaka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 66:586-90. 2004
    ..Recently, a new generation of catalytic nucleic acid composed of DNA, named DNA enzyme (DNAzyme), has been developed...
  20. doi request reprint Participation of autophagy in renal ischemia/reperfusion injury
    Chigure Suzuki
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 368:100-6. 2008
    ..Furthermore, inhibition of autophagy significantly inhibited H(2)O(2)-induced cell death. In conclusion, high turnover of autophagy may lead to autophagic cell death during I/R injury...
  21. doi request reprint Nonerythropoietic derivative of erythropoietin protects against tubulointerstitial injury in a unilateral ureteral obstruction model
    Harumi Kitamura
    Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871 Japan
    Nephrol Dial Transplant 23:1521-8. 2008
    ..Accordingly, we hypothesized that treatment with CEPO, which would not increase Hb concentrations, would protect against tubular damage and thereby inhibit tubulointerstitial injuries...
  22. doi request reprint Chloroquine in cancer therapy: a double-edged sword of autophagy
    Tomonori Kimura
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer Res 73:3-7. 2013
    ..Here, we summarize the functions of autophagy in cancer and kidney injury, especially focusing on the use of chloroquine to treat cancer, and address the possible side effects in the combined use of chloroquine and anticancer drugs...
  23. ncbi request reprint The protective role of autophagy against aging and acute ischemic injury in kidney proximal tubular cells
    Yoshitaka Isaka
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Autophagy 7:1085-7. 2011
    ..We demonstrated the critical role of autophagy in normal proximal tubule function and protection against acute tubular injury...
  24. doi request reprint Specialist care and improved long-term survival of dialysis patients
    Yoshiyuki Furumatsu
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephrol Dial Transplant 25:1930-5. 2010
    ..We sought to determine whether specialist care can actually be associated with better survival rates in a nationwide Japanese dialysis cohort...
  25. ncbi request reprint Gene therapy in renal diseases
    Enyu Imai
    Division of Nephrology, Department of Internal Medicine, Osaka University Graduate School of Medicine, Japan
    Kidney Int 65:1551-5. 2004
    ..The importation of the novel technology, for example hybrid stem cell-gene therapy could promote the gene therapy of renal diseases toward clinical application...