Tetsuya Sugiyama

Summary

Affiliation: Osaka Medical College
Country: Japan

Publications

  1. ncbi request reprint Effects of advanced glycation end products on hyaluronan photolysis: a new mechanism of diabetic vitreopathy
    Chihiro Katsumura
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Ophthalmic Res 36:327-31. 2004
  2. ncbi request reprint [A case of normal-tension glaucoma with impaired eye movements in a young patient]
    Yukiko Yoshida
    Department of Ophthalmology, Ujigawa Hospital 31 Oinoki, Ogura cho, Uji 611 0042, Japan
    Nihon Ganka Gakkai Zasshi 110:477-83. 2006
  3. doi request reprint Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 52:64-9. 2011
  4. doi request reprint Involvement of P2X7 receptors in the hypoxia-induced death of rat retinal neurons
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 51:3236-43. 2010
  5. doi request reprint Use of laser speckle flowgraphy in ocular blood flow research
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Japan
    Acta Ophthalmol 88:723-9. 2010
  6. doi request reprint Effect of unoprostone on topographic and blood flow changes in the ischemic optic nerve head of rabbits
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City 569 8686, Japan
    Arch Ophthalmol 127:454-9. 2009
  7. doi request reprint Changes in optic nerve head blood flow induced by the combined therapy of latanoprost and beta blockers
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Japan
    Acta Ophthalmol 87:797-800. 2009
  8. ncbi request reprint Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Daigaku machi 2 7, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 85:406-12. 2007
  9. ncbi request reprint Advanced glycation end products induce death of retinal neurons via activation of nitric oxide synthase
    Takatoshi Kobayashi
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 81:647-54. 2005
  10. doi request reprint Effects of gelatin hydrogel containing chymase inhibitor on scarring in a canine filtration surgery model
    Shota Kojima
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 52:7672-80. 2011

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Effects of advanced glycation end products on hyaluronan photolysis: a new mechanism of diabetic vitreopathy
    Chihiro Katsumura
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Ophthalmic Res 36:327-31. 2004
    ..To test the effects of advanced glycation end products (AGEs), which are increased in vitreous of diabetic patients, on photolysis of hyaluronan...
  2. ncbi request reprint [A case of normal-tension glaucoma with impaired eye movements in a young patient]
    Yukiko Yoshida
    Department of Ophthalmology, Ujigawa Hospital 31 Oinoki, Ogura cho, Uji 611 0042, Japan
    Nihon Ganka Gakkai Zasshi 110:477-83. 2006
    ..We report a case of normal-tension glaucoma(NTG) with impaired eye movements in a young patient...
  3. doi request reprint Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 52:64-9. 2011
    ..To investigate the effects of fasudil, a Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor, on normal or impaired optic nerve head (ONH) blood flow in a rabbit model...
  4. doi request reprint Involvement of P2X7 receptors in the hypoxia-induced death of rat retinal neurons
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 51:3236-43. 2010
    ..To investigate the hypoxia-induced death of rat retinal neurons and to determine whether P2X(7) activation is involved in this type of neuronal death...
  5. doi request reprint Use of laser speckle flowgraphy in ocular blood flow research
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Japan
    Acta Ophthalmol 88:723-9. 2010
    ..Unresolved issues concern the effect of pupil size on measurement results, the effects of various stimulations, and how to measure choroidal and retinal blood flow velocity separately without using the blue-component of argon laser...
  6. doi request reprint Effect of unoprostone on topographic and blood flow changes in the ischemic optic nerve head of rabbits
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City 569 8686, Japan
    Arch Ophthalmol 127:454-9. 2009
    ..To determine whether subconjunctival injection of unoprostone isopropyl alters changes in the topography and blood flow of the optic disc induced by endothelin 1 (ET-1) in rabbits...
  7. doi request reprint Changes in optic nerve head blood flow induced by the combined therapy of latanoprost and beta blockers
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Japan
    Acta Ophthalmol 87:797-800. 2009
    ..To assess the effects of combined therapy with latanoprost and beta blockers on optic nerve head (ONH) blood flow in normal-tension glaucoma (NTG) patients...
  8. ncbi request reprint Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Daigaku machi 2 7, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 85:406-12. 2007
    ..Our findings indicate the ARB may inhibit the development of diabetic retinopathy by reducing the accumulation of pentosidine, one of AGEs and expression of VEGF in the retina...
  9. ncbi request reprint Advanced glycation end products induce death of retinal neurons via activation of nitric oxide synthase
    Takatoshi Kobayashi
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 81:647-54. 2005
    ..These results indicate that AGEs are neurotoxic to retinal neurons in culture through the activation of NOS. Apoptotic pathways may be in part involved in the death of the neurons...
  10. doi request reprint Effects of gelatin hydrogel containing chymase inhibitor on scarring in a canine filtration surgery model
    Shota Kojima
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 52:7672-80. 2011
    ..To investigate the effects of gelatin hydrogel (GH) containing a chymase inhibitor (CI) on intraocular pressure (IOP) and conjunctival scarring in a canine model of glaucoma surgery...
  11. doi request reprint A pilot study for the effects of donepezil therapy on cerebral and optic nerve head blood flow, visual field defect in normal-tension glaucoma
    Yukiko Yoshida
    Department of Ophthalmology, Ujigawa Hospital, vji, Kyoto, Japan
    J Ocul Pharmacol Ther 26:187-92. 2010
    ....
  12. doi request reprint Involvement of angiotensin II-dependent vascular endothelial growth factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model
    Masanori Fukumoto
    Department of Pharmacology, Osaka Medical College, Osaka, Japan
    Curr Eye Res 33:885-91. 2008
    ..In SDT rats, the plasma glucose level and angiotensin-converting enzyme (ACE) levels were measured, and effects of angiotensin II receptor blocker (ARB) and angiotensin II were also studied...
  13. ncbi request reprint Amelioration of endothelin-1-induced optic nerve head ischemia by topical bunazosin
    Wakana Goto
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Curr Eye Res 30:81-91. 2005
    ....
  14. ncbi request reprint Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis
    Denan Jin
    Department of Pharmacology, Osaka Medical College, Japan
    J Pharmacol Sci 109:275-84. 2009
    ....
  15. ncbi request reprint Adenosine protects cultured retinal neurons against NMDA-induced cell death through A1 receptors
    Hidehiro Oku
    Department of Ophthalmology, Osaka Medical, Osaka, Japan
    Curr Eye Res 29:449-55. 2004
    ....
  16. ncbi request reprint Effect of P2X7 receptor activation on the retinal blood velocity of diabetic rabbits
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Arch Ophthalmol 124:1143-9. 2006
    ..To test the effect of activation of P2X7 receptors on retinal blood velocity in diabetic rabbits...
  17. ncbi request reprint Effects of chymase on the macular region in monkeys and porcine muller cells: probable involvement of chymase in the onset of idiopathic macular holes
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, 27 Daigaku cho, Takatsuki, Osaka 569 8686, Japan
    Ophthalmic Res 38:201-8. 2006
    ..To investigate chymase involvement in idiopathic macular hole onset, the effects of chymase on monkey eyes and cultured Muller cells were investigated...
  18. ncbi request reprint Effects of caffeine on microcirculation of the human ocular fundus
    Takashi Okuno
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Jpn J Ophthalmol 46:170-6. 2002
    ..To determine the effect of caffeine on microcirculation in the human ocular fundus...
  19. doi request reprint Disruption of gap junctions may be involved in impairment of autoregulation in optic nerve head blood flow of diabetic rabbits
    Maho Shibata
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 52:2153-9. 2011
    ..To determine whether an impairment of the autoregulatory mechanism of blood flow in the optic nerve head (ONH) is present in diabetic rabbits and whether the impairment results from the uncoupling of gap junctions...
  20. doi request reprint Involvement of NADPH oxidase and protein kinase C in endothelin-1-induced superoxide production in retinal microvessels
    Junko Matsuo
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 89:693-9. 2009
    ..The activation of PKC may be involved in the mechanism. Thus, ET-1 may augment its vasoconstrictive effects through the formation of superoxide, which may impair the bioavailability of nitric oxide in the retinal microvasculature...
  21. ncbi request reprint Endothelin-1 (ET-1) causes death of retinal neurons through activation of nitric oxide synthase (NOS) and production of superoxide anion
    Hidehiro Oku
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi Takatsuki Osaka, 569 8686 Japan
    Exp Eye Res 86:118-30. 2008
    ..These results indicate that the neuronal death caused by ET-1 is most likely mediated by the activation of NOS in association with the formation of superoxides and peroxynitrite...
  22. ncbi request reprint Endothelin-1 enhances glutamate-induced retinal cell death, possibly through ETA receptors
    Takatoshi Kobayashi
    Department of Ophthalmology, Osaka Medical College, Takatsuki Osaka, Japan
    Invest Ophthalmol Vis Sci 46:4684-90. 2005
    ..To determine the modification of the glutamate-induced death of retinal neurons by endothelin (ET)-1...
  23. doi request reprint Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve
    Hidehiro Oku
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Curr Eye Res 33:611-20. 2008
    ..To determine the alterations in the expression of endothelin-1 (ET-1) and its specific receptors in the sensory retina after optic nerve injury...
  24. doi request reprint Effect of hypoxia on susceptibility of RGC-5 cells to nitric oxide
    Takaki Sato
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Invest Ophthalmol Vis Sci 51:2575-86. 2010
    ..To determine whether retinal neurons become more susceptible to injury by nitric oxide (NO) under hypoxic conditions...
  25. ncbi request reprint Effects of poly(ADP-ribose) polymerase inhibitor on NMDA-induced retinal injury
    Hidehiro Oku
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Curr Eye Res 29:403-11. 2004
    ..The purpose of this study was to determine whether inhibition of PARP has some neuroprotective effects on the N-methyl-D-aspartate (NMDA)-induced functional and morphological injury to the rabbit retina...
  26. doi request reprint Involvement of glial cells in the autoregulation of optic nerve head blood flow in rabbits
    Maho Shibata
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 53:3726-32. 2012
    ..To investigate the involvement of glial cells in the autoregulation of optic nerve head (ONH) blood flow in response to elevated intraocular pressure (IOP)...
  27. doi request reprint Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation
    Masahiro Tonari
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Invest Ophthalmol Vis Sci 53:3490-500. 2012
    ..The purpose of this study was to determine whether blocking the ET signals will protect retinal ganglion cells (RGCs) from optic nerve injury...
  28. ncbi request reprint Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test
    Teruyo Kida
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Graefes Arch Clin Exp Ophthalmol 245:1289-93. 2007
    ..To determine the relationship between the changes in optic nerve head (ONH) circulation and the level of plasma endothelin-1 (ET-1) during the glucose tolerance test (GTT)...
  29. ncbi request reprint Amelioration by topical bunazosin hydrochloride of the impairment in ocular blood flow caused by nitric oxide synthase inhibition in rabbits
    Wakana Goto
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku cho Takatsuki Osaka, 569 8686 Japan
    J Ocul Pharmacol Ther 19:63-73. 2003
    ..The enhancement of basal vascular tone due to deprivation of continuous NO production may be diminished by this alpha(1)-adrenergic blocker...
  30. ncbi request reprint Evaluation of nitric oxide synthesis in the optic nerve head in vivo using microdialysis and high-performance liquid chromatography and its interaction with endothelin-1
    Takashi Okuno
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Ophthalmic Res 35:78-83. 2003
    ..To investigate the relationship between nitric oxide synthesis and endothelin-1 (ET-1) in the optic nerve head in vivo...
  31. doi request reprint Changes in optic nerve head blood flow, visual function, and retinal histology in hypercholesterolemic rabbits
    Maho Shibata
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 93:818-24. 2011
    ..Downregulation of eNOS activity might be one of the causes for impairment of the autoregulation. Enhanced activity of iNOS might be involved in the impaired visual function and histology...
  32. pmc Effects of mitomycin C on the expression of chymase and mast cells in the conjunctival scar of a monkey trabeculectomy model
    Kouhei Okada
    Department of Ophthalmology, Takatsuki Red Cross Hospital, Osaka, Japan
    Mol Vis 15:2029-36. 2009
    ..To determine the effects of mitomycin C (MMC) on the expression of chymase and mast cells in the conjunctival scar after trabeculectomy...
  33. ncbi request reprint Correlation between angiotensin-converting enzyme, vascular endothelial growth factor, and matrix metalloproteinase-9 in the vitreous of eyes with diabetic retinopathy
    Eisuke Ishizaki
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    Am J Ophthalmol 141:129-134. 2006
    ....
  34. ncbi request reprint Effects of adenosine on optic nerve head circulation in rabbits
    Mami Hirao
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 79:729-35. 2004
    ..Activation of K(ATP) channels is strongly related to the mechanism of adenosine-induced increase in ONH blood flow, while the participation of adenylate cyclase is less likely...
  35. ncbi request reprint Long-term effect of topically applied isopropyl unoprostone on microcirculation in the human ocular fundus
    Yukiko Makimoto
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Jpn J Ophthalmol 46:31-5. 2002
    ..To investigate the long-term effect of 0.12% isopropyl unoprostone (Rescula) on microcirculation in the human ocular fundus...
  36. doi request reprint Involvement of P2X(7) receptors in retinal ganglion cell death after optic nerve crush injury in rats
    Keigo Kakurai
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    Neurosci Lett 534:237-41. 2013
    ..Collectively, these results suggest that P2X(7) antagonists prevent loss of RGCs after ONC, and that this protective effect is possibly mediated through suppressing the upregulation of retinal P2X(7) expression...
  37. ncbi request reprint Evidence that nitric oxide is involved in autoregulation in optic nerve head of rabbits
    Takashi Okuno
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki, Osaka, 569 8686 Japan
    Invest Ophthalmol Vis Sci 43:784-9. 2002
    ..To determine the role played by nitric oxide (NO) in the autoregulation of circulation in the optic nerve head (ONH)...
  38. doi request reprint Electroretinographic study of spontaneously diabetic Torii rats
    Takashi Okuno
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi Takatsuki, Osaka, 569 8686, Japan
    Doc Ophthalmol 117:191-6. 2008
    ..These depressed ERGs may reflect vascular and neuronal damage throughout the retina as are seen in the advanced stages of human diabetic retinopathy. Thus, the SDT rat can be used to study the retinal physiology of diabetic retinopathy...
  39. ncbi request reprint Glutamate level in optic nerve head is increased by artificial elevation of intraocular pressure in rabbits
    Takashi Okuno
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku cho Takatsuki Osaka 569 8686 Japan
    Exp Eye Res 82:465-70. 2006
    ..012; and IOP120, P=0.005: repeated measures ANOVA). Elevation of the IOP causes an increase in the glutamate levels in the ONH of rabbits. This suggests a possible interaction between glutamate metabolism and the IOP in the ONH...
  40. doi request reprint Nitric oxide potentiates TNF-α-induced neurotoxicity through suppression of NF-κB
    Atsuko Nakaizumi
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, 569 8686, Japan
    Cell Mol Neurobiol 32:95-106. 2012
    ..These results indicate that NO potentiates the neurotoxicity of TNF-α by suppressing NF-κB...
  41. doi request reprint Relationship between diabetic macular edema and peripheral Th1/Th2 balance
    Kyoko Itoi
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Ophthalmologica 222:249-53. 2008
    ..To determine whether inflammatory reactions are involved in the pathogenesis of diabetic macular edema, we examined the relationship between diabetic macular edema and the ratio of T helper 1 (Th1) to T helper 2 (Th2) cells...
  42. ncbi request reprint Change in retinal arterial blood flow in the contralateral eye of retinal vein occlusion during glucose tolerance test
    Teruyo Kida
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigakucho, Takatsuki, 569 8686, Japan
    Graefes Arch Clin Exp Ophthalmol 240:342-7. 2002
    ..To investigate the changes in retinal blood flow (RBF) during a 75-g oral glucose tolerance test in the contralateral eye of patients with retinal branch vein occlusion (BRVO)...
  43. pmc Systemic Simvastatin Rescues Retinal Ganglion Cells from Optic Nerve Injury Possibly through Suppression of Astroglial NF-κB Activation
    Seita Morishita
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    PLoS ONE 9:e84387. 2014
    ..We conclude that systemic simvastatin can reduce the death of RGCs induced by crushing the optic nerve possibly by suppressing astroglial NF-κB activation. ..
  44. doi request reprint Clinical results of selective laser trabeculoplasty in open-angle glaucoma in Japanese eyes: comparison of 180 degree with 360 degree SLT
    Maho Shibata
    Department of Ophthalmology, Osaka Medical College, Daigaku machi, Takatsuki shi, Osaka, Japan
    J Glaucoma 21:17-21. 2012
    ....
  45. ncbi request reprint Renin-angiotensin system in proliferative diabetic retinopathy and its gene expression in cultured human müller cells
    Teruyo Kida
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Jpn J Ophthalmol 47:36-41. 2003
    ..We also investigated whether the genes of the RAS factors were expressed by cultured human Müller cells...
  46. ncbi request reprint Changes in orbital hemodynamics induced by nipradilol in healthy volunteers
    Megumi Nakanishi
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    J Ocul Pharmacol Ther 20:25-33. 2004
    ..The current study suggests that nipradilol may dilate the CRA as a result of reduced vascular resistance in humans...
  47. ncbi request reprint Role of chymase on growth of cultured canine Tenon's capsule fibroblasts and scarring in a canine conjunctival flap model
    Midori Maruichi
    Department of Pharmacology, Osaka Medical College, 2 7 Diagaku machi, Takatsuki City, Osaka 569 8686, Japan
    Exp Eye Res 79:111-8. 2004
    ..6% compared with that in placebo-treated treated eyes. In conclusion, chymase stimulates proliferation of fibroblasts derived from canine Tenon's capsule and chymase may play an important role in scarring after glaucoma surgery...
  48. pmc P2X₇ receptor activation may be involved in neuronal loss in the retinal ganglion cell layer after acute elevation of intraocular pressure in rats
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Mol Vis 19:2080-91. 2013
    ..To investigate whether the P2X₇ receptor is involved in retinal ganglion cell (RGC) death after the intraocular pressure (IOP) is elevated in rats...
  49. pmc The first report on intermediate-term outcome of Ex-PRESS glaucoma filtration device implanted under scleral flap in Japanese patients
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Clin Ophthalmol 5:1063-6. 2011
    ..This paper compares the outcomes of the Ex-PRESS(®) Glaucoma Filtration Device (Alcon, Fort Worth, TX) implant observed in Japanese patients for 1 year with those of patients undergoing trabeculectomy...
  50. pmc A case involving an Ahmed™ glaucoma valve transferred from the vitreous into the anterior chamber of the eye with a silicone oil tamponade for the treatment of neovascular glaucoma
    Michiko Miki
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan
    Clin Ophthalmol 7:449-53. 2013
    ....
  51. ncbi request reprint Comparative study of cerebral blood flow in patients with normal-tension glaucoma and control subjects
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Am J Ophthalmol 141:394-6. 2006
    ..To evaluate regional cerebral blood flow (rCBF) in normal-tension glaucoma patients (NTGs) compared with normal volunteers (controls) in a pilot study...
  52. ncbi request reprint Transforming growth factor beta(2) increases in subretinal fluid in rhegmatogenous retinal detachment with subretinal strands
    Kumiko Hirase
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Ophthalmologica 219:222-5. 2005
    ..To compare transforming growth factor (TGF) beta(2) levels in subretinal fluid of rhegmatogenous retinal detachment with or without subretinal strand formation...
  53. doi request reprint Experimental autoimmune uveoretinitis initiated by non-phagocytic destruction of inner segments of photoreceptor cells by Mac-1(+) mononuclear cells
    Sayako Miura-Takeda
    Department of Physiology, Osaka Medical College, Takatsuki, Osaka, Japan
    Microbiol Immunol 52:601-10. 2008
    ..These results indicate that EAU was initiated by non-phagocytic destruction of inner segments of photoreceptor cells by Mac-1(+) mononuclear cells...
  54. ncbi request reprint Chymase and angiotensin converting enzyme activities in a hamster model of glaucoma filtering surgery
    Hitoshi Sakaguchi
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Curr Eye Res 24:325-31. 2002
    ..In this work, we created sclerocorneal wounds in hamster eyes and measured the levels of ACE and chymase activities in the eye during the wound healing process...
  55. ncbi request reprint Effect of chymase on intraocular pressure in rabbits
    Takashi Konno
    Drug Research Section II, Fukushima Research Laboratories, Yuno, Iizaka machi, Fukushima City, Fukushima, Japan
    Eur J Pharmacol 524:132-7. 2005
    ....
  56. ncbi request reprint Enhancement of P2X(7)-induced pore formation and apoptosis: an early effect of diabetes on the retinal microvasculature
    Tetsuya Sugiyama
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, USA
    Invest Ophthalmol Vis Sci 45:1026-32. 2004
    ....
  57. pmc ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina
    Hajime Kawamura
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor 48105, USA
    J Physiol 551:787-99. 2003
    ..Thus, ATP not only affects the contractility of individual pericytes, but also appears to regulate the spatial and temporal dynamics of the vasomotor response...
  58. ncbi request reprint CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules
    Satoshi Ueha
    Department of Molecular Preventive Medicine and SORST, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    J Leukoc Biol 82:1230-8. 2007
    ..Taken together, these data provide the evidence that CCR7 mediates nTreg migration to the paracortical areas of lymph nodes under steady-state conditions; however, CCR7-independent migration also takes place in the medulla...
  59. ncbi request reprint Regulation of P2X7-induced pore formation and cell death in pericyte-containing retinal microvessels
    Tetsuya Sugiyama
    Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA
    Am J Physiol Cell Physiol 288:C568-76. 2005
    ..Conversely, dysfunction of these protective mechanisms may be a previously unrecognized cause of cell death within the retinal microvasculature...