Y Suzuki

Summary

Affiliation: Osaka Medical Center for Cancer and Cardiovascular Diseases
Country: Japan

Publications

  1. ncbi Detection of kanamycin-resistant Mycobacterium tuberculosis by identifying mutations in the 16S rRNA gene
    Y Suzuki
    Department of Pathology, Osaka Prefectural Institute of Public Health, Japan
    J Clin Microbiol 36:1220-5. 1998
  2. ncbi Rapid detection of pyrazinamide-resistant Mycobacterium tuberculosis by a PCR-based in vitro system
    Yasuhiko Suzuki
    Department of Pathology, Osaka Prefectural Institute of Public Health, Higashinari ku, Osaka 537 0025, Japan
    J Clin Microbiol 40:501-7. 2002
  3. ncbi Expression of recombinant Norwalk-like virus capsid proteins using a bacterial system and the development of its immunologic detection
    T Yoda
    Division of Food Microbiology, Osaka Prefectural Institute of Public Health, Osaka, Japan
    J Med Virol 60:475-81. 2000
  4. ncbi Escherichia coli heat-labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine
    S Tamura
    Department of Pathology, National Institute of Health, Tokyo, Japan
    Vaccine 12:1083-9. 1994
  5. ncbi Characterization of monoclonal antibodies generated against Norwalk virus GII capsid protein expressed in Escherichia coli
    T Yoda
    Division of Food Microbiology, Osaka Prefectural Institute of Public Health, Japan
    Microbiol Immunol 44:905-14. 2000
  6. ncbi Molecular cloning of a novel human collectin from liver (CL-L1)
    K Ohtani
    Department of Pathology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565, Japan
    J Biol Chem 274:13681-9. 1999
  7. ncbi Characterization of the rpsL and rrs genes of streptomycin-resistant clinical isolates of Mycobacterium tuberculosis in Japan
    C Katsukawa
    Laboratory of Microbiology, Osaka Prefectural Institute of Public Health, Japan
    J Appl Microbiol 83:634-40. 1997
  8. ncbi Antibody-forming cells in the nasal-associated lymphoid tissue during primary influenza virus infection
    S Tamura
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Gen Virol 79:291-9. 1998
  9. ncbi Antibody-independent classical complement pathway activation and homologous C3 deposition in xeroderma pigmentosum cell lines
    M Kurita
    Department of Immunology, Osaka Medical Centre for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537, Japan
    Clin Exp Immunol 116:547-53. 1999
  10. ncbi Cloning and characterization of a cDNA encoding bovine mannan-binding protein
    T Kawai
    Department of Food Microbiology, Osaka Prefectural Institute of Public Health, Japan
    Gene 186:161-5. 1997

Collaborators

Detail Information

Publications82

  1. ncbi Detection of kanamycin-resistant Mycobacterium tuberculosis by identifying mutations in the 16S rRNA gene
    Y Suzuki
    Department of Pathology, Osaka Prefectural Institute of Public Health, Japan
    J Clin Microbiol 36:1220-5. 1998
    ..Furthermore, we found that the genotypes of kanamycin-resistant strains can be discriminated from each other by digestion with a restriction endonuclease, BstUI or DdeI...
  2. ncbi Rapid detection of pyrazinamide-resistant Mycobacterium tuberculosis by a PCR-based in vitro system
    Yasuhiko Suzuki
    Department of Pathology, Osaka Prefectural Institute of Public Health, Higashinari ku, Osaka 537 0025, Japan
    J Clin Microbiol 40:501-7. 2002
    ..This fact suggested the possibility of the usefulness of this system for the rapid detection of PZA-resistant M. tuberculosis...
  3. ncbi Expression of recombinant Norwalk-like virus capsid proteins using a bacterial system and the development of its immunologic detection
    T Yoda
    Division of Food Microbiology, Osaka Prefectural Institute of Public Health, Osaka, Japan
    J Med Virol 60:475-81. 2000
    ..Our results strongly suggest that the immunologic detection of NLV antigens using anti-rV R-IgG is possible and seems a significant step toward simplification of an NLV detection test...
  4. ncbi Escherichia coli heat-labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine
    S Tamura
    Department of Pathology, National Institute of Health, Tokyo, Japan
    Vaccine 12:1083-9. 1994
    ..These results suggest that LTB containing a trace amount of LT can be used as a potent adjuvant for nasal vaccination of humans against influenza...
  5. ncbi Characterization of monoclonal antibodies generated against Norwalk virus GII capsid protein expressed in Escherichia coli
    T Yoda
    Division of Food Microbiology, Osaka Prefectural Institute of Public Health, Japan
    Microbiol Immunol 44:905-14. 2000
    ..It was also found that genogroup I recombinant NV96-908 (genogroup I, KY89 type) could be detected as sensitively as recombinant NV36 (genogroup II) by ELISA with a set of the MAbs produced here...
  6. ncbi Molecular cloning of a novel human collectin from liver (CL-L1)
    K Ohtani
    Department of Pathology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565, Japan
    J Biol Chem 274:13681-9. 1999
    ..These findings indicate that CL-L1 may be involved in different biological functions...
  7. ncbi Characterization of the rpsL and rrs genes of streptomycin-resistant clinical isolates of Mycobacterium tuberculosis in Japan
    C Katsukawa
    Laboratory of Microbiology, Osaka Prefectural Institute of Public Health, Japan
    J Appl Microbiol 83:634-40. 1997
    ..8%, whereas none of the streptomycin-sensitive isolates had mutations in either the rpsL or rrs gene...
  8. ncbi Antibody-forming cells in the nasal-associated lymphoid tissue during primary influenza virus infection
    S Tamura
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Gen Virol 79:291-9. 1998
    ..These results suggest that virus-specific IgA antibodies, produced by IgA AFCs in NALT, play an important role in recovery from infection...
  9. ncbi Antibody-independent classical complement pathway activation and homologous C3 deposition in xeroderma pigmentosum cell lines
    M Kurita
    Department of Immunology, Osaka Medical Centre for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537, Japan
    Clin Exp Immunol 116:547-53. 1999
    ..The possible relationship between the pathogenesis of XP and our findings is discussed...
  10. ncbi Cloning and characterization of a cDNA encoding bovine mannan-binding protein
    T Kawai
    Department of Food Microbiology, Osaka Prefectural Institute of Public Health, Japan
    Gene 186:161-5. 1997
    ..Finally, these genomic and biological analyses indicate that the cDNA obtained here encoded a bovine serum MBP...
  11. ncbi Molecular cloning and characterization of the gene coding for azoreductase from Bacillus sp. OY1-2 isolated from soil
    Y Suzuki
    Departments of Pathology, Food Microbiology, and Environmental Sanitation, Osaka Prefectural Institute of Public Health, 1 3 69, Nakamichi, Higashinari ku, Osaka 537 0025, Japan
    J Biol Chem 276:9059-65. 2001
    ..This is the first report describing the sequencing and characterization of a gene encoding the azo dye-reducing enzyme, azoreductase, from aerobic bacteria and its expression in E. coli...
  12. ncbi Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall
    S Tsuji
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    J Biol Chem 276:23456-63. 2001
    ..These results suggested that hIntL is a new type lectin recognizing galactofuranose, and that hIntL plays a role in the recognition of bacteria-specific components in the host...
  13. ncbi Characterization of Norwalk virus GI specific monoclonal antibodies generated against Escherichia coli expressed capsid protein and the reactivity of two broadly reactive monoclonal antibodies generated against GII capsid towards GI recombinant fragments
    T Yoda
    Division of Food Microbiology, Osaka Prefectural Institute of Public Health, Nakamichi 1 3 69, Higashinari ku, Osaka 537 0025, Japan
    BMC Microbiol 1:24. 2001
    ..In the same study, two broadly reactive monoclonal antibodies were observed to react with genogroup I recombinant protein...
  14. ncbi Mutations in rpoB gene of rifampicin resistant clinical isolates of Mycobacterium tuberculosis in Japan
    Y Suzuki
    Department of Pathology, Osaka Prefectural Institute of Public Health, Japan
    Kansenshogaku Zasshi 69:413-9. 1995
    ..tuberculosis. Our results suggest that direct DNA sequencing of the rpoB gene may be a reliable method for identifying rifampicin-resistant M. tuberculosis strains among Japanese clinical isolates...
  15. ncbi Zonisamide in West syndrome
    Y Suzuki
    Collaborate Clinical Research Group for Pediatric Neurology, Osaka University Medical School, Osaka, Japan
    Brain Dev 23:658-61. 2001
    ..No serious side effects have been reported so far. ZNS may be both effective and well tolerated for the initial treatment of selected patients with West syndrome...
  16. ncbi Bisphenol A in ambient air particulates responsible for the proliferation of MCF-7 human breast cancer cells and Its concentration changes over 6 months
    H Matsumoto
    Division of Food Chemistry, Department of Food and Drugs, Osaka Prefectural Institute of Public Health, Japan
    Arch Environ Contam Toxicol 48:459-66. 2005
    ..In spite of this decline, the possibility remains that the estrogenic activity mainly originated from BPA...
  17. ncbi Long-term response to zonisamide in patients with West syndrome
    Y Suzuki
    Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, Murodo cho, Izumi, Japan
    Neurology 58:1556-9. 2002
    ..No serious adverse reactions were noted. ZNS may be both effective and well tolerated for the treatment of West syndrome...
  18. ncbi Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients
    G Tamura
    Department of Pathology, Yamagata University School of Medicine, Japan
    Eur J Cancer 35:316-9. 1999
    ..In summary, mtDNA is mutated in a subset of benign and malignant gastric tumours, but, disruption of the mtDNA repair system appears not to be significantly involved in gastric tumours of Japanese patients...
  19. ncbi Analysis of genetic alterations in renal cell carcinoma using the polymerase chain reaction
    Y Suzuki
    Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan
    Virchows Arch 424:453-7. 1994
    ..The results suggest that the genetic pathway in the genesis of RCC differs considerably from that of other common human carcinomas...
  20. ncbi Synthesis of basement membrane by gastrointestinal cancer cell lines
    T Akashi
    Department of Pathology, Tokyo Medical and Dental University, Japan
    J Pathol 187:223-8. 1999
    ..This abnormality might play some role in stromal invasion by tumour cells in gastrointestinal cancer...
  21. ncbi Detection of culturable and nonculturable Legionella species from hot water systems of public buildings in Japan
    A Edagawa
    Department of Environment and Water, Osaka Prefectural Institute of Public Health, Higashinari ku, Osaka, Japan
    J Appl Microbiol 105:2104-14. 2008
    ..To investigate the prevalence of culturable and nonculturable Legionella species in hot water systems of public buildings in Japan and assess the risk factors associated with Legionella contamination in hot water systems...
  22. ncbi Effectiveness and safety of mutant Escherichia coli heat-labile enterotoxin (LT H44A) as an adjuvant for nasal influenza vaccine
    Y Hagiwar
    Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, 162-8640, Tokyo, Japan
    Vaccine 19:2071-9. 2001
    ..These results suggest that LT H44A, which can be produced in high yields in an E. coli culture (about 5 mg/l), could be used as one of the effective and safe adjuvants for nasal influenza vaccine in humans...
  23. ncbi Immune responses and protection in different strains of aged mice immunized intranasally with an adjuvant-combined influenza vaccine
    H Asanuma
    Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
    Vaccine 19:3981-9. 2001
    ..These results suggest that local Ab responses, as well as systemic Ab responses, are downregulated in aged mice, although the degree of the downregulation of immune responses differs from strain to strain...
  24. ncbi Immunohistochemical localization of heparan sulfate proteoglycan in human gastrointestinal tract
    M Oshiro
    Department of Pathology, Tosei General Hospital, 160 Nishi-Oiwake-Cho, Seto 489-8642, Japan
    Histochem Cell Biol 115:373-80. 2001
    ..These characteristic localizations of HS-PG in intestines and stomachs suggest that this kind of HS-PG staining could be a hallmark characteristic of the intestine...
  25. ncbi Cloning and sequencing of a cDNA coding for bovine conglutinin
    Y Suzuki
    Department of Pathology, Osaka Prefectural Institute of Public Health, Japan
    Biochem Biophys Res Commun 191:335-42. 1993
    ..Northern blot analysis of bovine tissues showed that conglutinin mRNA of about 1.5 kb is expressed in the liver and also slightly in the lung...
  26. ncbi Resistance to acidic and alkaline environments in the endodontic pathogen Enterococcus faecalis
    K Nakajo
    Division of Oral Ecology and Biochemistry, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Oral Microbiol Immunol 21:283-8. 2006
    ..These characteristics may account for why E. faecalis is frequently isolated from acidic caries lesions and from persistently infected root canals where calcium hydroxide medication is ineffective...
  27. ncbi Nested polymerase chain reaction for assessing the clinical course of tuberculous meningitis
    T Takahashi
    Division of Neurology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    Neurology 64:1789-93. 2005
    ..During anti-tuberculosis treatments, N-PCR results converted from positive to negative, correlating with the improvement of the patient's clinical condition...
  28. ncbi [Usefulness of self ligation mediated polymerase chain reaction: a rapid method for fingerprinting in molecular epidemiology of tuberculosis]
    A Ruhul
    Division of Organ Transplantation, Biomedical Research Center, Osaka University Graduate School of Medicine, Japan
    Kekkaku 76:9-18. 2001
    ..By using this method, M. tuberculosis strains can be differentiated within 8 hours...
  29. ncbi Occurrence of nonylphenol, nonylphenol ethoxylate surfactants and nonylphenol carboxylic acids in wastewater in Japan
    K Komori
    Water Environment Research Group, Public Works Research Institute, Tsukuba, Ibaraki, Japan
    Water Sci Technol 53:27-33. 2006
    ..removal efficiency for the short EO chain NPnEO was less significant than the long EO chain NPnEO, suggesting that the degradation rate of the short EO chain NPnEO was lower than that of the long EO chain NPnEO in the wastewater treatment..
  30. ncbi Abnormal messenger ribonucleic acid (mRNA) transcribed from a mutant insulin receptor gene in a patient with type A insulin resistance
    F Shimada
    Second Department of Internal Medicine, Chiba University School of Medicine, Japan
    Diabetologia 35:639-44. 1992
    ..Thus, the proband is a heterozygote for a single mutant allele. Abnormal mRNA transcribed from the mutant allele resulted in a decrease in insulin binding...
  31. ncbi Point mutations in the upstream region of the alpha-galactosidase A gene exon 6 in an atypical variant of Fabry disease
    S Ishii
    Department of Clinical Genetics, Tokyo Metropolitan Institute of Medical Sciences, Japan
    Hum Genet 89:29-32. 1992
    ....
  32. ncbi Epidemiological investigation of a fatal case of cholera in Japan by phenotypic techniques and pulsed-field gel electrophoresis
    M Matsumoto
    Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya, Aichi, Japan
    J Med Microbiol 51:264-8. 2002
    ..These results suggest that a new clone was introduced after 1993 from overseas and then disseminated into Aichi, and this may have been an important step in triggering the fatal case of cholera...
  33. ncbi Molecular analysis of the deletion mutants in the E homeotic complex of the silkworm Bombyx mori
    K Ueno
    National Institute for Basic Biology, Okazaki, Japan
    Development 114:555-63. 1992
    ..From these results, we conclude that the Bombyx E complex consists of the Ubx, abd-A and possibly Abd-B genes, which may play similar roles to their homologues in the Drosophila bithorax complex...
  34. ncbi A human gene responsible for Zellweger syndrome that affects peroxisome assembly
    N Shimozawa
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Science 255:1132-4. 1992
    ..The homozygous patient apparently inherited the mutation from her parents, each of whom was heterozygous for that mutation...
  35. ncbi Duck and human pandemic influenza A viruses retain sialidase activity under low pH conditions
    T Takahashi
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Shizuoka 422-8526, Japan
    J Biochem 130:279-83. 2001
    ....
  36. ncbi Analysis of the insulin-sensitive phosphodiesterase 3B gene in type 2 diabetes
    R Sano
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8670, Chiba, Japan
    Diabetes Res Clin Pract 54:79-88. 2001
    ..In conclusion, alterations in the PDE3B gene are unlikely to contribute importantly to the pathogenesis of type 2 diabetes mellitus or lipoatrophic diabetes mellitus in Japan...
  37. ncbi GM1-gangliosidosis: tandem duplication within exon 3 of beta-galactosidase gene in an infantile patient
    A Oshima
    Department of Clinical Genetics, Tokyo Metropolitan Institute of Medical Science, Japan
    Clin Genet 41:235-8. 1992
    ..A single base substitution 316Trp----Cys was found in the other allele. Family study showed that the duplication was transmitted from his father and the base substitution from his mother...
  38. ncbi Association of the mitochondrial DNA 5178A/C polymorphism with maternal inheritance and onset of type 2 diabetes in Japanese patients
    D Wang
    Third Department of Internal Medicine, Showa University School of Medicine, 1 5 8, Hatanodai, Shinagawa, Tokyo 142 8666, Japan
    Exp Clin Endocrinol Diabetes 109:361-4. 2001
    ..5 +/- 10.0 years; P = 0.0073). The mt5178A/C polymorphism may be associated with maternal inheritance of type 2 diabetes and may influence the age at onset through deterioration of mitochondrial function...
  39. ncbi Phylogenetic analysis of field isolates of feline calcivirus (FCV) in Japan by sequencing part of its capsid gene
    Y Sato
    Department of Microbiology, School of Veterinary Medicine, Azabu University, Fuchinobe, Kanagawa-ken, Japan
    Vet Res Commun 26:205-19. 2002
    ....
  40. ncbi Preventive effect of sulphated colominic acid on P-selectin-dependent infiltration of macrophages in experimentally induced crescentic glomerulonephritis
    D Ogawa
    Department of Medicine III, Okayama University Medical School, Japan
    Clin Exp Immunol 129:43-53. 2002
    ..Moreover, SCA may inhibit intraglomerular infiltration of macrophages by interfering with P-selectin-dependent adhesion pathway, and progression of experimental crescentic glomerulonephritis...
  41. ncbi Diversification of Cercopithifilaria species (Nematoda: Filarioidea) in Japanese wild ruminants with description of two new species
    S Uni
    Department of Medical Zoology, Osaka City University Medical School, Osaka 545 8585, Japan
    Parasite 9:293-304. 2002
    ..longa type derived from Eurasiatic ancestors, which has disappeared or, more probably, not yet been discovered...
  42. ncbi Natural history of extensive Mongolian spots in mucopolysaccharidosis type II (Hunter syndrome): a survey among 52 Japanese patients
    T Ochiai
    Department of Dermatology, Surugadai Nihon University Hospital, Tokyo, Japan
    J Eur Acad Dermatol Venereol 21:1082-5. 2007
    ..However, a statistical survey of the incidence and natural history of extensive Mongolian spots among the patients with Hunter syndrome is lacking...
  43. ncbi Bacterial superantigens and T cell receptor beta-chain-bearing T cells in the immunopathogenesis of ulcerative colitis
    N Shiobara
    Department of Rheumatology and Clinical Immunology, Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital, Kanagawa, Japan
    Clin Exp Immunol 150:13-21. 2007
    ..Future studies should strengthen our findings and increase understanding on the aetiology of IBD...
  44. ncbi Study on risk management of heavy metals for reuse of biosolids
    M Ozaki
    Material and Geotechnical Engineering Research Group, Public Works Research Institute, Tsukuba, Japan
    Water Sci Technol 53:189-95. 2006
    ..Therefore, it was considered that the acid extractable contents of heavy metal would be important...
  45. ncbi Association between ADAM33 polymorphisms and adult asthma in the Japanese population
    T Hirota
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan
    Clin Exp Allergy 36:884-91. 2006
    ..It is important to know whether the association exists in ethnically diverse populations...
  46. ncbi The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine
    T Sugai
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Pharmacogenomics J 6:351-6. 2006
    ..The mean score of nausea severity was corrected by the Bonferroni test. HTR3B gene polymorphisms are significant predictors of paroxetine-induced nausea...
  47. ncbi Development of on-site fish exposure system placed in water quality monitoring stations along a river
    T Higashitani
    Water Quality Research Team, Public Works Research Institute, 1 6, Minami hara, Tsukuba, Ibaraki, 305 8516 Japan
    Water Sci Technol 52:275-82. 2005
    ..Furthermore, after continuous 2-week exposure, the vitellogenin production of male medaka was reduced similar to the decrease of the concentrations of the estrone and the estrogenic activity of river water...
  48. ncbi The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma
    C Maesawa
    Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan
    J Pathol 176:249-58. 1995
    ..The considerable differences in the incidences of genetic alterations between gastric adenoma and carcinoma indicate that the sequential development of gastric carcinoma from adenoma is uncommon in gastric carcinogenesis...
  49. ncbi Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus
    M Murata
    Department of Medicine, Keio University, Tokyo, Japan
    Diabet Med 21:837-44. 2004
    ..To investigate possible associations between diabetic microangiopathy and genetic polymorphisms in factors relevant to arterial thrombosis...
  50. ncbi Load of heavy metals in the airborne dust particulates of an urban city of central India
    Manisha Thakur
    School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, India
    Environ Monit Assess 95:257-68. 2004
    ..These large levels of metal pollutants have also been correlated with some meteorological parameters like temperature, relative humidity and wind velocity, and strong positive correlations have been observed...
  51. ncbi Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan
    Y Suzuki
    Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Br J Cancer 90:1361-3. 2004
    ..84 (95% confidence interval 0.57-1.24, Trend P=0.69)...
  52. ncbi Removal of suspended substances by coagulation and foam separation from municipal wastewater
    Y Suzuki
    Department of Civil and Environmental Engineering, Miyazaki University, 1-1, Gakuen Kibanadainishi, Miyazaki 889-2192, Japan
    Water Sci Technol 46:183-8. 2002
    ..It became clear that coagulation and foam separation using casein as the collector is an effective method for removing suspended solids in municipal wastewater in a short time (within 10 min)...
  53. ncbi Intravenous catheter-related septic shock caused by Staphylococcus sciuri and Escherichia vulneris
    T Horii
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Scand J Infect Dis 33:930-2. 2001
    ..Our results also showed that S. sciuri is an important reservoir of genetic determinants of beta-lactam resistance as a human pathogen carrying the mecA and beta-lactamase genes...
  54. ncbi Water reuse in Japan
    M Ogoshi
    Advanced Wastewater Treatment Division, Public Works Research Institute, Ministry of Construction, Asahi 1, Tsukuba-shi, Ibaraki-ken 305-0804, Japan
    Water Sci Technol 43:17-23. 2001
    ..This paper summarizes the current status of water reuse in Japan and discusses dominant uses of reclaimed water, emphasizing non-potable urban applications such as toilet flushing, industrial reuse, and environmental water...
  55. ncbi Clinical and molecular analysis of a Japanese boy with Morquio B disease
    N Ishii
    Department of Clinical Genetics, Tokyo Metropolitan Institute of Medical Science, Japan
    Clin Genet 48:103-8. 1995
    ..Gene analysis revealed two mutant alleles, 83Tyr-->His (Y83H) and 482Arg-->Cys (R482C). The former expressed a low enzyme activity (2-5% of normal), and the latter expressed no detectable enzyme activity...
  56. ncbi [Epidemiological characteristics and virulence factor of verotoxin-producing Eschericia coli O121:H19 isolated in Akita Prefecture in July 1997]
    J Yatsuyanagi
    Akita Prefectural Institute of Public Health
    Kansenshogaku Zasshi 73:218-24. 1999
    ..Antiserum for E. coli serogroup O121 should be manufactured to clarify the epidemiology of the highly virulent VTEC strain...
  57. ncbi A novel nonsense mutation of the PEX7 gene in a patient with rhizomelic chondrodysplasia punctata
    N Shimozawa
    Department of Pediatrics, Gifu University School of Medicine, Japan
    J Hum Genet 44:123-5. 1999
    ..R232ter, which deletes all of the last two WP40 repeats in the PEX7 gene, is sufficient to inactivate functions of the PEX7 gene...
  58. ncbi A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro
    K Yagui
    Department of Internal Medicine II, Chiba University School of Medicine, Japan
    Diabetologia 41:1024-8. 1998
    ..The Arg140Trp mutation on CD38 thus appears to contribute to the development of Type II diabetes mellitus via the impairment of glucose-induced insulin secretion in the presence of other genetic defects...
  59. ncbi Molecular analysis of glycogen storage disease type Ib: identification of a prevalent mutation among Japanese patients and assignment of a putative glucose-6-phosphate translocase gene to chromosome 11
    S Kure
    Department of Medical Genetics, Tohoku University School of Medicine, Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Biochem Biophys Res Commun 248:426-31. 1998
    ..The W118R mutation was found in 4 out of 8 mutant alleles, suggesting that it is prevalent among Japanese patients...
  60. ncbi Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase
    T Aoyama
    Department of Biochemistry, Shinshu University School of Medicine, Nagano, Japan
    Biochem Biophys Res Commun 198:1113-8. 1994
    ....
  61. ncbi A new compound heterozygous mutation (W17X, 436 + 5G --> T) in the cytochrome P450c17 gene causes 17 alpha-hydroxylase/17,20-lyase deficiency
    Y Suzuki
    Department of Pediatrics, Gunma University School of Medicine, Japan
    J Clin Endocrinol Metab 83:199-202. 1998
    ..The present findings indicate that in this patient, 17 alpha-hydroxylase/17,20-lyase deficiency was caused by the compound heterozygous mutation of exon and splice site mutation in cytochrome P450c17 gene...
  62. ncbi Polymorphism in ALDH2-genotype in Japanese men and the alcohol-blood pressure relationship
    I Tsuritani
    Department of Hygiene, Kanazawa Medical University, Ishikawa, Japan
    Am J Hypertens 8:1053-9. 1995
    ..It can be concluded that polymorphism in the ALDH2-genotype found in Japanese men does not affect the individual sensitivity to the pressor effect of alcohol...
  63. ncbi Fourteen novel mucopolysaccharidosis IVA producing mutations in GALNS gene
    S Tomatsu
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Hum Mutat 10:368-75. 1997
    ..These findings, coupled with previously reported mutations, bring the total of different mutations to 41 among independent families with MPS IVA, illustrating the extensive allelic heterogeneity among mutations producing MPS IVA...
  64. ncbi Mutations in the TIGR gene in familial primary open-angle glaucoma in Japan
    Y Suzuki
    Am J Hum Genet 61:1202-4. 1997
  65. ncbi D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency: a newly identified peroxisomal disorder
    Y Suzuki
    Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan
    Am J Hum Genet 61:1153-62. 1997
    ..This seems to be the first report of D-bifunctional protein deficiency. Patients previously diagnosed as cases of L-bifunctional protein deficiency probably should be reexamined for a possible d-bifunctional protein deficiency...
  66. ncbi Mucopolysaccharidosis type I: identification of common mutations that cause Hurler and Scheie syndromes in Japanese populations
    A Yamagishi
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Hum Mutat 7:23-9. 1996
    ..These data continue to document the molecular heterogeneity and racial differences in mutations in MPS-I...
  67. ncbi Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines
    G Tamura
    Department of Pathology, Iwate Medical University School of Medicine, Uchimaru, Morioka
    Jpn J Cancer Res 87:1153-9. 1996
    ..These data provide support for classic two-hit inactivation of the E-cadherin gene in a high percentage of undifferentiated carcinomas of the scattered type...
  68. ncbi Four newly identified ornithine transcarbamylase (OTC) mutations (D126G, R129H, I172M and W332X) in Japanese male patients with early-onset OTC deficiency
    T Matsuura
    Department of Pediatrics, Kumamoto University School of Medicine, Japan
    Hum Mutat 3:402-6. 1994
  69. ncbi Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1
    K Inoue
    Osaka Prefectural Institute of Public Health, Japan
    Jpn J Hum Genet 39:337-43. 1994
    ..The results showed that three human CYP2C8, 2C9, and 2C10 cDNAs were located at the same subchromosomal region, 10q24.1...
  70. ncbi Serovars of Erysipelothrix species isolated from the tonsils of healthy cattle in Japan
    R Hassanein
    Department of Veterinary Microbiology, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
    Vet Microbiol 82:97-100. 2001
    ..Of 42 isolates identified as Erysipelothrix rhusiopathiae, 4, 6, 2, 3, 1,12, 13 and 1 isolates belonged to serovars 1b, 2, 5, 9, 12, 13, 19 and 21, respectively. One isolate belonged to Erysipelothrix tonsillarum serovar 3...
  71. ncbi Mannose-binding lectin gene: polymorphisms in Japanese patients with systemic lupus erythematosus, rheumatoid arthritis and Sjögren's syndrome
    A Tsutsumi
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tennodai, Japan
    Genes Immun 2:99-104. 2001
    ..We conclude that persons homozygous for codon 54 mutation of the MBL gene may be prone to occurrence of autoimmune disorders including SLE, in the Japanese. MBL may have protective effects on occurrence and progression of SLE...
  72. ncbi Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases
    K Yoshida
    Department of Clinical Genetics, Tokyo Metropolitan Institute of Medical Science, Japan
    Am J Hum Genet 49:435-42. 1991
    ..Genotype-phenotype correlations in GM1-gangliosidosis are briefly discussed...
  73. ncbi A new point mutation within exon 5 of beta-hexosaminidase alpha gene in a Japanese infant with Tay-Sachs disease
    T Nakano
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill
    Ann Neurol 27:465-73. 1990
    ....
  74. ncbi Two new mutations, Q473X and N487S, in a Caucasian patient with mucopolysaccharidosis IVA (Morquio disease)
    S Tomatsu
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Hum Mutat 6:195-6. 1995
  75. ncbi Mutations in the hepatocyte nuclear factor-4alpha gene in Japanese with non-insulin-dependent diabetes: a nucleotide substitution in the polypyrimidine tract of intron 1b
    K Sakurai
    Department of Internal Medicine II, Chiba University School of Medicine, Japan
    Horm Metab Res 32:316-20. 2000
    ....
  76. ncbi Heterogeneous mutations in the glycogen-debranching enzyme gene are responsible for glycogen storage disease type IIIa in Japan
    M Okubo
    Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan
    Hum Genet 106:108-15. 2000
    ..These results demonstrate the importance of the integrity of the carboxy terminal domain in the AGL protein and the molecular heterogeneity of GSD IIIa in Japan...
  77. ncbi Compound heterozygous patient with glycogen storage disease type III: identification of two novel AGL mutations, a donor splice site mutation of Chinese origin and a 1-bp deletion of Japanese origin
    M Okubo
    Department of Endocrinology and Metabolism, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan
    Am J Med Genet 93:211-4. 2000
    ..To our knowledge, this is the first report of a mutation identified in a GSD III patient from the Chinese population...
  78. ncbi Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase
    S M Najjar
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 34:9341-9. 1995
    ..These data suggest that tyrosine phosphorylation of pp120/HA4 may regulate Ca2+/Mg(2+)-dependent ecto-ATPase activity...
  79. ncbi Embryonic silk gland development in Bombyx: molecular cloning and expression of the Bombyx trachealess gene
    K Matsunami
    Graduate University for Advanced Studies, Myodaiji cho, Okazaki 444 8585, Japan
    Dev Genes Evol 209:507-14. 1999
    ..These results suggest that Bombyx trh plays a role in the formation of the trachea and the anterior silk glands...
  80. ncbi Alpha-galactosidase gene mutations in Fabry disease: heterogeneous expressions of mutant enzyme proteins
    T Okumiya
    Department of Clinical Genetics, Tokyo Metropolitan Institute of Medical Science, Japan
    Hum Genet 95:557-61. 1995
    ..Both A156V and L166V expressed significant amounts of residual enzyme activity (6.7% and 9.8%) and enzyme proteins (10% each), the latter were more thermolabile at neutral pH than at acid pH, in vitro...
  81. ncbi Mucopolysaccharidosis IVA: screening and identification of mutations of the N-acetylgalactosamine-6-sulfate sulfatase gene
    T Ogawa
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Hum Mol Genet 4:341-9. 1995
    ....
  82. ncbi [Outcome of initial treatment with high-dose vitamin B6, valproate sodium or clonazepam in West syndrome]
    Y Suzuki
    Department of Pediatrics, Osaka University Medical School
    No To Hattatsu 28:398-402. 1996
    ..Symptomatic "nonresponders" had the worst prognosis. Our results suggest that choice of drug in the initial treatment of West syndrome should be determined by clinical features (especially etiology)...